• Title/Summary/Keyword: Radiation resistance

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Application of Carbon Materials for the Development of Medical Devices (의료기기의 발전을 위한 탄소소재의 활용)

  • Yeong-Gon Kwak
    • The Korean Journal of Nuclear Medicine Technology
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    • v.27 no.1
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    • pp.23-28
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    • 2023
  • Carbon materials are widely used in many areas of our lives. A fiber having a carbon content of 90% or more obtained by heating an organic fiber precursor is referred to as a "carbon fiber". Carbon fibers are currently used in the medical market to manufacture radiation transmission device parts, artificial joints, and medical aids, as many developments have been made to utilize carbon fibers' characteristics such as light weight, radiation permeability, biocompatibility, high strength, high heat resistance, thermal conductivity, and electrical conductivity. In order to maintain body temperature and increase immunity in long-lasting nuclear medical examination and treatment through the idea of convergence of carbon materials and radiation technology, the quality of medical services can be improved by utilizing carbon materials. We should be aware of the domestic carbon-based medical device industry and make efforts to contribute to the development of medical devices. As a radiation expert, we should try to use our skills and experience to find items that can be fused with medical devices to develop various nuclear medical examination fields and radiographic examination fields that can be widely applied. We should actively engage in future technology development and carbon material research to strengthen the global competitiveness of the domestic medical device industry and improve the quality of medical services.

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Characteristics of Thermal Radiation Pastes Containing Graphite and Carbon Nanotube (흑연 및 탄소나노튜브 혼합 방열도료의 특성)

  • Lee, Ji Hun;Song, Man-Ho;Kang, Chan Hyoung
    • Journal of Surface Science and Engineering
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    • v.49 no.2
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    • pp.218-224
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    • 2016
  • Thermal radiation pastes were prepared by dispersing carbon materials as fillers with a content of 1 weight percent in an acrylic resin. The kind of fillers was as follows; $25{\mu}m$ graphite, $45{\mu}m$ graphite, $15{\mu}m$ carbon nanotube(CNT), a 1:1 mixture of $25{\mu}m$ graphite and $15{\mu}m$ CNT, and a 1:1 mixture of $45{\mu}m$ graphite and $15{\mu}m$ CNT. Thermal emissivity was measured as 0.890 for the samples with graphite only, 0.893 for that with CNT only, and 0.892 for those containing both. After coating prepared pastes on a side of 0.4 mm thick aluminium plate and placing the plate over an opening of a box maintained at $92^{\circ}C$ with the coated side out, the temperatures on the uncoated side of the plates were measured. The samples containing graphite and CNT showed the lowest temperatures. The paste with mixed fillers was coated on the back side of the PCB of an LED module and thermal analysis was carried out using Thermal Transient Tester (T3ster) in a still air box. The thermal resistance of the module with coated PCB was measured as 14.34 K/W whereas that with uncoated PCB was 15.02 K/W. The structure function analysis of T3ster data revealed that the difference between junction and ambient temperatures was $13.8^{\circ}C$ for the coated case and $18.0^{\circ}C$ for the uncoated. From the infrared images of heated LED modules, the hottest-spot temperature of the module with coated PCB was lower than that of the uncoated one for a given period of LED operation.

Complete genome sequence of Flavisolibacter tropicus LCS9T, a radiation resistant bacterium (방사선 내성 세균 Flavisolibacter tropicus LCS9T의 완전한 게놈 서열)

  • Kim, Myung Kyum;Sohn, Eun-Hwa;Jung, Hee-Young;Srinivasan, Sathiyaraj
    • Korean Journal of Microbiology
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    • v.54 no.1
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    • pp.87-89
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    • 2018
  • Flavisolibacter tropicus $LCS9^T$ was isolated from a soil sample collected from tropical zone within the Ecorium of the National Institute of Ecology in Seocheon, central-western Korea. In this study, we report the complete genome sequence of the bacterium Flavisolibacter tropicus $LCS9^T$, which possesses a circular chromosome comprised of 5, 940,863 bp with the G + C mol content of 41.5%. The genome sequence annotation showed that the complete genome includes 5,075 genes, 337 pseudogenes, and 59 rRNA genes. The radiation resistance genes such as excinuclease UvrABC complex and UvdE were present in the genome.

