• Toxicological Research
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• 제11권2호
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• pp.295-302
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• 1995

Menadione-ghitathione conjugate (MEN-SG), a metabolite of menadione, is known to be a redoxcycler in rat hepatocyte subcellular fraction. Therefore, it was assumed that MEN-SG could exert cytotoxlclty to ral platelets, another target tissue of menadione. We first synthesized MEN-SG, the identity of which was verified by mass, $^1{H}$-NMR and UV-visible spectra. In addition, the stability of MEN-SG was investigated in biological assay system. MEN-SG was degraded in a time-dependent manner in DMSO which had been used as a vehicle and thus, tris-HCl buffer was used as a vehicle of MEN-SG despite the low solubility in it. Perchloric acid as well as platelets itself did not affect the stability of MEN-SG. Our next attempt was the evaluation of cytotoxicity of MEN-SG in rat platelets. MEN-SG did not induce cytotoxicity to rat platelets measured by two different methods, LDH release and turbidity changes. The extents of oxygen consumption by MEN-SG in intact platelets were significantly lower than those by menadione, though it had been observed that oxygen consumptions by menadione and MENSG were similar in subcellular fractioas of platelets. These results suggest that MEN-SG is not toxic to rat platelets despite its redox cycling capacity and glutathione conjugation reaction of menadione could be regarded as a detoxification process.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제3권8호
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• pp.271-276
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• 2014

본 연구는 취약점 분석 평가 수행 시 N/A 점검항목이 보안 수준 결과에 미치는 영향 정도를 분석하였다. 이를 위하여, 본 논문에서는 취약점 분석 평가 범위 및 점검항목과 정량적 산출 방식을 이용하였으며, 항목의 중요성에 따른 등급과 가중치를 부여하였다. 또한, 주위 환경과 IT 기술 발달로 기관은 항상 위험에 노출되어 있으므로 위험 허용 수준을 적용하여 실증적 분석을 수행하였다. 분석한 결과, N/A 점검항목이 보안 수준에 영향을 미치는 요인으로 증명되었다. 즉, 취약점 분석 평가 수행 시 기관 특성상 연계성이 없는 점검항목은 제외시켜야 하는 것을 알 수 있었다. 본 연구에서는 실증검증을 토대로 기관 특성과 연계성을 갖지 않는 항목을 제외한 후 보안 수준 평가를 수행해야 함을 시사 하였으며, 기관 특성을 고려한 취약점 분석 평가 점검항목 정립 모델 연구가 필요함을 제시하였다.

• 천문학논총
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• 제32권1호
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• pp.235-237
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• 2017

The AKARI NEP Deep Field Survey is an international multiwavelength survey over $0.4deg^2$ of the sky. This is the deepest survey made by the InfraRed Camera (IRC) of the infrared astronomical satellite AKARI with 9 filters continuously covering the $2-25{\mu}m$ range, including three filters in the Spitzer gap between the IRAC and MIPS coverages. This enabled us to make sensitive MIR detection of AGN candidates at z~ 1, based on hot dust emission in the AGN torus. It is also efficient in detecting highly obscured Compton-thick AGN population. In this article, we report the first results of X-ray observations on this field. The field was covered by 15 overlapping Chandra ACIS-I observations with a total exposure of ~300 ks, detecting ${\approx}450$ X-ray sources. We utilize rest-frame stacking analysis of the MIR AGN candidates that are not detected individually. Our preliminary analysis shows a marginal detection of the rest-frame stacked Fe $k{\alpha}$ line from our strong Compton-thick candidates.

