• Journal of Korean Medicine Rehabilitation
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• v.33 no.3
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• pp.47-65
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• 2023

Objectives We evaluated the wound healing effects of Dangguijakyak-san (DJ) using C57BL/6 mice that were generated open wound. Methods The study was conducted with seven C57BL/6 mice assigned to each group, divided into the normal group, control group, vitamin E group, DJ low-dose group, DJ high-dose group. We measured total polyphenol, flavonoid contents, the size of the wound, liver function, pro-inflammatory cytokine activity in serum, inflammation-related proteins, adhesion molecules and chemokine proteins, collagen-related proteins in skin tissue and histopathological changes by H&E and Masson's staining. Results DJ treatment significantly reduced the area of the wound compared to the control group. Also, inflammatory cytokines were reduced and the expression of anti-inflammatory-related factors (interleukin-4 [IL-4] and IL-10) was significantly increased in the DJ treatment group. We identified that DJ treatment inhibits both pathways of inflammation, the mitogen-activated protein kinases and nuclear factor-κB pathway. Moreover, the protein expressions of Sirt1 (sirtuin 1), MCP-1 (monocyte chemoattractant protein 1), ICAM-1 (intercellular adhesion molecule 1), and VCAM-1 (vascular cell adhesion molecule 1) were decreased by DJ administration. Also, the expression of α-smooth muscle actin and collagen type I alpha 1, collagen-related proteins, that help skin recovery was significantly increased in the DJ treatment group. Histopathologically, a relatively thin epithelial layer could be observed in the DJ administration group, as well as an increase in fibroblasts and collagen fibers. Conclusions These data suggest that DJ treatment is effective in wound healing, suppressing inflammatory proteins, increasing skin repair factors and improving histopathological changes caused by wounds.

• Korean Journal of Ichthyology
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• v.35 no.4
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• pp.270-277
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• 2023

Since its introduction in 1973, the bass, Micropterus salmoides, has spread to dams and rivers in Korea, adversely affecting native fish communities. In this study, after complete removal of bass from Bukchosan Reservoir, an farm reservoir that has lost its function, an attempt was made to indirectly confirm the adverse effects of bass on fish by comparing fish communities in reservoirs of a similar size where bass inhabit. The study was conducted three times a year from 2019 to 2022. As a result of the study, in Bukchosan Reservoir, where the species composition of fish was judged to be simplified due to the habitat of bass, only four species such as Carassius auratus and Rhinogobius brunneus that could be used as a food source for bass appeared before the removal of bass, but after the removal of bass. The appearance and increase of the population of the introduced small freshwater fish (Oryzias sinensis, Rhinogobius giurinus) were confirmed. When comparing Gangjeong Reservoir, Susim Reservoir, which are other reservoirs inhabited by bass investigated in this study, and Bukchosan Reservoir, this result is judged to show a trend of stabilization and recovery of fish species after removal of bass in small reservoirs with high predation pressure of bass.

• Archives of design research
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• v.14
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• pp.121-138
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• 1996

The purpose of this study is to develop a new architectural language and design strategies that would anticipate and incorporate new historical situations and new paradigms to understand the world. It consists of four sections as follows: First, it presents a new interpretation of space, human body, and movement that we find in modern art and tries to combine that new artistic insight with environmental design to provide a theoretical basis for performance-event architecture. Second, it conceives of architectural environment as a combination of space, movement, and probabilistic situations rather than a mere conglomeration of material. It also perceives the environment as a stage for performance and the act of designing as a performance. Third, in this context, man is conceived of as an organic system that responds to, interacts with, and adapts himself to his environment through self-regulation. By the same token, architecture should be a dynamic system that undergoes a constant transformation in its attempt to accommodate human actions and behaviors as he copes with the contemporary philosophy characterized by the principle of uncertainty, fast-changing society, and the new developments in technology. Fourth, the relativistic and organic view-point that constitutes the background for all this is radically different from the causalistic and mechanistic view that characterized the forms and functions of modernistic design. The present study places a great emphases on dematerialistic conception of environment and puts forth a disprogramming method that would accommodate interchangeability in the passage of time and the intertextuality of form and function. In the event, performance-event architecture is a strategy based on the systems world-view that would enable the recovery of man's autonomy and the reconception of his environment as an object of art.