Studies on Resistance to Septoria Brown Spot(Septoria glycines Hemmi) in Native Soybean Collection (재래종 대두의 갈문병 저항성에 관한 연구)

  • Kwon, S.H.;Oh, J.H.;Kim, J.R.
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.25 no.1
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    • pp.47-53
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    • 1980
  • Of 1, 428 entries examined to locate gene sources resistant to Septoria brown spot from the Korean native soybean collection, most lines were evaluated as highly susceptible, showing numerous leaf spots with surrounding yellowing tissue, while 136 lines of the entries showed the leaf spots without the yellowing. However, leaf defoliation was so much higher in inoculated soybean plants than those of uninoculated, regardless of leaf yellowing that resistance to Septoria brown spot could not be characterized by the lesion type. Various yield composing characters were negatively correlated to the leaf defoliation, suggesting that early defoliation incited by Septoria brown spot might result in significant yield reduction in soybean.

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Electrical Properties of Metal-Oxide Quantum dot Hybrid Resistance Memory after 0.2-MeV-electron Beam Irradiation

  • Lee, Dong Uk;Kim, Dongwook;Kim, Eun Kyu;Pak, Hyung Dal;Lee, Byung Cheol
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.311-311
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    • 2013
  • The resistance switching memory devices have several advantages to take breakthrough for the limitation of operation speed, retention, and device scale. Especially, the metal-oxide materials such as ZnO are able to fabricate on the flexible and visible transparent plastic substrate. Also, the quantum dots (QDs) embedded in dielectric layer could be improve the ratio between the low and the high resistance becauseof their Coulomb blockade, carrier trap and induced filament path formation. In this study, we irradiated 0.2-MeV-electron beam on the ZnO/QDs/ZnO structure to control the defect and oxygen vacancy of ZnO layer. The metal-oxide QDs embedded in ZnO layer on Pt/glass substrate were fabricated for a memory device and evaluated electrical properties after 0.2-MeV-electron beam irradiations. To formation bottom electrode, the Pt layer (200 nm) was deposited on the glass substrate by direct current sputter. The ZnO layer (100 nm) was deposited by ultra-high vacuum radio frequency sputter at base pressure $1{\times}10^{-10}$ Torr. And then, the metal-oxide QDs on the ZnO layer were created by thermal annealing. Finally, the ZnO layer (100 nm) also was deposited by ultra-high vacuum sputter. Before the formation top electrode, 0.2 MeV liner accelerated electron beams with flux of $1{\times}10^{13}$ and $10^{14}$ electrons/$cm^2$ were irradiated. We will discuss the electrical properties and the physical relationships among the irradiation condition, the dislocation density and mechanism of resistive switching in the hybrid memory device.

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Feasibility in Differentiation of Resistance of Rice Varieties to Brown Planthopper (Nilaparvata lugens Stal) using Radisoisotope (P-32) Tracer-Technique (P-32를 이용한 벼멸구(Nilaparvata lugens Stal) 저항성 검정법에 관한 연구)

  • Chung K.H.;Kwon S.H.;Choi S.Y.
    • Korean journal of applied entomology
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    • v.20 no.4 s.49
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    • pp.207-211
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    • 1981
  • It has been documented that the resistance to planthoppers is attributed to the feeding preference of the insects. This might be related to difference in the amount of feeding plant sap between resistant and susceptible hosts. In this aspect, this study was conducted to verify it and to develop an effective screening method for resistance to planthoppers by tracer technique. An effective P-32 labelling of rice seedlings at $2\~3$ leaf stage was dipping the roots in concentration of $0.1{\mu}Ci/ml$ solution for 48 hours. Radioactivity was significantly higher in planthopers fed on susceptible variety for 48 hours as compared to those fed on resistant variety. Radioactivity of adults was higher than that of nymphs and also higher in female than male. The results were highly correlated to that indicated by the feeding preference of the insects and therefore, considered to be valid for a screening technique.

