• Molecular & Cellular Toxicology
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• 제4권3호
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• pp.260-266
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• 2008

Recently, there has been scientific discussion on the utility of -omics techniques such as genomics, proteomics, and metabolomics within toxicological research and mechanism-based risk assessment. Toxicogenomics is a novel approach integrating the expression analysis of genes (genomic) or proteins (proteomic) with traditional toxicological methods. Since 1999, the toxicogenomic approach has been extensively applied for regulatory purposes in order to understand the potential toxic mechanisms that result from chemical compound exposures. Therefore, this article's purpose was to consider the utility of toxicogenomic profiles for improved risk assessment, explore the current limitations in applying toxicogenomics to regulation, and finally, to rationalize possible avenues to resolve some of the major challenges. Based on many recent works, the significant impact toxicogenomic techniques would have on human health risk assessment is better identification of toxicity pathways or mode-of-actions (MOAs). In addition, the application of toxicogenomics in risk assessment and regulation has proven to be cost effective in terms of screening unknown toxicants prior to more extensive and costly experimental evaluation. However, to maximize the utility of these techniques in regulation, researchers and regulators must resolve many parallel challenges with regard to data collection, integration, and interpretation. Furthermore, standard guidance has to be prepared for researchers and assessors on the scientifically appropriate use of toxicogenomic profiles in risk assessment. The National Institute of Toxicological Research (NITR) looks forward to an ongoing role as leader in addressing the challenges associated with the scientifically sound use of toxicogenomics data in risk assessment.

• Smart Structures and Systems
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• 제22권5호
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• pp.509-525
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• 2018

Sensors and systems in Civionics technology play an important role for continuously facilitating real-time structure monitoring systems by detecting and locating damage to or degradation of structures. An advanced materials, design processes, long-term sensing ability of sensors, electromagnetic interference, sensor placement techniques, data acquisition and computation, temperature, harsh environments, and energy consumption are important issues related to sensors for structural health monitoring (SHM). This paper provides a comprehensive survey of various sensor technologies, sensor classes and sensor networks in Civionics research for existing SHM systems. The detailed classification of sensor categories, applications, networking features, ranges, sizes and energy consumptions are investigated, summarized, and tabulated along with corresponding key references. The current challenges facing typical sensors in Civionics research are illustrated with a brief discussion on the progress of SHM in future applications. The purpose of this review is to discuss all the types of sensors and systems used in SHM research to provide a sufficient background on the challenges and problems in optimizing design techniques and understanding infrastructure performance, behavior and current condition. It is observed that the most important factors determining the quality of sensors and systems and their reliability are the long-term sensing ability, data rate, types of processors, size, power consumption, operation frequency, etc. This review will hopefully lead to increased efforts toward the development of low-powered, highly efficient, high data rate, reliable sensors and systems for SHM.

• Structural Monitoring and Maintenance
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• 제4권4호
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• pp.301-329
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• 2017

Impedance-based damage detection method has been known as an innovative tool with various successful implementations for structural health monitoring of civil structures. To monitor the local critical area of a structure, the impedance-based method utilizes the high-frequency impedance responses sensed by piezoelectric sensors as the local dynamic features. In this paper, current advances and future challenges of the impedance-based structural health monitoring are presented. Firstly, theoretical background of the impedance-based method is outlined. Next, an overview is given to recent advances in the wireless impedance sensor nodes, the interfacial impedance sensing devices, and the temperature-effect compensation algorithms. Various research works on these topics are reviewed to share up-to-date information on research activities and implementations of the impedance-based technique. Finally, future research challenges of the technique are discussed including the applicability of wireless sensing technology, the predetermination of effective frequency bands, the sensing region of impedance responses, the robust compensation of noise and temperature effects, the quantification of damage severity, and long-term durability of sensors.

• 대한원격탐사학회지
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• 제36권4호
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• pp.609-626
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• 2020

Satellite-based land surface temperature (LST) has been used as one of the major parameters in various climate and environmental models. Especially, Moderate Resolution Imaging Spectroradiometer (MODIS) LST is the most widely used satellite-based LST product due to its spatiotemporal coverage (1 km spatial and sub-daily temporal resolutions) and longevity (> 20 years). However, there is an increasing demand for LST products with finer spatial resolution (e.g., 10-250 m) over regions such as urban areas. Therefore, various methods have been proposed to produce high-resolution MODIS-like LST less than 250 m (e.g., 100 m). The purpose of this review is to provide a comprehensive overview of recent research trends and challenges for the downscaling of MODIS LST. Based on the recent literature survey for the past decade, the downscaling techniques classified into three groups-kernel-driven, fusion-based, and the combination of kernel-driven and fusion-based methods-were reviewed with their pros and cons. Then, five open issues and challenges were discussed: uncertainty in LST retrievals, low thermal contrast, the nonlinearity of LST temporal change, cloud contamination, and model generalization. Future research directions of LST downscaling were finally provided.

• 유통과학연구
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• 제21권2호
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• pp.65-76
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• 2023

Purpose: This study examines the opportunities and challenges of sharia-based regional development bank spin-offs in supporting economic growth and income distribution through a board of commissioner's approach. Research design, data, and methodology: The research design is qualitative research with the main data collection technique through in-depth interviews. Results: The results of the study show that Bank Nagari can support the performance of the West Sumatra government, especially in regional finance. The positive influence is shown in the benefit aspect of 31% and the opportunity of 28% which is the priority value. The challenges that must be faced are technology services, improving the quality of human resources, socialization, and application of local wisdom which is by the philosophical values of the people of West Sumatra Adat Basandi Syara' Syara' Basandi Kitabullah. Conclusions: It can be concluded that the local government of West Sumatra has an essential contribution to the conversion of Bank Nagari to RDB Syariah as a whole. The expected implication is that the local government and shareholders cooperate well in supporting the transformation to realize West Sumatra Mandani through the populist economy of the people of West Sumatra.

