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http://dx.doi.org/10.4333/KPS.2006.36.4.245

Release Profile of Peptide from Biodegradable Microspheres: Comparison of Blending and Multiple Emulsion Method  

Jung, Goo-Young (College of Pharmacy, Chungnam National University)
Kim, Jung-Kwoun (Department of Pharmaceutical Research, Dongkook Pharmaceutical Research Institute)
Park, Mork-Soon (Department of Pharmaceutical Research, Dongkook Pharmaceutical Research Institute)
Myung, Pyung-Keun (College of Pharmacy, Chungnam National University)
Publication Information
Journal of Pharmaceutical Investigation / v.36, no.4, 2006 , pp. 245-251 More about this Journal
Abstract
The novel microsphere blending and multiple emulsion method by single process was tried to prepare sustained release microspheres which release a physiologically active substance for long periods of time. A drug was separately dissolved in each of two or more oils containing biodegradable polymers to give the primary oil phases. The primary oil phases were dispersed in single aqueous phase in succession. From the drug-dispersed solution, the organic solvent was removed to produce microspheres. The accelerated drug release from the microsphere formulation prepared by single process through the multiple emulsion method was very similar to a physical blending of separately prepared microspheres using the same polymers. But long term release was not same. In this study, leuprorelin acetate loaded poly(lactide-co-glycolide) microsphere formulation for one-month delivery was developed by the multi-emulsion method followed by solvent extraction/evaporation method.
Keywords
Microspheres; Biodegradable polymers; Blending; Multiple emulsion;
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