• Proceedings of the Korea Information Processing Society Conference
• /
• 2024.05a
• /
• pp.807-809
• /
• 2024

대규모 언어 모델의 발전은 텍스트 생성 및 정보 제공 분야에서 큰 진전을 이루었으며 사용자와의 원활한 소통을 가능하게 했다. 그러나 언어 모델은 특화된 정보 제공에 한계를 가지며 때때로 부정확한 정보를 생성할 수 있다. RAG(Retrieval-Augmented Generation) 기법은 이러한 한계를 극복하기 위해 제안되었다. 본 연구에서는 RAG 의 답변품질과 효율성을 높이기 위해 외부 문서 정보와 단어 단위로 카테고리화된 인덱싱 데이터 세트를 함께 제공하여 보다 정확하고 신뢰성 있는 문서 생성을 가능하게 하는 접근법을 제시한다.

• Journal of Aquaculture
• /
• v.22 no.1
• /
• pp.79-82
• /
• 2009

Reciprocal interspecific hybrids between two bitterling species Rhodeus uyekii (RU) and R. notatus (RN) were genetically identified based on the partial sequence analysis of recombination activating gene-1 (RAG-1) gene. Out of 863 bp positions analyzed, 13 nucleotide substitutions were detected between the two parental species (RU and RN genotypes). Both the induced hybrids (RU female$\times$RN male; UN genotype) and their reciprocal counterparts (RN female$\times$RU male; NU genotype) displayed the double peaks (or polymorphism) of sequence chromatograms at the 13 diagnostic positions, indicating that those hybrids were actual karyogamy derived from the two parental haploid genomes. However, it was not possible to distinguish between the reciprocal interspecific hybrids.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.17 no.4
• /
• pp.1037-1049
• /
• 2003

Numerous lines of evidence indicate that some of the neurotoxicity associated with Alzheimer's disease (AD) is due to proteolytic fragments of the amyloid precursor protein (APP). Most research has focused on the amyloid 6 (M). However, the possible role of other cleaved products of APP is less clear. Lately It has been reported that a recombinant carboxy-terminal 105 amino acid fragment (CT105) of APP induced strong nonselective inward currents in Xenopus oocyte. In a brain with Alzheimer's disease (AD), to investigate the roles of carboxyl-terminal fragment (CT105) of amyloid precursor protein (APP) in apoptosis processes possibly linked to neurodegeneration associated with AD, we examined the effects of the CT of APP with 105 amino acid residues (CT105) on the alteration of apoptosis triggers in neubroblastoma cells. We have investigated whether Radix Polygalae and Rhizoma Acori Graminei mixture extract (RP+RAG) inhibits CT105-induced apoptosis of neuroblastoma cells. We found that RP+RAG inhibits CT105-induced apoptosis in SK-N-SH cells. Treatment of the cells with RP+RAG inhibited CT105-induced DNA fragmentation and Tunel assay of nuclear chromatin and inhibited the caspase-3 expression in SK-N-SH cells. As the result of this study, In RP+RAG group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of neuroblastoma cells by CT105 expression is promoted. These results indicate that RP+RAG possess strong inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of neuroblastoma cells by CT105 expression

• Journal of Intelligence and Information Systems
• /
• v.29 no.4
• /
• pp.129-164
• /
• 2023

In a situation where the use and introduction of Large Language Models (LLMs) is expanding due to recent developments in generative AI technology, it is difficult to find actual application cases or implementation methods for the use of internal company data in existing studies. Accordingly, this study presents a method of implementing generative AI services using the LLM application architecture using the most widely used LangChain framework. To this end, we reviewed various ways to overcome the problem of lack of information, focusing on the use of LLM, and presented specific solutions. To this end, we analyze methods of fine-tuning or direct use of document information and look in detail at the main steps of information storage and retrieval methods using the retrieval augmented generation (RAG) model to solve these problems. In particular, similar context recommendation and Question-Answering (QA) systems were utilized as a method to store and search information in a vector store using the RAG model. In addition, the specific operation method, major implementation steps and cases, including implementation source and user interface were presented to enhance understanding of generative AI technology. This has meaning and value in enabling LLM to be actively utilized in implementing services within companies.

