• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.420-420
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• 2023

하천의 유량 자료는 하천 관리에 필수적인 요소로, 지속적인 유량측정을 위해 국가 유량 측정망을 구성하여 주요 지점을 대상으로 유량 측정을 수행하고 있다. 측정된 유량자료는 일반적으로 수위-유량 관계곡선식을 개발하여 제공되고 있으며, 홍수파와 배수 영향 등으로 인해 수위-유량 관계곡선식에서 발생하는 산포로 인한 신뢰도에 문제가 우려되는 경우에는 실시간의 정확한 유량자료를 제공하기 위해 H-ADCP를 설치하여 지표유속법 기반의 실시간 유량 자료 생산하여 제공하고 있다. 그러나 H-ADCP를 이용한 유량 측정 방법은 장비의 한계로 인해 상대적으로 규모가 작고 수심이 얕은 하천에 적용하기 어려운 문제가 있다. 따라서, 최근에는 자동유량관측소 지점 확대를 위해 비접촉식 유속계를 활용한 자동유량관측소 운영이 점차 고려되고 있다. 이에 따라 비접촉식유속계를 이용한 유량 측정 결과의 검증 및 유지 관리를 위한 소프트웨어가 필요하다. 이에 본 연구에서는 비접촉식유속계 중 전자파를 이용하여 수표면의 표면유속을 측정할 수 있는 장비인 RQ-30의 측정결과를 분석하기 위해 Microsoft Visual Studio(C#) 사용하여 측정결과의 검토 및 자료 관리를 위한 후처리 소프트웨어를 개발하였다. 개발한 소프트웨어는 측정 원시자료를 읽고, 도시하여 측정 결과를 확인할 수 있으며, 머신러닝 기반의 알고리즘을 적용하여 수위 및 유속 시계열 자료에서 발생하는 이상치를 탐색할 수 있도록 개발하였다. 그리고 탐지된 이상치에 대한 보정을 위해 선형보간, LOESS, SuperSmoother를 사용하여 이상치를 보정하여 결과를 도출할 수 있도록 개발하였다. 추후 본 연구를 통해 개발된 프로그램을 활용하여 측정 자료의 유지 관리 효율성을 증대시킬 수 있을 것으로 기대되며, 지속적인 프로그램의 개선을 통해서 실무적으로 활용이 가능할 것으로 판단된다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.255-255
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• 2022

안정적이고 효율적인 물 배분과 관리를 위해 하천유량 외에도 하천수 사용량 파악에 대한 관심이 높아짐에 따라 다양한 하천수 사용량 계측방법의 검증 및 표준화로 하천수 사용량 자료의 신뢰도 및 활용성을 개선할 필요가 있다. 다양한 계측방법 중에서도 전자파표면유속계는 비접촉식 유속계이므로 안전적인 측면으로 유리하고 실시간 자료처리 및 계측이 용이하여 활용도가 높다. 본 연구에서는 만경강의 하천수 사용량 파악을 위해 어우보 취수로에 설치된 전자파 표면유속계(RQ-30)를 활용하여 보정계수(K-factor)가 적용된 표면유속을 활용한 유량산정방법, 표면유속과 평균유속의 일정비율로 유량을 산정하는 방법(ISO 748), Chiu의 유속분포법을 활용한 유량산정방법, 지표유속과 인력(人力)에 의한 측정유속과의 관계인 지표유속-평균유속관계곡선식으로 환산된 유량산정 방법등을 비교·검토하고 최적의 유량산정방법을 제시하였다. 향후 전자파표면유속계를 활용한 하천수 사용량의 비교결과를 통하여 더욱 효율적이며 신뢰도 높은 하천수 관리와 실시간 물배분 효과를 기대할 수 있다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.48-54
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• 2004

