• 한국자기공명학회논문지
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• 제22권4호
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• pp.76-81
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• 2018

Investigation of the protein-protein interaction mode at atomic resolution is essential for understanding on the underlying functional mechanisms of proteins as well as for discovering druggable compounds blocking deleteriou interprotein interactions. Solution NMR spectroscopy provides accurate and precise information on intermolecular interactions even for weak and transient interactions, and it is also markedly useful for examining the change in the conformation and dynamics of target proteins upon binding events. In this mini-review, we comprehensively describe three unique and powerful methods of solution NMR spectroscopy, paramagnetic relaxation enhancement (PRE), pseudo-contact shift (PCS), and residual dipolar coupling (RDC), for the study on protein-protein interactions.

• 공업화학
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• 제30권3호
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• pp.379-383
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• 2019

The capability of detecting amyloid beta 42 ($A{\beta}42$), a biomarker of Alzheimer's disease, using a thiolated protein A-functionalized bimetallic surface plasmon resonance (SPR) chip was investigated. An optimized configuration of a bimetallic chip containing gold and silver was obtained through calculations in the intensity measurement mode. The surface of the SPR bimetallic chip was functionalized with thiolated protein A for the immobilization of $A{\beta}42$ antibody. The response of the thiolated protein A-functionalized bimetallic chip to $A{\beta}42$ in the concentration range of 50 to 1,000 pg/mL was linear. Compared to protein A without thiolation, the thiolated protein A resulted in greater sensitivity. Therefore, the thiolated protein A-functionalized bimetallic SPR chip can be used to detect very low concentrations of the biomarker for Alzheimer's disease.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 추계학술대회 논문집 Vol.16
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• pp.356-359
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• 2003

This paper deals with a flat type ultrasonic motor, which uses a longitudinal-bending multi mode vibrator of rectangular form. This ultrasonic motor was designed by combination of the first longitudinal and eighth bending mode, and the motor consisted of a straight aluminum alloy bar bonded with piezoelectric ceramic elements as a driving element. The geometrical dimensions of the rectangular aluminum vibrator were determined by Euler-Bernoulli theory In the experimental device, piezoelectric ceramics ( a piece of ceramic for the L-mode, $24\;{\times}\;8\;{\times}\;1[mm]$, and four pieces for the B-mode, $12.5\;{\times}\;8\;{\times}\;1[mm]$) were attached to one side of a aluminum plate($100\;{\times}\;8\;{\times}\;1[mm]$), and the stator was supported with a plastic case. As results, no-load rpm was 50[rev./m] when applied voltage was 150[Vrms] at the resonance frequency, and as the voltage was increased, the rpm was increased.

• Investigative Magnetic Resonance Imaging
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• 제1권1호
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• pp.66-74
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• 1997

혈액의 산소화와 불 산소화에 따른 국부적인 자화율 효과의 변화에 의한 자장의 불 균일성에 민감한 경사 자장 에코 기법은 현재의 뇌기능 MR 영상의 기본이 되고 있다. 일반적으로 이러한 경사 자장 에코기법은 $T2^{*}$ 혹은 BOLD효과에 의한 자장의 불 균일성의 증가가 신호의 감소로 나타난다. BOLD 효과는 주자장에 대한 핏줄의 방향이나 영상 형식, 즉, 횡단면, 관상면, 또는 시상면에 따라 달라진다. 그래서 영상 형식과 영상면에 대한 기울임 각에 따른 신호의 변화와 BOLD 효과의 변화에 대한 정량적인 연구를 하였다. 연구는 자화율 효과에 대해 다른 민감도를 가지는 TRFGE 와 CGE 기법으로 이루어졌다. 컴퓨터 모의 실험과 실험 결과를 본 논문에 나타내었다.

• 소음진동
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• 제11권3호
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• pp.410-415
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• 2001

This paper describes an experimental analysis for improving the stability of blade failure due to the vibration resonance, which happens in the low-pressure steam turbine. Some cracks due to high cycle fatigue were found in the blades of a low-pressure turbine after long time operation. Impact test showed that such failure was mainly caused by the resonance. In other words, since one of the natural frequencies of the grouped blade is very close to the excitation frequency of the nozzle, the resonant vibration leads to a large amplitude of displacement and results in a large amount of stress that may cause fatigue failures in the blades. It is interesting that the blade failures occur only at blades neighboring with the nodal points of the natural vibration mode whose natural frequency is close to the nozzle passing frequency. The effective methods for increasing the reliability against the blade vibration are a heightening the fatigue limit of the blade using an advanced material and a removing the resonance away from the operating speed. It is well known that the removal of theresonance could be obtained by the installation of different types of shrouds, wires, and links between the blades as well as by the chance of the number of nozzles. In the present work, two kinds of modification for avoiding the resonance haute been considered; 1) slot-type finger, 2) long span cover. Full-scale mockup tests have been performed in order to confirm the verification for modification in the shop. Test results show that the use of long span cover is very useful to change the natural frequencies of the grouped blade and to avoid the resonance effectively.

• Journal of Biosystems Engineering
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• 제27권4호
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• pp.293-300
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• 2002

Surface crack detection is an important aspect in the quality control process of egg markets. The acoustic vibration of an egg could be used as a critical factor in evaluating the eggshell quality. The mode shape indicates the egg vibration behavior at different locations with respect to the input impulse and provides important information for the optimum sensor location to obtain the desired acoustic measurements. Theoretical analysis and experimental measurements were conducted to determine the acoustic vibration modes in eggs. The resonant fiequencies of the first and second resonance mode of intact eggs were found to be distributed between 2kHz and 7kHz range. The measured mode shapes of an egg were similar to theoretical shapes of homogeneous, elastic spheres. An elliptical deformation at the equator ring of the egg was observed. The frequency peak of this mode was dominantly present in the frequency spectrum of an intact egg impacted at its sharp position. The mode shapes related to the first resonant frequency of an egg shelved that the optimum location for the measuring sensor was the 180 degrees position. A optimum location for the egg support was found to be the 90 degrees position having the smallest vibration magnitude.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1986년도 하계학술대회논문집
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• pp.609-613
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• 1986

The resonance frequency and the gain for oscillation of external cavity diode lasers are derived by approximating the phase and the gain conditions. By modifying single mode rate equations for the external cavity diode laser, steady state solutions and their stability are studied.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2003년도 High Temperature Superconductivity Vol.XIII
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• pp.35-35
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• 2003

• 한국광학회:학술대회논문집
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• 한국광학회 2007년도 하계학술발표회 논문집
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• pp.115-116
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• 2007

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 추계학술대회 논문집
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• pp.61-62
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• 2009