• Investigative Magnetic Resonance Imaging
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• 제20권4호
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• pp.231-240
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• 2016

Purpose: To determine whether liver stiffness (LS) measured by magnetic resonance elastography (MRE) can predict the outcome of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) patients. Materials and Methods: A total of 107 patients with Child-Pugh class A liver function who were treated with RFA for single HCC and who had undergone a gradient-echo MRE within 6 months before RFA were included. We evaluated the relationship between the LS values and the ablation volume, local tumor progression (LTP), and intrahepatic distant recurrence (IDR). We also constructed receiver operating characteristic (ROC) curves to examine the role of LS in predicting liver function deterioration, which was defined as an increase of Child-Pugh score by one point or more at 1 year after RFA. Results: There was no significant correlation between LS and ablation volume, and neither time to LTP nor IDR was associated with LS. Among the 66 patients who did not have recurrence 1 year after RFA, 5 patients (7.6%) developed liver function deterioration. A high LS value was significantly associated with development of liver function deterioration after RFA and the area under the ROC curve was 0.764 (95% CI 0.598-0.929, P = 0.003). Conclusion: LS measured by MRE could not predict ablation volume and tumor recurrence. However, high LS values were significantly associated with development of liver function deterioration.

• Imaging Science in Dentistry
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• 제45권3호
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• pp.169-174
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• 2015

Purpose: This study was performed to evaluate the diagnostic efficacy of panoramic radiography and cone-beam computed tomography (CBCT) in detecting sinus pathology. Materials and Methods: This study was based on a retrospective evaluation of patients who had undergone both a panoramic radiograph and a CBCT exam. A total of 100 maxillary sinuses were evaluated. Four examiners with various levels of expertise evaluated the images using a five-point scoring system. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of the two modalities. The image analysis was repeated twice, with at least two weeks between the evaluation sessions. Interobserver reliability was assessed using Cronbach's alpha, and intraobserver reliability was assessed using Cohen's kappa. Results: Maxillary sinus pathology was detected in 72% of the patients. High interobserver and intraobserver reliability were observed for both imaging modalities and among the four examiners. Statistical analyses using ROC curves demonstrated that the CBCT images had a larger area under the curve (0.940) than the panoramic radiographs (0.579). Conclusion: Three-dimensional evaluation of the sinus with CBCT was significantly more reliable in detecting pathology than panoramic imaging.

• Imaging Science in Dentistry
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• 제45권3호
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• pp.153-158
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• 2015

Purpose: The purpose of this study was to evaluate and compare the efficacy of cone-beam computed tomography (CBCT) and digital intraoral radiography in diagnosing simulated small external root resorption cavities. Materials and Methods: Cavities were drilled in 159 roots using a small spherical bur at different root levels and on all surfaces. The teeth were imaged both with intraoral digital radiography using image plates and with CBCT. Two sets of intraoral images were acquired per tooth: orthogonal (PA) which was the conventional periapical radiograph and mesioangulated (SET). Four readers were asked to rate their confidence level in detecting and locating the lesions. Receiver operating characteristic (ROC) analysis was performed to assess the accuracy of each modality in detecting the presence of lesions, the affected surface, and the affected level. Analysis of variation was used to compare the results and kappa analysis was used to evaluate interobserver agreement. Results: A significant difference in the area under the ROC curves was found among the three modalities (P=0.0002), with CBCT (0.81) having a significantly higher value than PA (0.71) or SET (0.71). PA was slightly more accurate than SET, but the difference was not statistically significant. CBCT was also superior in locating the affected surface and level. Conclusion: CBCT has already proven its superiority in detecting multiple dental conditions, and this study shows it to likewise be superior in detecting and locating incipient external root resorption.

• Journal of Periodontal and Implant Science
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• 제46권1호
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• pp.10-21
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• 2016

