• Journal of Applied Reliability
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• v.11 no.4
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• pp.409-417
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• 2011

In this paper, we consider a replacement model following the expiration of warranty. In other words, this paper proposes the optimal replacement policy for a repairable system following the expiration of payable renewing replacement-non-renewing minimal repair warranty. The expected cost rate per unit time from the user's perspective is used to determine the optimality of the replacement policy. Thus, we derive the expressions for the expected cycle length and the expected total cost to obtain the expected cost rate per unit time. Finally, the numerical examples are presented for illustrative purpose.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.2205-2210
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• 2003

The 1st stage bucket of the 170MW simple cycle gas turbine is one of the components that is normally run in exposed state at the highest thermally stressful environment while the turbine is operating. After certain period operation, various type of damages are easily found and the damages are identified as due to the turbine operating mode of which the demand of the electricity power is very peaking and cyclic. Since this trend is more evident at some part of power plants in Korea and it has caused higher scrap rate of the bucket at the first repair interval than other country. Therefore, demand for the higher capability and alternative technologies which allow salvaging more buckets and preventing from severe damages is always high. In this study, a review and estimation of the repair technologies for the past 5 years to present have been conducted and show results.

• Journal of Applied Reliability
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• v.13 no.2
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• pp.77-86
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• 2013

Recently, an extended warranty of a system following the expiration of the basic warranty is becoming increasingly popular to the user. In this respect, we suggest a replacement model following the expiration of extended warranty with minimal repair warranty from the user's point of view in this paper. Under extended warranty, the failed system is minimally repaired by the manufacturer at no cost to the user during the original extended warranty period. As a criterion of the optimality, we utilize the expected cost rate per unit time during the life cycle from the user's perspective and suggest the optimal replacement period after extended warranty. Finally, a few numerical examples are given for illustrative purpose.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1999.04a
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• pp.305-312
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• 1999

This study is intended to propose a systematic and practical life cycle cost(LCC) model for the development of the reliability-based seismic safety and cost-effective performance criteria for design and upgrading of long-span PC bridges. The LCC models consist of five cost functions such as initial cost, repair/replacement cost, human losses, road user cost, and indirect losses of regional economy. The proposed model Is successfully expressed in temrs of Park-Ang damage indices and life cycle damage probability obtained from SMART-DRAIN-2DX which is an existing algorithm for nonlinear time history analysis. The proposed LCC model is successfully applied to a viaduct constructed by PSM, in Seoul. Based on the observations, the proposed systematic procedure for the formulation of LCC model may be useful for the development of the reliability-based seismic safety and cost-effective performance criteria for design and upgrading of long-span PC bridges.

• Journal of the Korean Solar Energy Society
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• v.31 no.1
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• pp.23-30
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• 2011

International cooperation to reduce greenhouse gas emissions is expected to provide a big crisis and a great opportunity at the same time for our industry that heavily consumes energy. To cope actively with the international environmental regulation, such as the Framework Convention on Climate Change, quantitative measurement of the volume of greenhouse gases emitted by various industries and quantitative prediction of the greenhouse gas emissions of the future are becoming more important than anything else at the national level. This study aims to propose the calculation process of carbon dioxide($CO_2$) emission for building in life cycle. This paper describes and compares 9 different tool for environmental load estimation with LCA. This study proposed the calculation process for quantitatively predicting and assessing $CO_2$ emissions during the life cycle of buildings based on the life cycle assessment(LCA). The life cycle steps of buildings were divided into the design/supervision, new construction, repair, renovation, use of operating energy in buildings, maintenance, and reconstruction stage in the life cycle inventory analysis and the method of assessing the environmental load in each stage was proposed.

• Smart Structures and Systems
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• v.30 no.6
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• pp.571-582
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• 2022

Optimal life-cycle management is a challenging issue for deteriorating regional bridges. Due to the complexity of regional bridge structural conditions and a large number of inspection and maintenance actions, decision-makers generally choose traditional passive management strategies. They are less efficiency and cost-effectiveness. This paper suggests a deep reinforcement learning framework employing double-deep Q-networks (DDQNs) to improve the life-cycle management of deteriorating regional bridges to tackle these problems. It could produce optimal maintenance plans considering restrictions to maximize maintenance cost-effectiveness to the greatest extent possible. DDQNs method could handle the problem of the overestimation of Q-values in the Nature DQNs. This study also identifies regional bridge deterioration characteristics and the consequence of scheduled maintenance from years of inspection data. To validate the proposed method, a case study containing hundreds of bridges is used to develop optimal life-cycle management strategies. The optimization solutions recommend fewer replacement actions and prefer preventative repair actions when bridges are damaged or are expected to be damaged. By employing the optimal life-cycle regional maintenance strategies, the conditions of bridges can be controlled to a good level. Compared to the nature DQNs, DDQNs offer an optimized scheme containing fewer low-condition bridges and a more costeffective life-cycle management plan.

