• Journal of Physiology & Pathology in Korean Medicine
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• v.38 no.5
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• pp.187-195
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• 2024

Bones and teeth impact quality of life and serve as important indicators of overall health, and diseases such as osteoporosis and periodontitis are emerging as increasingly significant health issues in aging societies. In traditional Korean medicine(TKM), bones and teeth are classified under the kidneys, explaining their interrelationship, and biomedical studies have been published on this connection. This study aims to compare the perspectives of TKM and biomedicine on the relationship between the kidneys, bones, and teeth, focusing on similarities between the two disciplines. The fact that the kidneys produce active vitamin D, which contributes to skeletal formation, and that sex hormones, which influence the lifespan of osteoclasts and osteoblasts, resemble the role of the kidneys(腎) in TKM, which are associated with growth and reproduction, aligns with the TKM concept that "the kidneys govern the bones" (腎主骨). Furthermore, the histological similarity between bones and teeth, as well as the metabolic parallels involving osteoclast metabolism, retinoic acid metabolism, and vitamin D, support the idea that "teeth are the surplus of bones" (齒者骨之餘). In addition to the kidneys acting on the shared pathways of bones and teeth, the pathological link between kidney deficiency(腎虛) and dental diseases-caused by aging, overwork, or congenital deficiencies-explains the concept that "the kidneys govern the teeth"(腎主齒). This study contributes to an integrated understanding of both disciplines by comparing the TKM concept with biomedical explanations concerning the kidneys, bones, and teeth. Through this approach, it can be demonstrated that TKM concepts remain valid in modern contexts, while also suggesting the potential to explain less clearly understood TKM theories in this manner.

• The Journal of Korean Medicine
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• v.22 no.2
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• pp.94-101
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• 2001

Background and Purpose : Relationship between 17-KS.17-OHCS in 24hrs urine and Deficiency Syndrome of the Kidneys had been examined, but the study about 17-KS.17-OHCS in stroke patients was rare6'. In this study, we aimed to investigate the usefulness of 24hrs urine 17-KS.17-OHCS in stroke patients as an index for the Differentiation of Deficiency Syndrome of the Kidneys. Subjects : 66 stroke patients(male : female =2 9 : 37) were selected, they were admitted in the hospital of oriental medicine, Kyunghee university(from November 1 st, 1998 to May 30th, 2000). Their age was over 65 years. The patients who had renal malfunction, hyperthyroidism, hypothyroidism were excluded and who took chlorpromazine, spironolactone, digoxin, reserpine, hormonal agent were also excluded. Methods : After we selected the patients, we investigated the Differentiation of Syndrome by use of Diagnostic Paper and examined the level of 17-KS.17-OHCS in 24hrs urine. We compared Deficiency Syndrome with non-Deficiency Syndrome of the Kidneys using of 17-KS.17-OHCS in 24hrs urine. Results : 1. Stroke did not affect 17-KS.17-OHCS excretion in 24hrs urine. 2. In 24hrs urine, 17-KS of male stroke patients and 17-OHCS of female stroke patients were lower in patients diagnosed as a Deficiency Syndrome than non-Deficiency Syndrome of the Kidneys(p<0.05). 3. Among Deficiency Syndrome of Yin, Yang, Yang and Yin of the Kidneys group, there was no differentiation of 17-KS.17-OHCS in 24hrs urine(p>0.05).

• Journal of Veterinary Science
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• v.24 no.6
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• pp.75.1-75.8
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• 2023

Background: In veterinary medicine, previous studies regarding the diagnostic performance of shear wave elastography (SWE) in chronic kidney disease (CKD) are not consistent with each other. Moreover, there has been no study evaluating the relationship between symmetric dimethylarginine (SDMA) concentration and renal shear wave velocity (SWV) using two-dimensional SWE (2D SWE) in dogs with CKD. Objectives: This study aimed to evaluate the diagnostic capability of 2D SWE in dogs with CKD and to assess the relationship between renal SWV and SDMA concentration. Methods: Dogs with healthy kidneys and dogs with CKD underwent 2D SWE and SDMA assay. Renal stiffness was estimated as renal SWV in m/s. Results: SDMA concentration had a weak positive correlation with the left (r = 0.338, p = 0.022) and right renal SWV (r = 0.337, p = 0.044). Renal SWV was not significantly different between healthy kidney and CKD groups in the left (p = 0.085) and right (p = 0.171) kidneys. Conclusions: 2D SWE may could not distinguish between dogs with healthy kidney and dogs with early stage of CKD, but it would be useful for assessing the serial change of renal function in dogs.

