• Journal of the Korean Operations Research and Management Science Society
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• v.41 no.1
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• pp.99-111
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• 2016

This paper presents a framework to analyze the change in the research and development (R&D) efficiency of government-funded research institutes (GRIs) in Korea. Cumulative data envelopment analysis/Malmquist index method is utilized to analyze the changes in R&D efficiency of GRIs. Data analysis of the R&D activities of 10 GRIs in Korea Research Council of Fundamental Science & Technology showed that the average R&D efficiency of the 10 GRIs improved from 2009 to 2013. However, the efficiency of a few GRIs decreased in terms of the catch-up index. The proposed framework can help management teams diagnose the current state of R&D activities and determine the efficacy of strategic actions by comparing efficiencies in the past.

• Journal of Korea Technology Innovation Society
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• v.14 no.3
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• pp.431-465
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• 2011

Focusing on open innovation which is regarded as an important framework for strengthening technological innovation capabilities, in this study empirical analysis is conducted on Korean manufacturing companies, particularly based on the survey results of 149 domestic manufacturing companies that carry out innovation activities in order to identify influence factors for open innovation activities. Analysis on the influence factors of open innovation activities categorized into characteristics of environment, firm-specific characteristics, and characteristics of institutions revealed that characteristics of environment in terms of the degree of market competition and technological changes influence outside-in open innovation activities. Such results suggest that companies respond to increased market competition or technological changes by promoting research and development (R&D) and maintaining or acquiring market competitiveness through introduction of external technology and utilization of external information by means of research collaboration, user innovation, and so on. In terms of firm-specific characteristics, outside-in open innovation activities are influence by R&D personnel, R&D investment, number of international business, export, and openness of corporate culture while inside-out open innovation activities are influenced by characteristics of international organization and CEO's capabilities. In order for companies to strengthen outside-in open innovation activities emphasis on research personnel, R&D input factors such as research funds are necessary whereas to increase inside-out open innovation activities organization solely responsible for international affairs should be established while the CEO needs to focus on open and cooperative entrepreneurship rather than internal technological innovation activities. In terms of characteristics of institutions, outside-in innovation activities are influenced by technological networking whereas inside-out innovation activities are influenced by networking for development of technology and the presence in industrial cluster. This means that the government needs to establish industrial clusters and try to expand technological networking to facilitate open innovation activities.

• Korea Trade Review
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• v.44 no.4
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• pp.87-100
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• 2019

A country's participation in international technical standards development directly relates to its trade competitiveness. Many countries adopt international standards or influence their development process through the ISO/IEC. This study applies the ABCD Model to assess such activities through a constructed ITS index, not only in terms of 'level' of contribution but also in terms of 'process' participation that can give important implications related to the future potential influence of countries in standards development. Having examined seven countries, Korea showed the lowest score implying the need to enhance its performance in both 'international standards adoption' and 'internationalization of domestic standards'. Korea needs to more actively participate in currently on-going standards development processes, establish more offices that improve accuracy in the development, and consider participating in additional committees where domestic interests may potentially be at stake. Although KATS has improved greatly in regards to its relevant activities and database construction, a more active and specific plan must be made to allow its efforts to successfully influence Korea in international standards development. Confronted with strong challenges from directly competing countries in trade like China and Japan that showed better ITS scores, there is a need for Korea to step up its research and participation in this field.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.21-32
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• 2003

Developments and applications of the structural health monitoring (SHM) systems have become active particularity for long-span bridges in Korea. They are composed of sensors, data acquisition system, data transmission system, information processing, damage assessment, and information management. In this paper, current status of research and application activities on SHM systems for civil infra-structures in Korea are briefly introduced by 4 parts: (1) current status of bridge monitoring systems on existing and newly constructed bridges, (2) research and development activities on smart sensors such as optical fiber sensors and piezo-electric sensors, (3) structural damage detection methods using measured data, and (4) a test road project for pavement design verification and enhancement by the Korea Highway Corporation. Finally the R＆D activities of a new engineering research center entitled Smart Infra-Structure Technology Center at Korea Advanced Institute of Science and Technology are also briefly described.

• Journal of Agricultural Extension & Community Development
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• v.26 no.3
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• pp.153-163
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• 2019

The study aims to examine the psychological effects of insect-based experience activities. A sample of 167 elementary students was hired for the study. Students in the experimental group participated in insect-based experience activities using swallowtail butterfly. Collected data are analyzed with analysis of variance and paired-sample T-test in SPSS 25.0. The results of this study are as follows 1) Insect based experience activities show positive effects in psychological and physiological aspects, 2) and students and teacher showed high satisfaction in insect-based program. In conclusion, this study contributes to providing fundamental information for the development of agro-healing programs using insect and design guidelines for identifying the characteristics of each healing program. Further research should be extended to different types of student and the development of diverse insect-based activities.