• Journal of Sasang Constitutional Medicine
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• v.17 no.1
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• pp.130-141
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• 2005

1. Objectives The present study was carried out to investigate the effects of Chungpyesagan-tang on the $CCI_4-induced$ Liver Damage in Rats. 2. Methods Sprague-Dawley rats were devided into 5 experimental groups : Normal, $NS+CCI_4(Solid$ extract of $CCI_4$ injection group after Normal Saline feed), $CP+CCI_4(Solid$ extract of $CCI_4$ injection group after Chungpyesagantang feed), $CCI_4+NS(Nomal$ Saline feed group after $CCI_4$ injection), $CCI_4+CP(Solid$ extract of Chungpyesagantang feed group after $CCI_4$ injection). Biochemical assays for serum enzyme activities such as AST, ALT, ALP, BUN, Creatinine, Uric Acid, Total Protein, Albumin, Total Cholesterol, Triglyceride, Glucose, and mRNA Revelation of Cytochrome p450 and activities such as LPO(Lipid Peroxidation), GSH(Glutathione), GST(Glutathione-S- Transferase), Glutathione Reductase, Glutathione Peroxidase, SOD(Superoxide Dismutase), Catalase, Hydroxyproline, and ${\beta}-Glucuronidase$ were performed. 3. Results 1) $CP+CCI_4$ showed significantly lower relation of Cytochrome p450 than $NS+CCI_4$. 2) As to LPO Hydroxyproline, $CCI_4+CP$ showed significantly lower activity than $CCI_4+NS$. 3) As to GSH GST Glutathione Peroxidase Catalase, $CP+CCI_4$ showed higher activity than $NS+CCI_4$, $CCI_4+CP$ showed significantly higher activity than $CCI_4+NS$. 4) As to Glutathione Reductase SOD, $CCI_4+CP$ showed significantly higher activity than $CCI_4+NS$. 5) As to ${\beta}-Glucuronidase$, $CP+CCI_4$ showed signficantly lower activity than $NS+CCI_4$. 4. Conclusions Chungpyesagantang has the recovering effects on the $CCI_4-induced$ Liver Damage.

• Journal of the Korean Applied Science and Technology
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• v.40 no.2
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• pp.258-267
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• 2023

In this study, to investigate the possibility of using ethanol extract of Petasites japonicus (PJE) as a functional material, we investigated the activity of improving skin barrier and inflammation through UVB-induced human keratinocyte (HaCaT cell). As a result of confirming the antioxidant effect through DPPH radical scavenging activity, ABTS⁺ radical scavenging activity, and hydrogen peroxide scavenging activity, it was confirmed that it had an antioxidant effect similar to that of ascorbic acid, a control, at a concentration of 1 mg/ml. As a result of confirming the mRNA expression of the production ability of filaggrin and aquaporin-3 in HaCaT cells induced by UVB, it was confirmed that the reduced expression level by UVB stimulation increased in a concentration-dependent manner when the PJE was treated. It was confirmed that the mRNA expression of TNF-𝛼 and IL-1𝛽 were increased by UVB stimulation and decreased when the PJE was treated. As a result of the migration assay, it was confirmed that the proliferation of skin keratinocytes and the recovery rate of wounds were increased in a concentration-dependent manner. Based on the experimental results, it suggests that Petasites japonicus can be used as a functional cosmetic product that can improve skin moisturizing and skin barrier function.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.4
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• pp.242-248
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• 2022

Recently, through the development of CAD/CAM technology, it is also being used for fabricating dentures. Compared to conventional methods, when digital dentures are fabricated, the fabrication process is facilitated, and the number of visits to hospitals is reduced and errors are reduced. In this case, the vertical dimension was increased using a CAD program in a patient who needed vertical dimension recovery due to the use of old dentures, and the final denture was fabricated using a monolithic disc through the milling method. The centric relation was recorded using existing dentures, and using the information from the intraoral scan and the existing denture model scan, a trial denture was fabricated and delivered to the patient to evaluate the midline and occlusion. Based on the evaluation of the trial denture, the final denture was fabricated using a milling method and a monolithic disc, and the final denture showed satisfactory results functionally and aesthetically.

• Journal of Korean Society of Forest Science
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• v.106 no.2
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• pp.267-273
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• 2017

This study was conducted to construct a empirical yield table for Pinus densiflora in real forest. Since existing normal yield tables have been derived by studying and analyzing communities in ideal environment for tree growth, those tables provide more over-estimated values than ones from real forest. Because of this, there are some difficulties to apply the tables to empirical forest except for normal forest. In this study, therefore, we estimated stand growth for real forest on P. densiflora as the representative species of conifers. We used 1,957 sample plot data of P. densiflora in central Korea from National Forest Inventory (NFI) system, and analyzed through estimation, recovery and prediction in order by using Weibull function as a diameter distribution model. Weilbull and Schumacher models were applied for estimating mean DBH and mean basel area and it was found that the site index for P. densiflora in central Korea ranges from 8 to 14 at reference age 30. According to site 12 in the stand yield table, the Mean Annual Increment (MAI) of P. densiflora was $4.42m^3/ha$ at 30 years of age. Compared to existing volume table constructed before, it is showed that MAI of this study were lower. According to the paired t-test that is conducted with the gap of volume values between normal forest and real forest by site index and age, the P-value was less than 0.001 which is recognized to have a statistically significant difference. Based on the results in this study, it is considered to be helpful for practical management and management policy on P. densiflora in central Korea.