• The Korea Journal of Herbology
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• v.23 no.2
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• pp.67-79
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• 2008

Objectives : The author studied on criterions and concepts of the four seasons, and also examined about outbreak, rise and decline, remedy and prescription of diseases. Methods : We researched that increase and decrease of vigor and up and down of Yin and Yang in human body are controled by sunlight through the literature. Results : The relationship between the human's five viscera and four seasons has the homeostasis as a result of the compatibility and rivalry process. Between of the human's five viscera and four seasons, the spleen plays important role of four seasons. The reason is that the liver, the heart, the lungs and the kidneys manages the 72 days in spring, summer, autumn and winter, repectively. However, the spleen arranges and regulates the liver, the heart, the lungs and the kidneys through the 18days of each season's ending, respectively. These are the basis of Lee Dong Won's(李東垣) 'The Spleen Strength Theory(補脾論). In four seasons, We make prescription harmonized with the energy such as rising in spring, floating in summer, astriction in autumn, preservation in winter. Conclusions : These results suggest that the criterion and the conception of the four seasons may be important role to remedy for diseases and to prescribe and to use of medicine.

• Journal of Sasang Constitution and Immune Medicine
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• v.31 no.1
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• pp.13-25
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• 2019

Objectives Lee Je-Ma's Sasang-philosophy that was discussed in Donguisusebowon is Maeumron and Qi-philosophy. Sasang-philosophy has a direct origin to Mencius, which discusses the Maeumron of Confucianism. Therefore the relationship between Maeumron of Donguisusebowon and Mencius Chapter 3 will be examined. Methods Materials and references were collected about the literature survey. Lee Je-Ma's books such as Donguisusebowon, Gyeokchigo and a book of Confucianism including the Mencius. Results and Conclusions Hoyeonjiqi in 'Sadanron' of Donguisusebowon encompasses the Qi of metaphysical personality and physiological Qi, and it can be seen that it is the Qi that fuses body and mind together. Benevolence, righteousness, propriety and wisdom are directly linked to the personal mind of Sasangin. Unlike the mencius's four clues of virtue, the Sadan is discussed in terms of the large and small organs in four constitution such sa lungs, spleen, liver, and kidneys. Next, In the relationship between Taesim of 'Whoakchungron' and greed of Mencius, if discuss a relationships between 'I understand language' and Taesim, Deceptive speech connects with the dogmatism of Soeumin, Licentious speech connects with indulgence of Taeumin, Crooked speech connects with laziness of Soyangin and Evasive speech connects with selfishness of Taeyangin. Also in the relationship between taking delight gladness without real cause idleness arrogant and Taesim, taking Delight connects with the dogmatism of Soeumin, Gladness without real cause connects with selfishness of Taeyangin, Idleness connects with laziness of Soyangin, and Arrogant connects with indulgence of Taeumin. The next thing, people of Four types of 'Gwangjeseol' coincide with Mencius. Also Love benevolence and enjoy goodness, Envy benevolence and jealous talent in the 'Gwangjeseol' are able to find the source directly in Mencius.

• Journal of Korean Medical classics
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• v.33 no.4
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• pp.167-182
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• 2020

Objectives : The relationship between the Lungs, Stomach and Kidneys were examined in relation to their pulses continuously beating without rest as discussed in the 『Lingshu·Dongshu』, with other chapters in the 『Huangdineijing』. Methods : Chapters in the 『Huangdineijing』 and annotations were referenced in relation to the contents in question of the 『Lingshu·Dongshu』. Results & Conclusions : In 『Lingshu·Dongshu』, the Stomach of the Zuyangming is central. In the flow of Qi that is produced and circulated from the Stomach, we can see that Ancestral qi that is created in the Stomach ascends and accumulates in the chest area to disperse Qi throughout the entire body according to breathing and pulsation, while Nutrient qi exits from the middle energizer and ascends to the Lungs, circulates the entire body and Qi that is partially similar to Defense qi moves upwards to the head and circulates. In the lower part of the body, Qi flows to the Zushaoyin that is associated with Jing qi to assist with actions of the Extra meridians, while it connects to the Ancestral sinew through Zujueyin allowing for smooth movement of the muscles and joints. The special emphasis on the pulsation points of the three meridians, Shoutaiyin, Zuyangming and Zushaoyin, is based on the Qi thoroughfare[氣街] theory, where production and circulation of all Qi in the upper, middle, and lower energizers of the body manifest as pulse movement of the three meridians, which are the fundamental rhythms and movements of life.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1265-1268
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• 2023