• 천문학논총
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• 제32권1호
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• pp.239-244
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• 2017

How does the presence of an AGN influence the total SFR estimates of galaxies and change their distribution with respect to the Galaxy Main Sequence? To contribute to solving this question, we study a sample of 1133 sources detected in the North Ecliptic Pole field (NEP) by AKARI and Herschel. We create a multi-wavelength dataset for these galaxies and we fit their multi-wavelength Spectral Energy Distribution (SED) using the whole spectral regime (from 0.1 to $500{\mu}m$). We perform the fit using three procedures: LePhare and two optimised codes for identifying AGN tracers from the SED analysis. In this work we present an overview of the comparison between the estimates of the Infrared bolometric luminosities (between 8 and $1000{\mu}m$) and the AGN fractions obtained exploiting these different procedures. In particular, by estimating the AGN contribution in four different wavelength ranges ($5-40{\mu}m$, $10-20{\mu}m$, $20-40{\mu}m$ and $8-1000{\mu}m$) we show how the presence of an AGN affects the PAH emission by suppressing the ratio $\frac{L_{8{\mu}m}}{L_{4.5{\mu}m}}$ as a function of the considered wavelength range.

• 한국의학물리학회지:의학물리
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• 제6권1호
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• pp.13-18
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• 1995

고선량의 RALS(Remote Afterloding Syetem)를 이용한 근접조사에서 선원의 위치에 따라 선량분포는 거리제곱의 반비례 형태로 변화되므로, 관심점의 흡수선량은 선원의 교정에 의해 크게 영향을 받는다. 자궁경부암 강내치료시 정확한 흡수선량을 결정하고자 선원을 교정하고, 선원의 위치에 따른 선량분포도에 의한 계산값과 반도체 검출기와 전리함을 이용한 설측값과 차이를 비교하고 보정 방법을 논의 하였다. Bulcher-RALS를 이용하여 치료에 사용된 선원의 교정은 공기커마와 사각형 아크랄 팬톰을 이용하여 r 인자에 의한 거리 역자승법칙으로 계산하였고, Co-60 선원의 8cm 거리에서 검교정된 측정기를 이용한 선량율을 비교치로 이용하였다. 선량측정치의 재현성은 팬톰내에서 0.3~1.1% 였으며, 측정치의 분포는 Bulcher-RALS 선량분포도에 의한 계산값과 팬톰측정치의 비교에서 -3~17%, 강내치료를 받은 18 명의 환자를 대상으로한 직장내 흡수선량에서 체내 실측값과 차이는 환자와 선원의 위치에 따라 -6~＋21%로 측정값이 평균 6.3% 높게 나타났다.

• Animal Bioscience
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• 제37권3호
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• pp.461-470
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• 2024

Objective: The objective of this study was to investigate the genetic diversity, population structure and whole-genome selection signatures of Luxi cattle to reveal its genomic characteristics in terms of meat and carcass traits, skeletal muscle development, body size, and other traits. Methods: To further analyze the genomic characteristics of Luxi cattle, this study sequenced the whole-genome of 16 individuals from the core conservation farm in Shandong region, and collected 174 published genomes of cattle for conjoint analysis. Furthermore, three different statistics (pi, F_st, and XP-EHH) were used to detect potential positive selection signatures related to selection in Luxi cattle. Moreover, gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analyses were performed to reveal the potential biological function of candidate genes harbored in selected regions. Results: The results showed that Luxi cattle had high genomic diversity and low inbreeding levels. Using three complementary methods (pi, F_st, and XP-EHH) to detect the signatures of selection in the Luxi cattle genome, there were 2,941, 2,221 and 1,304 potentially selected genes identified, respectively. Furthermore, there were 45 genes annotated in common overlapping genomic regions covered 0.723 Mb, including PLAG1 zinc finger (PLAG1), dedicator of cytokinesis 3 (DOCK3), ephrin A2 (EFNA2), DAZ associated protein 1 (DAZAP1), Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1), mediator complex subunit 13 (MED13), and decaprenyl diphosphate synthase subunit 2 (PDSS2), most of which were enriched in pathways related to muscle growth and differentiation and immunity. Conclusion: In this study, we provided a series of genes associated with important economic traits were found in positive selection regions, and a scientific basis for the scientific conservation and genetic improvement of Luxi cattle.