• 산경연구논집
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• 제15권6호
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• pp.9-15
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• 2024

Purpose: The primary aim of this study is to investigate the current issues in the leisure sports tourism and propose viable solutions based on a comprehensive review of existing literature. The specific objectives are to: (1) Identify the key challenges facing the leisure sports tourism industry. (2) Analyze the impact of these challenges on the industry's growth and sustainability. (3) Review and synthesize existing research to propose evidence-based solutions. Research design, data and methodology: The preliminary search yielded an extensive list of articles. These articles underwent a rigorous screening process based on their titles and abstracts. The inclusion criteria were: (1) studies focused specifically on the leisure sports tourism industry, (2) empirical research providing data on the identified issues, and (3) peer-reviewed journal articles. Results: The leisure sports tourism industry faces several pressing issues requiring effective solutions to ensure sustainability and growth. This section provides four critical solutions addressing the identified challenges: environmental sustainability, infrastructure and facility management, seasonality and economic impact, and health and safety concerns. Conclusions: The findings highlight several actionable solutions to the current issues faced by the leisure sports tourism industry. This industry can achieve a more stable and sustainable growth trajectory by addressing environmental sustainability, infrastructure and facility management, seasonality, and health and safety concerns.

• Asia pacific journal of information systems
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• 제29권3호
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• pp.503-523
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• 2019

Many cities in the world have increased initiative to realize smart tourism. There are unexplored challenges for the people which lead and manage smart tourism projects and realize its value in tourism (we call them as 'Smart tourism initiatives'), such as orchestrating of tourism complexity, developing and sharing tourism strategy, sustaining tourism projects and innovation. Concerning these challenges, we aim to design a holistic capability maturity model for sustainable and smart tourism governance enabling sustainable tourism innovations via tackling the challenges above. We adopted Dynamic capability theory as a theoretical lens and introduced Design science research methodology in order to develop a new capability maturity governance model as a design artifact. As a result of the study, we could synthesize findings from iterations of the design research cycle based on the IT Capability Maturity Model. Our result proposes a potential capability maturity model supporting effective communication and strategic alignment for the initiatives with illuminating future paths with evaluation methods on tourism capabilities for the initiatives. Throughout this study, we contribute to the body of knowledge as well as practice by proposing a new tourism capability governance model.

• 한국융합학회논문지
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• 제8권8호
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• pp.267-281
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• 2017

최근 강조되는 학제 간 융합연구의 중요성에도 불구하고 융합연구에서의 구체적인 경험에 대한 연구가 우리나라에서 거의 이뤄지지 않았다. 융합연구를 진행한 연구자의 실제 경험과 인식을 분석함으로써 융합연구의 현실적 도전과 성장을 이해하고 융합연구 증진을 위한 제도를 제안하기 위하여, 국내 한 대학교 내 융합연구 및 융합연구행정 전문가 전임교원 16명을 심층면접하고 근거이론의 패러다임 모형을 사용하여 분석하였다. 연구 결과, 현재 융합연구자들이 경험한 중심현상은 '융합연구가 효과적으로 이루어지지 못하고 있음'으로 나타났으며, 다양한 노력과 연구 환경 개선을 통해 융합연구의 성장을 경험하는 것이 발견되었다. 이러한 결과를 바탕으로 융합연구 증진을 위한 방안을 제안하였다.

• Clinical and Experimental Vaccine Research
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• 제13권3호
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• pp.175-183
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• 2024

Omicron variants present new challenges when it comes to understanding their impact on vaccines, antiviral strategies, and possible neurological consequences. This article describes the characteristics of the Omicron variant, its epidemiology, the efficacy of vaccines and monoclonal antibodies, and its association with lymphoid depletion. We also explore the neurological implications of Omicron, focusing on its association with encephalopathy and encephalitis. There are unique challenges associated with the Omicron variant, which is characterized by distinct mutations and increased transmissibility. For a better understanding of the effects of this disease and developing strategies to combat its spread, especially concerning neurological complications, ongoing research is necessary.

• International Journal of Knowledge Content Development & Technology
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• 제11권1호
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• pp.65-84
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• 2021

Our understanding of how barriers to access systematically varies with the compositional and contextual characteristics of users is incomplete. Using a public university library in Ghana, this study assessed the heterogeneous barriers or constraints students encounter in accessing electronic resources based on their demographic and contextual attributes. A descriptive survey design was adopted and structured questionnaires were administered randomly to 558 students in the four constituent colleges of the University of Cape Coast, Ghana. Data were collected and analysed using SPSS and descriptive statistics were generated. The results revealed that students faced six key challenges in accessing electronic information resources in the library namely delays in download of information, poor internet connectivity, and limited accessibility of university portal, inadequate computers in the library, poor lighting and limited ancillary services (on the spot printing facilities), with differences based on gender, academic level, and college affiliation. Only 24% males and 26% females had no challenges or problems with delays in download of electronic information. About three-fourth of all users had poor internet connectivity and complained about inadequate computers associated with accessing electronic resources. 40% percent of undergraduate students in the Colleges of Education Studies, Agriculture and Natural Sciences, and Humanities and Legal Studies each encountered four to six simultaneous challenges. Irrespective of gender, first year undergraduate students in all the four colleges were the least likely to report multiple challenges. This suggests the need for targeted and context-specific interventions to address the identified challenges.