• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1037-1040
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• 2015

Hepatitis C is a blood-borne infectious disease of liver, caused by a small enveloped, positive-single stranded RNA virus, called the hepatitis C virus (HCV). HCV belongs to the Flaviviridae family and has 6 genotypes and more than 100 subtypes. It is estimated that 185 million people are infected with HCV worldwide and 5% of these are in Pakistan. The study was designed to evaluate different genotypes of HCV circulating in District Mardan and to know about the behavior of these genotypes to different anti-viral regimes. In this study 3,800 patients were exposed to interferon alfa-2a plus Ribavirin treatment for 6-months and subjected to real-time PCR to check the viral response. Among these 3,677 (97%) patients showed no detectable HCV RNA while 123 (3%) patients (non-responders) remained positive for HCV RNA. Genotypes of their analyzed showed that most of them belonged to the 3a genotype. Non-responders (123) and relapsed (5) patients were subjected to PEG-interferon and Ribavirin therapy for next 6 months, which resulted into elimination of HCV RNA from 110 patients. The genotypes of the persisting resistant samples to anti-viral treatment were 3b, 2a, 1a and 1b. Furthermore, viral RNA from 6 patients remained un-typed while 4 patients showed mixed infections. HCV was found more resistant to antiviral therapy in females as compared to mals. The age group 36-45 in both females and males was found most affected by infection. In general 3a is the most prevalent genotype circulating in district Mardan and the best anti-viral therapy is PEG-interferon plus Ribavirin but it is common practice that due to the high cost patients receive interferon alfa-2a plus Ribavirin with consequent resistance in 3% patients given this treatment regime.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.40
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• pp.97-144
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• 2008

The purpose of this paper is to review the text of national legislation relating to the carrier's liability in respect of the carriage of passengers, baggage and cargo by air in major states such as United Kingdom, Germany, France, Canada, Russia and China, and to compare the air carrier's liability under the national legislations of above states with them under the Warsaw System relating to the international carriage by air. Also this paper reviews the text of the draft legislation relating to the carrier's liability in respect of the carriage by air in Korea. The Warsaw Convention for the Unification of Certain Rules Relating to International Carriage was adopted in 1929. In 1999, the ICAO adopted the Montreal Convention for the Unification of Certain Rules for International Carriage by Air vastly modernizing the unification of private air law. The Montreal Convention replaced the instruments of the “Warsaw System”, and came into force on 4 November 2003. The Montreal Convention is not only an international convention. It has also exercised a considerable influence on national legislation. A the Convention, or certain of its principles, with the object of regulating their national air transport. The main feature of the liability regime of the air carrier under the Montreal Convention is the two-tier liability system for death or injury of the passenger with strict liability up to 100,000 SDR and presumptive liability with a reversed burden of proof without any limit above that threshold. The principles of the liability of the air carrier under the Montreal Convention have been adopted into national legislations by the United Kingdom, Germany, France, Canada, Russia and China. Now the Ministry of Justice of Korea is proceeding to make a new national legislation relating to the liability of the air carrier in respect of the carriage by air. The draft legislation of the Part VI the Carriage by Air of the Commercial Code of Korea has adopted the main principles of the liability of the air carrier under the Montreal Convention. In conclusion, the national legislation relating to the liability of the air carrier in Korea will contribute to settle efficiently the dispute on the carrier's liability in respect of the carriage of passengers, baggage and cargo by air.

• Journal of Korean Society of Forest Science
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• v.97 no.4
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• pp.357-362
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• 2008

We compared the morphological characters and stable isotopes of seeds of wild simulated ginseng with those of cultivated field ginseng. Seeds were collected from ten areas for wild simulated ginseng and two areas for cultivated field ginseng. The length, width, thickness and number of seeds per gram were measured and the ratio of stable isotopes of carbon and nitrogen was analysed as well. There was a overlapping variation of morphological characters and the ratio of stable isotope of the wild simulated ginseng among study areas. In Geumsan area, compared with the seed of cultivated field ginseng, the seed of wild simulated ginseng was significantly small and light, and the ${\delta}^{15}N$(‰) of wild simulated ginseng was lower than that of cultivated field ginseng. However, it is somewhat impossible to compare the regional variation of the unique value of ${\delta}^{15}N$(‰) among study areas of wild simulated ginseng. We can suggest the value of ${\delta}^{15}N$(‰) can be used as detection factor for cultivation regime like chemical fertilization and organic farming.

