• 대한전자공학회논문지SD
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• 제45권6호
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• pp.43-48
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• 2008

일반적으로 자체 테스트 동작은 입력 벡터들 사이에 상호 연관성이 없기 때문에 더 많은 전력을 소비하는 것으로 알려져 있다. 이러한 점은 회로에 손상을 유발할 뿐 아니라 배터리 수명에도 악영향을 미치기 때문에 반드시 해결되어야 할 과제 중 하나이다. 이를 위해 본 논문에서는 새로운 방식의 BIST(Built-In Self Test) 구조를 제안하여 테스트 동작에서의 천이를 감소시키고, 이를 통해 전력소모를 줄이고자 한다. 제안하는 구조에서는 LFSR(Linear Feedback Shift Register)을 통해 생성되는 pseudo-random 테스트 벡터가 스캔 경로로 들어가기 전에 3 bit씩 모아 더 적은 천이를 가지는 4 bit의 패턴으로 변형한다. 이러한 변형과 그에 대한 복원 과정은 기존의 스캔 BIST 구조에서 Bit Generator와 Bit Dropper라는 모듈을 추가하여 간단히 구현하였다. 제안하는 구조를 ISCAS'89 benchmark 회로에 적용한 결과 약 62%의 천이 감소를 확인하였고 이를 통해 제안하는 구조의 효율성을 검증하였다.

• 한국지구과학회지
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• 제21권2호
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• pp.159-167
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• 2000

본 연구에서는 한반도의 지진활동을 공간 통계학 방법을 이용하여 지진발생의 무작위성에 대한 검정과 집중도의 추정을 수행하였다. 무작위성에 대한 통계적 검정은 검정통계량을 이용한 방법과 경험분포를 이용한 두 가지 방법을 사용하였다. 역사지진과 계기지진의 두 대상자료에 대하여 적용한 결과, 두 자료 모두 무작위적이지 않고 군집적인 분포를 가지고 있는 것으로 판명되었다. 한편 비모수 밀도함수 추정방법을 이용한 진앙지 분포의 집중도는 역사지진의 경우 한반도 중부, 충남, 전북, 경북지역에서 높게 나타났다. 또한 계기지진의 경우에는 황해도-충남 해안-경북 내륙을 연결하는 "L"자 형태의 집중도를 보인다.

• 한국소음진동공학회논문집
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• 제23권12호
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• pp.1035-1044
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• 2013

면내 하중을 지지하는 면재와 면외 하중을 지지하는 심재로 구성되는 샌드위치 패널 구조물은 높은 비강도와 비강성을 가지므로 경량화가 요구되는 대형 구조물에 자주 이용된다. 그러나, 이러한 구조물은 필연적으로 높은 하중에 대하여 유연성의 증가를 일으키게 되므로, 이에 대한 구조 안전성 분석이 이루어져야 한다. 이에 대해 실제 풍하중은 거스트 영향 등을 비롯한 비선형성을 가지는 요소들이 고려되어야 하며, 구조물의 안전성 분석을 위하여 입력 하중에 대해 보다 실제 물리현상에 근접하게 모사되어야 한다. 이에 이 연구에서는 유체-구조 연성해석 기법을 이용하여 대형 등격자-보강 패널 구조물에 대한 구조 안전성 분석이 수행되었다. 입력하중인 풍하중에 대하여 보다 실제적 모사를 위해 불규칙 변동 속도성분인 거스트 영향이 고려된 랜덤분포 풍하중에 대한 유동장을 생성하여 압력-변위 사상을 통하여 연성해석이 수행되었다.

• The Journal of Korean Physical Therapy
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• 제21권1호
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• pp.19-25
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• 2009

Purpose: We investigated the changes that effects of load stimulation (LS) on static balance and muscle activities in normal healthy elders and chronic stroke patients. Methods: Subjects were instructed twenty normal healthy elders (8 men and 12 women) and ten chronic stroke patients (4 men and 6 women). They were tested while standing on a force platform under two conditions; LS, no LS were applied in random order. Prior to testing, adhesive surface EMG electrodes were fastened to the skin overlying the right (non-paralytic side in stroke patient) bellies of tibialis anterior (TA) and lateral gastrocnemius (LG) muscles. They were assessed on postural sway and %MVC (Maximum voluntary contraction) of TA and LG. Results: Participants showed that the application of LS brought about a decrease in postural sway as expressed by average sway path and velocity. %MVC of TA and LG were increased. The application of LS to normal and stroke patients decreases postural sway during quite stance. Conclusion: These findings the application of LS to normal and stroke patients improves static balance.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1355-1360
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• 2012

