• Biomolecules & Therapeutics
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• 제28권5호
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• pp.482-489
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• 2020

G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of pathological cardiac hypertrophy. To discover novel scaffolds that selectively inhibit GRK5, we have identified a novel small molecule inhibitor of GRK5, KR-39038 [7-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-2-(2-chlorophenyl)-6-fluoroquinazolin-4(3H)-one]. KR-39038 exhibited potent inhibitory activity (IC₅₀ value=0.02 µM) against GRK5 and significantly inhibited angiotensin II-induced cellular hypertrophy and HDAC5 phosphorylation in neonatal cardiomyocytes. In the pressure overload-induced cardiac hypertrophy mouse model, the daily oral administration of KR-39038 (30 mg/kg) for 14 days showed a 43% reduction in the left ventricular weight. Besides, KR-39038 treatment (10 and 30 mg/kg/day, p.o.) showed significant preservation of cardiac function and attenuation of myocardial remodeling in a rat model of chronic heart failure following coronary artery ligation. These results suggest that potent GRK5 inhibitor could effectively attenuate both cardiac hypertrophy and dysfunction in experimental heart failure, and KR-39038 may be useful as an effective GRK5 inhibitor for pharmaceutical applications.

• Steel and Composite Structures
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• 제25권6호
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• pp.663-670
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• 2017

The problem of layup optimization of the composite laminates involves a very complex multidimensional solution space which is usually non-exhaustively explored using different heuristic computational methods such as genetic algorithms (GA). To ensure the convergence to the global optimum of the applied heuristic during the optimization process it is necessary to evaluate a lot of layup configurations. As a consequence the analysis of an individual layup configuration should be fast enough to maintain the convergence time range to an acceptable level. On the other hand the mechanical behavior analysis of composite laminates for any geometry and boundary condition is very convoluted and is performed by computational expensive numerical tools such as finite element analysis (FEA). In this respect some studies propose very fast FEA models used in layup optimization. However, the lower bound of the execution time of FEA models is determined by the global linear system solving which in some complex applications can be unacceptable. Moreover, in some situation it may be highly preferred to decrease the optimization time with the cost of a small reduction in the analysis accuracy. In this paper we explore some machine learning techniques in order to estimate the failure of a layup configuration. The estimated response can be qualitative (the configuration fails or not) or quantitative (the value of the failure factor). The procedure consists of generating a population of random observations (configurations) spread across solution space and evaluating using a FEA model. The machine learning method is then trained using this population and the trained model is then used to estimate failure in the optimization process. The results obtained are very promising as illustrated with an example where the misclassification rate of the qualitative response is smaller than 2%.

• 대한기계학회논문집A
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• 제36권3호
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• pp.245-252
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• 2012

본 연구는 간단한 수치해석적 방법을 통해 연성재료의 파괴를 예측하는 방법을 소개하였다. 응력에 의해 계산된 파괴 변형률을 통해 손상을 계산하는 과정을 다중 관통균열이 있는 평판 인장시험편의 유한요소 해석을 통해 구현하였다. 이 기법은 ABAQUS 에서 제공하는 user-defined subroutine 을 이용하여 구현되었다. 제시된 기법을 적용하여 다중균열 해석을 수행하였고 이 결과를 일본 연구자에 의해 수행된 실험 결과와 비교하였다. 해석결과와 실험결과가 비교적 잘 일치함을 확인하였고 이를 통해 제시된 기법의 타당성을 검증할 수 있었다.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1997년도 춘계학술발표회논문집(1)
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• pp.484-488
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• 1997

Fission product release (FPR) assessment for 100% reactor outlet header (ROH) break in CANDU reactor loaded with CANFLEX-NU fuel bundles has been performed. The predicted results are compared with those for the reactor loaded with standard 37-element bundles. The fuel failure thresholds for the CANFLEX and standard bundle elements are very similar. All the sheaths at the corresponding fuel failure thresholds for the CANFLEX and standard bundles fail due to the significant cracks in the surface oxide, except those for the CANFLEX inner element at burnups of 220 to 240 MW.h/kg(U), which fail due to the excessive diametral strain. The fuel failure analysis predicts that the number of failed fuel elements for the CANFLEX bundle case is none, while that for the standard bundle case is 1827. The total (gap plus bound) I-131 releases for the CANFLEX and standard bundles are none and 5889 TBq, respectively The significant reduction of the number of failed fuel elements and FPR for the CABFKEX fuel bundle is attributed to the lower linear power of the CANFLEX fuel bundle compared with the standard fuel bundle.

• 한국농공학회지
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• 제31권2호
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• pp.43-53
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• 1989

In this research programs, a series test was conducted to show the effects of freeze/thaw process on the various soil properties. The tests were carried out taken from the west sea shore of Korean peninsular and the west sea shore of Scotland, and their results are as follows; 1. There was a positive total heave in a freezing run, although water may he expelled for the sample initially. The water flow must he reverse' from expulsion to intake. 2. The confining pressure had an overriding influence on the heave and frost penetration, a sudden change of the axial strain at failure with strain rate was observed occuring at a strain rate between 10-5 and 10-6, and the initial friction angle of frozen clay was appeared zero. 3. There was shown a significant decrease in liquid limit of soil which was subjected to freeze/thaw process for the initial value of about 20% because of soil particles aggregation. 4. The cyclic freeze/thaw caused a sinificant reduction in shear strength and its thixotropic regain. The frozen/thawed soil exibited negative strength regain, particularly at high freeze/thaw cycles. 5. The freezing temperature greatly influenced on the failure strength of soils and this. Trend was more pronounced the lower the freezing temperature and shown the ductile failure with indistinct peaks.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 추계학술대회 논문집 전기물성,응용부문
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• pp.151-159
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• 2003

According to the records, approximately 50 percent of power failure were caused by lightning. Conventional fault preventive measures against lightning include reduction of the footing resistance of the tower, multiplication of overhead ground wires and unbalanced insulation of the double circuit transmission tower. In addition to these, transmission line arresters have been recently appeared as an alternatives. In this paper an unbalanced insulation method with transmission line arrester was assumed as another countermeasure against simultaneous double circuit trip of 154 kV transmission line by lightning strike. The lightning performance of line arrester was compared with conventional insulation concept using different numbers of porcelain and glass insulator. Larger numbers of insulator simply increase flashover current level by lightning but the lightning performance doesn't proportional to it. EMTP simulation and predictive calculation of lightning failure rate were carried out to evaluate the performance.