• 한국콘텐츠학회논문지
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• 제17권10호
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• pp.616-623
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• 2017

본 연구는 H대학교의 교양교육 만족도와 교양필수과목인 <커뮤니케이션 영어>, <사고와 표현>에 대한 교육만족도를 분석하고 알아보는데 목적이 있다. 분석 결과, 학생들은' 교양학점비율', '교양수업 학급당 학생수', '교양교육 과정의 체계성' 순으로 높게 조사되었다. <커뮤니케이션 영어>와 <사고와 표현> 과목에서는 '외국인교수의 의사소통'과 '말하기 표현능력 향상', '맞춤법 및 문법능력 향상' 등이 높게 조사되었다. 낮은 항목은 교양 과목의 취업 연계성 부족이 3개의 영역에서 공통적으로 조사되었다. 따라서 교양과목의 취업 영역 설정 개발 및 구체화와 더불어 대학 취업부서등과의 연계하여 효율성을 강화하는 방향이 요구되었다.

• 한국안광학회지
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• 제17권3호
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• pp.311-319
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• 2012

목적: 안경의 조제가공에 있어서 동공중심과 교정렌즈의 광학중심이 일치하지 않으면 안경이 프리즘을 발생시켜 사위가 유발되고 유발된 사위는 안정피로를 일으키는 요인으로 작용한다. 동공의 중심과 교정렌즈 광학중심의 불일치로 인해 발생하는 유발프리즘에 대해 알아보고자 하였다. 방법: 본 연구는 총 103명을 대상으로 착용 안경렌즈의 광학중심과 동공중심의 일치 여부를 수평방향과 수직방향으로 나누어 조사하였고, 그리고 그 결과들을 안경의 구조에 따라 4개의 그룹으로 분류하였다. 프리즘유발에 안경테의 효과를 보기 위해 프리즘의 총량을 비교하였고, 측정된 프리즘 값들은 독일의 RAL-RG 915 규약과 비교하였다. 결과: 수평방향의 경우 10.7%의 실험 대상자에서는 유발프리즘을 관찰할 수 없었고, 73.8%의 실험 대상자들은 유발프리즘에 의해 영향을 받았으나 그 범위는 허용 수준 내에 있었다. 하지만 15.5%의 실험 대상자들은 허용 범위를 초과하여 프리즘에 의해 영향을 받는 것으로 나타났다. 수직방향의 경우, 23.3%의 실험 대상자들은 안경의 초기 착용시 프리즘에 의한 영향이 없었고, 54.4%의 실험 대상자들은 허용 범위 내의 극히 적은 프리즘에 영향을 받았으며, 22.3%의 실험대상자들은 허용 범위를 초과하는 프리즘 영향을 받는 것으로 나타났다. 이러한 결과는 안경조정(fitting)이 가능한 요소가 적은 그룹 A와 B에서 그룹 C와 D에 비해 보다 많은 수평, 수직 방향의 유발프리즘이 발생한 것을 보여준다. 결론: 안경 착용자의 굴절이상도가 높을수록 안경테 전조정(pre-fitting)을 통하여 동공중심과 렌즈의 광학중심점을 일치시킴으로서 수평, 수직방향 유발프리즘을 최소화시켜 안정피로를 줄일 수 있을 것이다. 따라서 시지각력을 향상시키기 위해 단안PD와 단안Oh의 정확한 설계와 적절한 안경테 조정을 통해 정확한 안경의 조제가공이 필요하다고 사료된다.

