• Title/Summary/Keyword: Radical Innovation

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Stabilization of Quercetin using Organo-hectorite and Its Application in Sunscreen Cosmetics (오가노 헥토라이트를 이용한 쿼세틴 안정화 및 자외선 차단 제품 응용에 관한 연구)

  • Sang Uk Kim;Ji Yeon Hong;Yong Woo Kim;In Ki Hong;Song Hua Xuan;Mid Eum Yun;Sung Ho Lee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.50 no.1
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    • pp.1-10
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    • 2024
  • In this study, a quercetin benton gel (QUERPLEX) that stabilized quercetin was prepared using organo hectorite, and its efficacy was confirmed. In addition, a comparative study was conducted on the stability and effectiveness of applying this to sunscreen cosmetics. It was confirmed that QUERPLEX remained stable without showing crystal precipitation and growth for 4 weeks. As a result of measuring antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), it showed antioxidant activity depending on the concentration, and showed a radical elimination ability of 70% or more at a concentration of 2,500 ppm or more, confirming a significant effect. Anti-inflammatory activity experiments using RAW 264.7 cells confirmed that NO production decreased in a concentration-dependent manner by reducing NO production by 8% at 25 ㎍/mL, 23% at 50 ㎍/mL, and 84% at 100 ㎍/mL. As a result of confirming the stability of the formulation according to the method of quercetin in the sunscreen formulation, the stability of the formulation was improved when quercetin was added directly to the formulation. It also improved the UV protection index on in vitro and in vivo, which is expected to have the potential as a component that can have a new boosting effect on UV protection. These results suggest that organo hectorite is very effective as a quercetin carrier and that it can be applied in cosmetic formulations by not only expressing the efficacy of quercetin but also bringing about additional effects.

Antioxidant and Anti-inflammatory Activities of Broccoli Florets in LPS-stimulated RAW 264.7 Cells

  • Hwang, Joon-Ho;Lim, Sang-Bin
    • Preventive Nutrition and Food Science
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    • v.19 no.2
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    • pp.89-97
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    • 2014
  • Broccoli (Brassica oleracea var. italia) florets were extracted with 80% methanol and the extract was sequentially fractionated with n-hexane, ethyl acetate, n-butanol, and distilled water. The extract and the fractions were evaluated for total phenolic content, sulforaphane content, antioxidant activity, and anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The total phenolic content and sulforaphane content of the ethyl acetate fraction (EF) were 35.5 mg gallic acid equivalents/g and $620.2{\mu}g/g$, respectively. These values were higher than those of the 80% methanol extract and organic solvent fractions. The oxygen radical absorbance capacity of the EF [$1,588.7{\mu}M$ Trolox equivalents (TE)/mg] was 11-fold higher than that of the distilled water fraction ($143.7{\mu}M\;TE/mg$). The EF inhibited nitric oxide release from LPS-stimulated RAW 264.7 cells in a dose-dependent manner and inhibited $I{\kappa}B-{\alpha}$ degradation and nuclear factor-${\kappa}B$ activation in LPS-stimulated RAW 264.7 cells. In conclusion, the EF of broccoli florets exerted potent antioxidant and anti-inflammatory effects.

Doble Contexts for Reading Manfredo Tafuri's Criticism of Ideology (만프레도 타푸리의 이데올로기 비판 독해를 위한 이중의 문맥)

  • Park, Junghyun
    • Journal of architectural history
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    • v.25 no.2
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    • pp.21-30
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    • 2016
  • Autonomia movement that emerged in Italy in the 1960s from workerist (operaismo) communism gives historical and discursive context to Manfredo Tafuri's famous criticism of ideology. His thesis on the death of architecture was a radical criticism of Keynesian intervention which was a strategy to cope with the Great Depression. For him, this capitalist development had taken away ideological prefiguration from architecture. At least Tafuri's this early intellectual phase was formed in the wake of magazine Contrapiano and Antonio Negri's influence. Tafuri almost entirely adapted Negri's thought on the importance of capitalist innovation that was uncovered by Keynes, Schumpeter, and Manheim and the periodization in modern history. When we read Tafuri's text with this concrete context, we can avoid being plunged into his abstruseness. On the other hand, 1980's Korea cannot understand Tafuri comprehensibly. 1980's situation to struggle to acquire democracy prescribed only one mode of reception of Tafuri's historiography in Korea. Tafuri's so-called pessimist view point could not satisfy student activists. They want to take intellectual means to sustain student movement and to secure political dynamics of protest. But at the same time they have anxiety to understand tafuri's thesis that they consider ad a critical theory for Korean Architecture. Double contexts of Tafuri's criticism of ideology bring to light to historicize both Tafuri's historiography itself and reception of his text in Korea.

