• Journal of Elementary Mathematics Education in Korea
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• v.20 no.2
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• pp.283-309
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• 2016

The purpose of this study is to investigate gifted students in elementary mathematics how they understand of situations involving multiplication and concepts of multiplication. For this purpose, first, this study analyzed the teacher's guidebooks about introducing the concept of multiplication in elementary school. Second, we analyzed multiplication problems that gifted students posed. Third, we interviewed gifted students to research how they understand the concepts of multiplication. The result of this study can be summarized as follows: First, the concept of multiplication was introduced by repeated addition and times idea in elementary school. Since the 2007 revised curriculum, it was introduced based on times idea. Second, gifted students mainly posed situations of repeated addition. Also many gifted students understand the multiplication as only repeated addition and have poor understanding about times idea and pairs set.

• Journal of Microbiology and Biotechnology
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• v.16 no.12
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• pp.1874-1881
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• 2006

Flocculation of Candida tropicalis HY200 was systemically investigated to elucidate its mechanism, and used for cell cycles in repeated-batch cultivations for the production of xylitol from xylose. Flocculation occurred only after the late exponential phase of growth in the culture media and buffer within the narrow pH range of 3.0-5.0. The flocculation was completely inhibited by treatments of cells with proteases and partially reduced by treatments with carbohydrate-hydrolyzing enzymes and by the presence of mannose and glucose. The addition of calcium ions significantly enhanced the flocculation during cultivation, which was completely abolished by the addition of EDTA. The flocculent yeast HY200 provided repeated-batch cultivations employing cell recycles by flocculation over 6 rounds of cultivation for the production of xylitol from xylose, resulting in a relatively high productivity of averaged 4.6 g xylitol/l h over six batches and maximal 6.3 g xylitol/l h in the final sixth batch. Cell recycle by flocculation was fast and convenient, which could be applicable for the industrial scale of xylitol production.

• Journal of Microbiology and Biotechnology
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• v.21 no.9
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• pp.972-978
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• 2011

In this study, we investigated the performance of an immobilized ${\beta}$-galactosidase inclusion bodies-containing Escherichia coli cell reactor, where the cells were immobilized in alginate beads, which were then used in repeated-batch operations for the hydrolysis of o-nitrophenyl-${\beta}$-D-galactoside or lactose over the long-term. In particular, in the Tris buffer system, disintegration of the alginate beads was not observed during the operation, which was observed for the phosphate buffer system. The o-nitrophenyl-${\beta}$-D-galactoside hydrolysis was operated successfully up to about 80 h, and the runs were successfully repeated at least eight times. In addition, hydrolysis of lactose was successfully carried out up to 240 h. Using Western blotting analyses, it was verified that the ${\beta}$-galactosidase inclusion bodies were sustained in the alginate beads during the repeated-batch operations. Consequently, we experimentally verified that ${\beta}$-galactosidase inclusion bodies-containing Escherichia coli cells could be used in a repeated-batch reactor as a biocatalyst for the hydrolysis of o-nitrophenyl-${\beta}$-D-galactoside or lactose. It is probable that this approach can be applied to enzymatic synthesis reactions for other biotechnology applications, particularly reactions that require long-term and stable operation.

• Biomolecules & Therapeutics
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• v.19 no.1
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• pp.45-51
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• 2011

These experiments were designed to use typical makers from behaviors and molecular basis in addicted animals of morphine and cocaine. Morphine has been widely abused with a high physical dependence liability. Morphine withdrawal activates the intracellular cAMP signaling pathway and further leads to changes in the expression of the cAMP response element binding protein (CREB), which may be important to the development and expression of morphine dependence. From these experiments, repeated morphine (10 mg/kg, twice per day for 7 days) developed physical dependence. Withdrawal signs were precipitated by naloxone and also increased the expression of the CREB. In addition, repeated exposure of cocaine (15 mg/kg) to mice develops locomotor sensitization and produced lasting behavioral sensitivity. Cocaine- and amphetamine-regulated transcript peptide (CART) peptide was up-regulated by repeated administration of cocaine in the striatum. Therefore, repeated morphine induced the development of physical dependence and increased pCREB. In addition, repeated cocaine induced locomotor sensitization and over-expressed CART peptide. In conclusion, the development of physical dependence and pCREB for morphine, and locomotor sensitization and CART peptide over-expression for cocaine would be useful markers to predict the abuse potential of opioid analgesics and pychostimulant drugs in animals, respectively.

