Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. It has been shown that repeated injections of cocaine produce increase in locomotor activity, expression of the immediate-early gene, c-fos in the nucleus accumbens (NAc), which was one of the main dopaminergic terminal areas. Herbal-acupuncture as a therapeutic intervention has been widely used for the treatment of many functional disorders such as drug abuse. Coptidis Rhizoma (CR) and its main component, berberine (BER) were selected as herbal medicine of herbal-acupuncture. Both medicines have been known to have the therapeutic effect on the central nervous system. In order to investigate the effects of CR and BER herbalacupuncture at shenmen (HT7) point (CR/H and BER/H) on the cocaine-induced behavioral sensitization, the influence of CR/H and BER/H on repeated cocaine-induced locomotor activity, the change of c-Fos expression in the brain by immunohistochemistry were examined. Male SD rats were given CR/H (0.4mg/kg) and BER/H (0.1mg/kg) 30 min before daily injections of cocaine hydrochloride (15mg/kg. i.p.) 10 days. After 3 days withdrawal, rats received a challenge injection of cocaine (15mg/kg, i.p.). Systemic challenge with cocaine produced much larger increased locomotor activity, accumbal Fos-like immunoreactivity in the NAc. Pretreatment with CR/H and BER/H significantly inhibited cocaine-induced locomotor activity, the change of c-Fos expression in the rats. Our data demonstrated that the inhibitory effects of cocaine-induced behavioral sensitization by CR/H and BER/H were closely associated with the reduction of presynaptic dopamine release in the NAc. These results suggest that CR/H and BER/H can be effectively applied to cocaine addiction.
Jun, Sung-Kwon;Yoon, Dong-Ho;Song, Jae-Joon;Kim, Se Hyung
Tunnel and Underground Space
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v.29
no.5
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pp.346-355
/
2019
When evaluating pillar stability in very closely spaced tunnels, a local safety factor (strength/stress ratio) at the minimum width has been widely used. Tension bolts have been frequently applied as reinforcement for the cases where safety factors are less than 1.0 from FEM stress analysis. However, the local safety factor shows a constant value irrespective of the change in pillar width/tunnel diameter (PW/D) and the safety factor of the pillar is underestimated because the variation of deviation stress is relatively small even when the pre-stressing is applied to the tension bolt. In addition, the average safety factor proposed by Hoek and Brown(1980) was reviewed, but the pillar safety factor was relatively overestimated when the width of the pillar was increased. As an alternative, the SRM safety factor using shear strength reduction method shows the effect of changing the safety factor in the case of no reinforcement and tension bolt reinforcement as the pillar width/tunnel diameter(PW/D) changes. The failure shape is also similar to the previous limit theory result. In this study, the safety factor was evaluated without considering rock bolt and shotcrete to distinguish reinforcing effect of tension bolt.
Journal of the Computational Structural Engineering Institute of Korea
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v.32
no.5
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pp.287-296
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2019
In this study, the effect of ground boundary conditions on the evaluation of blast resistance performance of precast arch structures was evaluated by a numerical analysis method. Two types of boundary conditions, namely, fixed boundary conditions and a perfectly matched layer (PML) were applied to numerical models. Blast loads that were much higher than the design load of the target structure were applied to compare the effects of the boundary conditions. The distribution and path of the ground explosion pressure, structural displacement, fracture of concrete, stress of concrete, and reinforcing bars were compared according to the ground boundary condition settings. As a result, the reflecting pressure shock wave at the ground boundaries could be effectively eliminated using PML elements; furthermore, the displacement of the foundation was reduced. However, no distinct difference could be observed in the overall structural behavior including the fracture and stress of the concrete and rebar. Therefore, when blast simulations are performed in the design of protective structures, it is rational to apply the fixed boundary condition on the ground boundaries as conservative design results can be achieved with relatively short computation times.
