Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Release Profile of Peptide from Biodegradable Microspheres: Comparison of Blending and Multiple Emulsion Method

고분자 혼합법과 다중 에멀젼법에 의해 제조된 생분해성 미립구로부터 펩타이드의 용출에 관한 연구

  • Jung, Goo-Young (College of Pharmacy, Chungnam National University) ;
  • Kim, Jung-Kwoun (Department of Pharmaceutical Research, Dongkook Pharmaceutical Research Institute) ;
  • Park, Mork-Soon (Department of Pharmaceutical Research, Dongkook Pharmaceutical Research Institute) ;
  • Myung, Pyung-Keun (College of Pharmacy, Chungnam National University)
  • Published : 2006.08.21
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Abstract

The novel microsphere blending and multiple emulsion method by single process was tried to prepare sustained release microspheres which release a physiologically active substance for long periods of time. A drug was separately dissolved in each of two or more oils containing biodegradable polymers to give the primary oil phases. The primary oil phases were dispersed in single aqueous phase in succession. From the drug-dispersed solution, the organic solvent was removed to produce microspheres. The accelerated drug release from the microsphere formulation prepared by single process through the multiple emulsion method was very similar to a physical blending of separately prepared microspheres using the same polymers. But long term release was not same. In this study, leuprorelin acetate loaded poly(lactide-co-glycolide) microsphere formulation for one-month delivery was developed by the multi-emulsion method followed by solvent extraction/evaporation method.

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References

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