A comparison of antioxidant activity of Korean White and Red Ginsengs on H2O2-induced oxidative stress in HepG2 hepatoma cells |
Sohn, Sang-Hyun
(Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration)
Kim, Si-Kwan (Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University) Kim, Young-Ock (Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration) Kim, Hyung-Don (Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration) Shin, Yu-Su (Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration) Yang, Seung-Ok (Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration) Kim, Seung-Yu (Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration) Lee, Sang-Won (Department of Medicinal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration) |
1 | Seo SJ, Cho JY, Jeong YH, Choi YS. Effect of Korean red ginseng extract on liver damage induced by short-term and long-term ethanol treatment in rats. J Ginseng Res 2013;37:194-200. 과학기술학회마을 DOI ScienceOn |
2 | Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973;179:588-590. DOI ScienceOn |
3 | Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389-394. DOI ScienceOn |
4 | Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-474. DOI ScienceOn |
5 | Park WH, Lee SK, Kim CH. A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats. Life Sci 2005;76:1675-1690. DOI ScienceOn |
6 | Bak MJ, Jun M, Jeong WS. Antioxidant and hepatoprotective effects of the red ginseng essential oil in H(2) O(2)-treated HepG2 cells and CCl(4)-treated mice. Int J Mol Sci 2012;13:2314-2330. DOI |
7 | Nam KY. The comparative understanding between red ginseng and white ginsengs, processed ginsengs (Panax ginseng C. A. Meyer). J Ginseng Res 2005;29:1-18. 과학기술학회마을 DOI ScienceOn |
8 | Kitagawa I, Taniyama T, Shibuya H, Noda T, Yoshikawa M. Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. Yakugaku Zasshi 1987;107:495-505. DOI |
9 | Abdel-Wahhab MA, Ahmed HH. Protective effect of Korean Panax ginseng against chromium VI toxicity and free radicals generation in rats. J Ginseng Res 2004;28:11-17. DOI ScienceOn |
10 | Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997;82:291-295. DOI |
11 | Lim BV, Shin MC, Jang MH, Lee TH, Kim YP, Kim HB, Lee KS, Kim H, Kim EH, Kim CJ. Ginseng radix increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes. Biol Pharm Bull 2002;25:1550-1554. DOI ScienceOn |
12 | Naval MV, Gomez-Serranillos MP, Carretero ME, Villar AM. Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocytes primary culture. J Ethnopharmacol 2007;112:262-270. DOI ScienceOn |
13 | Yun TK, Yun YS, Han IW. Anticarcinogenic effect of long-term oral administration of red ginseng on newborn mice exposed to various chemical carcinogens. Cancer Detect Prev 1983;6:515-525. |
14 | Xu LL, Han T, Wu JZ, Zhang QY, Zhang H, Huang BK, Rahman K, Qin LP. Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus. Phytomedicine 2009;16:609-616. DOI ScienceOn |
15 | Yoshikawa M, Morikawa T, Kashima Y, Ninomiya K, Matsuda H. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins. J Nat Prod 2003;66:922-927. DOI ScienceOn |
16 | Zheng PH, Li CY, Pang SF, Guan YM, Shao C, Xu SQ, Liu JY, Hou W, Lei XJ, Wang YP. Effects of steaming on chemical composition of Panax ginseng hairy roots and Panax ginseng. J Med Plants Res 2012;6:2812-2815. |
17 | Jeong TC, Kim HJ, Park JI, Ha CS, Park JD, Kim SI, Roh JK. Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in Sprague Dawley rats. Planta Med 1997;63:136-140. DOI ScienceOn |
18 | Jeon BH, Seong GS, Chun SG, Sung JH, Chang CC. Antioxidative effects of white ginseng and red ginseng on liver of high fat diet-treated mice. J Ginseng Res 2005;29:138-144. 과학기술학회마을 DOI ScienceOn |
19 | Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012;24:981-990. DOI ScienceOn |
20 | Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95. DOI |
21 | Mari M, Colell A, Morales A, von Montfort C, Garcia-Ruiz C, Fernandez-Checa JC. Redox control of liver function in health and disease. Antioxid Redox Signal 2010;12:1295-1331. DOI ScienceOn |
22 | Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84. DOI ScienceOn |
23 | Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ. Mechanisms of hepatotoxicity. Toxicol Sci 2002;65:166-176. DOI ScienceOn |
24 | Kang KS, Yokozawa T, Kim HY, Park JH. Study on the nitric oxide scavenging effects of ginseng and its compounds. J Agric Food Chem 2006;54:2558-2562. DOI ScienceOn |
25 | Vaca CE, Wilhelm J, Harms-Ringdahl M. Interaction of lipid peroxidation products with DNA: a review. Mutat Res 1988;195:137-149. DOI ScienceOn |
26 | Ramesh T, Kim SW, Hwang SY, Sohn SH, Yoo SK, Kim SK. Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats. Nutr Res 2012;32:718-726. DOI ScienceOn |
27 | Park HM, Kim SJ, Mun AR, Go HK, Kim GB, Kim SZ, Jang SI, Lee SJ, Kim JS, Kang HS. Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the MAPK pathway in TIB-73 cells. J Ethnopharmacol 2012;141:1071-1076. DOI ScienceOn |
28 | Zhang QH, Wu CF, Duan L, Yang JY. Protective effects of ginsenoside Rg(3) against cyclophosphamide-induced DNA damage and cell apoptosis in mice. Arch Toxicol 2008;82:117-123. DOI |
29 | Kang KS, Kim HY, Yamabe N, Park JH, Yokozawa T. Preventive effect of 20(S)-ginsenoside Rg3 against lipopolysaccharide- induced hepatic and renal injury in rats. Free Radic Res 2007;41:1181-1188. DOI ScienceOn |
30 | Kim GN, Lee JS, Song JH, Oh CH, Kwon YI, Jang HD. Heat processing decreases Amadori products and increases total phenolic content and antioxidant activity of Korean red ginseng. J Med Food 2010;13:1478-1484. DOI ScienceOn |
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