• 한국화재소방학회논문지
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• 제22권1호
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• pp.84-92
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• 2008

본 연구에서는 영동지역의 대표 수종인 소나무와 떡갈나무를 대상으로 주요 부위별 열적특성을 고찰하고자 콘칼로리미터 시험을 수행하여 중량변화, 착화시간, 화염유지시간, 발열량 그리고 CO와 $CO_2$ 배출농도를 비교 분석하였다. 소나무와 떡갈나무 모두 가지의 총중량감소가 가장 크게 나타났으며, 낙엽의 착화시간이 9 s 정도로서 가장 빠르게 나타났다. 낙엽과 수피부위의 화염유지시간은 $640{\sim}1,016s$ 정도였으며, 총방출열량은 낙엽비 생엽의 2배 정도인 60.1 $MJ/m^2$로 가장 높게 나타났다. 또한, CO 및 $CO_2$의 최대 배출농도는 떡갈나무의 가지부위가 소나무의 가지보다 2.82배 이상 높게 나타남으로써 소나무와 떡갈나무의 열적특성은 부위별로 많은 차이가 있음을 확인하였다.

• ETRI Journal
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• 제42권5호
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• pp.721-733
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• 2020

Recently, there is an increasing demand for ultra-low-latency (ULL) services such as factory automation, autonomous driving, and telesurgery that must meet an end-to-end latency of less than 10 ms. Fifth-generation (5G) New Radio guarantees 0.5 ms one-way latency, so the feasibility of ULL services is higher than in previous mobile communications. However, this feasibility ensures performance at the radio access network level and requires an innovative 5G network architecture for end-to-end ULL across the entire 5G system. Hence, we survey in detailed two the 3rd Generation Partnership Party (3GPP) standardization activities to ensure low latency at network level. 3GPP standardizes mobile edge computing (MEC), a low-latency solution at the edge network, in Release 15/16 and is standardizing time-sensitive communication in Release 16/17 for interworking 5G systems and IEEE 802.1 time-sensitive networking (TSN), a next-generation industry technology for ensuring low/deterministic latency. We developed a 5G system based on 3GPP Release 15 to support MEC with a potential sub-10 ms end-to-end latency in the edge network. In the near future, to provide ULL services in the external network of a 5G system, we suggest a 5G-IEEE TSN interworking system based on 3GPP Release 16/17 that meets an end-to-end latency of 2 ms.

• 한국응용과학기술학회지
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• 제32권2호
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• pp.202-214
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• 2015

Stimuli-responsive biomaterials that alter their function through sensing local molecular cues may enable technological advances in the fields of drug delivery, gene delivery, actuators, biosensors, and tissue engineering. In this research, pH-responsive hydrogel which is comprised of dimethylaminoethyl methacylate (DMAEMA) and 2-hydroxyethyl methacrylate (HEMA) was synthesized for the effective delivery of doxorubicin (Dox) to breast cancer cells. Cancer and tumor tissues show a lower extracellular pH than normal tissues. DMAEMA/HEMA hydrogels showed significant sensitivity by small pH changes and each formulation of hydrogels was examined by scanning electron microscopy, mechanical test, equilibrium mass swelling, controlled Dox release, and cytotoxicity. High swelling ratios and Dox release were obtained at low pH buffer condition, low cross-linker concentration, and high content of DMAEMA. Dox release was accelerated to 67.3% at pH 5.5 for 6-h incubation at $37^{\circ}C$, while it was limited to 13.8% at pH7.4 at the same time and temperature. Cell toxicity results to breast cancer cells indicate that pH-responsive DMAEMA/HEMA hydrogels may be used as an efficient matrix for anti-cancer drug delivery with various transporting manners. Also, pH-responsive DMAEMA/HEMA hydrogels may be useful in therapeutic treatment which is required a triggered release at low pH range such as gene delivery, ischemia, and diabetic ketoacidosis.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.161-165
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• 2014

The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidine in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and characterized in terms of preparation, viscosity and in vitro release. The viscosity of the gellan gum formulations in solution increased with increasing concentrations of gellan gum. In vitro study showed that the release of ranitidine from these gels was characterized by an initial phase of high release (burst effect) and translated to the second phase of moderate release. Single photon emission computing tomography technique was used to evaluate the stomach residence time of gel containing $^{99m}Tc$ tracer. The animal experiment suggested in situ gel had feasibility of forming gels in stomach and sustained the ranitidine release from the gels over the period of at least 8 h. In conclusion, the in situ gel system is a promising approach for the oral delivery of ranitidine for the therapeutic effects improvement.

• 한국농공학회논문집
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• 제56권3호
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• pp.11-17
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• 2014

We investigated the applicability of steel slag as a capping material in order to minimize phosphorus(P) release into seawater. Steel slag is a byproduct from the iron and steel industries and the use of steel slag has some advantages in respect of both cost and environmental concern. P removal by steel slag were studied in a batch system with respect to changes in contact time and initial concentration. Kinetic adsorption data were described well by pseudo 2nd order model, indicating rate limiting step for P adsorption to steel slag is chemical sorption. Equilibrium adsorption data fitted well to Langmuir isotherm model which describes for single layer adsorption. The maximum P adsorption capacity of steel slag was 7.134 mg-P/L. Increasing the depth of steel slag produced a positive effect on interruption of P release. More than 3 cm of steel slag was effective for blocking P release and 5 cm of steel slag was recommended as the depth for capping of P contaminated marine sediments. Increasing P concentration and flow rate had a negative effect on P removal ratio. It was concluded that the steel slag has a potential capping material for blocking P release from marine sediments.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.263-272
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• 2011