One important issue in using radiopharmaceuticals as therapeutic and imaging agents is predicting different organ absorbed dose following their injection. The present study aims at extrapolating dosimetry estimates to a female phantom from the animal data of ⁸⁹Zr radionuclide accumulation using the Sparks-Idogan relationship. The absorbed dose of ⁸⁹Zr radionuclide in different organs of the human body was calculated based on its distribution data in mice using both MIRD method and the MCNP simulation code. In this study, breasts, liver, heart wall, stomach, kidneys, lungs and spleen were considered as source and target organs. The highest and the lowest absorbed doses were respectively delivered to the liver (4.00E-02 and 3.43E-02 mGy/MBq) and the stomach (1.83E-03 and 1.66E-03 mGy/MBq). Moreover, there was a good agreement between the results obtained from both MIRD and MCNP methods. Therefore, according to the dosimetry results, [⁸⁹Zr] DFO-CR011-PET/CT seems to be a suitable for diagnostic imaging of the breast anomalies for CDX-011 targeting gpNMB in patients with TNBC in the future.

• The Journal of Korean Medical History
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• v.31 no.1
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• pp.23-42
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• 2018

This study examines the variation in diagrams of the kidney, and the effects on location of the Life Gate as a result. My study analyzes diagrams of kidney form and location, such as appearance, the vertebral spine, ShenXi, and "Life Gate", and also explores the causes for such variations. The kidney is commonly described as having the shape of a bean, which throughout medical history has showed almost no variation. The spine was initially described with a total of 21 vertebrae, and later with a range of 19-25 vertebrae. Regarding the height of kidney in relationship to the spine, it was initially described as beginning at the 14th vertebrae, and later changed to the 15th or 17th vertebrae. However, there have been no changes in the perception of the height of kidney. Initially, the location of the Life Gate could not be identified. Three different suggestions of its location were found throughout historical literature, including: (1) at or within the right kidney; (2) between two kidneys; and (3) between 14th-15th spine. There were also variations noted in the process of copying diagrams of kidney in many books not only because the work of copying was not precise, but also because each medical practitioner had a different interpretation of the kidney's form and function in Traditional Korean and Chinese Medicine. It appears that some practitioners may have been influenced by their understandings of theory of Life Gate.

• Korean Journal of Veterinary Research
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• v.39 no.4
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• pp.832-837
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• 1999

lntrarenal resistive index (RI) was determined in normal, sedated and diuretic kidneys. The mean RI values of normal dogs were $0.64{\pm}0.03$ without statistically significant difference between left and right kidney. Interrenal RI difference (${\Delta}RI$) was $0.03{\pm}0.01$. No significant relationship was found between mean intrarenal RI versus body weight. The mean intrarenal RI values after administration of acepromazine, xylazine, thiopental, and ketamine were $0.66{\pm}0.03$, $0.64{\pm}0.03$, $0.56{\pm}0.05$, and $0.50{\pm}0.05$, respectively. After administration of acepromazine or xylazine, a significant change of the RI was not found. But, a significant decrease of the RI following thiopental or ketamine administration could be observed as compared with the normal RI. The mean intrarenal RI values were $0.63{\pm}0.06$ and $0.62{\pm}0.04$ at 10 minutes and 30 minutes after injection of furosemide, respectively. No significant change of intrarenal RI was found after administration of furosemide. But, mannitol significantly decreased mean intrarenal RI to $0.57{\pm}0.02$ and $0.58{\pm}0.03$ at 30 minutes and 60 minutes, respectively. Based on the obtained results, values of 0.72 and 0.05 may be proposed as the reasonable upper limits of RI and ${\Delta}RI$ of normal average. Acepromazine or xylazine are recommended as anesthetics for renal diseases because they have less effect on the RI. Further study using mannitol injection to increase ${\Delta}RI$ may be suggested in unilateral urinary tract obstruction since mannitol more effectively changed mean RI than furosemide.

• Journal of the Korean Applied Science and Technology
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• v.33 no.3
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• pp.474-482
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• 2016

The black raspberry (Rubus coreanus Miquel) contains anthocyanin, tannins, gallotannin, gallic acid, ferulic acid and phenolics. It brightens the eyes and protects the liver and kidneys. It was effective for anti-aging. Thus, the purpose of this study was to inform the excellence of black raspberry and to screen antioxidant activity to ensure the possibility as a functional material. In this study, bioactive compounds in black raspberry were determined. Additionally, black raspberry was extracted by CM (chloroform:methanol, 2:1, v/v), 70% methanol and 70% ethanol, and were investigated and compared in vitro methods. Total phenol and flavonoid contents were measured to compare each different solvents. In addition, DPPH radical scavenging activity and ABTS radical scavenging activity, ferric reducing antioxidant power, reducing power were determined to measure the antioxidant activity. The results were the highest in 70% ethanol extracts, and the higher the concentration showed a significantly higher antioxidant capacity. When observed the relationship between the study, antioxidant activity of black raspberry was supposed to affect by the anthocyanin, phenol and flavonoid contents.