• Journal of Chest Surgery
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• v.13 no.4
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• pp.346-355
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• 1980

It has been proposed that wide individual variation in response to heparin be not considered in the conventional set protocol for the control of heparin and protamine during extracorporeal circulation. In this paper, two protocol of heparin and protamine therapy were compared to assess the role of the Activated Clotting Time [ACT] in relation to heparin, protamine, and postoperative blood loss and transfusion. The study groups consisted of the 31 patients [adults 15 and children 16] anticoagulated with the conventional heparin protocol and the 31 patients [adults 15 and children 16] anticoagulated with ACT protocol during extracorporeal circulation. In the conventional heparin protocol, two mg of heparin per kg was administered initially with an additional 0.75 mg of heparin per kg every 30 minutes of extracorporeal circulation, and reversal was accomplished with protamine in a dose of 1.5 times the total milligram of heparin. In the ACT protocol, two mg of heparin per kg was administered initially with an additional dose of heparin enough to reach an ACT of 480 seconds [within safe zone 300 to 600 seconds] from the patient`s dose response curve every 1 hour of extracorporeal circulation, and reversal was done with protamine in a dose of 1.3 times the milligram of the residual heparin. The results were summarized as follows. After a dose of 2 mg per kg of heparin, the patient`s ACT varied from 240 to 600 seconds in adults and from 240 t~ 660 seconds in children. In the ACT group the total amount of heparin administered was markedly reduced when compared to the conventional group, and less protamine was required to neutralize heparin. The dose of heparin administered decreased from 7.07 [SE 0.42] mg/kg of the conventional group to 4.92 [SE 0.32] mg/k8 of the ACT group in adults and from 10.17 [SE 1.15] mg/kg to 5.23 [SE 0.24] mg/kg in children, which represent 30.4% and 48.6% decrease respectively. The dose of protamine administered for reversal decreased from 10.6 [SE 0.63] mg/kg of the conventional group to 3.35 [SE 0.35] mg/kg of the ACT group in adults and from 15.7 [SE 1.70] mg/kg to 3.26 [SE 0.27] mg/kg in children, which represent 68.4% and 79.2% respectively. The ratio of protamine to heparin administered in the conventional group was 1.50:1 in adults and 1.54:1 in children, but in the ACT group 0.68:1 in adults and 0.62:1 in children. Postoperative blood loss and transfusion revealed no statistically significant difference between the two groups. Although six patients in the conventional group and one in the ACT group needed re-exploration for continuous hemorrhage, no case of generalized oozing was encountered, and in each case a definite bleeding site was identified. Author would like emphasizing the value of the ACT protocol in controlling heparin and protamine administration during extracorporeal circulation.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.48 no.3
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• pp.1-10
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• 2011

Social network service is defined as an online service or communication service based on social relations among people applied the concept of social network. Social collaborative service included in social network service is characterized by the new value of modified content or recreated content made through collaborative creation process between members of the group. It has the remarkable merits such as sharing and collaboration. But, at the same time, it has the latent problems such as content reuse or copy that is not allowed for members to use. It has been emerged that UCC which is a typical example of recreated or modified content has the copyright issues in both creation and publishing step. To resolve this matter, we don't have many appropriate methods except CCL so far. So, in this paper, we define the problem and implement the UCC metadata manager to control metadata reflecting the feature of UCC. We draw the reference metadata element to identify original content utilized re-creation process. After that we define the R.Metadata Loader module based on the use case. Finally, the proposed UCC metadata manager provides the information of referenced content and lets us to identify the relationship between reference contents. So as to implement prototype, we use Kaltura which is CMS using open source and obtain functional extensibility of metadata manager by using open API.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.23 no.5
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• pp.73-86
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• 2020

In the modern era, the elementary schools in the Republic of Korea are advanced with the competitive world. Thus advancement in technology, and other factors in the elementary schools are releases some kind of particulate matter (PM), which causes deleterious effects on school students health, academic program, growth and development. The school students are susceptible to PM particularly, PM₁₀ and PM_2.5. Based on this hazardous effect of PM on school students we conducted the research on the elementary schools class rooms by introducing vertical gardening system to get the schools "ever green". The main aim of this study is to investigate the environmental factors in the educational effect program in the class rooms and indoor air quality changes. For the educational effect, the 4th operation program was applied to 2 schools for 2 hours once a month from September to December 2019. Each school conducted a survey on satisfaction, plant friendliness, and environmental sensibilities, targeting classes that participated in the green school program and those who did not. The environmental effects were monitored by installing indoor air quality facility in the program participating classes and the non-participating classes. From November 2019 to December 2019, three factors were measured: PM10, PM2.5, and humidity. The results were analyzed by T-test using the SPSS 24.0 software program. As a result of the analysis, student's overall satisfaction with the program and their intention to re-engage were high in terms of educational effect. It was also found to be effective in emotional, educational, social, and physical aspects. In particular, it was found that there was a statistically significant effect on improving plant friendliness in terms of plant friendliness and environmental sensitivity. In terms of environmental effects, it was found that there was a significant difference between the program-applied and non-programmed classes in PM10, PM2.5, and humidity. Through this study, it was confirmed that the plant education program using vertical gardens is effective in both the educational effect and the improvement of indoor air quality in the classroom. In conclusion, vertical gardening system in the elementary schools should implement for the beneficial of young generation development and back bone to the nation.

