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http://dx.doi.org/10.3348/kjr.2018.19.6.1161

Diffusion Tensor-Derived Properties of Benign Oligemia, True "at Risk" Penumbra, and Infarct Core during the First Three Hours of Stroke Onset: A Rat Model  

Chiu, Fang-Ying (Department of Medical Imaging and Radiological Sciences, College of Medicine, I-Shou University)
Kuo, Duen-Pang (Department of Radiology, Taoyuan Armed Forces General Hospital)
Chen, Yung-Chieh (Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University)
Kao, Yu-Chieh (Translational Imaging Research Center, College of Medicine, Taipei Medical University)
Chung, Hsiao-Wen (Graduate Institute of Biomedical Electrics and Bioinformatics, National Taiwan University)
Chen, Cheng-Yu (Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University)
Publication Information
Korean Journal of Radiology / v.19, no.6, 2018 , pp. 1161-1171 More about this Journal
Abstract
Objective: The aim of this study was to investigate diffusion tensor (DT) imaging-derived properties of benign oligemia, true "at risk" penumbra (TP), and the infarct core (IC) during the first 3 hours of stroke onset. Materials and Methods: The study was approved by the local animal care and use committee. DT imaging data were obtained from 14 rats after permanent middle cerebral artery occlusion (pMCAO) using a 7T magnetic resonance scanner (Bruker) in room air. Relative cerebral blood flow and apparent diffusion coefficient (ADC) maps were generated to define oligemia, TP, IC, and normal tissue (NT) every 30 minutes up to 3 hours. Relative fractional anisotropy (rFA), pure anisotropy (rq), diffusion magnitude (rL), ADC (rADC), axial diffusivity (rAD), and radial diffusivity (rRD) values were derived by comparison with the contralateral normal brain. Results: The mean volume of oligemia was $24.7{\pm}14.1mm^3$, that of TP was $81.3{\pm}62.6mm^3$, and that of IC was $123.0{\pm}85.2mm^3$ at 30 minutes after pMCAO. rFA showed an initial paradoxical 10% increase in IC and TP, and declined afterward. The rq, rL, rADC, rAD, and rRD showed an initial discrepant decrease in IC (from -24% to -36%) as compared with TP (from -7% to -13%). Significant differences (p < 0.05) in metrics, except rFA, were found between tissue subtypes in the first 2.5 hours. The rq demonstrated the best overall performance in discriminating TP from IC (accuracy = 92.6%, area under curve = 0.93) and the optimal cutoff value was -33.90%. The metric values for oligemia and NT remained similar at all time points. Conclusion: Benign oligemia is small and remains microstructurally normal under pMCAO. TP and IC show a distinct evolution of DT-derived properties within the first 3 hours of stroke onset, and are thus potentially useful in predicting the fate of ischemic brain.
Keywords
Diffusion tensor imaging; True penumbra; Infarct core; Benign oligemia; Pure anisotropy; Diffusion magnitude;
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