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Evaluation of Native Soybean Collection for Resistance to Purple Blotch (수집재래종대두의 자주빛무늬병(Cercospora kikuchii)에 대한 저항성검정)

  • Oh Jeung Haing;Kwon Shin Han
    • Korean journal of applied entomology
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    • v.20 no.3 s.48
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    • pp.131-134
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    • 1981
  • Native soybean collections were evaluated to search a resistant gene source to purple blotch caused by Cercospora kikuchii. Among 467 native lines, about $28.9\%$ of the lines was less than $0.1\%$ and $13.4\%$ was over $2\%$ in natural infection of purple blotch. Natural infection seemed to be significantly associated with weather conditions at the early podding stage. A significant correlation between natural infection and purple discoloration by seed inoculation was observed and this method seemed to be effective as a preliminary screening technique for resistance to purple blotch. Most of the late maturing native soybeans showed susceptible reaction by the seed inoculation contrary to low infection under natural conditions, indicating that the low natural infection might be due to disease escaping by the late maturing instead of their genetic resistance.

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Differential Expressions of Apoptosis-related Genes in Lung Cancer Cell Lines Determine the Responsiveness to Ionizing Radiation

  • Lee, Su-Yeon;Choi, Moon-Kyung;Lim, Jung-Min;Wu, Hong-Gyun;Kim, Ju-Han;Park, Woong-Yang
    • Genomics & Informatics
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    • v.6 no.1
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    • pp.36-43
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    • 2008
  • Radiotherapy would be the choice of treatment for human cancers, because of high cost-effectiveness. However, a certain population of patients shows a resistance to radiotherapy and recurrence. In an effort to increase the efficacy of radiotherapy, many efforts were driven to find the genes causing the unresponsiveness to ionizing radiation. In this paper, we compared the gene expression profiles of two lung cancer cell lines, H460 and H1299, which showed differential responses to ionizing radiations. Each cell were irradiated at 2 Gy, and harvested after 0, 2, 4, 8, 12 and 24 hours to examine the expressions. Two-way ANOVA analysis on time-series experiments of two cells could select 2863 genes differentially expressed upon ionizing radiation among 32,321 genes in microarray (p<0.05). We classified these genes into 21 clusters by SOM clustering according to the interaction between cell types and time. Two SOM clusters were enriched with apoptosis-related genes in pathway analysis. One cluster contained higher levels of phosphatidyl inositol 3-phosphate kinase (PI3K) subunits in H1299, radio-resistant cells than H460, radiosensitive cells. TRAIL receptors were expressed in H460 cells while the decoy receptor for TRAIL was expressed in H1299 cells. From these results, we could characterize the differential responsiveness to ionizing radiation according to their differential expressions of apoptosis-related genes, which might be the candidates to increase the power of radiotherapy.

Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance

  • Im, Chang-Nim;Kim, Byeong Mo;Moon, Eun-Yi;Hong, Da-Won;Park, Joung Whan;Hong, Sung Hee
    • Genomics & Informatics
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    • v.11 no.4
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    • pp.245-253
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    • 2013
  • A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

A Study on the Ultraviolet Aging Characteristics of Outdoor Polymeric Insulating Materials (옥외용 고분자 절연재료의 자외선 열화특성 연구)

  • Kim, Yeong-Seong;Jeong, Sun-Ok
    • Korean Journal of Materials Research
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    • v.9 no.4
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    • pp.409-413
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    • 1999
  • Recently, the polymeric insulators have been accepted in several countries for the outdoor high voltage applications. In comparison with the conventional porcelain, polymeric insulators offer various advantages such as light weight, superior vandal resistance and better contamination performance. The outdoor polymeric insulating materials such as silicone rubber, ethylene propylene diene monomer(EPDM), ethylene vinyl acetate(EVA) and epoxy are aged such as silicone rubber, ethylene propylene diene monomer(EPDM), ethylene vinyl acetate(EVA) and epoxy are aged under the various natural environment with the long-term performance in outdoor. In this paper, the effects of UV-under the various natural environment with the long-term performance in outdoor. In this paper, the effects of UV-ray on the surface of silicone rubber were investigated by using the weather-Ometer. The accelerated aging stresses were simulated by UV radiation, high temperature and humidity as well as water spray. These aging characteristics were examined through contact angle measurements, tracking resistance test, FT-IR and SEM/EDS analysis. The experimental results showed that tracking resistance decreases with increase in the UV-ray irradiation period. But the surface of silicone rubber kept hydrophobicity. It is found that the inorganic filler such as)$ Al(OH_3$ improves tracking resistance and the $Tio_2$is very effective in preventing degradation of silicone rubber surface from UV-ray.

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