• 제목/요약/키워드: Real-world evidence

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Study for Clinicians' Perception on the Acupuncture Research and Ways to Symbiosis between Basic Research and Clinical Practice (침 연구에 대한 한의사의 인식과 연구방향에 대한 조사)

  • Kim, Song-Yi;Chae, Youn-Byoung;Lee, Hyang-Sook;Ko, Yu-Mi;Lee, Hye-Jung;Park, Hi-Joon
    • Korean Journal of Acupuncture
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    • 제29권2호
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    • pp.224-238
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    • 2012
  • Objectives : From mechanism studies using animal models to high-level evidence based research such as randomized controlled trials or systematic reviews, various acupuncture studies have been performed. Nevertheless, the current research appears insufficient to satisfy clinicians' needs. We aimed at investigating clinicians' perception on the translational research and suggesting ways of symbiosis between basic research and clinical practice. Methods : Data were collected using a web-based questionnaire made available to Korean medicine doctors who were informed through social networking service or e-mail. The survey participants indicated their awareness of acupuncture research and their thoughts on the applicability of research in practice. Results : Forty-seven clinicians completed the survey. While most respondents agreed that acupuncture research is very important, only 40% of them answered that the results of acupuncture research are useful to their own practice. In more than half of those who responded to the survey, the current acupuncture research is not viewed as reflecting clinical practice very much. Respondents agreed that acupuncture research should be based on clinical practice, and they recognized the need to collect valid clinical data from real-world practice. Also, as many as 77% of clinicians had no scruple to participate in research programs. Conclusions : There is no doubt among practitioners that acupuncture research is necessary. More importantly, practice-based research remains essential in order to feed-back research outcomes to clinical practice. Communications and academic exchanges between clinicians and researchers can mutually benefit research and practice with better information, resulting in symbiosis.

A Study of imagification of space laying emphasis on representation (표상성을 중심으로한 공간 이미지화에 관한 연구)

  • Hwang Yong-Seup;Park Chan-Ho
    • Korean Institute of Interior Design Journal
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    • 제14권5호
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    • pp.106-113
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    • 2005
  • New images percolate through human consciousness by the media such as movies, TV programs, and brilliant advertisements. These images reproduce new ' things ' throughout the ' semantic processes ' by those who experience and recognize them. Alvin Toffler describes it as the ' information bomb ' and ' image fragments ' in his talk about the new paradigm of information-oriented era. The increasing number of images and their accelerating rate of appearance imply that images become more momentary, and are evidence that they are transforming entire human life and consciousness. Such awareness means a lot to a designer. Especially, the subject that how modern space-dominating images are related to the structure and materials constituting the space and communicate with human mind will be an important factor in establishing the human-space relationship in the future. Furthermore, the present age overspread with various medium is not the only one privileged of the images that exist within space. They are the results of continuous expansion of existing images, and also process of evolution of space powered by the fusion of images and digital media. Imagified space is a boundary layer of Cyberspace, and the space itself becomes an interface by human recognition and participation. Now, the functional classification of spaces such as ' office, ' ' cafe, ' and ' school ' is meaningless. Whatever it may be, the function of a space is defined by the information it interfaces, and therefore it becomes an interface to information through a large number of images. Based on this idea, we will observe the imagificaiton of space in the form of discussion, and from that, try to understand the phenomenon through the real world examples.

Exploring the Key Technologies on Next Production Innovation (4차 산업혁명 차세대 생산혁신 기술 탐색: 키워드 네트워크를 중심으로)

  • Lee, Suchul;Ko, Mihyun
    • Journal of the Korea Convergence Society
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    • 제9권9호
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    • pp.199-207
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    • 2018
  • This study aims to analyze Next Production Revolution (NPR) technologies through evidence-based keyword network in order to cope with the change of production paradigm called the Fourth Industrial Revolution (4IR). For the analysis, a total of 441 papers related to NPR or 4IR were extracted and the NPR technology network was constructed based on the simultaneous appearance relationship of the author keywords of these papers. Based on the NPR technology network, we explored key technologies through analysis of centrality and keyword group. As a result, technologies such as 'digital twin' and 'modeling and simulation', discovering insights by connecting the virtual and physical world in real time and reflecting them into design and process, are analyzed as key technologies.

An Overview of Using Serious Games for the Effective Development in Health and Medicine (보건 의료용 기능성 게임의 효과적 개발 방향 연구)

  • Lee, Hye Rim;Jeong, Eui Jun
    • Journal of Korea Game Society
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    • 제13권4호
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    • pp.73-90
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    • 2013
  • Serious games allow learners to experience situations that are impossible in the real world for various purposes. To date the major applications of serious games include military, government, education, corporate and healthcare applications. This paper aims to provide an overview of the applications of serious games for various health-related purposes, particularly for Health and Medicine education, health risk prevention, behavioral intervention, and disease self-management. These games identified numerous papers reporting empirical evidence about the impacts and outcomes. There is potential promise for serious games to improve health outcomes. We discuss implications of using serious games for health-related purposes and future direction for research in this area.