Although the soil nailing method is generally used as a gravity grouting, the development and application of pressurized grouting method has recently increased to address the problem of joint generation and filling due to grouting. Pressurized grouting of the soil nailing method is generally used in combination with ordinary portland cement and water. In the field, the cement is mixed with the rapid setting cement to reduce curing time because ordinary portland cement takes more than 10 days to satisfy the required strength. In this study, uniaxial compression tests and laboratory tests were carried out to confirm the efficiency of the grouting material according to the mixing ratio of rapid setting cement. The mixing ratio of 30% grouting satisfies the required strength within 7 days and satisfies the optimum gel time. As a result of the laboratory test with granite weathered soil, the reinforcing effect was confirmed to be 1.5 times as compared with the gravity type at an injection time of 10 seconds and a strain of 15%. The friction resistance increases linearly with the increase of the injection time, but it is confirmed that the friction resistance decreases due to the hydraulic fracturing effect at the injection time exceeding the limit injection pressure. Numerical analysis was performed to compare the stability of slopes not reinforced with slopes reinforced with gravity and pressurized soil nailing.
This study examines the effect of collector well installed to reduce groundwater level in the regions with the occurrence of landcreep, a soil mass movement triggered by instability on slopes. Slopes are prone to failure as a result of instability caused by its internal, topographic and geological properties as well as due to external factors such as rainfall and earthquake. In Korea during the rain season, rainfall infiltration affects the groundwater level in soil, building up porewater pressure and load, and finally drives slopes to collapse. Slope failure caused by rainfall infiltration has been leading to a drastic forest degradation. The studied slope is located adjacent to a valley, its terrain corresponds to piedmont gentle slope, while the upper part of the failure surface is steep. After reinforcing the terrain where landcreep had occurred and installing collector well on the slope, we measured the changes in the groundwater level. In order to analyze the relationship between the well and the slope, we calculated the ratio of groundwater level to rainfall before and after the installation of the collector well. As a result, it is confirmed that the ratio increases after the installation of the well, which in turn reduces the groundwater level. Analysis of the change in groundwater level after 3, 7, 15 days antecedent rainfall showed that the higher the overall groundwater level, the less the value ($r_p$) of groundwater level-rainfall ratio is, while the value becomes relatively greater when the groundwater level is low. In particular, if a slope has a large catchment basin as is in the case of the studied site, antecedent rainfall affects groundwater level in the order of 3 < 7 < 15 days.
Jo, Young-Seok;Kim, Yun-Hee;Hong, Ji-Yeon;Kim, Dong-Gyou;Kim, Bumjoo
Journal of Korean Tunnelling and Underground Space Association
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v.23
no.2
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pp.119-131
/
2021
In general, the stress is concentrated on the pillar of very near parallel tunnel (VNPT), and the pillar has been reinforced by using steel-wires to maintain the stability of the tunnel. However, since the strength of the pillar decreases in the soil layer, the reinforcing pillar with the steel-wires is insufficient for tunnel stability. In this study, the laboratory tunnel experiment was conducted to examine the reinforcement effect for a new method, of which the pillar of VNPT is strengthened by using steel-pipes. As a result, against overburden stress, the bearing capacity of the steel-pipe reinforcement was 22% greater than that of the steel-wire reinforcement. In using the Particle Image Velocimetry method, the analysis shows that the steel-pipe reinforcement forms a more favorable condition of which uniformly the overburden load acts on the VNPT and the pillar than the steel-wire reinforcement. Based on the results, the steel-pipe reinforcement is expected to bring a more positive effect on tunnel stability than the steel-wire reinforcement.
Lee, Kwang Hoon;Park, Yong Chan;Moon, Sung Jin;You, Kwang Ho
KSCE Journal of Civil and Environmental Engineering Research
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v.42
no.6
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pp.825-836
/
2022
Micropiles can be used to support additional load in extended building structures. However, their use brings about a risk of exceeding the bearing capacity of existing piles. In this study, pre-compression was applied to distribute the load of an existing building to micropiles, and an indoor loading test was performed to confirm the structural applicability of a wedge-type anchorage device designed to improve its capacity. According to the test results, the maximum strain of the anchorage device was 0.63 times that of the yield strain, and the amount of slip generated at the time of anchorage was 0.11 mm, satisfying structural standards. In addition, using MIDAS GTS, a geotechnical finite element analysis software, the effect of the size of the pre-compression, the thickness of the soil layer, and the ground conditions around the tip on the reaction force of the existing piles and micropiles were analyzed. From the numerical analysis, as the size of the pre-compression load increased, the reaction force of the existing pile decreased, resulting in a reduction rate of up to 36 %. In addition, as the soil layer increased by 5 m, the reduction rate decreased by 4 %, and when the ground condition at the tip of the micropile was weathered rock, the reduction rate increased by 14 % compared with that of weathered soil.