• Journal of Korea Water Resources Association
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• v.41 no.7
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• pp.711-723
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• 2008

In this study, Hydrologic regime alterations(magnitude, magnitude and duration of annual extreme, frequency and duration of high and low pulse, rate and frequency of water condition changes, Range of Variability Approach) were analyzed by using Indicators of Hydrologic Alterations at the 11 major multi-purpose dam. The analysis result of the magnitude of monthly water conditions during drought season, inflow was $6.38m^3/sec{\sim}39.84m^3/sec$ and outflow was $20.36m^3/sec{\sim}49.43m^3/sec$, was increased $1.84%{\sim}200.98%$. The analysis result of the magnitude of monthly water conditions during flood season, inflow was from $79.06m^3/sec{\sim}137.12m^3/sec$ and outflow was from $65.32m^3/sec{\sim}80.16m^3/sec$, was decreased from $18.19%{\sim}40.39%$. The analysis result of the magnitude and duration of annual extreme, 1-day minimum was increased $82.86%{\sim}2,950%$, but 1-day maximum was decreased $34.78%{\sim}83.96%$. The analysis result of the frequency and duration of high and low pulse, low pulse count was decreased $29.67%{\sim}99.07%$ and high pulse count was also decreased $4.6%{\sim}92.35%$ after dam operation. Hydrograph rise rate was decreased $15.84%{\sim}79.31%$ and fall rate was $1.97%{\sim}107.10%$. RVA of 1-day minimum was increased $0.60{\sim}2.67$, also RVA of 1-day maximum was decreased $0.50{\sim}1.00$.

• Journal of the Korean Geographical Society
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• v.29 no.3
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• pp.233-252
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• 1994

One of major advantages of Lumped model is its ability to simulate extended flows. A further advantage is that it requires only conventional, readily available hydrological data (rainfall, evaporation and runoff). These two advantages commend the use of this type of model for the analysis of the hydrological effects of landuse change. Experimental Catchment(K11) of Kimakia site in Kenga experienced three phases of landuse change for sixteen and half years. The Institute of Hydrology offered the hydrological data from the catchment for this research. On basis of Blackie's(l972) 9-parameter model, a new model(R1131) was reorganized in consideration of the following aspects to reflect the hydrological characteristics of the catchment: 1) The evapotranspiration necessary for the landuse hydrology, 2) high permeable soils, 3) small catchment, 4) input option for initial soil moisture deficit, and 5) othel modules for water budget analysis. The new model is constructed as a 11-parameter, 3-storage, 1-input option model. Using a number of initial conditions, the model was optimized to the data of three landuse phases. The model efficiencies were 96.78%, 97.20%, 94.62% and the errors of total flow were -1.78%, -3.36%, -5.32%. The bias of the optimized models were tested by several techniques, The extended flows were simulated in the prediction mode using the optimized model and the data set of the whole series of experimental periods. They are used to analyse the change of daily high and low-flow caused by landuse change. The relative water use ratio of the clearing and seedling phase was 60.21%, but that of the next two phases were 81.23% and 83.78% respectively. The annual peak flows of second and third phase at a 1.5-year return period were decreased by 31.3% and 31.2% compared to that of the first phase. The annual peak flow at a 50-year return period in the second phase was an increase of only 4.8%, and that in the third phase was an increase of 12.9%. The annual minimum flow at a 1.5-year return period was decreased by 34.2% in the second phase, and 34.3% in the third phase. The changes in the annual minimum flows were decreased for the larger return periods; a 20.2% decrease in the second phase and 20.9% decrease in the third phase at a 50-year return period. From the results above, two aspects could be concluded. Firstly, the flow regime in Catchment K11 was changed due to the landuse conversion from the clearing and seedling phade to the intermediate stage of pine plantation. But, The flow regime was little affected after the pine trees reached a certain height. Secondly, the effects of the pine plantation on the daily high- and low-flow were reduced with the increase in flood size and the severity of drought.