• 대한약침학회지
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• 제7권3호
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• pp.5-25
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• 2004

Objectives : To observe changes in the serum proteins before and after intravenous injection of wild ginseng herbal acupuncture. Methods : Blood was collected before and after the administration of wild ginseng herbal acupuncture and only the serum was centrifuged. Then differences in the spots on the scanned image after running 2-Dimensionl electrophoresis were located and conducted mass analysis and protein identification. Results : Following results were obtained from the comparative analysis of serum proteins before and after the administration of wild ginseng herbal acupuncture. 1. 28 spots were identified before and after the administration. 2. In confirming manifestation degree, spots with more than two-times increase were 204, 803, 1505, 2205, 3105, 7104, 9001 spots, with more than one-time increase were 1101, 1302, 2013, 3009, 3010, 4002, 4009, 6706, 7103, 8006, 8101, and spots with decrease were 205, 801, 3205, 5202, 6105. 3. After conducting protein identification, proteins 205, 804, 1302, 4009, 6105, 6106 are unidentified yet, and 1101 is unnamed protein. Protein 204 is identified as complement receptor CR2-C3d, 801 as YAP1 protein, 803 as antitrypsin polymer, 1505 as PRO0684, 2013 and 3010 as proapolipoprotein, 2205 as USP48, 2403 as vitamin D binding protein, 3009 as complement component 4A preprotein, 3105 as immunoglobulin lambda chain, 3205 as transthyretin, 4002 as Ras-related protein Ral-A, 4204 as beta actin, 5202 and 7104 as apolipoprotein L1, 6704 as alpha 2 macroglobulin precursor, 7103 as complement component 3 precursor, 8006 as testis-specific protein Y, 8101 as Transferrin, 9001 as(Alpha-Oxy, Beta-(C112g)deoxy) T-State Human Hemoglobin, and 9003 as human hemoglobin. 4. Immune protein CR2-C3d, which acts against microbes and pathogenic organisms, and Antitrypsin(803), which is secreted with inflammatory response in the lungs, were increased by more than 200% after the administration of herbal acupuncture. 5. Immunoglobulin lambda chain(3105), Alpha-Oxy, Beta-(C112g)deoxy T-State Human Hemoglobin(9001), and human hemoglobin(9003) were increased by more than two-times after the administration of herbal acupuncture. 6. Proapolipoprotein(2013, 3010) and apolipoprotein(7104), key components of the HDL-cholesterol which plays an important role in preventing arteriosclerosis, were increased after the administration of herbal acupuncture. 7. Vitamin D binding protein(DBP, 2403), protecting the lung at the time of inflammatory response, was increased after the administration of herbal acupuncture. 8. Transthyretin(TTR, 3205), which is the main protein causing familial aimyloid polyneuropathy(FAP), was decreased after the administration of herbal acupuncture. 9. Ras-related protein Ral-A(4002) that controls phospholipid metabolism, cytoskeletal formation, and membrane traffic, was increased after the administration of herbal acupuncture. 10. Testis-specific protein Y(8006), which takes part in determination of the gender, was increased by more than two-times after the administration of herbal acupuncture. 11. Transferrin(8101), T-State Human Hemoblobin(9001), and Human Hemoblobin(9003) which balances the iron level in the body, were increased after the administration of herbal acupuncture. Conousion : Above results support the notion that intravenous injection of cultivated wild ginseng herbal acupuncture induce changes in serum proteins and this research can be a pioneer work in finding biomarkers.

• 천문학논총
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• 제32권1호
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• pp.281-285
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• 2017

We present a summary of our spectroscopic redshift catalogue of 404 sources in the AKARI Deep Field South (ADF-S). We have used the AAOmega spectrograph to target mid-infrared and far-infrared sources selected primarily from AKARI observations in this field for which we were able to obtain optical counterparts. Our sources with identified redshifts include 316 with $H{\alpha}$ detections at $z{\leq}0.345$ and 15 sources at z > 1 with MgII or $Ly{\alpha}$ emission lines. About 13% of our $z{\leq}0.345$ sources are dominated by active galactic nuclei (AGN) emission, although many show emission from both star formation and AGNs. The median Balmer decrement is 5.9. Ultra-luminous infrared galaxies (ULIRGs) were found only in the higher-redshift sources. Optical and near infrared data will be available shortly, enabling calibration of the line luminosities and spectral energy distribution (SED) fitting for these sources.