Purpose: How to build the attitude on brand is very important, because it affects the positive word of mouth and revisit intention. Brand attachment, brand name, and image congruence play important role on consumer behavior in terms of reinforcing consumers' perception of food service companies and differentiating them from competing brands. Following the planned behavior theory, this paper examines the effect of linking brand attitude to word-of-mouth and revisit intentions in the restaurant sector. Research design, data, and methodology: This paper examines the structural relationship among brand attachment, brand name, image congruence, brand attitude, WOM, and revisit intention. In order to test the purposes of this study, research model and hypotheses were developed. The questionnaire items were modified and used according to the content of this study based on previous studies. All constructs were measured by multiple items tested and developed in the previous research. The study is based on the quantitative method and considered 519 questionnaires fulfilled by customers of restaurants. The data were explored employing the partial least square-structural equation modelling (PLS-SEM). Frequency analysis was conducted to identify the general characteristics of the survey subjects. To measure the reliability and validity of the measurement tools, confirmatory factor analysis was conducted. Structural model analysis was conducted to verify the research model. Result: The findings demonstrate that brand attachment and brand name had positive effects on attitude while image congruence did not have. Also, attitude had positive effect on WOM and revisit intention. Conclusions: This study expands the literature about WOM and revisit intentions. This study expands prior research in a similar field to which the theory of planned behavior (TPB) is applied, and reveals that brand attachment, brand name, and brand image congruence play an important role in developing brand attitude that affect revisit intention and WOM. And provide guidelines on how to enhance competitiveness in the restaurant sector based on understanding of linking brand attitude to customer loyalty and repeat business. By putting into practice these suggestions in the restaurant industry, brands can easily build up their attitude and boost a positive WOM and the intention to revisit.
Park, Jong-Gun;Seo, Dong-Ju;Lim, Doo-Yeol;Lee, Yu-Jae;Heo, Gwang-Hee
Journal of the Korea institute for structural maintenance and inspection
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v.26
no.3
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pp.72-83
/
2022
This paper studied the effect on the microstructure, electrical properties, and compressive strength of cement mortar containing carbon fiber (CF) and steel fiber (SF), which are conductive materials. The resistivity of conductive fiber-reinforced cement mortar (FRCM) was measured using the 4-probe method, and the compressive strength was measured based on the compression test. Their performance was compared and reviewed with plain mortar (PM). Furthermore, the surface shape and composition of the fracture surface of the conductive FRCM were analyzed using a scanning electron microscope (SEM) and an energy disperse X-ray spectrometer (EDS). The results showed that the resistivity gradually increased as the curing time increased in all specimens, whereas the resistivity decreased significantly as the fiber volume fraction increased. Adding steel fibers up to 1.25% did not affect the resistivity of cement mortar considerably. On the contrast, the resistivity of carbon fiber was somewhat decreased even at low contents (ie, 0.1 to 0.3%), and thereafter, it was significantly decreased. The percolation threshold of the conductive CFRCM containing CF used in this experiment was 0.4%, and it is judged to be the optimum carbon fiber dosage to maximize the conductive effect while maintaining the compressive strength performance as much as possible. For the surface shape and composition analysis of conductive FRCM, the fracture surface was observed through SEM-EDS. These results are considered to be very useful in establishing the microstructure mechanism of reinforcing fibers in cement mortars.
KSCE Journal of Civil and Environmental Engineering Research
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v.43
no.5
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pp.577-585
/
2023
Lateral torsional buckling causessafety accidentssuch as collapse accidents during erection. Therefore, anaccurate safety designshould be conducted. Lateral torsional buckling canbe prevented by reinforcing the end orreducing the unbraced length. The method ofreducing the unbraced length by installing a crossframe has high material and installation costs and low maintenance performance.In addition, structuralsafety may be deteriorated due to cracks. The end reinforcement method using Concrete Filled Half Pipe Stiffeneris a method ofreinforcing the end of a plate girder using a stiffenerin the form of a semi-circular column. This method increasesthewarping strength ofthe girder and increasesthe lateral torsional buckling strength.In thisstudy, the effect ofincreasing the warping strengthof plate girders with concrete filled half pipe stiffeners was confirmed. To verify the effect, the results ofthe designequationand the finite element analysis were compared and verified through a experiment. As a result, the plate girderwithCFHPS increased thewarping strengthand confirmed that the lateral torsional buckling strength was increased.
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