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http://dx.doi.org/10.17661/jkiiect.2021.14.5.403

Review : Effectiveness of transcranial direct current stimulation in rodent models of Alzheimer's disease  

Kim, Ji-Eun (Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine)
Park, Ye-Eun (Department of Biomedical Engineering, Catholic Kwandong University)
Jeong, Jin-Hyoung (Department of Biomedical IT, Catholic Kwandong University)
Lee, Sang-Sik (Department of Biomedical Engineering, Catholic Kwandong University)
Publication Information
The Journal of Korea Institute of Information, Electronics, and Communication Technology / v.14, no.5, 2021 , pp. 403-412 More about this Journal
Abstract
Alzheimer's disease (AD) is the most common cause of dementia, showing progressive neurodegeneration. Although oral medications for symptomatic improvement still take a huge part of treatment, there are several limitations caused by pharmacology-based real world clinic. In this respect, non-pharmacologic treatment for AD is rising to prominence. Transcranial direct current stimulation (tDCS) is a one of the non-invasive neuromodulation technique, using low-voltage direct current. In terms of safety, tDCS already has been proven through numerous previous reports. This review focused on behavioral, neurophysiologic and histopathologic improvement by applying tDCS in AD rodent models, thereby suggesting reliable background evidence for human-based tDCS study.
Keywords
Alzheimer's Disease; AD rodent model; Brain stimulation; Depression; tDCS;
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