• Development and Reproduction
• /
• v.18 no.2
• /
• pp.99-106
• /
• 2014

Fish larvae are immediately exposed to microbes from hatching to maturation of their lymphoid organs, therefore effective innate mechanisms is very important for survival. However, the knowledge of the development of immune system in fish is limited and in demand now. In vertebrates, recombination-activating gene 1 (RAG-1) and immunoglobulin M (IgM) have been considered as very useful markers of the physiological maturity of the immune system. In this study, the expression of the both genes was assessed throughout the early developmental stages of olive flounder larvae (5-55 dph) and used as markers to follow the development of immune system. RAG-1 and IgM mRNA expression was detectable at 5 dph and remained so until 55 dph. These patterns of expression may suggest that the olive flounder start to develop its function around 5 dph. Tissue distribution was found that both genes mRNAs are only expressed in the immune-related organ such as spleen, kidney and gill. The early detection of IgM mRNA led to the investigation of its presence in oocytes. Both RAG-1 and IgM mRNA transcripts were detected in unfertilized oocytes, suggesting that they are maternally transferred. The biological significance of such a phenomenon remains to be investigated.

• Proceedings of the KIEE Conference
• /
• 1999.07e
• /
• pp.2239-2241
• /
• 1999

The most important question is how to use which kind of switch in pulsed power generation. There are many kinds of commercial closing switches, which have advantages and disadvantages. The most popular closing switch is the spark gap, but it has a disadvantage in life time, because of erosion of electrodes by arc heating. The Rotary Arc Gap (RAG) switch, especially Walkie-Edgar type RAG switch, was proposed to solve such problems in spark gap. It has a simple and special structure for arc moving caused from self-induced electromagnetic force, because moving arc makes less erosion on the electrodes. In this study we have made an Walkie-Edgar type RAG switch, tested the switching with capacitive energy storage system, and measured rotating arc speed in different peak current.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2024.05a
• /
• pp.745-748
• /
• 2024

글로벌 시장에서 Large Language Model(LLM)의 발전이 급속하게 이루어지며 활용도가 높아지고 있지만 특정 유형이나 전문적 지식이 부족할 수 있어 일반화하기 어려우며, 새로운 데이터로 업데이트하기 어렵다는 한계점이 있다. 이를 극복하기 위해 지속적으로 업데이트되는 최신 정보를 포함한 외부 데이터베이스에서 정보를 검색해 응답을 생성하는 Retrieval- Augmented Generation(RAG, 검색 증강 생성) 모델을 도입하여 LLM의 환각 현상을 최소화하고 효율성과 정확성을 향상시키려는 연구가 활발히 이루어지고 있다. 본 논문에서는 LLM의 검색 기능을 강화하기 위한 RAG의 연구 및 평가기법에 대한 최신 연구 동향을 소개하고 실제 산업에서 활용하기 위한 최적화 및 응용 사례를 소개하며 이를 바탕으로 향후 연구 방향성을 제시하고자 한다.

• Korean Journal of Ichthyology
• /
• v.29 no.1
• /
• pp.1-12
• /
• 2017

A natural hybrid of interspecific between the Coreoleuciscus splendidus and C. aeruginos (Cypriniformes: Cyprinidae) was captured in the Hwang-ji Stream, a tributary of the Nakdong River basin in Korea. An interspecific hybrid between C. splendidus and C. aeruginos was genetically identified based on morphological characteristics and the sequence analysis of nuclear recombination activating gene 1 (RAG1) gene (1,334 bp) and mitochondrial cytochrome c oxidase subunit 1 (CO1) gene (1,551 bp). As a result of morphological variations, the natural hybrid appeared to have an intermediate character between two parental species (C. splendidus and C. aeruginos) in three variations of black array (s) on dorsal, caudal and anal fin rays. Phylogenetic analysis inferred from RAG1 and CO1 sequence data revealed that Coreoleuciscus populations from Hwang-ji stream consist of two pure Coreoleuciscus species and a hybrid individual group. The individuals were clearly identified the cross and reciprocal hybrid by CO1 gene analysis. In RAG1 gene, 13 nucleotide variation loci were detected and the hybrid individuals displayed the double peaks of sequence chromatograms at the 9 diagnostic positions. In this study, molecular data and morphological variations were clearly demonstrated that hybridization did occur between C. splendidus and C. aeruginos. However, F2 hybrid generation and reproductive capacity of F1 hybrid individuals were not demonstrated.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2004.02a
• /
• pp.96-96
• /
• 2004

• Proceedings of the Korean Vacuum Society Conference
• /
• 2004.02a
• /
• pp.102-102
• /
• 2004