• Biomedical Science Letters
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• v.29 no.4
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• pp.287-295
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• 2023

Amifostine was developed to protect cells, but it is known to induce cytotoxicity and apoptosis, and the exact mechanism is unknown. In this study, we investigated how the DNA mismatch repair (MMR) system interacts with p53 to prevent apoptosis, cell cycle arrest, and cytoprotective effects induced by amifostine. HCT116 colon cancer cells sublines HCT116/p53+,HCT116/p53+, HCT116/p53-, HCT116/E6 and HCT116+ch3/E6 cells were used for evaluation. Amifostine induced G1 arrest and increased toxicity two-fold in p53- cells regardless of MMR expression. Both G1 cell cycle arrest and induction of p53 protein peaked at 24 h after the start of amifostine exposure. Both G1 cell cycle arrest and induction of p53 protein peaked at 24 h after the start of amifostine exposure. Amifostine induced the expression of p21 protein in both p53+ and p53- cells. As for apoptosis, compared to p53- cells, p53+ cells showed 3.5~4.2 times resistance to amifostine-induced apoptosis. HCT116+E6 with both p53 and MMR loss showed maximum apoptosis at 48 h, and HCT116+ch3/E6HCT116+ch3/E6 with p53 loss showed maximum apoptosis at 24 h. As a result, it was confirmed through in vitro experiments that amifostine-induced G1 cell cycle arrest and apoptosis are mediated through a pathway dependent on MMR and p53 protein.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.4 s.70
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• pp.445-452
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• 2005

This paper presents a design method to minimize Life Cycle Cost (LCC) of steel box girders. The LCC considered in this paper includes initial cost, expected life-cycle maintenance cost and repair cost. A load carrying capacity curve is derived from a condition grade curve of steel girders and load tarrying capacity that is measured in safety diagnostic test. And then, optimal design of steel box girders is performed on the basis of load carrying capacity curve. In this paper time and number of times for repair of steel girders are determined based on the calculated load carrying capacity curve. Also, annual costs considering real discount rate are compared and analyzed in various cases. It is concluded that the optimal design of steel box gilders considering LCC by the presented method will lead to more economical and safer girders than conventional design.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7043-7048
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• 2014

Inhibition of heat shock protein 90 (Hsp90) leads to inappropriate processing of proteins involved in DNA damage repair pathways after DNA damage and may enhance tumor cell radio- and chemotherapy sensitivity. To investigate the potentiation of antitumor efficacy of lidamycin (LDM), an enediyne agent by the Hsp90 inhibitorgeldanamycin (GDM), and possible mechanisms, we have determined effects on ovarian cancer SKOV-3, hepatoma Bel-7402 and HepG2 cells by MTT assay, apoptosis assay, and cell cycle analysis. DNA damage was investigated with H2AX C-terminal phosphorylation (${\gamma}H2AX$) assays. We found that GDM synergistically sensitized SKOV-3 and Bel-7402 cells to the enediyne LDM, and this was accompanied by increased apoptosis. GDM pretreatment resulted in a greater LDM-induced DNA damage and reduced DNA repair as compared with LDM alone. However, in HepG2 cells GDM did not show significant sensitizing effects both in MTT assay and in DNA damage repair. Abrogation of LDM-induced $G_2/M$ arrest by GDM was found in SKOV-3 but not in HepG2 cells. Furthermore, the expression of ATM, related to DNA damage repair responses, was also decreased by GDM in SKOV-3 and Bel-7402 cells but not in HepG2 cells. These results demonstrate that Hsp90 inhibitors may potentiate the antitumor efficacy of LDM, possibly by reducing the repair of LDM-induced DNA damage.

• Journal of the Korea Society for Simulation
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• v.20 no.3
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• pp.119-127
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• 2011

Overhaul and repair service means the sequential processes of disassembly, repair and reassembly for a product which has been used for a long time. Overhaul is required for the companies producing airplanes, ships, trains, military weapons and heavy industrial equipments which are very expensive and have a long life cycle. The most important performance measure of the overhaul repair shop is usually the lead time. Thus, how to design the manufacturing system to meet the delivery date is a major concern in overhaul repair shop. This paper introduces the case study of an overhaul repair shop producing military weapon systems with the 3D simulation tool, $QUEST^{TM}$. At first, the characteristics of overhaul shop and what should be considered for simulation modeling are explained. Then, various simulation scenarios including two types of disassembly systems, one is flow line system and the other is cell system, are discussed with the results of simulation experiments.