The effects of injector spacing s and injector diameter d on mixing are numerically investigated in supersonic combustor with perpendicular injection behind a backward-facing step. Simulations are reported for airstream Mach number of 2.4. Parameters are changed on following 4 cases to investigate the effects of injector configuration on mixing efficiency $\eta_m$. In the case of varying d or s, dynamic pressure ratio $Rq(=(pu^2)_j/(pu^2)_a)$ is also varied to keep bulk equivalence ratio $\Phi({\oe})Rq.d^2/s)$ constant. (l) Injector spacing s is varied at constant $\Phi$=0.5, 1, 2 for injector diameter d=6mm. In the case of $\Phi$=1, $\eta_m$ has its maximum value at s=24mm. The reason is that increase of $\eta_m$. , by widening spacing at Rq=constant competes with decrease of $\eta_m$ by increasing Rq at s=constant. When spacing is narrow, the flow field of vicinity of injector becomes two-dimensional because adjacent jets interferes each other. By widening spacing, air is easily entrained by three-dimensional effect. This mechanism also appears in the case of $\Phi$=0.5, 2 for d=6mm, and $\eta_m$. reaches its maximum value at s=24mm for $\Phi$=0.5 and at s=42mm for $\Phi$=2. (2) In the case of injector diameter d varied at $\Phi$=1 for s=30mm, $\eta_m$. has its maximum value at d=3mm. The reason is that decrease of $\eta_m$ by increasing injector diameter competes with increase of $\eta_m$ by decreasing Rq at d=constant.(3) In the case of s varied at $\Phi$=0.5, 1,2 for d=3mm, the injector spacing at which mixing efficiency has its maximum value is s= 18mm for $\Phi$=0.5, s=24mm for $\Phi$=1, s=24mm for $\Phi$=2. Therefore it is found that d=3mm and s=24mm can be optimum configuration over a range of $\Phi$=0.5~2.(4) The effect of h on the optimum spacing is investigated. s is varied for d=6mm at step height h=4, 6, 8mm. The simulation results do not show significant change on the step height.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4457-4463
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• 2015

Common genetic variation Q192R in the paraoxonase 1 (PON1) gene has been considered to be implicated in the development of many cancers. Nevertheless, results from the related studies were inconsistent. To elucidate the association, we performed a meta-analysis for 8,112 cases and 10,037 controls from 32 published case-control studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association by STATA 12.0 software. Overall, we revealed that the PON1-192R allele was associated with a reduced risk of the overall cancers. Moreover, in the stratified analysis by cancer types (breast cancer, prostate cancer, brain cancer etc.), the results showed that PON1-192R allele was associated with a decreased risk in breast cancer (R vs Q: OR=0.605, 95% CI=0.378-0.967, $P_{heterogeneity}=0.000$; RR vs QQ: OR=0.494, 95% CI=0.275-0.888, $P_{heterogeneity}=0.002$; RQ vs QQ: OR=0.465, 95% CI=0.259-0.835, $P_{heterogeneity}=0.000$; and RR+RQ vs QQ: OR=0.485, 95% CI=0.274-0.857, $P_{heterogeneity}=0.000$), and associated with prostate cancer in homozygote (RR vs QQ: OR=0.475, 95% CI=0.251-0.897, $P_{heterogeneity}=0.001$) and recessive models (RR vs RQ+QQ: OR=0.379, 95% CI=0.169-0.853, $P_{heterogeneity}=0.000$), while an increased risk was identified in lymphoma (R vs Q: OR=1.537, 95% CI=1.246-1.896, $P_{heterogeneity}=0.944$; RR vs QQ: OR=2.987, 95% CI=1.861-4.795, $P_{heterogeneity}=0.350$; RR+RQ vs QQ: OR=1.354, 95% CI=1.021-1.796, $P_{heterogeneity}=0.824$; and RR vs RQ+QQ: OR=2.934, 95% CI=1.869-4.605, $P_{heterogeneity}=0.433$), and an increased risk in prostate cancer under heterozygote comparison (RQ vs QQ: OR=1.782, 95% CI=1.077-2.950, $P_{heterogeneity}=0.000$) and dominant models (RR+RQ vs QQ: OR=1.281, 95% CI=1.044-1.573, $P_{heterogeneity}=0.056$). When subgroup analysis that performed by the control source (hospital based or population based), a decreased risk of the overall cancers was revealed by homozygote (RR vs QQ: OR=0.601, 95% CI=0.366-0.987, $P_{heterogeneity}=0.000$) and dominant models (RR vs RQ+QQ: OR= 0.611, 95% CI=0.384-0.973, $P_{heterogeneity}=0.000$) in hospital based group. Stratifying by ethnicity, a significantly reduced risk of the overall cancers under allele contrast model (R vs Q: OR=0.788, 95% CI=0.626-0.993, $P_{heterogeneity}=0.000$) was uncovered in Caucasian. In summary, these findings suggested that PON1 Q192R polymorphism was associated with a reduced risk of the overall cancers, nevertheless, it might increase cancer susceptibility of prostate and lymphoma risk. Large well-designed epidemiological studies will be continued on this issue of interest.

