• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.471-475
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• 2004

Tamsulosin has been frequently used for the treatment of benign prostatic hyperplasia. To avoid dose-dependent side effects of tamsulosin upon oral administration, the development of sustained-release delivery system is required, that can maintain therapeutic drug levels for a longer period of time. The aim of this study was therefore to formulate sustained-release tamsulosin matrix tablets and assess their formulation variables. We designed enteric coated sustained-release tamsulosin matrices to fulfill above statement. Aqueous microchannels in the enteric film need to be formed in order to obtain tamsulosin release even in an acidic environment such as gastric region. In the sustained-release tamsulosin matrix, low viscosity hydroxypropylmethylcellulose was used as a rate controller. Povidone K30 was also added to the matrices to facilitate water uptake so that a decrease in the release rate of tamsulosin as time elapses was prevented, possibly leading to pseudo zero-order release of the drug. The matrices were enteric-coated with hydroxypropylmethylcellulose phthalate (HPMCP), along with povidone K30 as an aqueous microchannel former. With the aqueous microchannels formed within the enteric film, tamsulosin could be released in an acidic condition. The release of tamsulosin decreased with increasing thickness of HPMCP membrane while the release rates of tamsulosin from those having different HPMCP thickness in pH 7.2 aqueous media were not considerably different, indicating that the enteric film was promptly dissolved at pH 7.2. These results clearly suggest that the sustained-release oral delivery system for tamsulosin could be designed with satisfying drug release profile approved by the KFDA.

• Journal of the Korea Society of Computer and Information
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• v.14 no.7
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• pp.1-8
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• 2009

In this paper, make a study decision problem called an optimal release policies after testing a software system in development phase and transfer it to the user. The optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement is generally accepted. The Bayesian parametric inference of model using log Poisson execution time employ tool of Markov chain(Gibbs sampling and Metropolis algorithm). In a numerical example by T1 data was illustrated. make out estimating software optimal release time from the maximum likelihood estimation and Bayesian parametric estimation.

• Journal of Photoscience
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• v.9 no.2
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• pp.427-429
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• 2002

We studied iron release from ferritin by irradiating the visible light, and then followed ferritin-mediated lipid peroxidation in the rod outer segment (ROS) fraction of the porcine retina. In the presence of several phosphorus compounds such as ADP and ATP, iron release from ferritin at pH 7.0 could be induced by irradiation of the visible light to the reaction mixtures. Furthermore, iron release from ferritin in the presence of ADP depended on the incubation time and the visible light irradiation. Moreover, we investigated lipid peroxidation level in the ROS fraction by two independent assay systems including the thiobarbituric acid (TBA) and ferrous oxidation/xylenol orange (FOX) methods. The visible light induced ferritin-mediated lipid peroxidation in the ROS fraction in time- and irradiance-dependent manners. In the dark condition, iron release and lipid peroxidation were not observed. Iron release from ferritin by irradiating the visible light may play an important role in the etiology of phototoxic injuries in vivo.

• YAKHAK HOEJI
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• v.31 no.1
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• pp.25-32
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• 1987

The effect of loading dose, plasticiser and PVA molecular weight on naproxen release from hydrophilic polymer matrix was examined. Hydrophilic polymer matrix was prepared with PVA and PVP by adding glycerine as plasticiser. The release of naproxen from polymer matrix was determined in phosphate buffer medium. The release rate of naproxen from the polymer matrix increased as drug loading dose and plasticiser percentage increased. Raproxen released from the polymer matrix showed the time square root kinetics. Without changing the release-pattern, the release rate of naproxen could not be changed by varying molecular weight of PVA. Linearly released time range increased as drug loading dose increased, whereas decreased as plasticiser percentage increased up to 30%.

• Nuclear Engineering and Technology
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• v.33 no.6
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• pp.557-565
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• 2001

Variations in the number of early health effects resulting from the severe accidents of the YGN 3&4 nuclear power plants were examined for different combinations of release parameters and meteorological data . The release parameters and meteorological data were selected in combination to define a limited number of basic spectra characterized by release height, heat content, release time, warning time, wind speed, rainfall rate, and atmospheric stability class. Variant seasonal spectra were also defined in order to estimate the potential significance of seasonal variations as a factor determining the incidence or number of early health effects. The results show that there are large differences in consequences from spectrum to spectrum, although an equal amount and mix of radioactive material is released to the atmosphere in each case. Also, there are large differences in the estimated number of health effects from season to season due to distinct seasonal variations in meteorological combinations in Korea. Therefore, it is necessary to consider seasonal characteristics in developing optimum emergency response strategies.