• Journal of Korea Water Resources Association
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• v.45 no.5
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• pp.445-454
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• 2012

The present study aims to investigate the long-term channel morphological changes derived from channelization, embankment and levee construction works in unregulated fluvial channel of the Jiseock River. Analyses of aerial photographs taken past (Year 1966) and recent (Year 2002) showed the temporally remarkable changes in channel planform such as channel shape, bar migration, vegetation encroachment in bar. During the period, the natural single threading changed into braided types together with decreasing sinuosity by 9.2%, increasing vegetation occupied bar ranged 97% of total bars area. Because such channel morphological changes are closely similar to those in dam downstream channels, we assume that both/either flow regime alteration and/or sediment transport discontinuity may be critical for the fixed channel and spread of vegetated bars even in unregulated river without dam reservoir upstream. We found more reduced frequency and magnitude of flooding water level comparing with past, but no significant alteration of inter annual water level variation. Bed material has been coarsened by 4~5 times and the riverbed has been degraded in overall channel but aggraded locally in conjunction reach of tributaries. The results indicates that reduced sediment dynamics in fluvial channel which derived by bed material coarsening, river bed degradation and unbalanced sediment transport capacity between tributary and mainstem can be a causal factor to trigger channel morphological changes even in unregulated rivers.

• Tunnel and Underground Space
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• v.25 no.4
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• pp.320-331
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• 2015

This paper presents a case study of an enhanced geothermal system(EGS) demonstration project conducted in $Gro{\ss}$ $Sch{\ddot{o}}nebeck$, Northerm Germany, focusing on hydraulic stimulation. The project was conducted with doublet system in sandstone and volcanic formations at 4 - 4.4 km depth. Under normal faulting to strike-slip faulting stress regime, hydraulic stimulations were conducted at injection and production wells by massive waterfrac and gel-proppant fracturing. Injectivity index increased from $0.97m^3/(hr^*MPa)$ to $7.5m^3/(hr^*MPa)$ and productivity index increased from $2.4m^3/(hr^*MPa)$ to $10.1m^3/(hr^*MPa)$ by a series of hydraulic stimulations at both wells. After circulation tests through injection and production wells, however, productivity index decreased from $8.9m^3/(hr^*MPa)$ to $0.6m^3/(hr^*MPa)$ in two years. Slip tendency analysis for the stimulation in volcanic layer estimated the required pressure for shear slip and its preferred orientations and it showed reasonable match with actual stimulation results. Through the microseismicity observation for the stimulation of volcanic formation, only 80 seismic events with its moment magnitudes in -1.8<$M_W$<-1.0 were observed, which are unexpectedly low for EGS hydraulic stimulation.

• Journal of Korea Water Resources Association
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• v.40 no.2 s.175
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• pp.101-112
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• 2007

In this study, a methodology was developed to evaluate the effects produced in the event of joint-operation of dams from the viewpoint of water use. It was applied to evaluating the actual results of dam operation in the Han River basin. In order to evaluate the effects of real joint-operation in terms of water supply and flow conditions, the methodology used the satisfaction rate of water requirement and the stability of flow conditions at the evaluation site as indicator. In order to evaluate the effects of joint-operation in terms of power generation, the total power generation produced by dams was used as evaluation indicator. Actual operation results were evaluated by comparison of evaluation indicators relating to single dam operation by which the notified mont of water was supplied, as well as to optimization models. Results of actual joint-operation of the Han River basin, from 2001 to 2004, were compared yearly with results from single operation and optimization model; in terms of water supply, the satisfaction ratio of water requirement stood at $94.36{\sim}99.68%$ for single operation, $97.16{\sim}99.90%$ for actual joint-operation, and 100.0 % for optimization model for all four years. The stability of flow condition was evaluated by the coefficient of river regime and coefficient of flow conditions definitely, indicating that flow conditions were more stable in case of actual operation and optimization models than in case of single operation. The actual total power generation was compared with that generated by other operation rules, indicating that the optimization model increased the power generation by $-3.47{\sim}6.54%$ compared with the actual total power generation, and that the single operation decreased the power generation amount by $12.68{\sim}38.94%$ compared with the actual total power generation.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.1
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• pp.97-106
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• 2011