• 한국식품위생안전성학회지
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• 제39권4호
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• pp.343-352
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• 2024

본 연구는 한국전통식품인 김치에서 분리한 W. cibaria SPM402, L. paracasei SPM412의 포괄적인 항 치주염 효과를 확인하였다. WC402 10 mg/mL농도에서 P. gingivalis 의 생물막 형성이 37.30±8.23%, LP412 10 mg/mL에서 51.36±5.95% 억제되었고, F. nucleatum의 생물막 형성의 경우 WC402 10 mg/mL에서 76.77±2.77%, LP412 10 mg/mL에서 95.99± 0.73% 억제되었다. LP412 10 mg/mL에서 P. gingivalis 부착소인 fimA의 RQ값이 0.08±0.05로 약 12배 감소함을 확인하였고, F. nucleatum의 부착소인 radD의 RQ값은 0.08±0.008으로 radD는 거의 90배 이상 억제되었다. 사람 잇몸 상피세포주인 YD-38에 Pg OMV에 의한 염증반응을 유도 후 WC402 15 mg/mL 처리 결과 IL-1β유전자 발현이 약 150배 가량 억제되었고, LP412 0.1 mg/mL 처리 결과 IL-1β유전자 발현이 약 3.6배 가량 억제됨을 확인하였다. YD-38세포주에 F. nucleatum에 의한 염증반응을 유도 후 1 mg/mL의 WC402를 처리한 결과 IL-8유전자 발현이 약 3배 정도, 1 mg/mL의 LP412를 처리한 결과 IL-8유전자 발현이 약 5.6배 정도 억제되었다. 이상의 결과를 볼 때 W. cibaria SPM402, L. paracasei SPM412는 구강병원성 세균의 생물막 형성 관련 병인인자 발현 억제, 직접적인 생물막 형성 억제 및 병원성 세균에 의해 유도된 염증반응을 효과적으로 억제하는 기능을 보유한 균주로 구강질환에 대한 치료제나 구강 건강에 도움이 되는 구강 건강기능성 식품으로 사용될 가능성이 있음을 확인하였다.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1161-1171
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• 2018

Objective: The aim of this study was to investigate diffusion tensor (DT) imaging-derived properties of benign oligemia, true "at risk" penumbra (TP), and the infarct core (IC) during the first 3 hours of stroke onset. Materials and Methods: The study was approved by the local animal care and use committee. DT imaging data were obtained from 14 rats after permanent middle cerebral artery occlusion (pMCAO) using a 7T magnetic resonance scanner (Bruker) in room air. Relative cerebral blood flow and apparent diffusion coefficient (ADC) maps were generated to define oligemia, TP, IC, and normal tissue (NT) every 30 minutes up to 3 hours. Relative fractional anisotropy (rFA), pure anisotropy (rq), diffusion magnitude (rL), ADC (rADC), axial diffusivity (rAD), and radial diffusivity (rRD) values were derived by comparison with the contralateral normal brain. Results: The mean volume of oligemia was $24.7{\pm}14.1mm^3$, that of TP was $81.3{\pm}62.6mm^3$, and that of IC was $123.0{\pm}85.2mm^3$ at 30 minutes after pMCAO. rFA showed an initial paradoxical 10% increase in IC and TP, and declined afterward. The rq, rL, rADC, rAD, and rRD showed an initial discrepant decrease in IC (from -24% to -36%) as compared with TP (from -7% to -13%). Significant differences (p < 0.05) in metrics, except rFA, were found between tissue subtypes in the first 2.5 hours. The rq demonstrated the best overall performance in discriminating TP from IC (accuracy = 92.6%, area under curve = 0.93) and the optimal cutoff value was -33.90%. The metric values for oligemia and NT remained similar at all time points. Conclusion: Benign oligemia is small and remains microstructurally normal under pMCAO. TP and IC show a distinct evolution of DT-derived properties within the first 3 hours of stroke onset, and are thus potentially useful in predicting the fate of ischemic brain.

