• Mass Spectrometry Letters
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• v.7 no.2
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• pp.31-40
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• 2016

The analysis of nuclear materials and environmental samples is an important issue in nuclear safeguards and nuclear forensics. An analysis technique for safeguard samples has been developed for the detection of undeclared nuclear activities and verification of declared nuclear activities, while nuclear forensics has been developed to trace the origins and intended use of illicitly trafficked nuclear or radioactive materials. In these two analytical techniques, mass spectrometry has played an important role in determining the isotope ratio of various nuclides, contents of trace elements, and production dates. These two techniques typically use similar analytical instruments, but the analytical procedure and the interpretation of analytical results differ depending on the analytical purpose. The isotopic ratio of the samples is considered the most important result in an environmental sample analysis, while age dating and impurity analysis may also be important for nuclear forensics. In this review, important aspects of these techniques are compared and the role of mass spectrometry, along with recent progress in related technologies, are discussed.

• Journal of the Korean Society for Library and Information Science
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• v.17
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• pp.49-83
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• 1989

A Full text retrieval system is a natural language document retrieval system in which the full text of all documents in a collection is stored on a computer so that every word in every sentence of every document can be located by the machine. This kind of IR System is recently becoming rapidly available online in the field of legal, newspaper, journal and reference book indexing. Increased research interest has been in this field. In this paper, research on full text databases and retrieval systems are reviewed, directions for research in this field are speculated, questions in the field that need answering are considered, and variables affecting online full text retrieval and various role that variables play in a research study are described. Two obvious research questions in full text retrieval have been how full text retrieval performs and how to improve the retrieval performance of full text databases. Research to improve the retrieval performance has been incorporated with ranking or weighting algorithms based on word occurrences, combined menu-driven and query-driven systems, and improvement of computer architectures and record structure for databases. Recent increase in the number of full text databases with various sizes, forms and subject matters, and recent development in computer architecture artificial intelligence, and videodisc technology promise new direction of its research and scholarly growth. Studies on the interrelationship between every elements of the full text retrieval situation and the relationship between each elements and retrieval performance may give a professional view in theory and practice of full text retrieval.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.10.1-10.11
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• 2018

Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an immense breakthrough in cancer therapeutics. Among the immune checkpoint inhibitors, PD-1/PD-L1 and CTLA-4 inhibitors showed promising therapeutic outcomes, and some have been approved for certain cancer treatments, while others are under clinical trials. Recent reports have shown that patients with various malignancies benefit from immune checkpoint inhibitor treatment. However, mainstream initiation of immune checkpoint therapy to treat cancers is obstructed by the low response rate and immune-related adverse events in some cancer patients. This has given rise to the need for developing sets of biomarkers that predict the response to immune checkpoint blockade and immune-related adverse events. In this review, we discuss different predictive biomarkers for anti-PD-1/PD-L1 and anti-CTLA-4 inhibitors, including immune cells, PD-L1 overexpression, neoantigens, and genetic and epigenetic signatures. Potential approaches for further developing highly reliable predictive biomarkers should facilitate patient selection for and decision-making related to immune checkpoint inhibitor-based therapies.

• Journal of Animal Science and Technology
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• v.66 no.1
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• pp.57-78
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• 2024

In a global context, bacterial diseases caused by pathogenic bacteria have inflicted sustained damage on both humans and animals. Although antibiotics initially appeared to offer an easy treatment for most bacterial infections, the recent rise of multidrug-resistant bacteria, stemming from antibiotic misuse, has prompted regulatory measures to control antibiotic usage. Consequently, various alternatives to antibiotics are being explored, with a particular focus on bacteriophage (phage) therapy for treating bacterial diseases in animals. Animals are broadly categorized into livestock, closely associated with human dietary habits, and companion animals, which have attracted increasing attention. This study highlights phage therapy cases targeting prominent bacterial strains in various animals. In recent years, research on bacteriophages has gained considerable attention, suggesting a promising avenue for developing alternative substances to antibiotics, particularly crucial for addressing challenging bacterial diseases in the future.