On validation of fully coupled behavior of porous media using centrifuge test results

  • Tasiopoulou, Panagiota;Taiebat, Mahdi;Tafazzoli, Nima;Jeremic, Boris
    • Coupled systems mechanics
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    • 제4권1호
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    • pp.37-65
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    • 2015
  • Modeling and simulation of mechanical response of infrastructure object, solids and structures, relies on the use of computational models to foretell the state of a physical system under conditions for which such computational model has not been validated. Verification and Validation (V&V) procedures are the primary means of assessing accuracy, building confidence and credibility in modeling and computational simulations of behavior of those infrastructure objects. Validation is the process of determining a degree to which a model is an accurate representation of the real world from the perspective of the intended uses of the model. It is mainly a physics issue and provides evidence that the correct model is solved (Oberkampf et al. 2002). Our primary interest is in modeling and simulating behavior of porous particulate media that is fully saturated with pore fluid, including cyclic mobility and liquefaction. Fully saturated soils undergoing dynamic shaking fall in this category. Verification modeling and simulation of fully saturated porous soils is addressed in more detail by (Tasiopoulou et al. 2014), and in this paper we address validation. A set of centrifuge experiments is used for this purpose. Discussion is provided assessing the effects of scaling laws on centrifuge experiments and their influence on the validation. Available validation test are reviewed in view of first and second order phenomena and their importance to validation. For example, dynamics behavior of the system, following the dynamic time, and dissipation of the pore fluid pressures, following diffusion time, are not happening in the same time scale and those discrepancies are discussed. Laboratory tests, performed on soil that is used in centrifuge experiments, were used to calibrate material models that are then used in a validation process. Number of physical and numerical examples are used for validation and to illustrate presented discussion. In particular, it is shown that for the most part, numerical prediction of behavior, using laboratory test data to calibrate soil material model, prior to centrifuge experiments, can be validated using scaled tests. There are, of course, discrepancies, sources of which are analyzed and discussed.

Herbal medicine prescription analyses of bronchiectasis patients with claim data during 5 years (2013~2017) (최근 5개년 (2013~2017)간 기관지확장증(J47) 환자에게 처방한 급여한약제제 현황 분석 - 건강보험청구자료 중심으로)

  • Kang, Sohyeon;Kim, Jinhee;Jang, Soobin;Lee, Mee-Young;Lee, Ju Ah;Park, Sunju
    • Journal of Society of Preventive Korean Medicine
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    • 제23권3호
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    • pp.1-12
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    • 2019
  • Objectives : Korean national health insurance data is a useful real-world data representing whole medical bills submitted to Health Insurance Review Agency. This study aims to understand recent benefit trend of insurance herbal preparations for treating bronchiectasis(disease code J47) utilizing insurance data. Methods : We reviewed national health insurance claims data from 2013 to 2017 which have main diagnosis or sub diagnosis code of J47 and with the record of prescribing insurance herbal medication. Frequency analysis was performed to analyze the most frequently prescribed prescription. Results & Conclusions : Both the number of claims statement(770 to 1,746cases) and patients(266 to 484) of insurance herbal preparations increased considerably from 2013 to 2017. Top 10 preparations based on the number of claims statement were 'Samso-eum', 'Yeonkyopaedok-san', 'Socheongryong-tang', 'Bojungikgi-tang', 'Hyangsapyungwi-san', 'Yijin-tang', 'Saengmaek-san', 'Jaeumganghwa-tang', 'Ojeok-san' and 'Gungha-tang'. Top 10 preparations based on the number of patients were 'Samso-eum', 'Socheongryong-Tang', 'Saengmaek-san', 'Yeonkyopaedok-san', 'Haengso-tang', 'Hyangsapyungwi-san', Yijin-tang', 'Jaeumganghwa-tang', 'Bojungikgi-tang' and 'Hyeonggaeyeongyo-tang' in respectiv order. Claims of top 10 frequent preparations occupied more than 60% of total claims. We hope this finding to be utilized as basic data for future research of evidence-based bronchiectasis treatment utilizing Korean traditional medicine.