• Nutrition Research and Practice
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• 제10권2호
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• pp.175-181
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• 2016

BACKGROUND/OBJECTIVES: The anti-obesity effect of quercetin-rich onion peel extract (OPE) was suggested in rats, but information from human studies is limited. This study aimed to investigate the effects of OPE on the body composition of overweight and obese subjects. MATERIALS/METHODS: In this 12-week, randomized, double-blind, placebo-controlled study, parallel clinical trials were performed in overweight and obese Korean subjects. Randomly assigned subjects were instructed to take daily either the placebo (male, 6 and female, 30) or OPE capsules containing 100 mg of quercetin (male, 5 and female, 31). Body composition was measured by using bioimpedance and dual-energy X-ray absorptiometry (DXA). Resting energy expenditure (REE) and respiratory quotient (RQ) were evaluated by using indirect calorie measurement methods. Fasting blood levels of glucose, insulin, lipids, and leptin were determined. RESULTS: Quercetin-rich OPE supplementation significantly reduced the weight and percentage of body fat as measured by DXA (P = 0.02). These effects were not shown in the control group. Levels of blood glucose (P = 0.04) and leptin (P = 0.001 for placebo, P = 0.002 for OPE) decreased in both groups. Significant increases in REE and RQ were observed in both groups (P = 0.003 for placebo, P = 0.006 for OPE) and in the OPE group alone (P = 0.02), respectively. CONCLUSIONS: Quercetin-rich OPE supplementation changed the body composition of the overweight and obese subjects. This result suggests a beneficial role of the anti-obesity effect of OPE human subjects.

• Journal of Microbiology and Biotechnology
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• 제25권2호
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• pp.185-195
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• 2015

Glucoamylase is an important industrial enzyme. Glucoamylase production by industrial Aspergillus niger strain featured with two major problems: (i) empirical substrate feeding methods deteriorating the fermentation performance; and (ii) the high raw materials cost limiting the economics of the glucoamylase product with delegated specification. In this study, we first proposed a novel three-stage varied-rate substrate feeding strategy for efficient glucoamylase production in a 5 L bioreactor using the standard feeding medium, by comparing the changing patterns of the important physiological parameters such as DO, OUR, RQ, etc., when using different substrate feeding strategies. With this strategy, the glucoamylase activity and productivity reached higher levels of 11,000 U/ml and 84.6 U/ml/h, respectively. The performance enhancement in this case was beneficial from the following results: DO and OUR could be controlled at the higher levels (30%, 43.83 mmol/l/h), while RQ was maintained at a stable/lower level of 0.60 simultaneously throughout the fed-batch phase. Based on this three-stage varied-rate substrate feeding strategy, we further evaluated the economics of using alternative carbon sources, attempting to reduce the raw materials cost. The results revealed that cornstarch hydrolysate could be considered as the best carbon source to replace the standard and expensive feeding medium. In this case, the production cost of the glucoamylase with delegated specification (5,000 U/ml) could be saved by more than 61% while the product quality be ensured simultaneously. The proposed strategy showed application potential in improving the economics of industrial glucoamylase production.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2159-2164
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• 2016

