• 한국의학물리학회지:의학물리
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• 제27권4호
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• pp.220-223
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• 2016

Generally, it is recommended that the dosimetric effect of carbon fiber couch should be considered especially for an intensity-modulated therapy with a large portion of monitor units from posterior angles. Even a flattening filter free (FFF) beam has been used for stereotactic body radiation therapy (SBRT), the effect of carbon fiber couch for FFF beam is not well known. This work is an effort to evaluate the dosimetric effect of carbon fiber couch for flattened and FFF beam of Elekta linac empirically. The absorbed doses were measured with Farmer type chamber and water-equivalent phantoms with and without couch. And differences of the absorbed doses between with and without couch defined as "couch effect". By comparing calculated dose in treatment planning system (TPS) with measured dose, the optimal density of couch was evaluated. Finally, differences on patient's skin dose and target dose by couch were evaluated in TPS. As a result, the couch effect for 6 and 10 MV flattened beam were -2.71% and -2.32%, respectively. These values were agreed with provided data by vendor within 0.5%. The couch effect for 6 and 10 MV FFF beam were -3.75% and -2.80%, respectively. The patient's skin dose was increased as 18.6% and target dose was decreased as 0.87%, respectively. It was realized that the couch effect of FFF beam was more severe than that of flattened beam. Patient's skin dose and target dose were changed by the couch effect.

• 한국광학회지
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• 제21권4호
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• pp.133-138
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• 2010

모든 복사온도계는 복사원 크기효과(Size-of-Source Effect, SSE)와 자기복사효과를 가지고 있다. 복사원의 직경에 따른 복사온도계의 검출기 신호세기로 정의된 SSE의 주원인은 회절이기 때문에 파장에 크게 좌우된다. 본 논문에서는 중저온영역에서 복사온도의 전달표준기로 많이 사용되고 있는 TRT2(Transfer Radiation Thermometer 2, HEITRONICS)의 SSE와 자기복사 특성을 측정하였다. 측정한 TRT2의 SSE 값을 사용하여 계산한 결과 흑체의 온도가 $300^{\circ}C$ 일 때, 개구 직경이 60 mm인 흑체와 10 mm인 흑체의 복사온도 차이가 저온모드($8-14\;{\mu}m$)에서 $3.5^{\circ}C$, 중온모드($3.9\;{\mu}m$)에서 $0.5^{\circ}C$인 것을 알 수 있었다. 또한, 복사온도계 몸체 온도가 $2.6^{\circ}C$ 변화했을 때 자기복사효과 때문에 흑체의 복사온도는 110 mK 다르게 측정되었다.

• Journal of Semiconductor Engineering
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• 제1권3호
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• pp.81-87
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• 2020

An instrumentation amplifier (IA) and an analog-to-digital converter (ADC) are essential circuit blocks for accurate and robust sensor readout systems. This paper introduces recent advances in radiation-hardening by design (RHBD) techniques applied for the sensor readout integrated circuits (IC), e.g., the three-op-amp IA and the successive-approximation register (SAR) ADC, operating against total ionizing dose (TID) and singe event effect (SEE) in harsh radiation environments. The radiation-hardened IA utilized TID monitoring and adaptive reference control to compensate for transistor parameter variations due to radiation effects. The radiation-hardened SAR ADC adopts delay-based double-feedback flip-flops to prevent soft errors which flips the data bits. Radiation-hardened IA and ADC were verified through compact model simulation, and fabricated CMOS chips were measured in radiation facilities to confirm their radiation tolerance.

• Radiation Oncology Journal
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• 제37권4호
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• pp.302-308
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• 2019

The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic lesion(s) at a non-irradiated distant site(s). Radiation therapy induced abscopal effects are believed to be mediated by activation and stimulation of the immune system. However, due to the brain's distinctive immune microenvironment, extracranial abscopal responses following cranial radiation therapy have rarely been reported. In this report, we describe the case of 42-year-old female patient with metastatic melanoma who experienced an abscopal response following her cranial radiation therapy for her brain metastasis. The patient initially presented with a stage III melanoma of the right upper skin of her back. Approximately 5 years after her diagnosis, the patient developed a large metastatic lesion in her upper right pectoral region of her chest wall and axilla. Since the patient's tumor was positive for BRAF and MEK, targeted therapy with dabrafenib and trametinib was initiated. However, the patient experienced central nervous system (CNS) symptoms of headache and disequilibrium and developed brain metastases prior to the start of targeted therapy. The patient received radiation therapy to a dose of 30 Gy delivered in 15 fractions to her brain lesions while the patient was on dabrafenib and trametinib therapy. The patient's CNS metastases improved significantly within weeks of her therapy. The patient's non-irradiated large extracranial chest mass and axilla mass also shrank substantially demonstrating the abscopal effect during her CNS radiation therapy. Following radiation therapy of her residual chest lesions, the patient was disease free clinically and her CNS lesions had regressed. However, when the radiation therapy ended and the patient continued her targeted therapy alone, recurrence outside of her previously treated fields was noted. The disease recurrence could be due to the possibility of developing BRAF resistance clones to the BRAF targeted therapy. The patient died eventually due to wide spread systemic disease recurrence despite targeted therapy.