• Development and Reproduction
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• v.25 no.4
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• pp.213-223
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• 2021

Controlled ovarian hyperstimulation (COH) is routinely used in the in vitro fertilization and embryo transfer (IVF-ET) cycles to increase the number of retrieved mature oocytes. However, the relationship between repeated COH and ovarian function is still controversial. Therefore, we investigated whether repeated ovarian stimulation affects ovarian aging and function, including follicular development, autophagy, and apoptosis in follicles. Ovarian hyperstimulation in mice was induced by intraperitoneal injection with pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG). Mice subjected to ovarian stimulation once were used as a control group and 10 times as an experimental group. Repeated injections with PMSG and hCG significantly reduced the number of primary follicles compared to a single injection. The number of secondary and antral follicles increased slightly, while the number of corpus luteum increased significantly with repeated injections. On the other hand, repeated injections did not affect apoptosis in follicles associated with follicular atresia. The expression of autophagy-related genes Atg5, Atg12, LC3B, and Beclin1, cell proliferation-related genes mTOR, apoptosis-related genes Fas, and FasL was not significantly different between the two groups. In addition, the expression of the aging-related genes Dnmt1, Dnmt3a, and AMH were also not significantly different. In this study, we demonstrated that repeated ovarian stimulation in mice affects follicular development, but not autophagy, apoptosis, aging in ovary. These results suggest that repetition of COH in the IVF-ET cycle may not result in ovarian aging, such as a decrease in ovarian reserve in adult women.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.10 no.1
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• pp.125-134
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• 1990

In order to utilize coal ash, which we go to great expense to scrap, as subba se course material, this study attempts to examine the deformation characteristics of coal ash with the addition of some cement when repeated loads are applied. The material of coal ash is obtained from Young dong and Youngwol thermal power plant. The results are : Unconfined compression strength shows rectilineal increase in propotion to the cement addition ratio. Within the scope of repeated loads of experimental condition, modulus of elasticity tends to decrease while compression strength shows about 21% increase.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.4
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• pp.148-153
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• 2010

Concrete used as structural materials in construction fields is supplied as a type of carry and placement by ready-mixed concrete (RMC) truck after proportioning in batch plant. However, during conveying of concrete to the field, due to traffic jam, weather, etc., it is not easy to maintain adequate slump. In this case, we think that the insert of an admixture to concrete has no problem in concrete. For RMC, when the slump is not sufficient, the truck driver insert water additionally without any considerations. After that, concrete is placed after re-mixing and this leads to serious reasons such as strength reduction less than design strength considered in the structural design. Accordingly, in this study, to solve the problem to insert water without realistic reasons in RMC, basic experimental studies were performed. Admixtures used frequently in fields were selected and addition's repeated time and elapsed time interval after initial addition of the admixture were selected as main variables. Authors want that the results of this study is used as basic data to resolve the question.

• Journal of information and communication convergence engineering
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• v.20 no.4
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• pp.235-241
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• 2022

A dispersion map was proposed to improve the compensation effect of a distorted WDM (wavelength division multiplexed) channel in a dispersion-managed link coupled with optical phase conjugation. The dispersion map is an origin-symmetric structure around the optical phase conjugator in the middle of the transmission path. In addition, the dispersion map has a form in which a constant dispersion accumulation pattern is repeated regularly. Through simulation, we confirmed that the application of the origin-symmetric dispersion map with a repetitively shaped configuration was more effective in compensating for the distorted WDM channel than in the dispersion-managed link with a conventional dispersion map. In addition, we confirmed that the compensation effect could be increased when the cumulative dispersion distribution of the origin-symmetric distribution map had a positive value in the first half section and a negative value in the second half section. Further, we observed that as the number of repeated dispersion accumulation patterns increased, the residual dispersion per span should also be increased.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.319-323
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• 2005

This study is concerned with development of efficient culture methods for lactic acid fermentation of Lactobacillus sp. RKY2. The cell-recycle repeated batch fermentation using cheese whey and corn steep liquor as raw materials was tried in order to further enhance the productivity of lactic acid. In addition, fermentation efficiencies could be considerably enhanced by cell-recycle continuous culture. Through the cell-recycle repeated batch fermentation, lactic acid productivity was maximized to 6.34 $g/L{\cdot}h,$ which corresponded to 6.2 times higher value than that of the batch fermentation. During the cell-recycle continuous fermentation, the last dry cell weight at the end of fermentation could be increased to 25.3 g/L.

• International Journal of Highway Engineering
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• v.10 no.1
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• pp.49-62
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• 2008

This paper presents the results of a study that was performed to evaluate the characteristics of deformation under repeated loadings in unbound geomaterials of pavements. Two important parameters, resilient and permanent deformation were estimated using the repeated load triaxial test. In addition, the effects of different stress state and environmental conditions with various materials were evaluated. Due to the locking mechanism and resiliency of unbound geomaterials, a consistent increase in permanent deformation on unbound geomaterials was observed and the asymptotic condition is slightly reached. In conclusion, the results show that selected models and parameters are satisfactory to predict permanent deformations after a certain number of loadings.