• Journal of dental hygiene science
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• v.9 no.3
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• pp.361-367
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• 2009

This study was conducted to know oral maxillofacial symptoms accroding to dental fear and dental use behavior. 334 persons Older than junior high school students in Daegu, South Korea who visited to dental clinic were targeted From March 1.2008 to March 15, 2008. Statistics tool was SPSS 12.0 for Windows. General characteristics and response degree according to oral maxillofacial symptoms was analyzed by frequency study. Fear and difference according to oral maxillofacial symptoms we re conducted by T-test and One-Way ANOVA. Correlation analysis was used to verify relation between fear and oral maxillofacial symptoms. Results are followings. 1. Women felt fear higher than men did. Persons who were older felt fear higher and these were statistically related. 2. Extraoral external was 62.9%, hightest on the symptoms response degree according to oral maxillofacial symptoms. Feeling back side of the head on the strain and neck was stiff on the items were high. 3. Oral maxillofacial symptoms were high in the case when they had regular inspection, experience of scaling, experience of anesthesia and visited to the clinic often. And. Two cases(having regular inspection and visiting to the clinic often) were statistically related. Conclusion: Each pan of oral maxillofacial symptoms in the high fear group according to oral maxillofacial symptoms and it was all statistically related. And, fear and each oral maxillofacial pains were positively related and it was statistically related.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.11
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• pp.9-16
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• 2005

This paper proposes a programmable PLL (phase locked loop) based clock generator supporting a wide-range-frequency input and output for high performance and low power SoC with multiple clock frequencies domains. The propose system reduces the locking time and obtains a wide range operation frequency by using a dual-charge pumps scheme. For low power operation of a chip, the locking processing circuits of the proposed PLL doesn't be working in the standby mode but the locking data are retained by the DAC. Also, a tracking ADC is designed for the fast relocking operation after stand-by mode exit. The programmable output frequency selection's circuit are designed for supporting a optimized DFS operation according to job tasks. The proposed PLL-based clock system has a relock time range of $0.85{\mu}sec{\sim}1.3{\mu}sec$($24\~26$cycle) with 2.3V power supply, which is fabricated on $0.35{\mu}m$ CMOS Process. At power-down mode, PLL power saves more than $95\%$ of locking mode. Also, the PLL using programmable divider has a wide locking range ($81MHz\~556MHz$) for various clock domains on a multiple IPs system.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4671-4676
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• 2014

Background: MicroRNA-200a (miR-200a) has been reported to regulate tumour progression in several tumours but little is known about its role in neuroblastoma. Our aim was to investigate the potential role and mechanism of miR-200a in neuroblastomas. Materials and Methods: Expression levels of miR-200a in tissues were determined using RT-PCR. The effect of miR-200a and shAP-$2{\gamma}$ on cell viability was evaluated using MTS assays, and target protein expression was determined using Western blotting and RT-PCR. Luciferase reporter plasmids were constructed to confirm direct targeting. Results were reported as mean${\pm}$S.E.M and differences were tested for significance using the 2-tailed Students t-test. Results: We determined that miR-200a expression was significantly lower in neuroblastoma tumors than the adjacent non-cancer tissue. Over-expression of miR-200 are reduced cell viability in neuroblastoma cells and inhibited tumor growth in mouse xenografts. We identified AP-$2{\gamma}$ as a novel target for miR-200a in neuroblastoma cells. Thus miR-200a targets the 3'UTR of AP-$2{\gamma}$ and inhibits its mRNA and protein expression. Furthermore, our result showed that shRNA knockdown of AP-$2{\gamma}$ in neuroblastoma cells results in significant inhibit of cell proliferation and tumor growth in vitro, supporting an oncogenic role of AP-$2{\gamma}$ in neuroblastoma. Conclusions: Our study revealed that miR-200a is a candidate tumor suppressor in neuroblastoma, through direct targeting of AP-$2{\gamma}$. These findings re-enforce the proposal of AP-$2{\gamma}$ as a therapeutic target in neuroblastoma.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.21 no.6
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• pp.470-479
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• 2009

