• Journal of Veterinary Clinics
• /
• v.30 no.6
• /
• pp.482-485
• /
• 2013

This case report describes the increment of regulatory T cells in thyroid carcinoma of a mixed breed dog compared with normal dogs. A mixed breed dog was referred for a submandibular mass and hyperthermia. Right cervical mass was detected during the physical examination and radiography identified right cervical mass suspected thyroid gland. Accurate location and size of mass was confirmed using computed tomography and 3D reconstructed images. After confirmation of mass, surgical resection was performed and evaluation of regulatory T cells in blood of this patient was performed using flow cytometric assay. The percentage of regulatory T cells was 38.28% of all CD4 (+)/CD25 (+) T cells. This result was higher than median percentage of regulatory T cells of healthy 8 beagles ($7.66{\pm}1.65%$ (p<0.01) of all CD4 (+)/CD25 (+) T cells). And masses were confirmed as giant cell thyroid carcinoma based on histopathologic examination. After surgical resection of cervical mass was performed, the owner didn't want chemotherapy. Seven days later, cervical mass came out again. And CBC showed severe leukocytosis (WBC $47.6{\times}10^3/{\mu}L$) and non-regenerative anemia (PCV 21%). Suspected pulmonic metastasis regions became more severe. Finally the dog died of severe anemia and respiratory disorder.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.11 no.2
• /
• pp.9-19
• /
• 2016

The purpose of this paper is to examine the effect of entrepreneurial self-efficacy on entrepreneurial intention. Further, the paper aims to study the moderating effect of regulatory focus in the relationship between entrepreneurial self-efficacy and entrepreneurial intention. As per regulatory focus theory, individuals have different goal attainment approaches and underlying motivations; this posits two distinct orientations: promotion focus and prevention focus. Consequently, we hypothesize that the effect of entrepreneurial self-efficacy on entrepreneurial intention would differ depending on the individual's regulatory focus, either promotion or prevention. In order to test the hypotheses, we select a random sample of 494 entrepreneurship students at six universities across the country. The analysis includes a survey of 309 students. The results indicate that students' entrepreneurial self-efficacy has a positive effect on their intention to become entrepreneurs. Further, regulatory focus moderates the relationship between entrepreneurial self-efficacy and entrepreneurial intention. Specifically, the impact of entrepreneurial self-efficacy on entrepreneurial intention is greater in promotion-focused students than in prevention-focused students. The results highlight the need for education methodology that enhances students' entrepreneurial self-efficacy and specialized entrepreneurship education for prevention-focused students.

• Journal of Science and Technology Studies
• /
• v.18 no.1
• /
• pp.129-175
• /
• 2018

This paper examines asbestos activism in South Korea by focusing on the politics of knowledge between the asbestos activist group and regulatory agency on the risk of asbestos exposure. Asbestos activism has contributed to establishing asbestos pollution an important safety and public health agenda in South Korea. Asbestos pollution investigation is key to core argument of the activism that asbestos pollution is pervasive especially in urban environment and a serious environmental health problem with its worst consequences has not yet seen. A distinctive characteristic of such asbestos investigation is the use of "settled dust analysis," non-standard, non-legislated analysis method. In this paper, literary technologies used in asbestos investigation report written by activists and controversies over asbestos pollution measurement in Samsung's head office building. Asbestos activists successfully concentrated media's attention on their argument and mobilize resources needed to make policy decisions, by using settled dust analysis data. Regulatory agency and expert group, however, neither saw settled dust analysis nor activists argument persuasive enough to make policy changes, base on their evaluation on the use of standards and evidentiary context for analyzing measured data. While its explanatory power is partially acquired, through the dispute between asbestos activists and regulatory agencies unspoken assumptions of regulatory science was revealed and became the matter of social debate. Settled dust analysis captures the characteristic of asbestos analysis which combined social movement and science to challenge the regulatory agency and expert group.