• The Journal of Korean Academy of Prosthodontics
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• v.52 no.3
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• pp.239-245
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• 2014

Complete denture prosthodontics includes replacement of natural teeth and associated maxillary and mandibular structures for full edentulous patients. The final objectives of prosthodontic treatment include esthetic and functional rehabilitation. Because the esthetic demand of senior patients has increased esthetic requirement should not be overlooked in denture treatment. In complete denture treatment, attempts have been made to reproduce tooth wear, arrangement, recession of cervical gingiva, staining, improved gingival shade and so on. This 61 year old female patient came to the Department of Prosthodontics with the chief complaint that dentures made 5 years ago in a local clinic were broken and did not fit well. The patient put more emphasis on fabrication of natural and esthetic dentures than recovery of masticatory function. Remake of maxillary complete denture and mandibular implant retained overdenture was planned. In order to create esthetic and natural contour, Aesthetic Color Set Easy system$^{(R)}$ (Candulor dental GmbH, Wangen, Germany) was used to make complete dentures reproducing various gingival shades. Patient's esthetic satisfaction was high. When complete denture prosthodontics treatment involves appropriate expression of individual characteristics in addition to proper selection of esthetic materials, treatment will give satisfaction to both dentist and patient.

• Journal of Korean Society of Forest Science
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• v.101 no.4
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• pp.599-605
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• 2012

The purpose of this study is to estimate diameter distribution, volume per hectare, and carbon stock for Quercus variabilis stand. 354 Quercus variabilis stands were selected on the basis of age and structure, the data and samples for these stands are collected. For the prediction of diameter distribution, Weibull model was applied and for the estimation of the parameters, a simplified method-of-moments was applied. To verify the accuracy of estimates, models were developed using 80% of the total data and validation was done on the remaining 20%. For the verification of the model, the fitness index, the root mean square error, and Kolmogorov-Smirnov statistics were used. The fitness index of the site index, height, and volume equation estimated from verification procedure were 0.967, 0.727, and 0.988 respectively and the root mean square error were 2.763, 1.817, and 0.007 respectively. The Kolmogorov-Smirnov test applied to Weibull function resulted in 75%. From the models developed in this research, the estimated volume and above-ground carbon stock were derived as $188.69m^3/ha$, 90.30 tC/ha when site index and stem number of 50-years-old Quercus variabilis stand show 14 and 697 respectively. The results obtained from this study may provide useful information about the growth of broad-leaf species and prediction of carbon stock for Quercus variabilis stand.

• Physical Therapy Korea
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• v.4 no.2
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• pp.1-9
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• 1997

Skeletal muscle fatigue is often associated with diminished athletic performance and inability to maintain an expected force output as a function of time. The purpose of this study was to compare the effect of duration of exercise on skeletal muscle fatigue between Weight Lifters(WL) and Non-Weight Lifters(NWL). There were twelve normal healthy adult volunteers, ranging in age from 18 to 35 years. The group consisted of six NWL and six WL. Randomized cross-over design was set up and work-rest cycle was 8 minutes work and 1 minute rest based on 15% MVC. Muscle fatigue was measured by the amount of force produced by the wrist flexor muscle and EMG amplitude over time. Repeated measures ANOVAs($2{\times}4$) were used to determine two types of subjects(WL, NWL) during four different duration of exercises(16, 32, 48, 64 minutes). The force decreased over time in NWL and WL, but there was no significant difference(F=2.83, p>0.05). However, the EMG amplitude increased in WL(0.8200) and NWL(0.6348). The WL exhibited an increase in EMG at the end of the period, especially at 48 minutes of exercises than did the NWL(F=9.58, p<.05). This suggests the WL were able to adjust to prolonged effort with adaptations in neural effect over time, resulting in higher EMG amplitude. That is, WL may be able to learn to recruit more motor units with training. It is important to the degree of neuromuscular fatigue and the time needed for recovery may differ considerably between WL and NWL, there is a need to plan proper strength training or rehabilitation protocols to match with the requirements in different characteristics of groups.