• 한국정밀공학회지
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• 제30권1호
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• pp.85-95
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• 2013

As the conventional hydraulic power steering system in the passenger vehicles is being rapidly replaced by EPS (Electric Power Steering) system, performance evaluation of the EPS system has become an important issue in the automotive industries. But the evaluation process takes significant expertise since steering conditions in the test protocols must be implemented with high accuracy. EPS HILS (Hardware-In the-Loop Simulation) system is developed together with robot steering system in this study. Main components of EPS HILS system include: C-EPS hardware, CarSim vehicle model, and road reaction force generation system powered by servo motor. The robot steering system, operated by another servo motor, was combined with EPS HILS system to substitute for steering efforts of human driver. The road reaction force generation system and the robot steering system were carefully validated by using the data obtained from vehicle tests. An on-center handling test was conducted by using EPS HILS system combined with the robot steering system. In the result of this study, robot-steered EPS HILS system developed with its high reliability and no need of skilled driver's, can be widely adopted to evaluate any performance of EPS system.

• 한국컴퓨터게임학회논문지
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• 제31권4호
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• pp.1-8
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• 2018

성인보다 주의 집중력이 낮은 아동의 인지력을 측정하는 것은 매우 어려운 일이다. 기능성 게임은 아동의 동기와 주의집중을 높이는 효과적인 방법으로 아동의 인지력 측정을 위한 좋은 대안이 될 수 있다. 본 연구는 주의력 측정을 위해 사용되는 TMT(Trail Making Test)를 기능성 게임으로 제작하여 아동의 주의력을 측정하고 그 결과를 검증하고자 하고자 하였다. 이를 위해 기능성 게임으로 제작된 TMT는 주의 속도와 선택적 주의를 측정하는 유형A와 주의 전환을 측정하는 유형B로 설계되었으며, 검사결과를 아동의 학업성취도와 연결하여 검사의 타당도를 검증하고자 하였다. 284명의 아동을 기능성 게임을 통해 주의력을 검사한 결과, 유형A의 반응속도(Reaction Time) 그리고 유형B의 정오율과 학업성취도간 상관이 나타났다. 이러한 결과는 본 기능성 게임이 주의력의 여러 목표한 측정 요소를 잘 반영하고 있음을 시사한다. 기존의 단순한 결과만을 산출하는 지필검사와는 다르게 본 기능성게임은 주의와 관련된 여러 가지 행동 데이터를 제공해주고, 재미와 집중을 높여 아동에게 보다 긍정적이고 생태학적인 측면이 강화된 인지측정 도구를 제공해 줄 수 있을 것으로 기대한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권4호
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• pp.1543-1561
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• 2020

Taxonomy of human brain activity is a complicated rather challenging procedure. Due to its multifaceted aspects, including experiment design, stimuli selection and presentation of images other than feature extraction and selection techniques, foster its challenging nature. Although, researchers have focused various methods to create taxonomy of human brain activity, however use of multivariate pattern analysis (MVPA) for image recognition to catalog the human brain activities is scarce. Moreover, experiment design is a complex procedure and selection of image type, color and order is challenging too. Thus, this research bridge the gap by using MVPA to create taxonomy of human brain activity for different categories of images, both colored and gray scale. In this regard, experiment is conducted through EEG testing technique, with feature extraction, selection and classification approaches to collect data from prequalified criteria of 25 graduates of University Technology PETRONAS (UTP). These participants are shown both colored and gray scale images to record accuracy and reaction time. The results showed that colored images produces better end result in terms of accuracy and response time using wavelet transform, t-test and support vector machine. This research resulted that MVPA is a better approach for the analysis of EEG data as more useful information can be extracted from the brain using colored images. This research discusses a detail behavior of human brain based on the color and gray scale images for the specific and unique task. This research contributes to further improve the decoding of human brain with increased accuracy. Besides, such experiment settings can be implemented and contribute to other areas of medical, military, business, lie detection and many others.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.179-186
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• 2007

