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Neck Node Bolus Technique in the Treatment of Nasopharyngeal Carcinoma with Intensity-modulated Radiotherapy

  • Phua, Chee Ee;Ung, Ngie Min;Tan, Boon Seang;Tan, Ai Lian;Eng, Kae Yann;Ng, Bong Seng
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.12
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    • pp.6133-6137
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    • 2012
  • Purpose: To study the effect of bolus versus no bolus in the coverage of the nodal tumour volume with intensity-modulated radiotherapy (IMRT) for the treatment of nasopharyngeal carcinoma (NPC). Methods and Materials: This retrospective study used data from 5 consecutive patients with NPC who were treated with bolus for large neck nodes using IMRT from November 2011-January 2012 in our institute. All these patients were treated radically with IMRT according to our institution's protocol. Re-planning with IMRT without bolus for these patients with exactly the same target volumes were done for comparison. Comparison of the plans was done by comparing the V70 of PTV70-N, V66.5 of PTV70-N, V65.1 of PTV70-N and the surface dose of the PTV70-N. Results: The mean size of the largest diameter of the enlarged lymph nodes for the 5 patients was 3.9 cm. The mean distance of the GTV-N to the skin surface was 0.6 cm. The mean V70 of PTV70-N for the 5 patients showed an absolute advantage of 10.8% (92.4% vs. 81.6%) for the plan with bolus while the V66.5 of PTV70-N had an advantage of 8.1% (97.0% vs. 88.9%). The mean V65.1 also had an advantage of 7.1% (97.6% vs. 90.5%). The mean surface dose for the PTV70-N was also much higher at 61.1 Gy for the plans with bolus compared to only 23.5 Gy for the plans without bolus. Conclusion: Neck node bolus technique should be strongly considered in the treatment of NPC with enlarged lymph nodes treated with IMRT. It yields a superior dosimetry compared t o non-bolus plans with acceptable skin toxicity.

Treatment Outcome with Brachytherapy for Recurrent Nasopharyngeal Carcinoma

  • Cheah, Soon Keat;Lau, Fen Nee;Yusof, Mastura Md;Phua, Vincent Chee Ee
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6513-6518
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    • 2013
  • Background: To evaluate the treatment outcome and major late complications of all patients with recurrent nasopharyngeal carcinoma (NPC) treated with intracavitary brachytherapy (ICBT) in Hospital Kuala Lumpur. Materials and Methods: This retrospective study was conducted at the Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Malaysia. All patients with histologically confirmed recurrent NPC in the absence of distant metastasis treated in the period 1997-2010 were included in this study. These patients were treated with ICBT alone or in combination with external beam radiotherapy (EBRT). Treatment outcomes measured were local recurrence free survival (LRFS), disease free survival (DFS) and overall survival (OS). Results: Thirty three patients were eligible for this study. The median age at recurrence was 56 years with a median time to initial local recurrence of 27 months. Majority of patients were staged as rT1-2 (94%) or rN0 (82%). The proportion of patients categorised as stage III-IV at first local recurrence was only 9%. Twenty one patients received a combination of ICBT and external beam radiotherapy while 12 patients were treated with ICBT alone. Median interval of recurrence post re-irradiation was 32 months (range: 4-110 months). The median LRFS, DFS and OS were 30 months, 29 months and 36 months respectively. The 5 year LRFS, DFS and OS were 44.7%, 38.8% and 28.1% respectively. The N stage at recurrence was found to be a significant prognostic factor for LRFS and DFS after multivariate analysis. Major late complications occurred in 34.9% of our patients. Conclusions: Our study shows ICBT was associated with a reasonable long term outcome in salvaging recurrent NPC although major complications remained a significant problem. The N stage at recurrence was a significant prognostic factor for both LRFS and DFS.