• Journal of Korean Neurosurgical Society
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• 제53권3호
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• pp.150-154
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• 2013

Objective : To evaluate the effect of electromagnetic (EM) navigation system on ventriculoperitoneal (VP) shunt failure rate through comparing the result of standard shunt placement. Methods : All patients undergoing VP shunt from October 2007 to September 2010 were included in this retrospective study. The first group received shunt surgery using EM navigation. The second group had catheters inserted using manual method with anatomical landmark. The relationship between proximal catheter position and shunt revision rate was evaluated using postoperative computed tomography by a 3-point scale. 1) Grade I; optimal position free-floating in cerebrospinal fluid, 2) Grade II; touching choroid or ventricular wall, 3) Grade III; tip within parenchyma. Results : A total of 72 patients were participated, 27 with EM navigated shunts and 45 with standard shunts. Grade I was found in 25 patients from group 1 and 32 patients from group 2. Only 2 patients without use of navigation belonged to grade III. Proximal obstruction took place 7% in grade I, 15% in grade II and 100% in grade III. Shunt revision occurred in 11% of group 1 and 31% of group 2. Compared in terms of proximal catheter position, there was growing trend of revision rate according to increase of grade on each group. Although infection rate was similar between both groups, the result had no statistical meaning (p=0.905, chi-square test). Conclusion : The use of EM navigation in routine shunt surgery can eliminate poor shunt placement resulting in a dramatic reduction in failure rates.

• 대한치과교정학회지
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• 제44권1호
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• pp.44-49
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• 2014

Objective: To evaluate the effects of ultrasonic instrumentation with different scaler-tip angulations on the shear bond strength (SBS) and bond failure mode of metallic orthodontic brackets. Methods: Adhesive pre-coated metallic brackets were bonded to 72 extracted human premolars embedded in autopolymerizing acrylic resin. The teeth were randomly divided into 3 groups (n = 24 each) to undergo no treatment (control group) or ultrasonic instrumentation with a scaler-tip angulation of $45^{\circ}$ ($45^{\circ}$-angulation group) or $0^{\circ}$ ($0^{\circ}$-angulation group). SBS was tested in a universal testing machine, and adhesive remnant index (ARI) scores were recorded. The Kruskal-Wallis test and Mann-Whitney U-test were used for statistical analysis. Results: The control group had a significantly higher mean SBS value than the treated groups, which showed no significant differences in their mean SBS values. The ARI scores were not significantly different among the groups. Conclusions: Ultrasonic instrumentation around the bracket base reduces the SBS of metallic orthodontic brackets, emphasizing the need for caution during professional oral hygiene procedures in orthodontic patients. The scaler-tip angulation does not influence the SBS reduction and bond failure mode of such brackets.

• Journal of Mechanical Science and Technology
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• 제14권2호
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• pp.152-158
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• 2000

The contents of this paper include the evaluation of corrosion characteristics and the behaviour of stress corrosion cracking (SCC) for the weldment and post weld heat treatment (PWHT) specimen and parent of HT -60 steel using a slow strain rate test (SSRT) in synthetic seawater. Corrosion characteristics were obtained from the polarization curves by potentiostat, and SCC phenomena were evaluated through the parameters such as reduction of area and time to failure by comparing the experimental results in corrosive environment with those obtained in air. Corrosion rate of the weldment was the fastest, followed by parent and PWHT specimen. SCC phenomena between the weldment of HT-60 steel and synthetic seawater were shown. Besides, SCC was dependent upon the pulling speed greatly. Maximum severity of SCC was obtained at a speed of $10^{-6}mm/min$, whereas SCC could not be seen almost at $10^{-4}mm/min$. The resistance to SCC for PWHT specimen was improved considerably compared that of the weldment at $10^{-6}mm/min$. In case of SCC failure, it was verified from SEM examination that brittle mode and lots of pits could be seen at the fractured region near the surface of the specimen.

• Computational Structural Engineering : An International Journal
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• 제1권1호
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• pp.1-9
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• 2001

Collapse behavior of Mission-Gothic Undercrossing under Northridge earthquake is studied by performing nonlinear time-history analysis and three-dimensional nonlinear finite element method for flared columns. Bridge structural model is characterized as three-dimensional with consideration of columns, superstructures, and abutment conditions. Three components of ground motion, corresponding to bridge's longitudinal, transverse, and vertical direction and their combinations are used to investigate bridge collapse. Studies indicate that bridge collapse is dominantly caused by transverse ground motion and the consideration of three-dimensional ground motion leads to a more accurate assessment. Failure mechanism of flared columns is analyzed applying nonlinear finite element method. Reduction of column capacity is observed due to orientation of flare. Further investigation demonstrates that the effects of flare play an important role in predicting of bridge failure mechanism. Suggestions are offered to improve the performance of bridges during severe earthquake.