• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.89.1-89.8
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• 2018

Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. Methods: Between 1980 and 2015, 281 patients with low-risk GTN were treated. Of these 281 patients, 178 patients were primarily treated with 5-day intramuscular methotrexate (MTX; n=114) or 5-day drip infusion etoposide (ETP; n=64). We examined the remission rates, the drug change rates, and the outcomes of second-line chemotherapy. Results: The primary remission rates and drug resistant rates of 5-day ETP were significantly higher (p<0.001) and significantly lower (p=0.002) than those of 5-day MTX, respectively. Forty-seven patients (26.4%) required a change in their chemotherapy regimen due to the SAEs (n=16) and drug resistance (n=31), respectively. Of these 47 patients failed the first-line regimen, 39 patients (39/47, 82.9%) were re-treated with single-agent chemotherapy, and 35 patients (35/39, 89.7%) achieved remission. Four patients failed second-line, single-agent chemotherapy and eight patients (17.0%) who failed first-line regimens were treated with combined or multi-agent chemotherapy and achieved remission. Conclusions: Patients with low-risk GTN were usually treated with single-agent chemotherapy, while 20%-30% patients had to change their chemotherapy regimen due to SAEs or drug resistance. The second-line regimens of single-agent chemotherapy were effective; however, there were several patients who needed multiple agents and combined chemotherapy to achieve remission.

• 대한치과보철학회지
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• 제41권1호
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• pp.71-80
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• 2003

Development of new ceramic and esthetic need of patient increased the use of ceramic restorations. The purpose of this study was to confirm the possibility of recycling for IPS Empress2 which has a lot of advantages in esthetics. 1st, 2nd and 3rd pressed disc-shaped($10{\times}1.5mm$) IPS Empress 2 specimens were made with IPS Empress ingot(shade 200, Ivoclar, Liechtenstein) and pressing furnace(IPS Empress EP 500, Ivoclar, Liechtenstein). Flexure strength was measured with universal testing machine(Zwick 145641, Zwick, Germany), and color change and staining resistance of specimens were evaluated with colorimeter (Model TC-6FX, Tokyo Denshoku Co., Japan). The followings were drawn from this study : 1. Flexure strength of the 1st, the 2nd, and the 3rd pressed specimens showed 236.78 MPa. 247.16MPa, and 220.72MPa, respectively. Flexure strength of the 2nd pressed specimens was higher than others, but there's no statistical difference between them. 2. The color difference between the 1st and the 2nd pressed specimens was 3.25, and that between the 1st and the 3rd pressed specimens was 3.63(P<0.05). 3. The color change after staining of the 1st, the 2nd. and the 3rd pressed specimens were 1.43, 2.64, and 1.45, respectively. In this study, reused IPS Empress 2 specimens showed insignificant change of flexure strength and stain resistance, but they showed some color change according to reuse. From this results, the limited possibility of reuse for IPS Empress 2 could be considered.

• 한국항행학회논문지
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• 제18권4호
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• pp.381-386
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• 2014

전기 커넥터에 영향을 주는 프레팅 부식 요인 중 하나인 접촉 부하의 영향을 조사하기 위하여, 프레팅 부식 표본 쌍을 두께 $3{\mu}m$의 두께를 갖는 주석으로 도금된 황동 표본을 사용하여 제조하였다. 접점의 전기저항은 프레팅 부식 시험 기간 동안 측정되었다. 프레팅 주기에서 저항은 증가하였다. 저항의 변화는 3단계로 나눌 수 있다. 첫 번째 단계는 미미하고 안정적인 저항을 나타내었다. 두 번째 단계는 저항이 꾸준한 증가를 보여 주었다. 그리고 세 번째 단계는 매우 높고 간헐적인 저항을 보여주었다. 실패주기(Nf)와 접촉력(P) 사이의 관계는 다음과 같이 표현될 수 있다. 각각의 하중, 변위, 온도 등 다양한 조건에서 프레팅 테스트를 통해 다양한 환경 조건 하에서 매우 높고 간헐적인 저항에 대응 전기 커넥터의 실패주기 예측공식의 표현이 가능할 것이다.

• 대한조선학회논문집
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• 제58권3호
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• pp.175-181
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• 2021

This study describes the model tests in ice according to the frictional coefficient of an ice-breaking ship and the change in ice resistance by the analysis method for each component of ice resistances. The target vessel is a 90K DWT ice-breaking tanker capable of operating in ARC7 ice conditions in the Arctic Ocean, and twin POD propellers are fitted. The hull was specially painted with four different frictional coefficients on the same ship model. The total ice resistance can be separated by ice breaking, ice buoyancy, ice clearing resistances through the tests in level ice, pre-sawn ice and creep test in pre-sawn ice under sea ice thickness of 1.2 m and 1.7 m. Ice resistance was analyzed by correcting the thickness and bending strength of model ice by the ITTC correction method. As the frictional coefficient between the hull and ice increases, ice buoyancy and clearing resistances increase significantly. When the surface of the hull is rough, it is considered that the broken ice pieces do not slip easily to the side, resulting in an increase in ice buoyancy resistance. Also, the frictional coefficient was found to have a great influence on the ice clearing resistance as the ice thickness became thicker.

