• Environmental Analysis Health and Toxicology
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• v.16 no.2
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• pp.43-50
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• 2001

A daily newspaper in Korea addressed an controversial issue recently that the concentration of radon measured from the groundwater in Taejon was found out a relatively high level. The cancer risk arising from ingestion of such radon should be derived from calculation of the dose absorbed by the tissues at risk. The study performed by the National Research Council in United States confirmed that the use of a PBPK model for the ingested radon could provide the useful information regarding the distribution of radon among the organs of the body. This study presents an approach for the internal dose assessment of ingested radon for this case. At first, the study develops a PBPK model for ingested radon. However, the important issue is how to simulate a more realistic situation using the model associated with repeated oral doses rather than a single oral dose. The simulations are performed for repeated oral exposures per 8-hour interval using the PBPK model for a male adult. The concentration and cumulative value of radon concentration are calculated and analyzed for lung tissue and adipose group, respectively. The results could be used for the realistic prediction of the internal dose of radon in the human body for repeated oral exposures.

• The Korean Journal of Pain
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• v.30 no.4
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• pp.243-249
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• 2017

Pain is subjective, while statistics related to pain research are objective. This review was written to help researchers involved in pain research make statistical decisions. The main issues are related with the level of scales that are often used in pain research, the choice of statistical methods between parametric or nonparametric statistics, and problems which arise from repeated measurements. In the field of pain research, parametric statistics used to be applied in an erroneous way. This is closely related with the scales of data and repeated measurements. The level of scales includes nominal, ordinal, interval, and ratio scales. The level of scales affects the choice of statistics between parametric or non-parametric methods. In the field of pain research, the most frequently used pain assessment scale is the ordinal scale, which would include the visual analogue scale (VAS). There used to be another view, however, which considered the VAS to be an interval or ratio scale, so that the usage of parametric statistics would be accepted practically in some cases. Repeated measurements of the same subjects always complicates statistics. It means that measurements inevitably have correlations between each other, and would preclude the application of one-way ANOVA in which independence between the measurements is necessary. Repeated measures of ANOVA (RMANOVA), however, would permit the comparison between the correlated measurements as long as the condition of sphericity assumption is satisfied. Conclusively, parametric statistical methods should be used only when the assumptions of parametric statistics, such as normality and sphericity, are established.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.22 no.3
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• pp.115-120
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• 1989

Physicochemical changes were investigated during repeated freezing and thawing processes using fish meat paste of alaska pollack (Theragra chalcogramma). During repeated thawing process, the solubility of myofibrillar protein, $Ca^{++}-ATPase$ activity, water holding capacity (WHC), electrophoretic patterns and rheological properties were evaluated at various thawing temperatures. Solubility of myofibrillar protein and $Ca^{++}-ATPase$ activity were decreased with increasing thawing temperatures. Thawing temperatures and the frequency of freezing and thawing processes did not affect WHC significantly. Upon repeated freezing and thawing cycles, electrophoretic patterns showed that only the amount of myosin heavy chain was decreased, whereas the amount of actin remained constant. Young's modulus for viscoelasticity of fish meat pastes increased with increasing thawing temperatures and the value showed maximum at third cycle and decreased thereafter.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.03a
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• pp.1071-1074
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• 2008

In this study, the behavior of dredged soil was measured by repeated tide and analyzed the change of settlements and cone penetration resistance by centrifuge model about dredged soil of Kunsan-Janghang site that maximum tidal range is 7.4m. Consequently the settlements of dredged soil by repeated tide in the 2nd month was 0.489 m. After 12th month, the total settlements was 0.524 m in the model. It meaned the settlements of dredged soil by repeated tide in the 2th month was 80% of the settlements. Also, with the lapse of time, cone penetration resistance increased centrifuge model test for catching the strength change of dredged soil by repeated tide. After 10th month, there were not almost changes. cone penetration resistance in 10th month was measured more 3.5~5.6 times than that in its early stages. Also, with the lapse of time, cone penetration resistance increased almost linearly. And, when we surveyed the relation between cone penetration resistance and time, as depth increased, cone penetration resistance rose.

• Toxicological Research
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• v.19 no.1
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• pp.51-66
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• 2003

This study was performed to evaluate single and repeated-dose toxicities of Bee Venom Extracts (F1, F3) in Spraque-Dawley. F1 was injected subcutaneously to rat at dose levels of 0, 0.0002, 0.002, 0.02 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. F3 was injected subcutaneously to rat at dose level of 0, 0.003, 0.03, 0.3 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. In both studies, there were no dose related changes in mortality, clinical sign, body weight change, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with Bee Venom (F1, F3). Gross and histopathological findings revealed no evidence of specific toxicity related to Bee Venom (F1, F3). These results suggest that the subcutaneous NOEL (No Observed Effect Level) of Bee Venom (F1, F3) may be over F1 -0.02 mg/kg, F3-0.3 mg/kg.

• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.12
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• pp.2062-2072
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• 2010

This research evaluates the change of the water absorbency and drying speed of a quick-drying knit fabric by repeated laundering and laundering conditions and investigates the influence of laundering conditions on the functional properties of the knit fabric. Four factors of laundering conditions were studied: detergent, water hardness, water temperature, and frequency of rotation. Knit fabrics were washed for 25 laundering cycles in a drum-type washing machine with nine different laundering conditions derived from an orthogonal array. The properties of knit fabrics were measured with a drop absorption test, a strip test, and a drying time test. Relaxation shrinkage pointed to a change in the structural characteristics of the knit fabric. Wetting time was faster and wickability was greater in the knit fabrics that underwent 5 laundering cycles; in addition, there were no obvious changes in wetting time and wickability. The detergent was the most important factor in wetting time (40.4%) and wickability (60% or above). Water hardness, water temperature and RPM had less of an effect on wetting time and wickability. There were no significant differences between the levels of laundering conditions (except for detergent) on wetting time and wickability. Drying times with neutral and alkali were slower by repeated laundering; however, there was no obvious change in drying time. Hardness, water temperature and RPM had less of an impact on drying time.

• Phonetics and Speech Sciences
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• v.6 no.4
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• pp.151-159
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• 2014

The study investigated the effects of reading intervention to enhance reading fluency for children from low-income families. The participants were 20 children from low-income families who are in grades 1 to 3. To qualify for participation in this study, all children had to score below 30 % ile on the Receptive vocabulary Test of the Expressive and Receptive Vocabulary Test or the Word reading fluency of the Korean Language-Based Reading Assessment. Participants were randomly assigned to the intervention (n=10) or control (n=10) group. The intervention group participated in the individualized intervention program using the guided repeated reading and the corrective feedback strategies. The results showed that participants in the intervention group performed better on reading fluency than those in the control group after participating in the intervention program. Specifically, guided repeated reading with corrective feedback strategies produced significant improvement on generalization to unpracticed passages as well as practiced passages. The results of this study suggest that guided repeated reading with corrective feedback is effective for enhancing reading fluency for children in Korea. Further study is needed in order to develop language-specific reading intervention.

• Journal of the Korean Society of Safety
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• v.9 no.2
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• pp.18-25
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• 1994

In this thesis, the fatigue tests were performed on a series of reinforced concrete to Investigate the variation of strength and the safety of reinforced concrete structures under fatigue load. The specimens were of the same rectangular cross-section, of effective height 24cm and width 30cm and their span was 330cm. The three point loading system is used in the fatigue tests. In these tests, the fracture mode of reinforced concrete structures under fatigue load, relationship between the repeated loading cycles and the mid-span displacement of the specimens were observed. According to the test results, the following fatigue behavior of reinforced concrete specimens were observed. By increasing of the number of repeated loading cycles, the mid-span displacement became greater, however the Incremental amounts of the displacement were reduced. It could be also known that the inelastic strain energy of the doubly reinforced rectangular beams was larger than that of the singly reinforced rectangular beams as increasing the number of repeated loading cycles. Compliance of reinforced concrete structures tended to be reduced as increasing the repeated loading cycles, and the compliance of the doubly reinforced rectangular beams was generally smaller than that of the singly reinforced rectangular beams. Based on the above investigation, it could be concluded that the doubly reinforced rectangular beams under fatigue load were more efficient to resist the brittle fracture than the singly reinforced rectangular beams.

• The Korean Journal of Community Living Science
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• v.26 no.3
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• pp.511-522
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• 2015

This study investigates the acute and repeated-dose oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum AF1 (Lb. plantarum AF1) and Lactobacillus plantarum HD1 (Lb. plantarum HD1) in male and female Sprague Dawley rats. In the acute toxicity study, crude antifungal compounds (500, 1,000, and 2,000 mg/kg) did not reduce mortality or produce significant changes in general behaviors or the gross appearance of external and internal organs. In the repeated-dose toxicity study, crude antifungal compounds were administered orally to rats at doses of 500, 1,000, and 2,000 mg/kg daily for 28 days. There were no test-article-related deaths, abnormal clinical signs, or body weight changes. In addition, there were no significant differences between groups treated with crude antifungal compounds and the control group in their organ weight, hematological and serum biochemical parameters, or any other factors. These results suggest that the acute or repeated-dose oral administration of crude antifungal compounds produced by Lb. plantarum AF1 plus Lb. plantarum HD1 is not toxic in male and female rats.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.252-257
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• 2000

An efficient method is developed for mold thermal cycle analysis in repeated forming process, which is well suited to the analysis in TV glass production. plunger, which is a mold to press-form the glass, undergoes temperature fluctuation during a cycle due to the repeated contact and separation from the glass, which attains a cyclic steady state in the end. If analyzed straightforwardly of this problem, it leads to more than 80 cycles to get reasonable solution, and it is yet hard to setup stopping creteria due to extremely slow convergence. An exponential fitting method is proposed to solve the problem, where an exponential function is found to best approximate temperature values of 3 consecutive cycles, and new cycle is restarted with the function value at infinite time. From numerical implementation, it is found that the method reduces the number of cycles dramatically to only $6{\sim}15$ cycles to reach accurate solution within $1^{\circ}$ error. A system for the analysis is contructed, in which the thermal analysis is performed by commercial software ANSYS, and the fitting of the result is done by IMSL library.