Microbiological Properties of Oiji (Korean Pickled Cucumbers) by the Addition of Pulsatilla koreana (할미꽃(백두옹, Pulsatilla koreana) 첨가량에 따른 오미지의 미생물학적 특성)

  • Han Bok-Ryo;Moon Hye-Kung;Jo Jung-Soon;Kim Jong-Kook;Kim Gwi-Young;Kim June-Han
    • Journal of the East Asian Society of Dietary Life
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    • v.15 no.5
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    • pp.613-618
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    • 2005
  • This study was performed to analyze the microbiological properties of Oiji soaking solution and Oiji preserved with $7\%$ brine and the others preserved with Pulsatilla koreana additives of various concentration$(0,\;3,\;6,\;9\%)$ during fermentation(24 days) at room temperature$(20\pm2^{\circ}C)$. The results of this experiment are as follows: The total number of microbes showed radical increase up to 6th day of growth period and decreased afterwards. Growth of microbes was impeded in the beginning of fermentation in the case of adding $6\%$ Pulsatilla koreana. The number of lactic acid bacteria tended to increase progressively until 15th day and then decreased, and that in the group of $6\%$ Pulsatilla koreana was relatively lower than those of other groups. Antimicrobial activity against Staphylococcus aereus and Micrococcus luteus was shown weakly from 9th day of fermentation regardless of the concentration of Pulsatilla koreana additives, but inactivated after 21st day of fermentation.

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A Study on the Futurist Manifestos and Clothing in Italy (이탈리아의 미래주의 복식 선언문과 그 복식연구)

  • Keum Hee Lee
    • The Research Journal of the Costume Culture
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    • v.8 no.1
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    • pp.102-114
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    • 2000
  • The works of the Futurism were developed along with manifestos and statement in publishing. Futurist aesthetic and ideological agenda on futurist fashion displayed in manifestos on clothes. Futurist fashion propagated in consummate Futurist style through the written manifesto. The Futurists anticipated much of modern fashion phenomenon. In Futurist Men's Clothing, men's clothing is aggressive, agile, dynamic, simple and comfortable, hygienic, gay, luminous, volatile, asymmetric and variable. In Futurist Manifesto on Woman's Clothing, woman is now a principal agent of revolt, a walking synthesis of the audacious, performance-oriented aesthetic of the futurist universe. For Futurist woman's clothing they claimed ingenuity, daring, and economy. The Futurist Manifesto of Italian Hat was continued with their provocative style and radical ambition. Their innovation will rescue a lagging Italian expert and restore the Italian male to his former Iatin Vigor. Speed, dynamic, utility, and funtionality are the main characters. In Futurist Manifesto of Italian Cravat, Futurist cravat is called Anti-cravatta, which is anti-traditional style and made of unconventional materials. In general, the Futurist argued for clothes that promoted simple and functionality. These Futurist fashion project were invention of the new style, avant-garde style, in daily wear and were realized for the renewal of taste in clothing design as a modernizing factors.