Background: The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of breast cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice. Materials and Methods: We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles published before Nov 2011. Summary odds ratio (OR) and 95% confidence interval (95% CI) incidence rates were calculated using a random-effects model with STATA (version 10.0) software. Results: A total of fifteen case-control studies, including 19,621 cases and 27,001 controls based on the search criteria, were included for analysis. A significant association was found between carrying the CHEK2 I157T variant and increased risk of unselected breast cancer (OR = 1.48, 95% CI = 1.31-1.66, P < 0.0001), familial breast cancer (OR = 1.48, 95% CI = 1.16-1.89, P < 0.0001), and early-onset breast cancer (OR = 1.47, 95% CI = 1.29-1.66, P < 0.0001). We found an even stronger significant association between the CHEK2 I157T C variant and increased risk of lobular type breast tumors (OR = 4.17, 95% CI = 2.89-6.03, P < 0.0001). Conclusion: Our research indicates that the CHEK2 I157T variant may be another important genetic mutation which increases risk of breast cancer, especially the lobular type.

• Asian-Australasian Journal of Animal Sciences
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• 제25권3호
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• pp.375-381
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• 2012

Two experiments were conducted to establish a digestible energy (DE) content prediction model of rapeseed meal for growing-finishing pig based on rapeseed meal's chemical composition. In experiment 1, observed linear relationships between the determined DE content of 22 rapeseed meal calibration samples and proximate nutrients, gross energy (GE) and neutral detergent fiber (NDF) were used to develop the DE prediction model. In experiment 2, 4 samples of rapeseed meal selected at random from the primary rapeseed growing regions of China were used for testing the accuracy of DE prediction models. The results indicated that the DE was negatively correlated with NDF (r = -0.86) and acid detergent fiber (ADF) (r = -0.73) contents, and moderately correlated with gross energy (GE; r = 0.56) content in rapeseed meal calibration samples. In contrast, no significant correlations were found for crude protein, ether extract, crude fiber and ash contents. According to the regression analysis, NDF or both NDF and GE were found to be useful for the DE prediction models. Two prediction models: DE = 16.775-0.147${\times}$NDF ($R^2$ = 0.73) and DE = 11.848-0.131${\times}$NDF+0.231${\times}$GE ($R^2$ = 0.76) were obtained. The maximum absolute difference between the in vivo DE determinations and the predicted DE values was 0.62 MJ/kg and the relative difference was 5.21%. Therefore, it was concluded that, for growing-finishing pigs, these two prediction models could be used to predict the DE content of rapeseed meal with acceptable accuracy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4699-4704
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• 2013

Background: MicroRNAs have been demonstrated to play important roles in the development and progression of colorectal cancer. Several studies utilizing microRNAs as diagnostic biomarkers for colorectal cancer (CRC) have been reported. The aim of this meta-analysis was to comprehensively and quantitatively summarize the diagnostic value of microRNAs for detecting colorectal cancer. Methods: We searched PubMed, Embase and Cochrane Library for published studies that used microRNAs as biomarkers for the diagnosis of colorectal cancer. Summary estimates for sensitivity, specificity and other measures of accuracy of microRNAs in the diagnosis of colorectal cancer were calculated using the bivariate random effects model. A summary receiver operating characteristic (SROC) curve was also generated to summarize the overall effectiveness of the test. Result: Thirteen studies from twelve published articles met the inclusion criteria and were included. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odd ratio of microRNAs for the diagnosis of colorectal cancer were 0.81 (95%CI: 0.79-0.84), 0.78 (95%CI: 0.75-0.82), 4.14 (95%CI: 2.90-5.92), 0.24 (95%CI: 0.19-0.30), and 19.2 (95%CI: 11.7-31.5), respectively. The area under the SROC curve was 0.89. Conclusions: The current evidence suggests that the microRNAs test might not be used alone as a screening tool for CRC. Combining microRNAs testing with other conventional tests such as FOBT may improve the diagnostic accuracy for detecting CRC.