Hot-Carrier-Induced Degradation of Lateral DMOS Transistors under DC and AC Stress (DC 및 AC 스트레스에서 Lateral DMOS 트랜지스터의 소자열화)

  • Lee, In-Kyong;Yun, Se-Re-Na;Yu, Chong-Gun;Park, J.T.
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.44 no.2
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    • pp.13-18
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    • 2007
  • This paper presents the experimental findings on the different degradation mechanism which depends on the gate oxide thickness in lateral DMOS transistors. For thin oxide devices, the generation of interface states in the channel region and the trapped holes in the drift region is found to be the causes of the device degradation. For thick devices, the generation of interface states in the channel region is found to be the causes of the device degradation. We confirmed the different degradation mechanism using device simulation. From the comparison of device degradation under DC and AC stress, it is found that the device degradation is more significant under DC stress than one under AC stress. The device degradation under AC stress is more significant in high frequency. Therefore the hot carrier induced degradation should be more carefully considered in the design of RF LDMOS transistors and circuit design.

Effectiveness of the Peripheral Transverse Line as Speed-Reduction Treatment on Korean Expressway Ramps (고속도로 노면표시 감속유도시설 효과평가)

  • Lee, Seongkwan Mark;Lee, Kiyoung;Kim, Seokchool
    • International Journal of Highway Engineering
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    • v.14 no.6
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    • pp.85-92
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    • 2012
  • PURPOSES : Since expressways in South Korea are toll roads, many trumpet type interchanges exist, resulting in the installation of loop ramps very frequently. While the travel speed of the main lane is designed to be 100-110 km/h, the structure of a loop ramp is different and is designed for a minimum speed of 40 km/h. In fact, most of the actual travel speeds measured on the ramp exceed the designated speed, which has been a major problem in traffic safety. In this research, a type of pavement marking speed-reduction treatment called the "Peripheral Transverse Line" is installed on expressway loop ramps in order to study the change of driving speeds after the installation. METHODS : To verify statistically the change, this speed-reduction treatment has been installed on the Chungju interchange and the Yeoju junction. The driving speeds before the installation were compared with driving speeds both one month and five monthsafter the installation. RESULTS : As a result, the reductions of the average driving speeds after the treatment were statistically significant. More specifically, the average driving speeds of the Chungju interchange were reduced by 7.1-7.7 % for its tangent road section, and the speeds decreased by 8.5-9.5 % for its curve section. Similarly, in the Yeoju junction, an average speed reduction of 2.9-4.8 % for its tangent section was measured, along with 3.9% long-term speed reduction for its curve section. CONCLUSIONS : Since the pavement marking speed-reduction treatment has been partially proven to be effective from this research, we expect to expand this treatment and re-confirm the effect from a long-term perspective in the future.

Improvement of physical fitness and work ability of the middle-aged and aged workers through exercise prescription program (운동처방 프로그램을 통한 중·고령 근로자의 체력향상을 통한 노동력 증진)

  • Yang, Dong Joo;Kang, Dongmug;Yang, Yeong Ae;Yu, Jang Jin;Kim, Yeun Hee
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.19 no.3
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    • pp.297-306
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    • 2009
  • The purposes of this study were to investigate whether the program of health promotion and follow up feedback by periods could improve physical fitness related to work ability of the middle-aged and aged workers. Subjects were composed of two groups; workers aged below forty five and forty five and over who had measured their health-related physical fitness twice for 2 years (2006 & 2007) through the program of health promotion operated by Korea Occupational Safety & Health Agency. Paired t-test was used to evaluate the difference between the first measurement and re-measurement of health-related fitness which was operated after six to twelve months from the first one. We used 0.05 level for statistical significance. The results of this study were as follows. All measurement items including body fat ratio(%), $VO_2max$, grip strength, sit-up, and trunk flexion were significantly improved in both groups. The improvement(%) of $VO_2max$, grip strength of workers of forty five and above was lower than those of workers of below forty five. Servicing the program of health promotion and follow up feedback by periods may help workers' improvement of health-related physical fitness related to work ability.

