• Proceedings of the KSR Conference
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• 2003.05a
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• pp.159-164
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• 2003

The purpose of this article is to comparatively depict the organizational effectiveness of two rail firms based on the cognitive response of employees(group of drivers). To attain this purpose, several aspects of current personnel and organization management system and organizational culture are surveyed through questionaire and analyzed by SPSS. The questionaire includes two parts of items. First, it includes items on personnel-related factors such as evaluation system, job, wage, role, leadership and job satisfaction. Second, it includes items on organizational culture model suggested by Rousseau. The major findings are : 1) In general, the cognitive response of drivers in two firms concerning personnel-related aspects is to a certain degree negative. 2) The cognitive response of drivers in two firms concerning culture-related aspects is also awfully negative. 3) Job satisfaction of drivers in the firm A is highly related to role and leadership factors in terms of personnel-related aspects, on the one hand, and to achievement factor in terms of culture, on the other hand. In case of the firm B, job satisfaction of drivers is highly related to personnel evaluation factor as well as role and leadership factors in terms of personnel-related aspects, on the one hand, and to affiliation, power, and bureaucracy factors in terms of culture, on the other hand.

• Mycobiology
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• v.45 no.2
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• pp.101-104
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• 2017

We identified two genes related to fungicide resistance in Fusarium fujikuroi through random mutagenesis. Targeted gene deletions showed that survival factor 1 deletion resulted in higher sensitivity to fungicides, while deletion of the gene encoding F-box/WD-repeat protein increased resistance, suggesting that the genes affect fungicide resistance in different ways.

• Proceedings of the Korean Geotechical Society Conference
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• 1999.03a
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• pp.277-284
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• 1999

This study describes the influence factors related to slope failure pattern and dimension in the southern Kyounggi area. Intrusive and metamorphic rocks are distributed in the study area. Geological condition, rainfall property and slope geometry are influence on slope failure characteristics in the study we& Geological factors related to slope failure are rock type, geological structure and weathering condition. Because of deep soil (RS-CW) depth of granite region, circular failure type is major failure pattern in granite region. Almost granite slopes with circular or surface failure pattern are failed during heavy rainfall season. But typical wedge failure type related to geological structure factor is a main failure pattern of metamorphic rock slope. Additionally failure dimension is influenced by geological factors and several factors, i.e. natural slope condition, failure type, rainfall intensity and etc. failure height/width ratio and thickness/length ratio of granite slope are 0.88 and 0.23. But the ratios of metamorphic rock slope are 1.36 and 0.19.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.53-59
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• 2023

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has no effect on normal cells, but selectively can induce apoptosis in tumor cells. Gartanin, a xanthone compound in mangosteen, has been shown to inhibit cancer cell growth by arresting the cell cycle and inducing autophage. In this study, we revealed that gartanin can sensitize TRAIL-induced human liver cancer cell death. We also found that gartanin enhances DR5 expression, a death receptor for TRAIL. This effect appears to be related to CHOP activation associated with the response of endoplasmic reticulum stress. Gartanin treatment also inhibited p62 protein expression and cleaved LC3 to activate autophagy flux, which is related with TRAIL-induced cell death. Pretreatment with autophagy flux inhibitor, LY294002, inhibited gartanin-induced DR5 expression. In summary, our results reveal that the combined treatment of gartanin and TRAIL can be a valuable tool for cancer treatment.

• Food Science and Biotechnology
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• v.17 no.2
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• pp.367-372
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• 2008

Cellular protection against carcinogens could be achieved by the induction of phase 2 detoxifying and antioxidant enzymes such as glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO1). Nuclear transcription factor E2-related factor 2 (Nrf2) binds to antioxidant response element (ARE) in the promoter region of these genes and the resulting transactivation occurs. In the present study the effect of gujeolcho (Chrysanthemum zawadskii) roots on the Nrf2-ARE pathway were investigated. C. zawadskii root extract was fractionated with a series of organic solvents and their ability to induce Nrf2-ARE pathway was examined. We separated the most potent dichloromethane (DCM) fraction into 12 sub-fractions and found several sub-fractions with strong effects on the Nrf2-ARE pathway. Fraction 4 strongly induced the ARE-reporter gene activity as well as Nrf2 expression. Sitosterol was isolated as a major compound in fraction 4 although its activity was not as potent as its mother fraction. These results indicate that C. zawadskii roots might be used as a potential natural chemopreventive source.

• The Journal of the Korea Contents Association
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• v.20 no.11
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• pp.391-401
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• 2020

This study verified the reliability and validity of the Korean version of the Student Career Construct Inventory(K-SCCI) that was translated into Korean language from the Student Career Construct Inventory (SCCI) developed by Savickas et al.(2018). To achieve this, this study conducted item content analysis, exploratory factor analysis, confirmatory factor analysis, and criterion-related validity in 530 university students. As a result of item content analysis and exploratory factor analysis, it was found that 4 factor models and 18 items were the most appropriate in K-SCCI. The 4 factors were named as crystallizing a vocational self-concept, exploring to gather information about occupations, deciding to commit to an occupational choic, and preparing to implement that choice. As a result of confirmatory factor analysis to verify the goodness-of-fit of the 4 factor models, it appeared to be appropriate. As a result of analyzing the correlation with related measures to verify the criterion-related validity of measures, it was found that student career construct was negatively correlated with employment anxiety but positively correlated with career adaptability.

