• Journal of Ginseng Research
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• v.28 no.1
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• pp.18-26
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• 2004

The effect of Panax ginseng administration in muscle inflammatory process induced after eccentric exercise, that causes myofibrillar disruption, was studied. Changes in lipid peroxidation, inflammation, glycogen levels in muscle and release of myocellular proteins to blood were measured. The analyses were performed immediately after eccentric exercise and over week since this period are necessary for the muscle damage-repair cycle. The ginseng extract (100 mg kg$^{-1}$ ) was orally administered to rats for three months, before the eccentric exercise performance. The results showed the protective role of ginseng against skeletal muscle damage. This effect could be associated with their membrane stabilising capacity since creatine kinase (CK) activity was significantly decreased 96 h post-exercise from 523$\pm$70 to 381$\pm$53 and 120 h post-exercise from 443$\pm$85 to 327$\pm$75 in treated animals. $\beta$-glucuronidase activity, as indicator of inflammation, showed a significant reduction of about 15-25% in soleus, vastus and triceps in these post-exercise times. The lipid peroxidation, measured by malondyaldehyde levels, was significantly decreased in the 24 h post-exercise period in soleus and vastus intermedius muscles and on the recovery period. Finally ginseng administration reduced significantly the decrease of the glycogen levels immediately after exercise and when the regenerative process took place (72-168 h post exercise). Collectively, the results have showed that ginseng did not inhibit the vital inflammatory response process associated with the muscle damage-repair cycle but presumably ameliorate the injury.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.159-175
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• 2002

The effect of Panax ginseng administration in muscle inflammatory process induced after eccentric exercise, that causes myofibrillar disruption, was studied. Changes in lipid peroxidation, inflammation, glycogen levels in muscle and release of myocellular proteins to blood were measured. The analyses were performed immediately after eccentric exercise and over week since this period are necessary for the muscle damage-repair cycle. The ginseng extract $(100\;mg\;kg^{-1})$ was orally administered to rats for three months, before the eccentric exercise performance. The results showed the protective role of ginseng against skeletal muscle damage. This effect could be associated with their membrane stabilising capacity since creatine kinase (CK) activity was significantly decreased 96 h post-exercise from $523{\pm}70\;to\;381{\pm}53$ and 120 h post-exercise from $443{\pm}85\;to\;327{\pm}75$ in treated animals. ${\beta}-glucuronidase$ activity, as indicator of inflammation, showed a significant reduction of about $15-25\%$ in soleus, vastus and triceps in these post-exercise times. The lipid peroxidation, measured by malondyaldehyde levels, was significantly decreased in the 24 h postexercise period in soleus and vastus intermedius muscles and on the recovery period. Finally ginseng administration reduced significantly the decrease of the glycogen levels immediately after exercise and when the regenerative process took place (72-168 h post exercise). Collectively, the results have showed that ginseng did not inhibit the vital inflammatory response process associated with the muscle damage-repair cycle but presumably ameliorate the injury.

• Journal of Animal Science and Technology
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• v.64 no.6
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• pp.1132-1143
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• 2022

Insects are a valuable natural source that can produce a variety of bioactive compounds due to their increasing species diversity. CopA3 is an antimicrobial peptide derived from Copris tripartitus (i.e., the dung beetle). It is known to increase the proliferation of colonic epithelial and neuronal stem cells by regulating cell cycle. This research hypothesized that CopA3 can promote the proliferation of porcine muscle satellite cells (MSCs). The effects of CopA3 on porcine MSCs, which are important for muscle growth and regeneration, remain unclear. Here, we investigated the effects of CopA3 on porcine MSCs. According to viability results, we designed four groups: control (without CopA3) and three treatment groups (treated with 5,10, and 25 ㎍/mL of CopA3). At a CopA3 concentration of 5 ㎍/mL and 10 ㎍/mL, the proliferation of MSCs increased more than that observed in the control group. Furthermore, compared to that in the control, CopA3 treatment increased the S phase but decreased the G0/G1 phase ratio. Additionally, early and late apoptotic cells were found to be decreased in the 5 ㎍/mL group. The expressions of the myogenesis-related transcription factor PAX7 and MYOD proteins were significantly upregulated in the 5 ㎍/mL and 10 ㎍/mL groups, whereas the MYOG protein remained undetected in all group. This study suggested that CopA3 promotes muscle cell proliferation by regulating the cell cycle of MSCs and can regulate the activity of MSCs by increasing the expressions of PAX7 and MYOD.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.3
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• pp.1-9
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• 2005

In this paper, an operation algorithm and a performance simulator are developed for a 42-volt ISG vehiclewhich consists of 5 kW ISG, 2500cc IC engine, torque converter and 4 speed automatic transmission. Modularapproach using MATLAB Simulink is used to construct a dynamic model of the vehicle powertrain which is obtainedfrom each component such as engine, battery, ISG, torque converter, etc.. An operation strategy for a 42-volt ISG vehicle including the function such as engine idle stop and regenerative braking is proposed. Performance simulator is developed based on the dynamic models of the powertrain. It is found from the simulation results that fuel economy can be improved as much as 6 percent for FTP75 driving cycle mostly owing to the engine idle stop.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.12
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• pp.2197-2210
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• 2016

Recently, the trend of zero emissions has increased in automotive engineering because of environmental problems and regulations. Therefore, the development of battery electric vehicles (EVs), hybrid/plug-in hybrid electric vehicles (HEVs/PHEVs), and fuel cell electric vehicles (FCEVs) has been mainstreamed. In particular, for light-duty electric vehicles, improvement in electric motor performance is directly linked to driving range and driving performance. In this paper, using an improved design for the interior permanent magnet synchronous motor (IPMSM), the EV driving range for the light-duty EV was extended. In the electromagnetic design process, a 2D finite element method (FEM) was used. Furthermore, to consider mechanical stress, ANSYS Workbench was adopted. To conduct a vehicle simulation, the vehicle was modeled to include an electric motor model, energy storage model, and regenerative braking. From these results, using the advanced vehicle simulator (ADVISOR) based on MATLAB Simulink, a vehicle simulation was performed, and the effects of the improved design were described.