Evaluation of the lateral ventricle using MRI in normal micropigs

  • Choi, Mihyun;Lee, Namsoon;Yi, Kangjae;Kim, Junyoung;Choi, Mincheol
    • Korean Journal of Veterinary Research
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    • v.51 no.3
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    • pp.227-231
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    • 2011
  • This study was undertaken to assess the lateral ventricle, which was some portion of brain and related to congenital anomalies, from 1, 2, 4, and 8 months of age in healthy micropigs. They were induced general anesthesia and performed magnetic resonance imaging (MRI) with a 0.3 Tesla magnet. Each age group was evaluated by three subjects such as lateral ventricular volume, ventricular volume ratio and asymmetry. T1 weighted transverse images were acquired for calculation of lateral ventricular and corresponding brain parenchyma areas. The ratio of bilateral ventricle areas used to analyze the asymmetry. The mean ventricular volumes of each month were $676.74{\pm}25.58mm^3$ (1 month-old), $630.64{\pm}143.84mm^3$ (2 month-old), $992.12{\pm}106.03mm^3$ (4 month-old) and $1172.62{\pm}237.57mm^3$ (8 month-old), respectively. The ventricular volume ratio was the smallest at 2 month-old and re-increased from that age. The ratio was significantly different between 2 month-old and other age groups (p < 0.05). The value of bilateral area ratio showed within 1.5 in all experimental animals. Consequently the lateral ventricle showed a positive correlation with aging and symmetric shapes in both sides. The developmental pattern of the lateral ventricle provides basic data in micropigs as an experimental animal model for physiological and neurosurgical approach.

ESCAPE OF RESONANTLY SCATTERED LYβ AND Hα FROM HOT AND OPTICALLY THICK MEDIA

  • Chang, Seok-Jun;Lee, Hee-Won;Ahn, Sang-Hyeon;Lee, Hogyu;Angeloni, Rodolfo;Palma, Tali;Di Mille, Francesco
    • Journal of The Korean Astronomical Society
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    • v.51 no.1
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    • pp.5-16
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    • 2018
  • We investigate the escape of $Ly{\beta}$ from emission nebulae with a significant population of excited hydrogen atoms in the level n = 2, rendering them optically thick in $H{\alpha}$. The transfer of $Ly{\beta}$ line photons in these optically thick regions is complicated by the presence of another scattering channel leading to re-emission of $H{\alpha}$, alternating their identities between $Ly{\beta}$ and $H{\alpha}$. In this work, we develop a Monte Carlo code to simulate the transfer of $Ly{\beta}$ line photons incorporating the scattering channel into $H{\alpha}$. Both $H{\alpha}$ and $Ly{\beta}$ lines are formed through diffusion in frequency space, where a line photon enters the wing regime after a fairly large number of resonance scatterings with hydrogen atoms. Various line profiles of $H{\alpha}$ and $Ly{\beta}$ emergent from our model nebulae are presented. It is argued that the electron temperature is a critical parameter which controls the flux ratio of emergent $Ly{\beta}$ and $H{\alpha}$. Specifically for $T\;=\;3{\times}10^4\;K$ and $H{\alpha}$ line center optical depth $\tau{\alpha}\;=\;10$, the number flux ratio of emergent $Ly{\beta}$ and $H{\alpha}$ is ~ 49 percent, which is quite significant. We propose that the leaking $Ly{\beta}$ can be an interesting source for the formation of $H{\alpha}$ wings observed in many symbiotic stars and active galactic nuclei. Similar broad $H{\alpha}$ wings are also expected in $Ly{\alpha}$ emitting halos found in the early universe, which can be potentially probed by the James Webb Telescope in the future.