Purpose: This review article was written to theoretically compare the depressing force (pressure, adhesion) to the cornea between when the spherical lenses were being tightly and flat fitted. Methods: Mathematical equations and their numerical solution programs (model) were formulated to calculate the depressing (adhesion) force to the cornea by both the tightly and flat fitted contact lenses. Based on this proposed model the effects of parameters characterizing a contact lens such as BCs, diameters, edge shape and corneal shape (ratio of long and short corneal axis, p) on the depressing force to the cornea were predicted/analyzed in both tightly and flat fitting regimes. Results: Corneal adhesion increased as the corneal p-value increased. Adhesion increase caused by the increased p-value was much larger in flat fitted case than in tight fitted one. Corneal adhesion reduced abruptly as the BC increased in flat fitting regimes while the adhesion rise was insignificant in tight fitting ones. Reduction in corneal adhesion due to lens-size increase was predicted to be insignificant in both tight and flat fitting regimes. Both the lens edge shape (edge angle) and thickness were relevant only in tight fitting regime. Corneal adhesion increased as the increased with tight-fitted lenses. As the thickness of tight fitted lenses increased, corneal adhesion inversely decreased. Conclusions: The two most significantly affecting the depressing force to cornea were found to be the degree of corneal bending toward the periphery and the BCs of lenses.

• Management & Information Systems Review
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• v.23
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• pp.75-97
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• 2007

In the meantime hospital system of Korea has institutionally performed its errand in stable circumstance, however the system now faces with new environment of change of customer's satisfaction, of regime, deepening of competition, and opening market. Under the rapidly and complicatedly changing circumstance, the hospital system is required to promote getting a dominant position in the competition, enhancing outcome, creating value added, and customer satisfaction in both internally and externally likewise other organizations, as they continuously introduce a knowledge management and originate, accumulate, and put the knowledge to practical use. This organization capacity of knowledge management involves a process of management that requires great change of all organizations and individuals and it is brought up through four steps which are Initiation, Propagation, Integration, and Networking. The main factors of successful knowledge management are intension of the chief executive officer(CEO), organizational culture, appraisal and compensation of work, knowledge controlling system, and organizational structure, and each of these five stage has got different characteristic. To be successful by introducing knowledge management, hospital organization should be based on these premises. Not only CEO or the director of a hospital, but also the constituent members should be fully aware of knowledge, the characteristic of knowledge management, and successful factors of this operation. Should understand step-by-step characteristic of knowledge management, therefore able to analyse a situation of specific hospital and see which step corresponds to that hospital. By analysing, constituents should make up for the weak points and ready to move on to next step. CEO or the director of a hospital should be aware of knowledge management as a strategic factor which is able to get a dominant position in the rapidly changing environment, and also it should be firm in the director's intention to introduce the knowledge management into the hospital. By continuously carrying out education and training constituent members, the director of a hospital should promote their interest and participation in knowledge management, and build an organization culture that ultimately creates, accumulates, shares, and put the knowledge to practical use. The hospital organization needs to systematize an institution of objective compensation that corresponds to objective appraisal of knowledge management outcome. The hospital ought to build knowledge controlling system in stages, in order to take the initiative in rapidly changing environment. By considering the characteristic of hospital system, it is required to change the organizational structure into self-managing team which is a sort of horizontal structure that allows members to make decisions and take the responsibility by themselves. The limitation of this study is experimental study. Positive investigation about successful factors of hospital knowledge management and characteristic of each steps is expected with following study.