• Corrosion Science and Technology
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• v.8 no.5
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• pp.184-187
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• 2009

The trend of the microjoining technology by the laser-soldering process has been reviewed. Among the production technologies, joining technology plays an important role in the fabrication of electronic components. This has led to an increasing attention towards the use of modern microjoining technology such as micro-resistance spot joining, micro-soldering, micro-friction stir joining and laser-soldering, etc. This review covers the recent technical trends of laser-soldering collected from the COMPENDEX DB analysis of published papers, research subject and research institutes.

• Journal of Korean Elementary Science Education
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• v.35 no.3
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• pp.288-304
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• 2016

The purpose of this study is a review of previous studies and principles of eye-tracking techniques that are actively applied in recent elementary science education. Also it proposes to utilize the direction of eye tracking techniques in elementary science education research. Recent eye-tracking technology was developed, using the infrared pupil and the corneal reflection can be safely and accurately track the eye movements of the participants. Eye tracking has the advantage of higher temporal resolution, accessibility, convenience, objectivity, stability and safety. Analysis of the previous studies, there was a difference in the study design and analysis. The workshops and seminars are needed for accurate understanding of eye-tracking method in elementary science education research. In conclusion, the eye-tracking can be utilized such as effectiveness analysis of teaching materials and media, behaviors analysis of teachers and students in a real class, cognitive strategies and attention analysis of the student, discriminating tool of various education evaluation, etc.

• Journal of Ocean Engineering and Technology
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• v.25 no.2
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• pp.127-133
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• 2011

The following Technology Report was written with respect to recent offshore technology development. This report was prepared with the purpose of suggesting recent offshore technology and upcoming visions by describing the principles of an offshore drilling operation, the NL Tensioner Cylinder Package R & D, and the general technology related to three offshore patent areas, as major contents.

• Bioinformatics and Biosystems
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• v.1 no.1
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• pp.17-27
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• 2006

Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of molecular imaging biological research. These tools have been validated recently in variety of research models, and have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide, magnetic resonance, and optical imaging technologies as they have been used in imaging gene delivery and gene expression for molecular imaging applications. The studies published to date demonstrate that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human diseases.

• The Transactions of the Korea Information Processing Society
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• v.6 no.11S
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• pp.3199-3208
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• 1999

Recently the number of Internet users have been drastically increased with the introduction of WWW browsers, which requires accommodation study of TCP/IP on ATM networks. There are a number of problems in operating IP-over-ATM efficiently because of limited functions and overhead of IP. According to recent research, the alternatives to TCP/IP efficiently because of limited functions and overhead of IP. According to recent research, the alternatives to TCP/IP over ABR or UBR have been suggested, and the required capacity of switch buffer and problems in TCP/IP over ABR have been researched. In this paper, we address problems caused by the features of HTTP traffic and suggest a solution for TCP over ABR. The performance of the methods suggested in this paper is verified through simulation under limited conditions.

• Clinical and Experimental Pediatrics
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• v.52 no.6
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• pp.649-654
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• 2009

The immune system is comprised of cells and molecules whose collective and coordinated response to the introduction of foreign substance is referred to as the immune response. Defense against microbes is mediated by the early reaction (innate immunity) and the late response (adaptive immunity). Innate immunity consists of the epithelial barrier, phagocytes, complement and natural killer cells. Adaptive immunity, a more complex defense reaction, consists of activation of later-developed lymphocytes that, when stimulated by exposure to infectious agents, increase in magnitude and defensive capabilities with each successive exposure. In this review we discuss recent advances in important primary immune deficiency disorders of innate immunity (chronic granulomatous disease, leukocyte adhesion deficiency) and adaptive immunity (severe combined immune deficiency, Wiskott- Aldrich syndrome).