• 대한핵의학회지
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• 제14권1호
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• pp.37-44
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• 1980

The usefulness of single, random measurements of serum FSH and LH in the diagnosis of primary amenorrhea by radioimmunoassay was investigated. The 16 patients were divided into 3 groups by the level of serum FSH and LH. The first group with increased level of serum FSH and LH is five patients, all of these are related to the acquired or congenital abnormality of the ovary. Further studies indicated include buccal smear, chromosome analysis, gynecography and laparosocopy. The second group with normal serum FSH and LH is nine patients, four patients of these are related to the developmental anomaly of the Mullerian duct and five patients are undo etermined origin. Further studies indicated include laparoscopy and gynecography. The third group with decreased serum FSH and normal or decreased serum LH is two patients, one of these is related to the pituitary function, isolated FSH deficiency, the other is undetermined origin. Further studies indicated include the pituitary function test, LH-RH stimulation test, skull radiography. Determination of serum FSH and LH levels does not permit a specific etiologic diagnosis of primary amenorrhea. However the serum levels of FSH and LH can be used to differentiate the principal area of the investigation and can be of assistance in choosing more specific testing procedures.

• Asian-Australasian Journal of Animal Sciences
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• 제17권1호
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• pp.7-12
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• 2004

Real time ultrasonic measurements for 13th rib fat thickness (LBF), longissimus muscle area (LEMA) and marbling score (LMS) of live animal at pre-harvest and subsequent carcass measurements for fat thickness (BF), longissimus muscle area (EMA), marbling score (MS) as well as body weight of live animal, carcass weight (CW), dressing percentage (DP), and total merit index (TMI) on 755 Korean beef steers were analyzed to estimate genetic parameters. Data were analyzed using multivariate animal models with an EM-REML algorithm. Models included fixed effects for year-season of birth, location of birth, test station, age of dam, linear and quadratic covariates for age or body weight at slaughter and random animal and residual effects. The heritability estimates for LEMA, LBF and LMS on RTU scans were 0.17, 0.41 and 0.55 in the age-adjusted model (Model 1) and 0.20, 0.52 and 0.55 in the weight-adjusted model (Model 2), respectively. The Heritability estimates for subsequent traits on carcass measures were 0.20, 0.38 and 0.54 in Model 1 and 0.23, 0.46 and 0.55 in Model 2, respectively. Genetic correlation estimate between LEMA and EMA was 0.81 and 0.79 in Model 1 and Model 2, respectively. Genetic correlation estimate between LBF and BF were high as 0.97 in Model 1 and 0.98 in Model 2. Real time ultrasonic marbling score were highly genetically correlated to carcass MS of 0.89 in Model 1 and 0.92 in Model 2. These results indicate that RTU scans would be alterative to carcass measurement for genetic evaluation of meat quality in a designed progeny-testing program in Korean beef cattle.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2223-2227
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• 2016

Background: Breast cancer is the most common cancer among Iranian women. Since development of the disease in Iranian women occurs relatively early, the survival rate matters considerably. In different countries, survival of breast cancer patients varies considerably. Therefore, the one-year, three-year, five-year, and ten-year survival rates for breast cancer in Iran were assessed using a meta-analysis. Materials and Methods: This systematic review and meta-analysis was based on valid Iranian sources including SID, MAGIRAN and IRANMEDEX, along with reliable English databases, namely, PUBMED and SCOPUS. In domestic databases, a search was conducted based on key words of breast cancer and survival rate, and in international databases, with "breast cancer" and the equivalent of "neoplasm" of Mesh Word, "survival rate" and "Iran." Then all reviewed papers and theses which met the inclusion criteria were selected for investigation. To conduct the analysis STATA 11.2 software and random-effects models were used. Results: In 24 studies, 22,745 participants were included. The one-year, three-year, five-year and ten-year survival rates were 0.956, 0.808, 0.695 and 0.559, respectively. The minimum and maximum survival rates for 5-years were 0.48 and 0.87. The average age of the onset of the disease was 48.3. Conclusions: As in Iran, since the onset of the disease is at low age, in spite of the relatively high survival rate as compared to other cancers, prevention and screening programs at early age for early stage diagnosis seems necessary.