• The Transactions of the Korean Institute of Power Electronics
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• v.15 no.6
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• pp.487-497
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• 2010

This paper describes the PSIM simulator for the analysis of the series type HEV operation. The traction force of the series type HEV of which engine is electrically coupled with a traction motor is supplied from the traction motor only. The rating of each power train components, such as gear, motor, ESS, ICE/generator, is designed with the Energy-Based Modeling method and the Electrical Peaking Hybrid(ELPH) method. Under driving cycle, the designed series HEV is evaluated with the developed PSIM simulator. A comparison between the conventional braking and the regenerative braking is performed with the average motor input power. And the fuel economy analysis is carried out on the basis of the simulation results.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.24 no.2
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• pp.121-128
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• 2012

Improvement in the energy efficiency has been studied of the desiccant cooling system by applying a vapor compression type heat pump to modify the system into a hybrid system. The cycle simulation was performed and the results were compared between a reference desiccant cooling system composed of a desiccant rotor, a sensible rotor and a regenerative evaporative cooler, and a hybrid desiccant cooling system with the sensible rotor being replaced by a heat pump. Though the electric consumption increases as much as the compressor power consumption, the total cooling capacity increases and the thermal energy input decreases by the addition of the heat pump. Therefore, the total energy efficiency can be improved if the increase in the electric consumption can be compensated with the increase in the cooling capacity and the decrease in the thermal energy input. The results showed that the total energy efficiency is optimized at a certain heat pump capacity. When the heat from the CHP plant is used for the thermal energy input, the energy consumption of the hybrid system is reduced by 20~30% compared with the reference system when the heat pump shares 30~40% of the total cooling capacity.

• 전기의세계
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• v.31 no.1
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• pp.50-58
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• 1982

As a method for improving the power factor and the waveform of ac line current drawn by ac to dc converters, converters of pulse-width control type with forced commutation circuits have been developed in recent years. However, these converters have rather complex commutation circuits which contain auxiliary thyristors in addition to the main thyristors, and their performance is not satisfactory. This paper proposes a new pulse-width controlled ac to dc converter, and analyses its commutation mechanism and its input and output characteristics. The proposed converter circuit consists of a usual thyristor bridge circuit with series diodes to which reactors and diodes are added. This circuit dose not contain auxiliary thyristors, and in this sense it is simpler than the previous converter circuits of pulse-width control type. Since the main thyristors of the converter can be forcedly turned off several times in a half cycle of source voltage, a pulse-width modulation control is possible in order to improve the current waveform as well as the power factor on ac line side. As to dc output side it is shown that the adjustable range of output voltage is wide and the voltage regulation is good due to a rapid reversal of voltage across the commutating capacitors by LC resonance during commutation period. It is also shown that the regenerative operation of the converter is possible.

• BMB Reports
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• v.52 no.7
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• pp.424-433
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• 2019

Autism spectrum disorder (ASD) is a complex neurodevelopmental monogenic disorder with a strong genetic influence. Idiopathic autism could be defined as a type of autism that does not have a specific causative agent. Among signalling cascades, mTOR signalling pathway plays a pivotal role not only in cell cycle, but also in protein synthesis and regulation of brain homeostasis in ASD patients. The present review highlights, underlying mechanism of mTOR and its role in altered signalling cascades as a triggering factor in the onset of idiopathic autism. Further, this review discusses how distorted mTOR signalling pathway stimulates truncated translation in neuronal cells and leads to downregulation of protein synthesis at dendritic spines of the brain. This review concludes by suggesting downstream regulators such as p70S6K, eIF4B, eIF4E of mTOR signalling pathway as promising therapeutic targets for idiopathic autistic individuals.

• International Journal of High-Rise Buildings
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• v.12 no.2
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• pp.121-128
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• 2023

Cities cover only 3% of the planet's surface, yet they are responsible for more than 75% of the global emissions. Given the projected urban built area will double by 2060, the carbon emitted from cities will further increase. SOM proposes the Urban Sequoia concept, for buildings that go beyond 'net zero' and absorb carbon from the atmosphere. This concept combines multiple strategies, including the use of an optimised building form with a highly efficient structural system, modularized prefabrication techniques, holistic integration of facade, MEP and interiors' components, bio-based materials, and Direct Air Capture (DAC) technology, to reduce a 40-storey building's whole life cycle carbon emissions by more than 300% over a 100-year lifespan. Calculations of embodied carbon emissions are performed with SOM's in-house Environmental Analysis (EA) Tool to demonstrate the effectiveness of employing Urban Sequoia's design strategies in the design of new buildings using current technologies.