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An Exploratory Study on the Factors of Assimilation Gap in Information Technology at the Individual Level (개인의 정보기술 수용격차 요인에 대한 탐색적 연구)

  • Baek, Sang-Yong
    • The Journal of Information Systems
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    • v.16 no.3
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    • pp.45-68
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    • 2007
  • This study aims to explore factors of Assimilation Gap(AG) which is proposed and illustrated by Fichman and Kemerer(1997). AG is defined as the time delay between adoption and deployment and mainly studied at the organizational level. This study derives the factor affecting AG through a review of technology acceptance models and agency theory. The research model consists of three groups of independent variables(IT knowledge burden, Individual characteristics, and organization characteristics) and a moderator, which is goal incongruence. Using multiple regression analyses, four groups of hypotheses are tested with data of 221 knowledge workers from various organizations through e-mail survey. The result shows that radicalness(a dimension of knowledge burden), personal innovativeness, self-efficacy, and organizational support are statistically significant factors while complexity, experience, and perceived critical mass are not supported. The moderator effects of goal incongruence are found in personal innovativeness and organizational support. The results of this study demonstrate that agency theory is a useful perspective to deal with AG, especially in radical innovation. In addition, IT practitioners should consider not only user training but also incentives and possible organizational controls in implementing a new information technology.

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Acetic acid fermentation properties and antioxidant activity of lemongrass vinegar (레몬그라스 식초의 초산발효 특성과 항산화 활성)

  • Yi, Mi-Ran;Kang, Chang-Hee;Bu, Hee-Jung
    • Food Science and Preservation
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    • v.24 no.5
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    • pp.680-687
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    • 2017
  • This study investigated acetic acid fermentation properties and antioxidant activity of vinegar by addition of lemon grass to develop high quality vinegar by using lemongreass. Traditional brown rice wine contained 5% lemongrass powder and had an alcohol content of 7.2%. The wine was fermented by Acetobacter. sp. RIC-V and made into lemongrass vinegar (LV). The pH and total acidity of the LV were 3.13% and 7.21%, respectively. Fructose was detected whereas glucose, sucrose, and maltose were not detected. Among organic acids, acetic acid was highest at 3658.6 mg%; trace amounts of lactic acid, citric acid, malic acid, tartaric acid, and oxalic aicd were detected. Of the 17 free amino acids, glutamic acid, histidine, alanine, and proline were mainly detected. To conduct total polyphenol content and ABTS radical scavenging activity, 3% and 5% lemongrass powder (P3LV, P5LV) and 1%, 2%, and 3% of lemongrass extract (E1LV, E2LV, E3LV) were added to LV, respectively. Total phenolics increased as the added lemongrass powder and extract increased. Total phenolics were 490.9, 559.4, and $895.7{\mu}g$ gallic acid equivalents/mL in brown rice vinegar, LV, P5LV. ABTS radical scavenging activities were 43.2%, 58.0%, and 91.0% in brown rice vinegar, LV, P5LV, respectively. These results show that lemongrass vinegar has considerable potential as a high quality functional vinegar with antioxidative effects.

Anti-oxidative and Anti-cancer Activities of Ethanol Extract of Litsea populifolia (인체 폐암 세포주 A549에서 Litsea populifolia 추출물의 항산화 및 항암활성 분석)

  • Jin, Soojung;Oh, You Na;Jeong, Hyun Young;Yun, Hee Jung;Park, Jung-ha;Kwon, Hyun Ju;Kim, Byung Woo
    • Journal of Life Science
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    • v.29 no.6
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    • pp.679-687
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    • 2019
  • Litsea populifolia, a plant species of the Lauraceae family, is widely distributed in the tropical and subtropical areas of Asia. The phylogenetic relationships and botanical characteristics of L. populifolia have been reported; however, its anti-oxidative and anti-cancer activities remain unclear. In this study, we evaluated the anti-oxidative and anti-cancer effects of ethanol extracts of L. populifolia (EELP) together with the molecular mechanism of its anti-cancer activity in human lung adenocarcinoma A549 cells. EELP showed significant anti-oxidative effects with a 50% inhibitory concentration at $11.71{\mu}g/ml$, which was measured by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. EELP exhibited cytotoxic activity and induced cell cycle arrest at the G1 phase in A549 cells in a dose-dependent manner, whereas EELP did not have the cytotoxic effect on the normal human lung cell line IMR90. Treatment with EELP also resulted in a decreased expression of G1/S transition-related molecules-including cyclin-dependent kinase (CDK) 2, CDK6, cyclin D1, and cyclin E-both for the transcription and translation levels. EELP-induced G1 arrest was associated with the phosphorylation of checkpoint kinase 2 (CHK2), p53, cell division cycle 25 homolog A (CDC25A), and the reduction of CDC25A expression in A549 cells. Collectively, these results suggest that EELP may exert an anti-cancer effect by cell cycle arrest at the G1 phase through both p53-dependent and p53-independent (ATM/CHK2/CDC25A/CDK2) pathways in A549 cells.