Identification of Group-Node using Genetic Algorithm, and Re-Construction Technique of Social Network (유전자 알고리즘을 사용한 그룹노드의 식별 및 소셜 네트워크의 재구성 기법)

  • Cho, Min-Ho
    • The Journal of the Korea institute of electronic communication sciences
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    • v.10 no.7
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    • pp.837-844
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    • 2015
  • A research of Social Network is focused to the single node and link. But when we consider the complexity of Social Network, I think we need the analysis of integrated influence by multiple nodes that satisfied with specific condition. But, the study of this area don't process apart from Sub-network concept. The purpose of this paper is to focus on the analysis of influence by multiple nodes. For it, I define a new term as Group Node, and it express multiple nodes that satisfied a specific condition. And I propose a method for reconstruction by using Group Node in Social Network. and I make a program that produce a Group Node satisfied with a special condition by using Genetic Algorithm, and show the result. I hope this result can be a start point of the Social Network analysis based on Group Node.

Trueness and precision of scanning abutment impressions and stone models according to dental CAD/CAM evaluation standards

  • Jeon, Jin-Hun;Hwang, Seong-Sig;Kim, Ji-Hwan;Kim, Woong-Chul
    • The Journal of Advanced Prosthodontics
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    • v.10 no.5
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    • pp.335-339
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    • 2018
  • PURPOSE. The purpose of the present study was to compare scanning trueness and precision between an abutment impression and a stone model according to dental computer-aided design/computer-aided manufacturing (CAD/CAM) evaluation standards. MATERIALS AND METHODS. To evaluate trueness, the abutment impression and stone model were scanned to obtain the first 3-dimensional (3-D) stereolithography (STL) file. Next, the abutment impression or stone model was removed from the scanner and re-fixed on the table; scanning was then repeated so that 11 files were obtained for each scan type. To evaluate precision, the abutment impression or stone model was scanned to obtain the first 3-D STL file. Without moving it, scanning was performed 10 more times, so that 11 files were obtained for each scan type. By superimposing the first scanned STL file onto the other STL files one by one, 10 color-difference maps and reports were obtained; i.e., 10 experimental scans per type. The independent t-test was used to compare root mean square (RMS) data between the groups (${\alpha}=.05$). RESULTS. The $RMS{\pm}SD$ values of scanning trueness of the abutment impression and stone model were $22.4{\pm}4.4$ and $17.4{\pm}3.5{\mu}m$, respectively (P<.012). The $RMS{\pm}SD$ values of scanning precision of the abutment impression and stone model were $16.4{\pm}2.9$ and $14.6{\pm}1.6{\mu}m$, respectively (P=.108). CONCLUSION. There was a significant difference in scanning trueness between the abutment impression and stone model, as evaluated according to dental CAD/CAM standards. However, all scans showed high trueness and precision.

The Analysis of Cognitive Reaction Time to the Intensity of Auditory Stimuli in Older People (청각자극의 세기에 따른 노인의 인지 반응시간 분석)

  • Kim, Kyeong-Mi;Chang, Moon-Young;Hong, Eun-Kyoung
    • The Journal of Korean Academy of Sensory Integration
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    • v.5 no.1
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    • pp.31-40
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    • 2007
  • Objective: The purpose of this study was to get the cognitive reaction time according to the intensity of auditory stimuli in older people and to differentiate the cognitive reaction time between older people and adults. Method: 49 subjects consisted of 32 older people and 17 adults. Cognitive reaction time was assessed with Simple Auditory Reaction of Foundation I in PSS CogReHab. Analysis of the data was done by using independent t-test. Results: The results were as follows: 1. There was a significant difference of the mean of cognitive reaction time to the intensity of auditory stimuli. 2. There was no significant difference from older people regardless of sexual distinction in mean of cognitive reaction time. However, there was a significant difference of the mean of cognitive reaction time in adults. 3. There was a significant difference between older people who got a job or not in 90 dB of auditory stimuli. 4. The mean of cognitive reaction time to the intensity of auditory stimuli in older people was slower than adults. There was a significant difference of the mean of cognitive reaction time between older people and adults in 70 dB of auditory stimuli. 5. The mean of cognitive reaction time to the intensity of auditory stimuli in older people did not have the significant difference in scholastic ability. Conclusions: The results of the study showed slowing of the cognitive reaction time in auditory stimuli to aging in older people. Therefore, applying silver industry and development of equipment for older people may maintain independent life.

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