Purpose: This study evaluated the predictive performance of a combination of self-report questionnaires, salivary hemoglobin levels, and age as a non-invasive screening method for periodontitis. Methods: The periodontitis status of 202 adults was examined using salivary hemoglobin levels, responses to 10 questions on a self-report questionnaire, and the Community Periodontal Index (CPI). The ability of those two variables and the combination thereof with age to predict the presence of CPI scores of 3-4 and 4 was assessed using logistic regression and receiver operating characteristic (ROC) curve analysis. Results: CPI scores of 3-4 and 4 were present among 79.7% and 46.5% of the sample, respectively. The area under the ROC curves (AUROCs) of salivary hemoglobin levels for predicting prevalence of CPI scores of 3-4 and 4 were 0.63 and 0.67, respectively (with sensitivity values of 71% and 60% and specificity values of 56% and 72%, respectively). Two distinct sets of five questions were associated with CPI scores of 3-4 and 4, with AUROCs of 0.73 and 0.71, sensitivity values of 76% and 66%, and specificity values of 63% and 69%. The combined model incorporating both variables and age showed the best predictive performance, with AUROCs of 0.78 and 0.76, sensitivity values of 71% and 65%, and specificity values of 68% and 77% for CPI scores of 3-4 and 4, respectively. Conclusions: The combination of salivary hemoglobin levels and self-report questionnaires was shown to be a valuable screening method for detecting periodontitis.

• 융합정보논문지
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• 제7권6호
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• pp.143-151
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• 2017

일반화된 허프변환은 임의의 형태의 2차원 모델을 입력영상에서 탐지 및 추출하는데 사용되어지는 효과적인 방법이다. 그러나 일반화된 허프변환의 단점으로 실행시간이 오래 걸린다는 것과 과도한 메모리 사용을 들 수 있다. 그래서 현재까지의 대부분의 연구는 일반화된 허프변환의 실행시간과 메모리 사용량을 줄이는데 집중되어왔다. 그러나 실행시간과 메모리 사용을 줄여서 개선된 알고리즘이 입력 영상에 존재하는 노이즈를 고려할 경우 어떤 성능을 제공하는가는 여전히 불분명하다. 그러므로 본 논문은 일반화된 허프변환의 성능 평가를 위한 새로운 프레임워크를 제안한다. 이를 위해 일반화된 허프변환을 신호탐지 이론의 탐지기로 간주하며 ROC 커브를 사용해서 일반화된 허프변환의 성능을 정의한다. 마지막으로 입력 영상에서의 노이즈를 고려한 정량적인 성능 평가가 가능함을 보인다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2781-2785
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• 2016

Background: Matric metalloproteinase (MMP) 13 gene expression is increased in esophageal squamous cell carcinomas (ESCCs) and associated with increasing tumor invasion, lymph node involvement and decreased survival rates. Levels of the circulating enzyme may be elevated and used as a marker of tumor progression. In this study, clinical application of MMP-13 serum levels was evaluated for early detection, prediction of prognosis and survival time of ESCC patients. Materials and Methods: Serum levels of MMP13 were determined by ELISA in 66 ESCC patients prior of any treatment and 54 healthy controls for comparison with clinicopathological data through statistical analysis with Man Whitney U and Log-Rank tests. In addition, clinical value of MMP13 levels for diagnosis was evaluated by receiver operating characteristic (ROC) test. Results: The serum level of MMP-13 in patients (>250 pg/ml) was significantly higher than in the control group (<100 pg/ml) (p value=0.004). Also the results showed a significant correlation between MMP-13 serum levels with tumor stage (p value = 0.003), depth of tumor invasion (p value=0.008), involvement of lymph nodes (p value = 0.011), tumor size (p value = 0.018) and survival time. While there were no significant correlation with grade and location of tumors. ROC analysis showed that MMP-13 level is an accurate diagnostic marker especially to differentiate pre-invasive/ invasive lesions from normal controls (sensitivity and specificity: 100%). Conclusions: These findings indicate a potential clinical significance of serum MMP13 measurement for early detection and prognostic assessment in ESCC patients.

• Journal of Yeungnam Medical Science
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• 제37권2호
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• pp.106-111
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• 2020

Background: Fever is a common cause of pediatric consultation in the emergency department. However, identifying the source of infection in many febrile infants is challenging because of insufficient presentation of signs and symptoms. Meningitis is a critical cause of fever in infants, and its diagnosis is confirmed invasively by lumbar puncture. This study aimed to evaluate potential laboratory markers for meningitis in febrile infants. Methods: We retrospectively analyzed infants aged <3 months who visited the emergency department of our hospital between May 2012 and May 2017 because of fever of unknown etiology. Clinical information and laboratory data were evaluated. Receiver operating characteristic (ROC) curves were constructed. Results: In total, 145 febrile infants aged <3 months who underwent lumbar punctures were evaluated retrospectively. The mean C-reactive protein (CRP) level was significantly higher in the meningitis group than in the non-meningitis group, whereas the mean white blood cell count or absolute neutrophil count (ANC) did not significantly differ between groups. The area under the ROC curve (AUC) for CRP was 0.779 (95% confidence interval [CI], 0.701-0.858). The AUC for the leukocyte count was 0.455 (95% CI, 0.360-0.550) and that for ANC was 0.453 (95% CI, 0.359-0.547). The CRP cut-off value of 10 mg/L was optimal for identifying possible meningitis. Conclusion: CRP has an intrinsic predictive value for meningitis in febrile infants aged <3 months. Despite its invasiveness, a lumbar puncture may be recommended to diagnose meningitis in young, febrile infants with a CRP level >10 mg/L.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.281-281
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• 2015