• Molecules and Cells
• /
• v.39 no.6
• /
• pp.468-476
• /
• 2016

PLZF-expressing invariant natural killer T cells and CD4 T cells are unique subsets of innate T cells. Both are selected via thymocyte-thymocyte interaction, and they contribute to the generation of activated/memory-like CD4 and CD8 T cells in the thymus via the production of IL-4. Here, we investigated whether $PLZF^+$ innate T cells also affect the development and function of $Foxp3^+$ regulatory CD4 T cells. Flow cytometry analysis of the thymus and spleen from both CIITA transgenic C57BL/6 and wild-type BALB/c mice, which have abundant $PLZF^+$ CD4 T cells and invariant natural killer T cells, respectively, revealed that $Foxp3^+$ T cells in these mice exhibited a $CD103^+$ activated/memorylike phenotype. The frequency of $CD103^+$ regulatory T cells was considerably decreased in $PLZF^+$ cell-deficient $CIITA^{Tg}Plzf^{lu/lu}$ and $BALB/c.CD1d^{-/-}$ mice as well as in an IL-4-deficient background, such as in $CIITA^{Tg}IL-4^{-/-}$ and $BALB/c.IL-4^{-/-}$ mice, indicating that the acquisition of an activated/ memory-like phenotype was dependent on $PLZF^+$ innate T cells and IL-4. Using fetal thymic organ culture, we further demonstrated that IL-4 in concert with TGF-${\beta}$ enhanced the acquisition of the activated/memory-like phenotype of regulatory T cells. In functional aspects, the activated/ memory-like phenotype of Treg cells was directly related to their suppressive function; regulatory T cells of $CIITA^{Tg}PIV^{-/-}$ mice more efficiently suppressed ovalbumin-induced allergic airway inflammation compared with their counterparts from wild-type mice. All of these findings suggest that $PLZF^+$ innate T cells also augmented the generation of activated/memory-like regulation via IL-4 production.

• Journal of Microbiology and Biotechnology
• /
• v.25 no.8
• /
• pp.1339-1348
• /
• 2015

Until now, considerable effort has been made to engineer novel nitrogen-fixing organisms through the transfer of nif genes from various diazotrophs to non-nitrogen fixers; however, regulatory coupling of the heterologous nif genes with the regulatory system of the new host is still not well understood. In this work, a 49 kb nitrogen fixation island from P. stutzeri A1501 was transferred into E. coli using a novel and efficient transformation strategy, and a series of recombinant nitrogen-fixing E. coli strains were obtained. We found that the nitrogenase activity of the recombinant E. coli strain EN-01, similar to the parent strain P. stutzeri A1501, was dependent on external ammonia concentration, oxygen tension, and temperature. We further found that there existed a regulatory coupling between the E. coli general nitrogen regulatory system and the heterologous P. stutzeri nif island in the recombinant E. coli strain. We also provided evidence that the E. coli general nitrogen regulator GlnG protein was involved in the activation of the nif-specific regulator NifA via a direct interaction with the NifA promoter. To the best of our knowledge, this work plays a groundbreaking role in increasing understanding of the regulatory coupling of the heterologous nitrogen fixation system with the regulatory system of the recipient host. Furthermore, it will shed light on the structure and functional integrity of the nif island and will be useful for the construction of novel and more robust nitrogen-fixing organisms through biosynthetic engineering.

• Journal of Legislation Research
• /
• no.44
• /
• pp.63-101
• /
• 2013

This article firstly explores into the concepts, components, and pictures of institutional realization of competition and diversity respectively on the premise that competition and diversity comprise the primary objectives to be pursued by the broadcasting-related laws which provide the concrete measures of media policy, and argues that while the competition objective has differentiation factors, there are also particularities in the diversity value in the broadcasting-related laws as sector-specific competition laws. Then assuming that special competition rules including structural regulatory measures particularly in the broadcasting market are required in order to realize values of competition and diversity harmoniously, this article suggests the following improvement directions for regulations aimed at protection of competition and diversity in the broadcasting-related laws. The first one is with the improvement method for regulations aimed at protection of competition. Regulation on share of audience as an ex ante regulation of status and regulation on prohibited activities as an ex post regulation of conduct may play important roles in substituting the causative regulation while seeking for diversity value. For this purpose, it is needed to develop a concrete method that incorporates diversity-related factors as consideration factors in the standard for determining illegality of prohibited activities by inference to methods of determining illegality in the competition law. The second one is with the improvement method for regulations aimed at protection of diversity. This could be considered from three viewpoints that are the setting of regulatory objectives, the identification of alternative regulatory measures, and the choice of regulatory measures and levels suitable for regulatory objectives. From these viewpoints, the regulatory framework should be improved mainly with institutional measures in which diversity value is used for tools of assessment and analysis, not just remaining as mere rhetorical devices, and whether or to what extent to maintain regulations seemingly unreasonable in terms of harmonization with economic objectives such as competition should be discreetly reviewed.