Tablet dosage forms have been preferred over other formulations for the oral drug administration due to their low manufacturing costs and ease of administrations, especially controlled-release applications. Controlled-release tablets are oral dosage forms from which the active pharmaceutical ingredient (API) is released over an intended or extended period of time upon ingestion. This may allow a decrease in the dosing frequency and a reduction in peak plasma concentrations and hence improves patient compliance while reducing the risk of undesirable side effects. Conventional singlelayered matrix tablets have been extensively utilized to deliver APIs into the body. However, these conventional single-layered matrix tablets present suboptimal delivery properties, such as non-linear drug delivery profiles which may cause higher side effects. Recently, a multi-layered technology has been developed to overcome or eliminate the limitations of the singlelayered tablet with more flexibility. This technology can give a good opportunity in formulating new products and help pharmaceutical companies enhancing their life cycle management. In this review, a brief overview on the multi-layered tablets is given focusing on the various tablet designs, manufacturing issues and drug release profiles.

• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.245-251
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• 2006

The novel microsphere blending and multiple emulsion method by single process was tried to prepare sustained release microspheres which release a physiologically active substance for long periods of time. A drug was separately dissolved in each of two or more oils containing biodegradable polymers to give the primary oil phases. The primary oil phases were dispersed in single aqueous phase in succession. From the drug-dispersed solution, the organic solvent was removed to produce microspheres. The accelerated drug release from the microsphere formulation prepared by single process through the multiple emulsion method was very similar to a physical blending of separately prepared microspheres using the same polymers. But long term release was not same. In this study, leuprorelin acetate loaded poly(lactide-co-glycolide) microsphere formulation for one-month delivery was developed by the multi-emulsion method followed by solvent extraction/evaporation method.

• Restorative Dentistry and Endodontics
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• 제15권1호
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• pp.88-96
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• 1990

The purpose of this study was to investigate the fluoride release and solubility of glass ionomer cement associated with three pH media. For this study, GC Fuji II discs (20.0mm in diameter ${\times}$ 1.5mm thick) were immersed in pH 4.0 lactic acid, pH 7.0 distilled water and pH 10.0 KOH solutions for 1, 7, 14 and 28 days. The amount of fluoride release from the cement into three pH media were measured by fluoride specific ion electrode and the solubility was measured by weight loss of discs. The results were as follows: 1. The lower was the pH of media, the more was the amount of release of fluoride. 2. The amount of fluoride release was increased with time lapse. 3. After I day, the solubility was the highest, and after 7 days that was the least. 4. The lower was the pH of media, the more was the solubility, but there was no statistical difference in solubility according to the pH change.

• 한국산학기술학회논문지
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• 제16권11호
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• pp.7549-7554
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• 2015

본 이 연구의 목적은 부유 기술을 이용하여 제형이 위에 더 오래도록 머무르면서 약물을 지속적으로 방출하는 이중정을 개발하는 것이다. 실험방법으로는 메트포르민을 주 약물로 선정하였는데, 그 이유는 메트포르민은 주로 소장 상부에서만 흡수되는 좁은 흡수 영역 대를 가지고 있는 점, 용해도가 매우 높아 약물 방출을 조절하는 것이 쉽지 않은 점 등 때문이다. 정제의 부유를 위한 가스를 생성하는 부분과 약물의 방출을 조절하는 부분의 간섭을 최소화하기 위해 이중정 타정 기를 사용해 이중정으로 제조하였으며, 정제의 모양, 질량 및 경도를 측정하였고, 부유정의 중요한 요소인 부유 촉발시간과 부유유지 시간을 평가하였다. 또, 약물의 방출 조절을 평가하기 위해 용출시험을 시행하였으며, 그 결과를 시판되고 있는 메트포르민 서방성 제제인 Glucopharge XR$^{(R)}$과 비교평가 하였다. 그 결과, 부유 촉발제인 $NaHCO_3$ 및 약물 방출 조절제인 hydroxypropyl methylcellulose (HPMC)의 사용량에 따라 13초의 부유 촉발시간, 10시간 이상의 부유 유지시간 및 시판 제제와 매우 유사한 약물 방출 거동을 확인할 수 있었다 ($f_2$: 89.6). 결론적으로 메트포르민을 함유한 위 체류 이중정을 성공적으로 개발할 수 있었으며, 그로 인해 메트포르민의 치료효과도 극대화 할 수 있을 것으로 예상된다.

• 응용통계연구
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• 제29권7호
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• pp.1257-1270
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• 2016

본 연구는 영화 흥행의 척도로서 총 관객수의 예측을 다루었다. 의사결정나무, MLP 신경망모형, 다항로짓모형, support vector machine과 같은 데이터마이닝 분류 기법들을 사용하여 개봉 전, 개봉 일, 개봉 1주 후, 그리고 개봉 2주 후 시점 별로 예측이 이루어진다. 국적, 등급, 개봉 월, 개봉 계절, 감독, 배우, 배급사, 관객수, 그리고 스크린 수와 같은 영화의 내재적인 속성을 나타내는 변수 뿐만 아니라 포털의 평점과 평가자 수, 블로그 수, 뉴스 수와 같은 온라인 구전 변수들이 예측변수로 사용되었다. 10-중 교차 검증에서 신경망모형의 정확도는 개봉 전 시점에서도 90% 이상의 높은 예측력을 보였다. 또한 최종 온라인 구전 변수의 추정치를 예측변수로 추가함으로서 예측의 정확도가 더 높아짐을 볼 수 있다.