Shallow landslide often occurs in areas of this topography where subsurface soil water flow paths give rise to excess pore-water pressures downslope. Recent hillslope hydrology studies have shown that subsurface topography has a strong impact in controlling the connectivity of saturated areas at the soil-bedrock interface. In this study, the physically based SHALSTAB model was used to evaluate the effects of three soil thicknesses (i.e. average soil layer, soil thickness to weathered soil and soil thickness to bedrock soil layer) and subsurface flow reflecting three soil thicknesses on shallow landslide prediction accuracy. Three digital elevation models (DEMs; i.e. ground surface, weathered surface and bedrock surface) and three soil thicknesses (average soil thickness, soil thickness to weathered rock and soil thickness to bedrock) at a small hillslope site in Jinbu, Kangwon Prefecture, eastern part of the Korean Peninsula, were considered. Each prediction result simulated with the SHALSTAB model was evaluated by receiver operating characteristic (ROC) analysis for modelling accuracy. The results of the ROC analysis for shallow landslide prediction using the ground surface DEM (GSTO), the weathered surface DEM and the bedrock surface DEM (BSTO) indicated that the prediction accuracy was higher using flow accumulation by the BSTO and weathered soil thickness compared to results. These results imply that 1) the effect of subsurface flow by BSTO on shallow landslide prediction especially could be larger than the effects of topography by GSTO, and 2) the effect of weathered soil thickness could be larger than the effects of average soil thickness and bedrock soil thickness on shallow landslide prediction. Therefore, we suggest that using BSTO dem and weathered soil layer can improve the accuracy of shallow landslide prediction, which should contribute to more accurately predicting shallow landslides.

• Genomics & Informatics
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• 제16권4호
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• pp.26.1-26.12
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• 2018

Shigella spp. constitutes some of the key pathogens responsible for the global burden of diarrhoeal disease. With over 164 million reported cases per annum, shigellosis accounts for 1.1 million deaths each year. Majority of these cases occur among the children of the developing nations and the emergence of multi-drug resistance Shigella strains in clinical isolates demands the development of better/new drugs against this pathogen. The genome of Shigella flexneri was extensively analyzed and found 4,362 proteins among which the functions of 674 proteins, termed as hypothetical proteins (HPs) had not been previously elucidated. Amino acid sequences of all these 674 HPs were studied and the functions of a total of 39 HPs have been assigned with high level of confidence. Here we have utilized a combination of the latest versions of databases to assign the precise function of HPs for which no experimental information is available. These HPs were found to belong to various classes of proteins such as enzymes, binding proteins, signal transducers, lipoprotein, transporters, virulence and other proteins. Evaluation of the performance of the various computational tools conducted using receiver operating characteristic curve analysis and a resoundingly high average accuracy of 93.6% were obtained. Our comprehensive analysis will help to gain greater understanding for the development of many novel potential therapeutic interventions to defeat Shigella infection.

• 한국인터넷방송통신학회논문지
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• 제19권1호
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• pp.29-35
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• 2019

4차 산업 혁명이 진행되며 많은 회사들의 스마트 팩토리에 대한 관심이 커지고 있으며 센서의 중요성 또한 대두되고 있다. 정보를 수집하기 위한 센서에서 고장이 발생하면 공장을 최적화하여 운영할 수 없기 때문에 이에 따른 손해가 발생할 수 있다. 이를 위해 센서의 상태를 진단하여 센서의 고장을 진단하는 일이 필요하다. 본 논문에서는 디지털 센서의 고장유형 중 Rising time과 Falling time 고장을 딥러닝 알고리즘 RNN의 LSTM을 통해 신호를 분석하여 고장을 진단하는 모델을 제안한다. 제안한 방식의 실험 결과를 정확도와 ROC 곡선 그래프의 AUC(Area under the curve)를 이용하여 Rule 기반 고장진단 알고리즘과 비교하였다. 실험 결과, 제안한 시스템은 Rule 기반 고장진단 알고리즘 보다 향상되고 안정된 성능을 보였다.