• Proceedings of the PSK Conference
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• 2002.10a
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• pp.232.1-232.1
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• 2002

Methods of 14C-radio isotope labeling of quinolone intermediates at four different sites are described. 14C-radio isotope labeled quinolone intermediates can be synthesized from 14C-1-malonic acid, 14C-2-malonic acid, 14C-benzene ring. and 14C-trimethyl orthoformate. The major site of 14C-radio isotope labeled quinolone intermediates is from 14C-2-malonic acid. We want to help customers to choose the best way for synthesis of 14C-radio isotope labeled quinolone derivatives. and give a general comprehension for 14C-radio isotope labeled pharmaceutical compounds. (omitted)

• Laboraroty Animal Research
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• v.34 no.4
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• pp.248-256
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• 2018

O-2-$^{18}F$-fluoroethyl-l-tyrosine ($[^{18}F]FET$) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to examine the value of $[^{18}F]FET$ for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic mouse model of GBM. Human U87MG cells were implanted into nude mice and then bevacizumab, a representative anti-angiogenic drug, was administered. We monitored the effect of anti-angiogenic agents using multiple imaging modalities, including bioluminescence imaging (BLI), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET/CT). Among these imaging methods analyzed, only $[^{18}F]FET$ uptake showed a statistically significant decrease in the treatment group compared to the control group (P=0.02 and P=0.03 at 5 and 20 mg/kg, respectively). This indicates that $[^{18}F]FET$ PET is a sensitive method to monitor the response of GBM bearing mice to anti-angiogenic drug. Moreover, $[^{18}F]FET$ uptake was confirmed to be a significant parameter for predicting the prognosis of anti-angiogenic drug (P=0.041 and P=0.007, on Days 7 and 12, respectively, on Pearson's correlation; P=0.048 and P=0.030, on Days 7 and 12, respectively, on Cox regression analysis). However, results of BLI or MRI were not significantly associated with survival time. In conclusion, this study suggests that $[^{18}F]FET$ PET imaging is a pertinent imaging modality for sensitive monitoring and accurate prediction of treatment response to anti-angiogenic agents in an orthotopic model of GBM.

• Journal of the korean veterinary medical association
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• v.9 no.3
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• pp.67-70
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• 1965

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.3 no.2
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• pp.54-58
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• 2017

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) is one of the powerful methods that enable analysis of small molecules as well as large molecules up to about 500,000 Da without severe fragmentation. MALDI-TOF MS, thus, has been a very useful an analytical tool for the confirmation of synthetic molecules, probing PTMs, and identifying structures of a given protein. In recent nuclear medicine, MALDI-TOF MS liner ion mode helps researcher calculate the average number of chelator(or linkage) per an antibody conjugate, such as DOTA-(or DFO-) trastuzumab for labeling a medical radioisotope. This simple technique can be utilized to improve the labeling method and control the quality at the development of antibody-based radiopharmaceuticals, which is very effected to diagnosis and therapy for in vivo tumor cells, with radioisotopes like $^{89}Zr$, $^{64}Cu$, and 177Lu. To minimize the error, MALDI-TOF MS measurement is repeatedly performed for each sample in this study, and external calibration is carried out after data collection.

• 유체기계공업학회:학술대회논문집
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• 2003.12a
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• pp.502-507
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• 2003

The HANARO, multi-purpose research reactor, 30 MWth open-tank-in-pool type, is under normal operation since it reached the initial critical in February 1995. The HANARO is used for fuel performance tests, radio isotope productions, reactor material performance tests, silicone semiconductor productions and etc. Specially, the HANARO is planning to produce a fission moly-99 of radio isotopes, a mother nuclide of Tc-99m, a medical isotope and is under developing a target handling tool for loading and unloading those at a flow tube (OR-5). The target should be sufficiently cooled in the flow tube without an interference with the cooling of the others and an induction of extremely vibration. This topic is described an analectic analysis for the cooling characteristics of the fission moly-99 target to find the minimum cooling water. It was confirmed through the analysis results that the minimum cooling water, about 2.717 kg/s flew through the flow tube under the worst case that the guide tube got no perforating holes for cooling water to pass through the holes and that the target was safely cooled under about seventy percent (70%) of the maximum allowable temperature of the target.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3768-3774
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• 2023

The purpose of the target system for the muon spin rotation, relaxation, and resonance (µSR) facility at the Rare isotope Accelerator complex for ON-line experiments (RAON) is to induce the production of a significant number of surface muons in thermally stable experiments. The manufactured target system was installed at RAON in the Sindong area near Daejeon in 2021. The design was made conservatively with a sufficient margin of safety through ANSYS calculations; however, verification experiments had to be performed on the ANSYS calculations. Because the 600-MeV proton beam has not yet been provided, an alternative way to reproduce the calculation conditions was required. The radio frequency (RF) heating method, which has not yet been applied to the target verification experiment but has several advantages, was used. It was observed that the RF heating method has promise for testing the thermal stability of the target, and whether the target system design process was performed conservatively enough was verified by comparing the RF heating experiments with the ANSYS calculations.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.10a
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• pp.205-205
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• 2003

• Journal of the Korean Society for Heat Treatment
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• v.35 no.2
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• pp.51-56
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• 2022

In this study, we controlled the shape of a carbon layer on gallium oxide templates. Gallium oxide layers were deposited on sapphire substrates using mist chemical vapor deposition. Subsequently, carbon layers were formed using radio frequency plasma chemical vapor deposition. Various shapes of carbon structures appeared according to the fraction of methane gas, used as a precursor. As methane gas concentration was adjusted from 1 to 100%, The shapes of carbon structures varied to diamonds, nanowalls, and spheres. The growth of carbon isotope structures on Ga₂O₃ templates will give rise to improving the electrical and thermal properties in the next-generation electronic applications.

• 전기의세계
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• v.14 no.3
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• pp.18-27
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• 1965

It is well known that the starting characteristics of the cold cathode type discharge tubes are irregular. We have two kinds of stabilization for starting characteristics of discharge tubes. Which are the aging test immediately after producing the tubes and the using characteristics. This paper was devoted primaliry to the empric study of relation between the aging and the manufacturing process. And then to stabilize the starting characteristics of discharge tubes by the irradiations of radio-isotope.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.144.2-144.2
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• 2008