• Journal of Pharmaceutical Investigation
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• v.30 no.1
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• pp.27-32
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• 2000

Various release test methods have been applied for the evaluation of nicotine release in vitro from commercial patches. However, whether and how the release data reflect the permeation of nicotine across the skin, is not fully elucidated. To predict in vivo bioavailability from in vitro release tests, correlation between in vitro release and in vitro skin permeation was assessed in the present study. Release of nicotine from three commercial patches was measured for 24 hours under nine experimental conditions which were classified depending on the apparatus (i.e., paddle over disk, cylinder and reciprocating holder) and dissolution media (i.e., phosphate buffer pH 7.4, water and the 1 % phosphoric acid pH 1.5). In vitro permeation of nicotine from the patches across the human cadaver skin was also measured using a diffusion cell. The release of nicotine was better explained by the Higuchi's equation rather than by the first order rate equation. Correlation between the release rate and the in vitro skin permeation differed among the patches. However, in general, the cylinder method, in which water is used as a dissolution medium, showed the highest correlation among the nine release test conditions.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.3
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• pp.111-123
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• 2009

The purpose of this study is to investigate the time-elapse change of oil-polluted Taean coastal area with by Herbei Spirit oil spill incident. From Mandae of Iwonmeyon to Padori beach of Sowonmeyon, field monitering was conducted at eleven surveying points surveying. The specific conclusions from this study are as follows. The residual oil was not founded at ten surveying points, but the crude oil remained under the ground at the Groompo beach one year passed since the oil spill. Because the efforts of volunteers over millionaires and inhabitants for cleaning and reciprocating actions of waves, the oil-polluted coastal area by Herbei Spirit oil spill incident. It is guessed that a part of stranded oil spilled from the incident was degraded by physical, chemical, and biological weathering and the residue was dispersed in tidal and subtidal zone with oil-minerals aggregates(OMA).

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.1353-1357
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• 2008

A sea water source cascade heat pump was designed and tested in this study. The system was designed to perform a single stage operation in summer, as well as a cascade operation in winter to ensure the high temperature lift. A steady-state simulation model was developed to analyze and optimize its performance. The simulation results show that the R717 exhibits best performance among combinations considered in this study. A R410A also exhibits the highest performance among HFCs with the smallest compressor displacement. A 15-RT R410A-R134a pilot system was installed in the 5-story commercial building at Samcheok City by the East Sea. A scroll type R410A compressor, a reciprocating type R134a compressor, plate type condenser/ evaporator/ cascade heat exchanger and two electronic expansion valves were used to build a pilot. A titanium plate type heat exchanger is also used for the heat exchanging with a sea water. The heat source/sink water is supplied from the well below the seashore in the depth of 5 m. In the initial test of the system, supply water temperature was rising up to $67^{\circ}C$ using a sea water heat source of $9^{\circ}C$, while an ambient temperature was $4.5^{\circ}C$.

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.1273-1278
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• 2008

A sea water source cascade heat pump was designed and tested in this study. The system was designed to perform a single stage operation in summer, as well as a cascade operation in winter to ensure the high temperature lift. A steady-state simulation model was developed to analyze and optimize its performance. The simulation results show that the R717 exhibits best performance among combinations considered in this study. A R410A also exhibits the highest performance among HFCs with the smallest compressor displacement. A 15-RT R410A-R134a pilot system was installed in the 5-story commercial building at Samcheok City by the East Sea. A scroll type R410A compressor, a reciprocating type R134a compressor, plate type condenser/ evaporator/ cascade heat exchanger and two electronic expansion valves were used to build a pilot. A titanium plate type heat exchanger is also used for the heat exchanging with a sea water. The heat source/sink water is supplied from the well below the seashore in the depth of 5 m. In the initial test of the system, supply water temperature was rising up to $67^{\circ}C$ using a sea water heat source of $9^{\circ}C$, while an ambient temperature was $4.5^{\circ}C$.

• Restorative Dentistry and Endodontics
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• v.38 no.4
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• pp.222-226
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• 2013

Objectives: The aim of this study was to assess the influence of operator experience level on the lifespan of the WaveOne Primary file (Dentsply Maillefer, Ballaigues, Switzerland) in extracted teeth. Materials and Methods: Moderately curved canals of extracted maxillary and mandibular molars were randomly distributed into 2 groups: experienced and inexperienced operators. Ten files were allocated to each group (n = 10). Each canal was prepared until the working length was reached, and the same file was used to prepare additional canals until it separated. The number of canals prepared before file separation was recorded. The fragment length of each file was measured, and the location of the fragment in the canal was determined. Data were statistically analysed using the independent 2-sample t-test. Results: The 2 operators prepared a total of 324 moderately curved canals of maxillary and mandibular molars. There was no significant intergroup difference in the mean number of canals prepared (p = 0.27). The average lifespan of the WaveOne Primary file was 17.1 and 15.3 canals, and the longest lifespan was 25 and 20 canals, when used by experienced and inexperienced operators, respectively. There were no statistically significant intergroup differences in separated fragment length and location. Conclusions: Within the limitations of this study, operator experience level appears to have no effect on the lifespan of the WaveOne Primary file in preparation of moderately curved canals. Single teeth with multiple canals can be prepared safely even by a novice operator by using a single file.