A simple, sensitive and selective liquid chromatographic/tandem mass spectrometric method (LC-MS/MS) was developed and validated for doxifluridine and 5-fluorouracil (5-FU) quantification in dog heparinized plasma. Sample preparation was based on liquid-liquid extraction using a mixture of isopropanol/ethyl acetate (1/9 v/v) to extract doxifluridine, 5-FU and 5-chlorouracil (5-CU, an internal standard) from plasma. Chromatography was performed on a C-18 analytical column and the retention times were 2.7, 1.5 and 1.7 min for doxifluridine, 5-FU and 5-CU, respectively with shorter analysis time within 5 min than previously reported methods. The ionization was optimized using ESI negative mode and selectivity was achieved by tandem mass spectrometric analysis by multiple reaction monitoring (MRM) using the transformations of m/z 244.8>107.6, 129.0>42.0 and 144.9>42.1 for doxifluridine, 5-FU and 5-CU, respectively. The achieved low limit of quantification was 20.0 ng/mL and the assay exhibited linear range of 20-2000 ng/mL ($R^2>0.99957$ for doxifluridine and $R^2>0.99857$ for 5-FU), using $100{\mu}L$ of plasma. Accuracy and precision of quality control samples for both doxifluridine and 5-FU met KFDA and FDA Guidance criteria of 15% for accuracy with coefficients of variation less than 15%. This method demonstrated adequate sensitivity, specificity, accuracy, precision and stability to support the simultaneous analysis of doxifluridine and 5-FU in dog plasma samples in pharmacokinetic and bioequivalence studies.

• 대한세포병리학회지
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• 제10권1호
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• pp.35-42
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• 1999

The accuracy of fine needle aspiration cytology(FNAC) of the lymph node was investigated through a review of 176 FNAC cases and the corresponding biopsies. We chose 157 FNAC cases after the exclusion of 19 inadequate ones. Sensitivity of malignancy was 94.0%, specificity 100%, false negativity 6.0%, and false positivity 0.0%. The overall diagnostic accuracy was 96.8%. Sensitivity of metastatic carcinoma was 98.0% and that of malignant lymphoma was 87.9%. False negative cases included one metastatic carcinoma and four malignant lymphomas. The aspirates of metastatic carcinoma with false negativity exhibited a diffuse smear of keratin debris without viable cells, which led to the difficulty in differentiation from benign epithelial cyst. The cases of malignant lymphoma with false negative diagnosis were two Hodgkin diseases, one Lennert's lymphoma, and one peripheral T cell lymphoma in the histologic sections. On the analysis of 39 cases of tuberculosis, 17 cases(43.6%) were diagnosed as tuberculosis, 4(10.3%) as granulomatous lymphadenitis, 3(7.7%) as necrotizing lymphadenitis, and 15(38.5%) as reactive hyperplasia or pyogenic inflammation. Sensitivity of tuberculosis was 53.9%. In conclusion, lymph node FNAC is an excellent non-invasive diagnostic tool for the diagnosis of metastatic carcinoma. The diagnostic accuracy of malignant lymphoma could be improved with flow cytometry or polymerase chain reaction for antigen receptor genes. For the FNAC diagnosis of tuberculosis, AFB stain, culture, and PCR would be helpful as adjuvant techniques.

• 한국수정란이식학회지
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• 제28권4호
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• pp.343-348
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• 2013

Cell-free fetal RNA has been highlighted as useful tools for the fetal sex determination or other genetic inherent disorder. However, there is no knowledge about the sex determination using cell free fetal RNA in bovine field. Thus, the present study aimed to evaluate the presence of transcripts of DDX3Y, USP9Y and ZRSR2Y genes in maternal plasma of pregnant cows to determine the sex of the fetus using real-time quantitative polymerase chain reaction assay, and verify its accuracy, sensitivity and specificity compared with the molecular testing and the calf sex at birth. Transcripts of USP9Y and DDX3Y genes were expressed in the all plasma of males and females both the control group and the experimental group. However, ZRSR2Y gene was matched up with the molecular testing and the true sex in control group and has an overall accuracy of 82.6%, a sensitivity of 75%, and a specificity of 100% in experimental group. Therefore, these results indicated that real time PCR technique, as a noninvasive and cost-efficient method, is possible to determination fetal sex in the bovine species using circulating cell free RNA in maternal plasma and especially ZRSR2Y gene could be a good candidate for the RNA based sex determination work.