A Study on the Problems of Procedural Law Against Cyber Crimes in Korea - On the Trend of Procedural Law Against Cyber Crimes of U.S - (우리 사이버범죄 대응 절차의 문제점에 관한 연구 - 미국의 사이버범죄대응절차법을 중심으로 -)

  • Lim Byoung-Rak;Oh Tae-Kon
    • Journal of the Korea Society of Computer and Information
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    • 제11권4호
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    • pp.231-241
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    • 2006
  • When current cyber attacks to information and communication facilities are examined, technologies such as chase evasion technology and defense deviation technology have been rapidly advanced and many weak systems worldwide are often used as passages. And when newly-developed cyber attack instruments are examined, technologies for prefect crimes such as weakness attack, chase evasion and evidence destruction have been developed and distributed in packages. Therefore, there is a limit to simple prevention technology and according to cases, special procedures such as real-time chase are required to overcome cyber crimes. Further, cyber crimes beyond national boundaries require to be treated in international cooperation and relevant procedural arrangements through which the world can fight against them together. However, in current laws, there are only regulations such as substantial laws including simple regulations on Punishment against violation. In procedure, they are treated based on the same procedure as that of general criminal cases which are offline crimes. In respect to international cooperation system, international criminal private law cooperation is applied based on general criminals, which brings many problems. Therefore, this study speculates the procedural law on cyber crimes and presents actual problems of our country and its countermeasures.

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Review : Effectiveness of transcranial direct current stimulation in rodent models of Alzheimer's disease (알츠하이머병 쥐 모델에서 경두개 직류 전기자극의 효용성 검토)

  • Kim, Ji-Eun;Park, Ye-Eun;Jeong, Jin-Hyoung;Lee, Sang-Sik
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • 제14권5호
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    • pp.403-412
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    • 2021
  • Alzheimer's disease (AD) is the most common cause of dementia, showing progressive neurodegeneration. Although oral medications for symptomatic improvement still take a huge part of treatment, there are several limitations caused by pharmacology-based real world clinic. In this respect, non-pharmacologic treatment for AD is rising to prominence. Transcranial direct current stimulation (tDCS) is a one of the non-invasive neuromodulation technique, using low-voltage direct current. In terms of safety, tDCS already has been proven through numerous previous reports. This review focused on behavioral, neurophysiologic and histopathologic improvement by applying tDCS in AD rodent models, thereby suggesting reliable background evidence for human-based tDCS study.

A Study on Interest Factors of Game-based Metaverse : focused on the topic analysis of user community (게임 기반 메타버스의 사용자 흥미 요인 연구 : <동물의 숲> 사용자 커뮤니티의 토픽 분석을 중심으로)

  • Ahn, Jin-Kyoung;Kwak, Chanhee
    • Journal of Convergence for Information Technology
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    • 제11권10호
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    • pp.1-9
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    • 2021
  • Although interest in the metaverse increases due to the pandemic, the understanding of the metaverse interest factor, which is an essential element for the sustainability of any metaverse platform, is lacking. This study aims to reveal the interest factors of metaverse services by analyzing user community discourse. We collected user community discourses from and applied LDA to extract topics. Further, we categorize the factors into growth and verifiable indicators, various levels of interaction, self-expression and freedom, and connection with the real world. The content planning direction of the game-based metaverse of utilization was derived. This study is meaningful in that it analyzes the interest factors of the metaverse based on the empirical evidence of user discourse data.

Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis

  • Yum, Hye Yung;Ha, Eun Kyo;Shin, Yoon Ho;Han, Man Yong
    • Clinical and Experimental Pediatrics
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    • 제64권8호
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    • pp.373-383
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    • 2021
  • Rhinitis is among the most common respiratory diseases in children. Nonallergic rhinitis, which involves nasal symptoms without evidence of systemic allergic inflammation or infection, is a heterogeneous entity with diverse manifestations and intensities. Nonallergic rhinitis accounts for 16%-89% of the chronic rhinitis cases, affecting 1%-50% (median 10%) of the total pediatric population. The clinical course of nonallergic rhinitis is generally rather mild and less likely to be associated with allergic comorbidities than allergic rhinitis. Here, we aimed to estimate the rate of coexisting comorbidities of nonallergic rhinitis. Nonallergic rhinitis is more prevalent during the first 2 years of life; however, its underestimation for children with atopic tendencies is likely due to low positive rates of specific allergic tests during early childhood. Local allergic rhinitis is a recently noted phenotype with rates similar to those in adults (median, 44%; range, 4%-67%), among patients previously diagnosed with nonallergic rhinitis. Idiopathic rhinitis, a subtype of nonallergic rhinitis, has been poorly studied in children, and its rates are known to be lower than those in adults. The prevalence of nonallergic rhinitis with eosinophilia syndrome is even lower. A correlation between nonallergic rhinitis and pollution has been suggested owing to the recent increase in nonallergic rhinitis rates in highly developing regions such as some Asian countries, but many aspects remain unknown. Conventional treatments include antihistamines, intranasal corticosteroids, and recent treatments include combination of intranasal corticosteroids with azelastin or decongestants. Here we review the prevalence, diagnosis, comorbidities, and treatment recommendations for nonallergic rhinitis versus allergic rhinitis in children.