The Post-IMF firm strategy and the corporate restructuring in the heavy & chemical industrial district: the case of Ulsan, Korea (울산 중화학공업의 재구조화 특성 - IMF 체제 이후의 기업전략을 중심으로 -)

  • Park, Yang-Choon
    • Journal of the Korean association of regional geographers
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    • v.7 no.2
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    • pp.17-34
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    • 2001
  • This paper is to analyze how firms in a large firm-led industrial city have carried out the restructuring in the face of radical shifts, with focus on the strategy and the restructuring of firms in Ulsan, a typical industrial district in Korea that is specialized in heavy & chemical industry. It has been well known that the local economy has been led by a small number of large firms, including affiliates of chaebol, and its industrial structure has also been characterised as a clear dichotomy between large firms as a customer and small and medium-size firms as a supplier, which can be called not horizontal but vertical relations. It can identify some tendencies, however, that local companies have been rather dynamically changing in response to increasingly turbulent environment since the Asian crisis. Some are radical, but some incremental. These can be summarized in four distinctive but interlinked ways. First, more than half of local companies surveyed have attempted to change their production systems, mainly from the fordist mass production towards the flexible mass production, seeking both economies of scale and scope. Second, local firms have vigorously continued to reorganize the boundary of the production and the organization, by specializing products and focusing on the core competence in order to save costs and cope with radically changing customer demands in a flexible way. Third, there have been various strategies for the organizational innovation such as the introduction of team organization, the boundary blurring between the managerial and production workers and the intra-firm spin-offs, so as to improve managerial efficiency and competence in the use of internal labour market. Finally, they have tried to be more sensitive to the market and customers. These tendencies seem to be increasingly critical to sustain their competitiveness. To do so, they tend to focus increasingly not only on the competing via the product quality rather than through price, but also to seek to diversify the market and customer firms beyond national boundary.

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Screening of Biological Activities of Extracts from Rhododendron mucronulatum Turcz. Flowers (진달래꽃(Rhododendron mucronulatum Turcz. Flower) 추출물의 생리활성 탐색)

  • Cho, Young-Je;Ju, In-Sik;Chun, Sung-Sook;An, Bong-Jeun;Kim, Jeung-Hoan;Kim, Myung-Uk;Kwon, Oh-Jun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.3
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    • pp.276-281
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    • 2008
  • Extracts from Rododendron mucronulatum Turcz. flowers were tested for antioxidant and their inhibitory activities of ${\alpha}$-amylase, ${\alpha}$-glucosidase and angiotensin converting enzyme (ACE). Total contents of phenolics were found as $30.6{\pm}0.14mg/g$ (60% EtOH extract) and $23.2{\pm}0.21mg/g$ (water extract). Electron donation ability (EDA), ABTS [2,2azinobis(3-ethylbenzothiazoline-6-sulfonic acid)] radical decolorization, Antioxidant protection factor (PF) and thiobarbituric acid reactive substance (TBARs) were measured for the antioxidative activity of the extracts from Rododendron mucronulatum Turcz. flowers. The water extract were determined as 97.5% at ethanol extract showed 83.2% and 60% EtOH extract were 89.7% in EDA. The water extract showed higher antioxidant activity than 60% EtOH extract when evaluated by ABTS radical decolorization and antioxidant PF. The TBARS of water extracts and 60% EtOH extracts were shown as $0.29{\times}10^2{\mu}M\;and\;0.28{\times}10^2{\mu}M$, respectively, and were lower than control. ACE inhibitory activity in water extract (67.6% inhibition) was higher than that of 60% EtOH extract (46.7% inhibition) at $200{\mu}g/mL$. Water extracts had higher inhibitory activities on ${\alpha}$-amylase and ${\alpha}$-glucosidase than 60% EtOH extracts. The result suggests that the water extract from Rododendron mucronulatum Turcz. flowers will be useful as natural antioxidants and functional foods.