• 한국임상수의학회지
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• 제33권5호
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• pp.266-269
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• 2016

Cell-free fetal RNA is useful to determine fetal sex and detect other inherent genetic disorders. However, non-invasive fetal sex determination methods using fetal RNA from maternal plasma is not yet well established in studies pertaining to bovine animals. Thus, the aim of this study was to systematically evaluate the presence of the male-specific ZRSR2Y gene transcript in maternal plasma using Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) assays, and to verify its accuracy, sensitivity, and specificity in determining fetal sex between 30 and 100 days of gestation. Overall accuracy, sensitivity, and specificity of the ZRSR2Y gene transcripts in determining fetal sex were 89.1%, 86.3%, and 100%, respectively. The 30 to 100 days of gestation were further classified into five stages of gestation, and each stage had relatively high accurate, sensitive, and specific results. Overall, these results indicate that the expression of the ZRSR2Y gene can be used for fetal sex determination in bovine animals using circulating cell-free RNA in maternal plasma during early pregnancy.

• 대한기계학회논문집A
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• 제35권9호
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• pp.1071-1076
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• 2011

본 연구에서는 산업용 다관절 로봇을 이용한 3 차원 곡면가공 방안에 대하여 연구하였다. 가반중량이 큰 산업용 로봇의 경우 반복위치정밀도가 높지 않아 위치오차와 가공 깊이 방향 오차를 발생시키며, 본 연구에서는 레이저 변위센서를 이용하여 이를 보정하는 방법을 제시하였다. 로봇교시포인터의 수를 줄이기 위하여 가공면의 특이점들만을 이용하여 곡면 가공이 가능하도록 로봇 궤적을 생성하는 방안을 연구하였다. 본 연구에서는 실제 산업용 로봇을 이용하여 가공시험을 수행하였다. 회전수, 가공각도, 가공깊이, 가공속도 등의 가공조건을 변경해가며, 표면조도, 실제 가공깊이, 진동 및 소음 발생에 대한 시험을 수행하여 적용 가능한 가공조건을 도출하였다.

• 한국인터넷방송통신학회논문지
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• 제21권6호
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• pp.77-82
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• 2021

요검사는 물리적 성상 검사, 화학적 검사, 현미경 검사 세 가지가 있다. 이 중에서 화학적 요검사는 일반인이 쉽게 접근하는 방법으로 요검사지의 화학반응을 눈으로 표준비색표와 비교하거나 휴대용 요검사기를 별도로 구매하여 검사를 진행한다. 현재는 스마트폰의 보급이 대중화되어 스마트폰을 활용한 요검사 서비스 연구가 높아지고 있다. 요검사 스크리닝 애플리케이션은 스마트폰을 활용한 요검사 서비스 중 하나이다. 그러나 요검사 스크리닝 애플리케이션으로 촬영한 요검사 패드 RGB 값은 조명영향으로 인해 큰 편차가 발생한다. 요검사 패드 RGB 값의 편차는 요검사 판별의 정확도를 떨어뜨린다. 따라서 본 논문에서는 스마트폰 기반 요검사 스크리닝 애플리케이션으로 촬영한 요검사지를 검사 항목별 요검사 패드로 분류한 후 CNN을 통해 요검사 패드 이미지 판별의 정확도를 높인다. 요검사지는 다양한 배경에서 촬영하여 CNN 이미지를 생성하였으며 ResNet-50 CNN 모델을 사용하여 요검사 판별을 분석하였다.

• 대한불안의학회지
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• 제18권1호
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• pp.32-37
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• 2022

Objective : Impaired working memory has been known to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD) with growing evidence. Delayed matching-to-sample task (DMST) is a working memory task which have an advantage in analyzing several different working memory processes in one task. However, most of the studies have failed to reveal the working memory impairment with the DMST. The aim of this study was to identify whether working memory deficit in OCD can be evaluated with the DMST. Methods : The participants included 20 OCD patients and 20 healthy volunteers. Working memory was evaluated with the DMST with two different working memory loads. Accuracy of response and mean response time were measured. Results : OCD patients showed a significantly longer reaction time and lower accuracy in DMST compared to healthy controls in the task with high working memory loads. Moreover, the difference in accuracy showed interaction with the working memory load. Conclusion : The present results indicate that working memory deficit in patients with OCD can be evaluated with the DMST. The findings also suggest that previous negative behavioral results using the DMST were from low working memory load of the task.