• 대한수의학회지
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• 제43권3호
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• pp.323-331
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• 2003

We performed this study to determine the late biological effect of gamma radiation and effect of Bu-Zhong-Yi-Qi-Tang (BZYQT), a prescription of traditional Oriental medicine, on radiation-induced late biological effect (survival, hematological change, carcinogenesis) of mice irradiated with 3 Gy of gamma-radiation. There were little difference in body weights between normal and irradiated mice. Survival rate were decreased in irradiated mice and the survival rate and mean survival time of the groups treated with BZYQT were far better than the irradiation control group. A significant elevation of total leukocyte or lymphocyte counts was seen at week 4 and 12 of the group treated with BZYQT. Stimulated recovery by the extract from BZYQT was also observed in thrombocyte. Main gross findings of irradiated mice were appeared as enlargement of spleen, thymus and liver, tumorous nodules of lung and cyst or mass of ovary. Microscopically, there were various findings including hematopoietic and lymphoid tumor, lung cancer, ovarian cancer and cancer of other lesions. BZYQT reduced the incidence of tumor development. Further studies are needed to characterize better the protective nature of ingredients and active compounds.

• 한국대기환경학회지
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• 제33권5호
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• pp.435-444
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• 2017

In this study, we investigated the effect of aerosol feedback on $PM_{10}$ simulation using a two-way coupled air quality model (WRF-CMAQ). $PM_{10}$ concentration over Korea in January 2014 was simulated, and the aerosol feedback effect on the simulated solar radiation was intensively examined. Two $PM_{10}$ simulations were conducted using the WRF-CMAQ model with (FB) and without(NFB) the aerosol feedback option. We find that the simulated solar radiation in the west part of Korea decreased by up to $-80MJ/m^2$ due to the aerosol feedback effect. The feedback effect was significant in the west part of Korea, showing high $PM_{10}$ estimates due to dense emissions and its long-range transport from China. The aerosol feedback effect contributed to the decreased rRMSE(relative Root Mean Square Error) for solar radiation (47.58% to 30.75%). Aerosol feedback effect on the simulated solar radiation was mainly affected by concentration of $PM_{10}$. Moreover, FB better matched the observed solar radiation and $PM_{10}$ concentration than NFB, implying that taking into account the aerosol direct effects resulted in the improved modeling performance. These results indicate that aerosol feedback effects can play an important role in the simulation of solar radiation over Korean Peninsula.

• Radiation Oncology Journal
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• 제12권3호
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• pp.285-293
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• 1994

Purpose : The study was designed to investigate the effect of cis-dichlorodiammineplatinum(II)(cis-DDP) on the radiation-induced cardiomyopathy in the rat. Materials and Methods : The myocardial damage was assessed by histopathologic changes. In radiation alone group, radiation dose ranged from 10-40 Gy X-ray in a single dose and in combined group, cis-dichlorodiammineplatinum(II) at a dose of 6 mg/kg was given intraperitoneally immediately after irradiation of same dose with X-ray alone group. Results : The early changes by radiation included congestion, inflammatory cell infiltrations and fibrosis in myocardial interstitium with focal myocardial necrosis, which was noted in 10 Gy group, Myocardial fibrosis was increased by increasing dose of radiation but myocardial necrosis was not Proportional to radiation dose. cis-DDP alone group showed minimal degeneration of myocardium with surrounded by inflammatory cell infiltrations. In combined group, myocardial fibrosis in 10 Gy group were similar to radiation alone group, but 30 Gy and 40 Gy groups showed severer changes. Electron microscopic examination showed disruption of Z-band and edema of mitochondria with decreased matrix density in 20 Gy radiation group which were severer in 40 Gy radiation group. Combined group showed endothelial changes and disruption of Z-band worse than radiation alone group as well as increased connective tissue, which was considered as a hallmark of late change in radiation-induced heart disease. Conclusion : This results showed minimal enhancement of the radiation-induced cardiomyopathy in rats by cis-DDP.

• ETRI Journal
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• 제29권1호
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• pp.124-126
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• 2007

In this letter, we study the impact of single event upsets (SEUs) in space or defense electronic systems which use memory devices such as EEPROM, and SRAM. We built a microcontroller test board to measure the effects of protons on electronic devices at various radiation levels. We tested radiation hardening at beam current, and energy levels, measured the phenomenon of SEUs, and addressed possible reasons for SEUs.

• Radiation Oncology Journal
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• 제33권3호
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• pp.256-260
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• 2015

Purpose: Mefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell death. In this study, the radioprotective effect of MEF was investigated against genotoxicity induced by ionizing radiation in human blood lymphocytes. Materials and Methods: Peripheral blood samples were collected from human volunteers and incubated with MEF at different concentrations (5, 10, 50, or $100{\mu}M$) for two hours. The whole blood was exposed to ionizing radiation at a dose 1.5 Gy. Lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis blocked binucleated lymphocyte. Results: A significant decreasing in the frequency of micronuclei was observed in human lymphocytes irradiated with MEF as compared to irradiated lymphocytes without MEF. The maximum decreasing in frequency of micronuclei was observed at $100{\mu}M$ of MEF (38% decrease), providing maximal protection against ionizing radiation. Conclusion: The radioprotective effect of MEF is probably related to anti-inflammatory property of MEF on human lymphocytes.

• KSBB Journal
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• 제27권3호
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• pp.195-198
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• 2012

This study was carried out to assess the effect of radiation on the changes of Hizikia fusiformis cooking juice ethanol extract and to compare the effect of gamma ray and electron beam. On the applying radiation, the dark color of cooking juice became changed with higher brightness and lower redness and yellowness. But, there was no difference between gamma ray radiation and electron beam radiation. 1,1-Diphenyl-2-picryl-hydrazyl radical scavenging activity and tyrosinase inhibitory activity of cooking juice were shown to be increased by radiation independent on the radiation source types. The reason for the increased biological activities was caused by higher content of total phenolic compounds. The results could be applied to investigate the effect of radiation source on the color and antioxidant activity of biomaterials, and it was thought that irradiation could be an promising method for enhancing the biological activity of biomaterials.