• Journal of Digital Convergence
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• v.11 no.9
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• pp.159-166
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• 2013

In this paper, make a study decision problem called an optimal release policies after testing a software system in development phase and transfer it to the user. When correcting or modifying the software, finite failure non-homogeneous Poisson process model, presented and propose release policies of the life distribution, half-logistic property model which used to an area of reliability because of various shape and scale parameter. In this paper, discuss optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement. In a numerical example, the parameters estimation using maximum likelihood estimation of failure time data, make out estimating software optimal release time. Software release time is used as prior information, potential security damages should be reduced.

• Journal of Korean Institute of Industrial Engineers
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• v.15 no.1
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• pp.51-63
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• 1989

This paper considers software release problems based on Goel-Okumoto and S-shaped reliability growth models. Test of the software system is terminated after a preassigned time T, and it is released to the operational phase. It is assumed that correction cost of an error is increasing with test or operation time. Optimum software release time is obtained using total expected cost on the software life time as a criterion for optimization. In addition, optimal software release policies under the constraint of a software reliability requirement are discussed.

• Korean Journal of Applied Biomechanics
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• v.29 no.2
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• pp.121-128
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• 2019

Objective: The aim of this study was to examine the relation between swing phase and airborne phase of Tkatchev motion which was successfully performed with following motion by excellent middle and high school athletes in horizontal bar. Method: The subjects for this study were 8 male middle and high school top athletes. After their Tkatchev motions were filmed by two digital highspeed camcorders setting in 90 frames/sec at the 44th National Gymnastics against Cities and Provinces, the % lapse time lapse time of each instant, inferred maximum force acting on horizontal bar, and other kinematical variables were calculated through DLT method. After the relations among the % lapse times of each instants of downswing-start, downswing-finish, whipswing-finish, release, peak-height, and lapse time of regrasp, the relation among maximum force acting on bar, % lapse time, peak height, and the relation between % lapse time and release height were examined, the biomechanical timing characteristics of Tkatchev motion were as follows. Results: Firstly, it was revealed that the whole lapse time was $1.62{\pm}.06s$ and the correlation between the % lapse time of downswing-start and % lapse time of release was .819. Secondly, it was revealed that the pattern of COG path was shifted forwardly and tilted 11 clockwise from origin. Thirdly, it was revealed that maximum force acting on bar was inferred in $2,283{\pm}425N$ ($4.7{\pm}.6BW$) and the correlation between maximum force and peak height was r = .893. Lastly, it was revealed that the horizontal and vertical component of body COG velocity was $-2.14{\pm}.29m/s$, $2.70{\pm}.43m/s$ respectively, release height was $.49{\pm}.12m$, and shoulder angle was $139{\pm}5deg$, and that the later the % lapse time of release, the higher the release height (r = .935). Conclusion: It is desired that the gymnastic athletes should delay the downswing-start near the horizontal plane on $2^{nd}$ quadrant because the later the % lapse time of downswing, the higher the release height. After all the higher release height could ensure the athletes to regrasp the bar safely, the athletes should exercise to make downswing-start delay.

• Food Science and Biotechnology
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• v.18 no.5
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• pp.1071-1075
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• 2009

Allyl isothiocyanate (AI), a volatile compound of mustard, has excellent antimicrobial effects, but its volatility hinders its wide usage as an ingredient of food products. Microencapsulation technique, therefore, was applied for delaying the release time of AI. For delaying the release time of AI, the mustard powder, which contained AI, was microencapsulated with 5% modified starch by using fluidized bed processing. The efficiency of the controlled release of AI at various pH was analyzed by the head space (HS) analysis and solid phase microextraction (SPME) method using gas chromatography (GC). Also, modified starch encapsulated powder was added into kimchi for applying in food industry. As the result, the release time of AI was delayed by microencapsulation with modified starch and the higher pH could be the faster release of AI. Also, the period until the pH values and total acidity of kimchi reached up to 4.5 and 0.6%, which give its malsour taste, was extended by microencapsulation. These results showed that modified starch encapsulated powder could prolong the preservation in food system.

• Coupled systems mechanics
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• v.11 no.3
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• pp.217-231
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• 2022

The present paper is concerned with a delamination analysis of a multilayered frame structure that exhibits non-linear creep behavior. A solution to the strain energy release rate is obtained by considering the time-dependent complementary strain energy in the frame. The mechanical behavior of the frame is treated by using a non-linear stress-strain-time relationship. The time-dependent solution to the strain energy release rate obtained in the present paper holds for a multilayered frame made of arbitrary number of adhesively bonded layers of different thicknesses and material properties. Besides, the dealamination is located arbitrary along the thickness. The solution to the strain energy release rate is verifiedby applying the J-integral approach. A parametric study of the strain energy release rate is carried-out. Two three-layered frame configurations are analyzed in order to evaluate the influence of the delamination crack location along the thickness on the strain energy release rate. The strain energy release is analyzed also for the case when a notch is cut-out in the inner delamination crack arm. The results obtained are compared with these for a frame without a notch.