Background: A diagnosis of chronic myeloid leukemia (CML) is made on discovery of the presence of a Philadelphia (Ph) chromosome. The success of the treatment of this form of leukemia with tyrosine kinase inhibitor (TKI) is monitored by reduction of the Ph chromosome. Objective: To compare the role of conventional cytogenetic (CC) methods with a real time quantitative polymerase chain reaction (RQ-PCR) and fluorescence in situ hybridization (FISH) for diagnosis and treatment monitoring of CML patients. The secondary outcome was to analyze the treatment responses to TKI in CML patients. Materials and Methods: This was a retrospective study of CML patients who attended the Hematology clinic at Chiang Mai University Hospital from 2005-2010. Medical records were reviewed for demographic data, risk score, treatment response and the results of CC methods, FISH and RQ-PCR. Results: One hundred and twenty three cases were included in the study, 57.7% of whom were male with a mean age of 46.9 years. Most of the patients registered as intermediate to high risk on the Sokal score. At diagnosis, 121 patients were tested using the CC method and 118 (95.9%) were identified as positive. Five patients failed to be diagnosed by CC methods but were positive for BCR-ABL1 using the FISH method. Imatinib was the first-line treatment used in 120 patients (97.6%). In most patients (108 out of 122, 88.5%), a complete cytogenetic response (CCyR) was achieved after TKI therapy and in 86 patients (70.5%) CCyR was achieved long term by the CC method. Five out of the 35 analyzed patients in which CCyR was achieved by the CC method had a positive FISH result. Out of the 76 patients in which CCyR was achieved, RQ-PCR classified patients to only CCyR in 17 patients (22.4%) with a deeper major molecular response (MMR) in 4 patients (5.3%) and complete molecular response (CMR) in 55 patients (72.4%). In the case of initial therapy, CCyR was achieved in 95 patients (79.1%) who received imatinib and in both patients who received dasatinib (100%). For the second line treatment, nilotinib were used in 30 patients and in 19 of them (63.3%) CCyR was achieved. In half of the 6 patients (50%) who received dasatinib as second line or third line treatment CCyR was also achieved. Conclusions: CML patients had a good response to TKI treatment. FISH could be useful for diagnosis in cases where CC analysis failed to detect the Ph chromosome. RQ-PCR was helpful in detecting any residual disease and determining the depth of the treatment response at levels greater than the CC methods.

• Animal Bioscience
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• 제35권5호
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• pp.690-697
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• 2022

Objective: This study aimed to evaluate the effect of the ad libitum and restricted feeding regimen on fasting heat production (FHP) and body composition. Methods: Twelve Hubbard broilers breeders were selected with the same body weight and submitted in two feeding regimes: Restricted (T1) with feed intake of 150 g/bird/d and ad libitum (T2). The birds were randomly distributed on the treatments in two runs with three replications per treatment (per run). The birds were adapted to the feed regimens for ten days. After that, they were allocated in the open-circuit chambers and kept for three days for adaptation. On the last day, oxygen consumption (VO₂) and carbon dioxide production (VCO₂) were measured by 30 h under fasting. The respiratory quotient (RQ) was calculated as the VCO₂/VO₂ ratio, and the heat production (HP) was obtained using the Brower equation (1985). The FHP was estimated throughout the plateau of HP 12 hours after the feed deprivation. The body composition was analyzed by dual-energy X-ray absorptiometry scanning at the end of each period. Data were analyzed for one-way analysis of variance using the Minitab software. Results: The daily feed intake was 30 g higher to T2 (p<0.01) than the T1. Also, the birds of the T2 had significatively (p<0.05) more oxygen consumption (+3.1 L/kg^0.75/d) and CO₂ production (+2.2 L/kg^0.75/d). That resulted in a higher FHP 359±14 kJ/kg^0.75/d for T2 than T1 296±17.23 kJ/kg^0.75/d. In contrast, the RQ was not different between treatments, with an average of 0.77 for the fasting condition. In addition, protein and fat composition were not affected by the treatment, while a tendency (p<0.1) was shown to higher bone mineral content on the T1. Conclusion: The birds under ad libitum feeding had a higher maintenance energy requirement but their body composition was not affected compared to restricted feeding.