• Archives of Pharmacal Research
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• v.29 no.8
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• pp.657-665
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• 2006

We recently reported that dimethylsphingosine (DMS), a metabolite of sphingolipids, increased intracellular pH and $Ca^{2+}$ concentration in U937 human monocytes. In the present study, we found that dimethylphytosphingosine (DMPH) induced the above responses more robustly than DMS. However, phytosphingosine, monomethylphytosphingosine or trimethylsphingosine showed little or no activity. Synthetic C3 deoxy analogues of sphingosine did show similar activities, with the C16 analogue more so than C18. The following structure-activity relationships were observed between DMS derivatives and the intracellular pH and $Ca^{2+}$ concentrations in U937 monocytes; 1) dimethyl modification is important for the DMS-induced increase of intracellular pH and $Ca^{2+}$, 2) the addition of an OH group on C4 enhances both activities, 3) the deletion of the OH group on C3 has a negligible effect on the activities, and 4) C16 appears to be more effective than C18. We also found that W-7, a calmodulin inhibitor, blocked the DMS-induced pH increase, whereas, KN-62, ML9, and MMPX, specific inhibitors for calmodulin-dependent kinase II, myosin light chain kinase, and $Ca^{2+}$-calmodulin-dependent phosphodiesterase, respectively, did not affect DMS-induced increases of pH in the U937 monocytes.

• The Journal of the Korea Contents Association
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• v.16 no.10
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• pp.140-149
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• 2016

This study aims to suggest the appropriate career educational policies in order to improve junior-high school students' career development competency through various school career educational activities with the hierarchical analysis by using data surveyed by 10,728 third grade junior high school students of 400 schools from the '2015 School Career Education Survey'. The results showed that 'career and occupations' subject learning, career psychological tests, and career experience activities were found to have statistically significant effects on career development competencies. These results in that 'career and occupations' subject learning, career psychological tests, and career experience activities help to enhance career development competency of junior-high school students. The implication of these results were discussed in terms of the importance and the need for school career educational activities, and suggestions for future research are provided.

• Journal of Applied Biological Chemistry
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• v.48 no.1
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• pp.26-28
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• 2005

Evaluation of larvicidal activities of Chamaecyparis obtusa and Thuja orientalis oils against 4th-instar larvae of Aedes aegypti and Culex pipiens pallens revealed larvicidal activities of leaf oils extracted from C. obtusa and T. orientalis were significantly higher than those of stem, fruit, and seed oils. Strong mortality was observed in age class II of C. obtusa and T. orientalis against Ae. aegypti and Cx. pipiens pallens larvae. These results show both leaf part and age class II of C. obtusa and T. orientalis have strong larvicidal activity against Ae. aegypti and Cx. pipiens pallens. Leaf oils of C. obtusa and T. orientalis leaves show promise as natural larvicides against Ae. aegypti and Cx. pipiens pallens.

• Journal of Ginseng Research
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• v.37 no.4
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• pp.442-450
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• 2013

The aim of this study was to determine and compare the preventive effect of Korean White Ginseng and Red Ginseng on oxidative stress in $H_2O_2$-treated HepG2 cells. The roots of ginseng were extracted with 70% methanol and partitioned with butanol to obtain saponin fractions, which have been known as bioactive constituents of ginseng. 2',7'-Dichlorofluorescein diacetate (DCF-DA) assay and malondialdehyde (MDA) content were measured for evaluating intracellular reactive oxygen species (ROS) generation. Also, mRNA expressions and activities of antioxidant enzymes were analyzed to determine the antioxidant activity of saponin or non-saponin fractions of ginsengs. According to DCF-DA assay, $H_2O_2$-induced MDA release and ROS generation were significantly reduced by treatment with saponin fractions of white and red ginseng roots. Also, saponin fractions increased effectively intracellular antioxidant enzyme activities including catalase, glutathione peroxidase and superoxide dismutase in $H_2O_2$-treated HepG2 hepatoma cells. In general, red ginseng was more effective than white ginseng for reducing oxidative stress. These results indicate that administration of red ginseng may certainly contribute relatively stronger than white ginseng to prevent from damaging liver function by oxidative stress.

• Fisheries and Aquatic Sciences
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• v.14 no.3
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• pp.179-185
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• 2011

The antioxidant activities of a methanolic extract of Eisenia bicyclis and its organic solvent fractions, including dichloromethane ($CH_2Cl_2$), ethyl acetate (EtOAc), n-butanol (n-BuOH), and water ($H_2O$) fractions, were investigated. Scavenging activities against DPPH, hydroxyl, superoxide anion, and peroxynitrite radicals were evaluated using electron spin resonance spectrometry; intracellular reactive oxygen species (ROS) were evaluated by a 2',7'-dichlorofluorescein diacetate assay using RAW264.7 mouse macrophages. The antioxidant activities of the individual fractions were: EtOAc>n-BuOH>$CH_2Cl_2$ >$H_2O$. The EtOAc fraction exhibited strong radical scavenging activity and a significantly reduced ROS level in RAW264.7 cells. Moreover, the phenolic contents of the extract and fractions followed the same order as their radical scavenging activities. Our results indicate that E. bicyclis is a valuable natural source of antioxidants that may be applicable to the functional food industry.