The local scour in waves can be thought of as very complex synthetic processes which is influenced by geology of bed material, bed flow in the sea and hydraulics condition. The most research until now be targeted at the scour depth and therefore the local scour width in waves has not been investigated as well. The size of wave or bottom velocity at the bed is direct cause of the local scour among lots of the scour effect factors, and the scour depth and width can be estimated through interrelationship analysis with scour area to use the dimensionless parameters including these such as Keulegan-Carpenter number, Ursell number etc. In this paper, to find out closely relation with the dimensionless parameters and scour width, performed an experiment with the variations of pipe diameters, wave heights and wave periods and then analyzed it. As the result, while Reynolds number and period parameter were seen to disperse local scour width largely, Shields number, KC number and Ursell number appeared good interrelationship. Specially, Shields number doesn't much affect the scour depth but has good relation for the scour width.

• Korean Security Journal
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• no.10
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• pp.127-147
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• 2005

This study (research) has been done on the job, job-satisfaction and job dedication of body guards from many sectors in Korea. This research is focused on the relationship of job, job-satisfaction and job-dedication in diverse aspects in order to build up a detailed theory, As a result, teams of body guard can enhance their systematic efficiency through the theory. Therefore in this chapter, it will re-examine the result of this research and discuss about the theoretical and practical aspect of the result. This study(research) will be the outset(start) for the organizational behavior study of the body guards in Korea. Especially, this research tries to distinguish the duty aspect and the general feature of the body guards, satisfaction along with the level of dedication. Therefore it will give the persons concerning the bodyguards many theoretical and practical points to consider. But there is a limitation as crossing research that in this research we didn't research in compensation for all internal body guards and accomplishment of research has achieved in a short-time. Though it will be necessary to accomplish in henceforth research, if at all possible, in compensation for all body guards and much more diverse security service classification, also for a long time extended vertical research.

• Journal of Science of Art and Design
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• v.3
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• pp.33-61
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• 2001

Dans les arts modernes, nous ressentons souvent un $probl\`{e}me$ $disloqu\'{e}par$ rapport aux humains. Ceci ne viendrait-il pas $peut-\^{e}tre$ do notre $pens\'{e}e$ dans l' $\'{e}change$ culturelle entre le monde et nous qui s' appuie trop une $temporalit\'{e}$ et logique? Cette $the\`{s}e$ approche ce $probl\`{e}me$ $\`{a}$ travers one perception anthropologique do monde, en $\'{e}tudiant$ les arts tridimensionnels avec ses $\'{e}schelles$ qui deviennes plus on plus agrandis. Maurice Merleau-Ponty, dans son livre 'la $ph\'{e}nom\'{e}nologie$ de la perception', bien $r\'{e}sumait$ une $intersubjectivit\'{e}$ entre l' espace et nous. Selon lui, l' homme prend conscience do la forme des objets avec son environnement parce quil est un corps on interaction avec eux. Donc nous $r\'{e}f\'{e}rons$ ce livre pour notre set. Et on essayera ici d' $\'{e}tudier$ le travail do Constantin Brancusi, de Alberto Giacometti, do Richard Serra et do quelques d' autres travaux d' artistes L' oeuvre do Brancusi 'la Colonne sans fin', la taille plus de 29 m, produit one impression sur le spectateur relativement $\grave{a}$ la forme continue et $r\'{e}p\'{e}t\'{e}e$ $\`{a}$ linfini de $mani\'{e}re$ unifome. La pratique de Giacometti qui tenait compte do son envergure et de la longueur do son corps ainsi que do distance et de la mesure do sos bras, Il $d\'{e}formait$ aussi les silhouettes et transformait les objects en les $\'{e}tirant$ dans la perspective. Rosalind Krauss parler $\`{a}$ loeuvre do Serra, dans son livre 'l' originalit de lavant-garde et sutres mythes modernistes' (pp. 319-333), le spectateur est toujours on mouvement on liaison entre l' horizon do corps et celui do monde. Cette $transitivit\'{e}$ abstraite $r\'{e}ciproque$ entre le regardeur et le $regard\'{e}$, qui est comme le sujet de nombreuses oeuvres do Serra. Cependant le Maximalisme est $\`{a}$ l' origine Minimalisme qui s' $\'{e}tend$ dans ses efforts $th\'{e}oriques$ jusqu' au l' espace architecturale. Ces sculptures do grandes dimensions so situent autour de $b\^{a}timent$ ou dans lespace environnementale, comme ils sent l' architecture et le paysage. On suppose ici, leurs concepts de l' espace $\'{e}largit$ $\`{a}$ celui d' architecture. La sculpture et l' architecture $r\'{e}ciproque$ l' espace tridimensionnel entre eux, mais selon l' argument do Herbert Read pour la distinction de ces deux arts originaux sont, deux saisies de l' espace, ici englobant, $l\`{a}$ $englob\'{e}$. On $\'{e}tudie$ dans co set de concept de l' espace et de l' $\'{e}chelle$ d' objet par rapport au corps humain.

• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.879-883
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• 2005

우리나라는 하천유역의 도시화 추세 속에 불투수층의 증가로 빗물의 일시 유출로 인한 홍수발생으로 많은 인명과 재산피해가 발생하고 있어 방재적 차원에서의 수자원관리가 시급한 실정이다. 또한, 초기 빗물과 합류식 하수도의 월류수에 의한 하천, 호소, 및 습지의 수질오염문제도 많이 발생하고 있다. 이러한 문제를 해결하기 위하여 콘크리트로 제작된 PC 지하식 빗물저류시설로서 상부의 공간은 공원, 운동장, 주차장 등 다양하게 이용하면서 방재와 치수를 가능케 할 수 있다. 또한, PC 콘크리트 빗물저류조는 현장 타설이 아닌 PC콘크리트 블록을 현장에서 조립하여 시공기간이 대폭적으로 단축되고, 작업환경 및 주변환경을 개선시킬 수 있다. 또한, 지하수의 보전, 회복을 위한 빗물저류 침투 시설 역할도 수행하여 비상용수를 확보하고 여름철 홍수 시 빗물을 가두어 재해를 방지하는 등의 다목적 시설로 활용된다. 지하 매립형 빗물저류조는 기존의 암거설계기준을 참조하여 일본의 내진설계 기준을 반영하였으며, 고강도 콘크리트를 사용하여 강도 또한 뛰어나다. 그리고 시공이 간편하고 공기의 단축에 탁월한 효과를 나타내며, 빗물저류조 설치는 다음과 같은 특징이 있다. 1. 지하저류형 빗물저류조 시설로 설계되어 토지의 효과적인 이용이 기대된다. 2. 공사기간이 짧아 경제적이다. 3. 안정된 구조체이다. 4. 부지의 형태에 맞춘 시공이 가능하다. 5. 소규모에서 대규모의 유수지까지 광범위하게 대응이 가능하다. 6. 방재역할 수행 및 빗물이용의 역할을 담당할 수 있다. 7. 불투수층이 증가하고 있는 도시지역에서 적극 활용가능하다.로 판단된다.한 예비방류의 시행과 강우종료 후에도 이수용량에는 손실이 없는 저수지의 관리방안의 지침이 되는데 효율적이라 판단되었다. 방법을 개발하여 개선시킬 필요성이 있다.>$4.3\%$로 가장 근접한 결과를 나타내었으며, 총 유출량에서도 각각 $7.8\%,\;13.2\%$의 오차율을 가지는 것으로 분석되어 타 모형에 비해 실유량과의 차가 가장 적은 것으로 모의되었다. 향후 도시유출을 모의하는 데 가장 근사한 유출량을 산정할 수 있는 근거가 될 것이며, 도시재해 저감대책을 수립하는데 기여할 수 있을 것이라 판단된다.로 판단되는 대안들을 제시하는 예비타당성(Prefeasibility) 계획을 수립하였다. 이렇게 제시된 계획은 향후 과학적인 분석(세부평가방법)을 통해 대안을 평가하고 구체적인 타당성(feasibility) 계획을 수립하는데 토대가 될 것이다.{0.11R(mm)}(r^2=0.69)$로 나타났다. 이는 토양의 투수특성에 따라 강우량 증가에 비례하여 점증하는 침투수와 구분되는 현상이었다. 경사와 토양이 같은 조건에서 나지의 경우 역시 $Ro_{B10}(mm)=20.3e^{0.08R(mm)(r^2=0.84)$로 지수적으로 증가하는 경향을 나타내었다. 유거수량은 토성별로 양토를 1.0으로 기준할 때 사양토가 0.86으로 가장 작았고, 식양토 1.09, 식토 1.15로 평가되어 침투수에 비해 토성별 차이가 크게 나타났다. 이는 토성이 세립질일 수록 유거수의 저항이 작기 때문으로 생각된다. 경사에 따라서는 경사도가 증가할수록 증가하였으며