• Journal of Service Research and Studies
• /
• v.6 no.3
• /
• pp.1-15
• /
• 2016

Despite that Korea has tried radical efforts in the global flow of regulatory reform in the past twenty years, the result was not radical at all, but rather disappointing. One examines the possibility of paradigm shift in regulatory reform based on new theoretic perspectives. Regulatory reform, one argues, is not just a neo-liberal approach to cut off overflowing regulation. It is a highly conflictual struggle in state order to move from industrial age paradigm to service age paradigm. In the process of the great shift states become integrated into the world of life constructed by the exercise of civil rights. The relation between the civic socio-economic life and the state apparatus became totally different. Past effort for deregulation missed this point without correct recognition of the role of civil freedom and rights in service economy. One treats three typical forms of regulation whereby conventional rules and regulations effectively damper the development of services: reciprocal perspective in contract management, industrial mind in urban and spaces design, and old way of human capital management. According these analyses a new initiative of regulatory reform is proposed to take place at the National Assembly.

• Korean Journal of Remote Sensing
• /
• v.35 no.2
• /
• pp.241-250
• /
• 2019

The current U.S. remote sensing act was made in 1992 and has been criticized for being outdated and inappropriate in view of the modern technological development. In order to enhance the American competitiveness and leadership in the world, President Trump announced Space Policy Directive (SPD) - 2 on May 24, which is designed to modernize the regulations related to commercial space activities including private remote sensing system operations. It should be noted that the regulatory reform efforts are made within broader terms of the National Security Strategy on Dec. 17, 2017, pursuing the enhancement of national security and economic prosperity as well. A legislative support in Congress has also been added to the Administration's efforts. The proposed regulatory reform on the licensing of commercial remote sensing system operations outlines the features of lessening administrative burden on applicants by simplifying the overall application process and of limiting the operations only when there is an impact upon the national security with clear and convincing evidence. But, due to a different regulatory system of each country, such a movement to expand an individual's freedom to explore and utilize outer space may result in an international dispute or a violation of international obligations, so there should be a merit in paying attention to the U.S. commercial remote sensing regulatory reform, and it is desirable to establish international norms as flexible and appropriate to the level of space technology and space industry.

• Science of Emotion and Sensibility
• /
• v.24 no.3
• /
• pp.27-40
• /
• 2021

Because of self-enhancement motives, when involved in social comparison, many people generally value things that are related to themselves, with the representative example being possessions, which is known as the endowment (ownership) effect. However, there are times when someone else's possessions appear to be better than our own, even if they are the same things, which is known as the endowment effect reversal. The purpose of this study was to explore the moderating variable that regulates the endowment effect and the endowment effect reversal by confirming whether the value estimation of others' belongings differed through a regulatory focus as it was surmised that the regulatory focus would moderate the endowment effect of the self versus the others' ownership. Foreign participants were shown the currency of a country they were unfamiliar with and asked to estimate the value in their home country currency. It was found that when people thought the money was their own, people with a promotion focus estimated the value to be higher than people with a prevention focus. However, when they thought it was someone else's money, the regulatory focus moderating effect was not found to be significant, which suggested that the endowment effect may be strengthened or eliminated depending on the individual's regulatory focus. Based on these study results, the implications, limitations, and suggestions for follow-up studies are discussed.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.16 no.6
• /
• pp.119-130
• /
• 2021

This study is a study on the regulatory focus and entrepreneurship that affect entrepreneurial motivation under uncertainty. In the empirical analysis results between the prevention focus, risk taking, and economic entrepreneurial motive, which were not observed in previous studies in Korea, this study tried to supplementally verify the previous studies by focusing on the limitations of the sample suggested as limitations. In particular, under a special external environment where uncertainty is deepening due to COVID-19 and the economic situation is being severely hit, we regressively analyze regulatory focus and risk taking, which are innate personal characteristics that can affect entrepreneurial motives. The mediating effect of risk taking was demonstrated. As a result of the empirical results, it was found that the prevention focus, risk taking, and economic entrepreneurial motivation had a significant effect, and it was shown that risk taking had a mediating effect between the prevention focus and the economic entrepreneurial motivation. This result is meaningful as a result not observed in previous studies, and it is judged that the control focus, which is an individual characteristic with a large innate tendency, interacts with the risk taking of the acquired tendency to influence the motivation to start a business. The results of this study can be of practical help by understanding and concentrating on regulatory focus and risk taking when conducting entrepreneurship or entrepreneurship education programs to entrepreneurs who dream of or want to start a business amid the growing uncertainty of the external environment. On the other hand, it is necessary to confirm whether these results, which are different from previous studies, are the effect of sample diversity or the external environment such as Corona 19, and re-verification through additional research is needed in the future.