• 경영정보학연구
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• 제10권3호
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• pp.257-287
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• 2008

IT의 기업 내 수용과 확산의 과정에서 나타나는 추진동기(motivation)와 IT저항 그리고 변화관리의 관계를 Product Lifecycle Management(PLM)를 적용하는 9개 자동차기업의 15개 의 다중사례를 기반으로 다루었다. 이를 통해서 추진동기가 IT의 조직 내 확산에 미치는 영향과 IT저항과의 역학적 관계, 그리고 이 과정에서의 변화관리의 역할과 그 중요성을 고찰하기 위한 탐색적 모델이 제안되었다. 또 추진동기에 영향을 미치는 요인으로서 (1)경쟁, 불확실성, 경향, 상호연결성과 같은 환경적요인, (2)중앙집중성, 규모, 리더, 혁신후원가 및 복잡성과 같은 조직적요인, (3)인지된용의성, 인지된유익성과 같은 기술적 요인들을 살펴보았고, 이와 관련된 주요 명제 6가지를 제안하였다. 여기서 추진동기가 IT저항을 충분히 극복할 경우에 수용 및 확산이 지속되고, 변화관리가 이 과정에서 추진동기에 정(+)의 작용을 하고, IT저항을 줄이는 방향으로 전개되는 것이 중요함이 논의되었으며, 환경요인, 조직요인 및 기술요인이 추진동기에 미치는 영향이 있음이 구체적으로 관찰되었다. 이를 통해서 IT의 조직 내 수용과 확산을 위한 요소들에 대한 정의와 그 시사점을 제시하였고, 특별히 PLM과 관련된 향후의 연구기반을 제공할 수 있었다.

• 대한기계학회논문집A
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• 제35권7호
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• pp.799-804
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• 2011

본 논문에서는 칩저항을 실장하는 솔더에 대한 온도사이클 시험을 수행하고, 그 결과로부터 고장 예지 실현을 위한 열하중에서의 솔더실장의 고장메커니즘을 연구하였다. 시험 중 솔더의 고장을 모니터링하기 위하여 실장된 칩저항 양단간의 저항 변화를 데이터 측정기로 실시간 관찰하였다. 관찰 데이터로부터 솔더의 크랙 진전 중과 크랙 진전 완료 시점의 고장 메커니즘을 제시하였다. 제시된 고장 메커니즘을 유한요소법으로 검증하여 솔더의 크랙이 진전 중에는 저온조건에서 크랙이 열리고 저항이 증가하며, 크랙의 진전이 완료된 후에는 고온조건에서 크랙이 열리고 저항이 증가하는 조건으로 바뀜을 보였다. 이런 결과에 기반하여 온도 사이클에서 저항측정을 통해 칩저항 실장 솔더의 고장예지가 가능함을 제시하였다.

• Korean Chemical Engineering Research
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• 제59권2호
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• pp.232-238
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• 2021

The development of a low cost catalyst with high performance and small amount of carbon deposition on catalyst from toluene steam reforming were investigated by using coal ash as a support material. Ni-loaded coal ash catalyst showed similar catalytic activity for toluene steam reforming compared with the Ni/Al2O3. At 800 ℃, the toluene conversion was 77% for Ni/TAL, 68% for Ni/KPU and 78% for Ni/Al2O3. Ni/TAL showed similar toluene conversion to Ni/Al2O3. However, Ni/KPU produced higher hydrogen yield at relatively lower toluene conversion. Ni/KPU catalyst showed a remarkable ability of suppressing the carbon deposition. The difference in coke deposition and hydrogen yield is due to the composition of KPU ash (Ca and Fe) which increase coke resistance and water gas shift reaction. This study suggests that coal ash catalysts have great potential for the application in the steam reforming of biomass tar.

• Journal of Information Technology Applications and Management
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• 제10권1호
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• pp.47-59
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• 2003

This study analyses the level of resistance which workers have against the adoption of ERP systems and the factors affecting the resistance to the adoption of the new systems. The major results of the study include 1) about 40% of workers showed resistance to the adoption of ERP systems, and 2) all six factors (technical characteristics of ERP system, functional characteristics of ERP system, implementation approach, task changes caused by the adoption of ERP system, attitude toward change, and altitude toward organization) were proved to affect the resistance to the adoption of the ERP systems. In practice, adoption of ERP system brings significant changes to workers. In order for an organization to succeed, it is necessary to reduce the resistance of workers. Since this study is performed based on a case study, the results of the study may not be generalized. However, the results of the study may provide guidance which organizations can refer in the course of effective personnel management.

• 대한치과보철학회지
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• 제38권4호
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• pp.492-499
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• 2000

This study was investigated to compare the staining resistance of soft denture liners. Specimens were made of Coe-soft, Coe-comfort, Soft-liner, Visco-gel, and were stored in 1% methyleneblue solution for 24 hours. The amounts of color change before and after treatment with mono-poly and thermocycling were measured by colorimeter(TC-6FX, Tokyo Denshoku Co. Ltd, Japan) for evaluation of staining resistance. The following conclusions were drawn from this study. 1. The staining resistance of Visco-gel was increased, but there was no changes of staining resistance in Coe-soft, Coe-comfort, and Soft-liner after treatment with monopoly. 2. The staining resistance of the Coe-comfort was the least in all soft denture liners. 3. The staining resistance of Visco-gel and Soft-liner were decreased after thermocycling.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제50권2호
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• pp.72-78
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• 2001

A compact size high voltage pulse generator with nanosecond rise time has been designed and investigated experimentally. The inductance of a pulse generator can be reduced by fixing the Marx generator and pulse forming network components into a single cylindrical unit. As a result, nanosecond rise time about $8{\sim}10[ns]$ and pulse width of several hundred [ns] can be obtained from a modified Marx pulse generator. And parametric studies showed that the rise time of the output pulse was depended little on the change of the load resistance and the charging capacitance while, the pulse width of the output pulse was depended greatly upon the change of the load resistance and the charging capacitance. The theoretical showed the possibility to design the laboratory-size pulse generator very fast rising time and a proper pulse width by minimizing stray inductance and varying resistance and capacitance.