• Restorative Dentistry and Endodontics
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• v.41 no.4
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• pp.304-309
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• 2016

Objectives: The purpose of this study was to compare the maximum screw-in forces generated during the movement of various Nickel-Titanium (NiTi) file systems. Materials and Methods: Forty simulated canals in resin blocks were randomly divided into 4 groups for the following instruments: Mtwo size 25/0.07 (MTW, VDW GmbH), Reciproc R25 (RPR, VDW GmbH), ProTaper Universal F2 (PTU, Dentsply Maillefer), and ProTaper Next X2 (PTN, Dentsply Maillefer, n = 10). All the artificial canals were prepared to obtain a standardized lumen by using ProTaper Universal F1. Screw-in forces were measured using a custom-made experimental device (AEndoS-k, DMJ system) during instrumentation with each NiTi file system using the designated movement. The rotation speed was set at 350 rpm with an automatic 4 mm pecking motion at a speed of 1 mm/sec. The pecking depth was increased by 1 mm for each pecking motion until the file reach the working length. Forces were recorded during file movement, and the maximum force was extracted from the data. Maximum screw-in forces were analyzed by one-way ANOVA and Tukey's post hoc comparison at a significance level of 95%. Results: Reciproc and ProTaper Universal files generated the highest maximum screw-in forces among all the instruments while M-two and ProTaper Next showed the lowest (p < 0.05). Conclusions: Geometrical differences rather than shaping motion and alloys may affect the screw-in force during canal instrumentation. To reduce screw-in forces, the use of NiTi files with smaller cross-sectional area for higher flexibility is recommended.

• Journal of the Korean Institute of Intelligent Systems
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• v.27 no.2
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• pp.106-112
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• 2017

In the paper, we propose a levitation and a propulsion controller for the magnetic levitation logistic transportation system. The levitation controller is designed considering the mutual influence of the electromagnets to minimize roll and pitch movements. In order to solve the structural disadvantages of the magnetic levitation transportation system, we improve the problem of the existing controller by applying the exponential filter to the reference input. DSP-based control hardware is developed and the levitation control method is verified by levitation experiments to the air gap goal. The propulsion controller uses the space vector voltage modulation method. The propulsion controller is designed to follow the position and velocity profile by detecting the absolute position from the bar code information attached to the rail. The position control result shows satisfactory performance through the propulsion control reciprocating motion experiment.

• Journal of the Korean Institute of Gas
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• v.15 no.2
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• pp.63-68
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• 2011

As an effective utilization of biomass, organic wastes and coal, attention has been made to use syngas to a reciprocating engine to generate power. However, significant component variation of syngas depending upon origin and gasification conditions, and its lower heating value than that of LPG and CNG can create difficulties in stable engine operation. Thus it is necessary to address these issues in order to successfully develop power generation engines. As a primary step to resolve these problems, effects of H2 content variation in syngas on engine performance and emission characteristics were discussed in this study. The results show that as H2 % in syngas increases, more stable combustion was achieved with retarded MBT spark timing and engine efficiency becomes maximum with syngas of 10% H2. In addition, NOx emission increased while THC emission decreased as H2 % rises in the syngas.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.4
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• pp.289-296
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• 2017

In this paper, geometrical optimization for newly designed flapping mechanism for insect-like micro air vehicle is presented. The mechanism uses strings to convert rotation of motor to reciprocating wing motion to reduce the total weight and inertial force. The governing algorithm of movement of the mechanism is established considering the characteristic of string that only tensile force can be acted by string, to optimize the kinematics. Modified pattern search method which is complemented to avoid converging into local optimum is adopted to the geometrical optimization of the mechanism. Then, prototype of the optimized geometry is produced and experimented to check the feasibility of the mechanism and the optimization method. The results from optimization and experiment shows good agreement in flapping amplitude and other wing kinematics. Further research will be conducted on dynamic analysis of the mechanism and detailed specification of the prototype.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.5
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• pp.113-120
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• 2013

Graphite is commonly used as a solid lubricant leading to low friction coefficient and abrasion. In this study, wear behavior of sealing graphite(HK-6) at elevated temperature was evaluated. Reciprocating wear test was carried out as wear occurred graphite as a seal(HK-6) is positioned between the liner and driving shaft. Variables which are temperature, sliding speed and contact load are set. This study suggest optimized environment conditions through the wear properties of graphite.