• Journal of Korean society of Dental Hygiene
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• v.6 no.1
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• pp.1-12
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• 2006

The purpose of this study was to examine what factors determined the image of dental hygienists. The subjects in this study were 396 patients and caregivers who visited 14 dental institutes in Seoul and Gyeonggi province. After a survey was conducted, the following findings were given: 1. As for what factors had a decisive impact on the image of dental hygienists, friendliness(4.53) ranked first. 2. The image of dental hygienists was decided by five different kinds of factors, which included institutional, subjective, work-related, formal and media factors. Those factors made a 57.827% prediction of the image of dental hygienists. 3. The relationship of their general characteristics to the decisive factors of dental hygienist image was as follows: 1) By age(pE0.01), marital status(pE0.01), education(pE0.01), occupation(pE0.001), were under the significantly different influence of the formal factor(pE0.01). 2) As to the type of dental institutes they visited, the subjective factor exercised a significantly different influence on the groups(pE0.01). 3) Regarding the frequency of visiting dental institutes, the institutional and work-related factors had a significantly different impact on the groups(pE0.05). 4) Concerning the experience of the caregivers, the work-related factor exercised a significantly different influence on the groups(pE0.05). 5) As to connections between their general characteristics and the decisive factors of dental hygienist image in different areas, the subjective factor mostly had the strongest impact, and the formal factor was least influential.

• Reproductive and Developmental Biology
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• v.29 no.2
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• pp.101-108
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• 2005

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a well-known inducer of apoptotic cell death in many tumor cells. 1RAIL is expressed in human placenta, and cytotrophoblast cells express 1RAIL receptors. However, the role of TRAIL in human placentas and cytotrophoblast cells is not. well understood. In this study a trophoblast cell line, JEG-3, was used as a model system to examine the effect of TRAIL. on key intracellular signaling pathways involved in the control of trophoblastic cell apoptosis and survival JEG-3 cells expressed receptors for 1RAIL, death receptor (DR) 4, DR5, decoy receptor (OcR) 1 and DeR2. Recombinant human TRAIL (rhTRAIL) did not have a cytotoxic effect determined by MIT assay and did not induce apoptotic cell death determined by poly-(ADP-ribose) polymerase cleavage assay. rhTRAIL induced a rapid and transient nuclear translocation of nuclear $factor-{\kappa}B(NF-{\kappa}B)$ determined by immunoblotting using nuclear protein extracts. rhTRAIL rapidly activated extracellular signal-regulated protein kinase (ERK) 1/2 as determined by immnoblotting for phospho-ERK1/2. However, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (p38MAPK) and Akt (protein kinase B) were not activated by rhTRAIL. The ability of 1RAIL to induce $NF-{\kappa}B$ and ERK1/2 suggests that interaction between TRAIL and its receptors may play an important role in trophoblast cell function during pregnancy.

• Environmental Engineering Research
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• v.13 no.3
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• pp.141-146
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• 2008

Transport of Escherichia coli ATCC 11105 through porous media was investigated in this study using two sets of column experiments to quantify the attachment-related parameters (sticking efficiency, attachment rate coefficient and filter factor). The first set of experiments was performed in quartz sand under different ionic strength conditions (1, 20, 100, 200 mM) while the second experiments were carried out in quartz sand mixed with metal oxyhydroxide-coated sand (0, 5, 10, 25%). The breakthrough curves of bacteria were obtained by monitoring effluent, and then bacterial mass recovery and attachment-related parameters were quantified from these curves. The first experiments showed that the mass recoveries were in the range of 13.3 to 64.7%, decreasing with increasing ionic strength. In the second experiments, the mass recoveries were in the range of 15.0 to 43.4%, decreasing with increasing coated sand content. The analysis indicated that the sticking efficiency, attachment rate coefficient and filter factor increased with increasing ionic strength and coated sand content. The value of filter factor in the first experiments ranged from 1.45 e-2 to 6.72 e-2 1/cm while in the second experiments it ranged from 2.78 e-2 to 6.32 e-2 1/cm. Our filter factor values are one order of magnitude lower than those from other studies. This discrepancy can be attributed to the size of sand used in the experiment. The analysis demonstrated that the travel distance of bacteria estimated using the filter factor can be varied greatly depending on the solution chemistry and charge heterogeneity of porous media.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.2
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• pp.95-111
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• 2022

Chronic obstructive pulmonary disease (COPD) is an important healthcare problem worldwide. Often, glucocorticoid (GC) resistance develops during COPD treatment. As a classic hypoglycemic drug, metformin (MET) can be used as a treatment strategy for COPD due to its anti-inflammatory and antioxidant effects, but its specific mechanism of action is not known. We aimed to clarify the role of MET on COPD and cigarette smoke extract (CSE)-induced GC resistance. Through establishment of a COPD model in rats, we found that MET could improve lung function, reduce pathological injury, as well as reduce the level of inflammation and oxidative stress in COPD, and upregulate expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), multidrug resistance protein 1 (MRP1), and histone deacetylase 2 (HDAC2). By establishing a model of GC resistance in human bronchial epithelial cells stimulated by CSE, we found that MET reduced secretion of interleukin-8, and could upregulate expression of Nrf2, HO-1, MRP1, and HDAC2. MET could also increase the inhibition of MRP1 efflux by MK571 significantly, and increase expression of HDAC2 mRNA and protein. In conclusion, MET may upregulate MRP1 expression by activating the Nrf2/HO-1 signaling pathway, and then regulate expression of HDAC2 protein to reduce GC resistance.