• Clinical and Experimental Reproductive Medicine
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• 제21권2호
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• pp.191-200
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• 1994

The influence of hypoxanthine and ovarian steroids on the meiotic maturation process of mouse oocytes was investigated for the qualified application of culture medium in in vitro fertilization(IVF). Mouse oocytes were cultured in hypoxanthine and various ovarian steroids(progesterone, estradiol-17${\beta}$ and testosterone) and their effects on the oocyte maturation had been observed. When mouse oocytes were cultured in the various concentration(1-4mM) of hypoxanthine, meiotic maturation of cumulus cell-enclosed oocytes was inhibited by presence itself, which was a dose-dependent effect in meiotic arrest of mouse oocytes. The presence of progesterone, estradiol-17${\beta}$ and testosterone have made the mouse oocyte mature properly. Meanwhile maturation of cumulus cell-enclosed oocyte was severely inhibited by 3 hoursculture in the media of progesterone supplemented with hypoxanthine. However the continuous presence lasting 24 hours of progesterone even supplemented with hypoxanthine had got rid of the inhibition of oocytes maturation. Not only estradiol-17${\beta}$ supplemented with hypoxanthine but also testosterone supplemented with hypoxanthine exert the severe inhibition of the maturation of cumulus cell-enclosed oocytes for 3-hours culture. However the continuous presence lasting 24 hours of estradiol-17${\beta}$ and testosterone even supplemented with· hypoxanthine had relieved the inhibition of oocytes maturation. These results make us suggest that hypoxanthine inhibits the mouse oocyte maturation, particularly markedly in conjunction with ovarian steroids for short period, which indicated some sort of the synergistic inhibitory retationship between the ovarian steroids and hypoxanthine.

• 한국자기학회지
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• 제26권3호
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• pp.86-91
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• 2016

BLDC 전동기의 코깅토크는 영구자석과 철심의 상호작용에 의해 발생하고 소음과 진동을 발생시키는 요인이다. 제조 과정에서 조립 공차로 인해 영구자석이 회전자 철심 면에 제대로 붙지 않을 경우 BLDC 전동기의 전자기적 구조가 변할 수 있다. 본 논문에서는 조립 공차로 인해 자석이 회전자 표면과 분리되었을 때 코깅토크에 미치는 영향에 대해 연구했다. 핵심적인 설계 요소들인 회전자와 자석 간 분리, 분리를 가진 자석 수, 이웃한 자석들 간의 여러 배치형태를 고려했다. 코깅토크 해석을 위해 유한요소법을 사용하였고, 소음진동을 발생시키지 않는 조립 공차를 제안했다. 제안된 조립 공차로 제작된 BLDC 전동기의 코깅토크는 감소되었고 소음진동 또한 줄어들 것이라고 판단된다.

• 대한인간공학회지
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• 제26권4호
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• pp.135-142
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• 2007

Icon conveys symbolic information which they have become ubiquitous as main element of GUI. However, users often cannot intuitively understand its functional meanings. Icon has to be designed for users to easily understand functional meanings. In order to evaluate icon, the spreading activation model can be used to effectively understand the process of information retrieval. In asymmetric spreading activation model is that in the two nodes the degree of spreading activation is different according to direction. Thus, asymmetric spreading activation theory was performed evaluating the strength of association when users see visual image to associate their verbal meaning (visual image - verbal meaning pair) and users see verbal meaning to associate their visual image (verbal meaning - visual image pair). According to the direction, this study hypothesizes that the well-designed icons have symmetric relationship rather than asymmetric relationship between the two pairs. The strength of association is measured through the reaction time and the accuracy rate. In performing SAT (spreading activation test), the ten icons were selected as word processing software icons. After first SAT, newly designed icons were developed based on Korean mental model, and second SAT was conducted using them. The results showed that the accuracy rate of newly designed icon has been improved. Also there is significant difference of reaction time between current icons and newly designed icons. Well-designed icon is confirmed that the strength of association relationship arises symmetrically rather than asymmetrically between the two pairs. User centered icons could be designed by improving the strength of association between the two pairs. Asymmetric SAT evaluates the strength of the association between the visual image and the verbal meanings to contribute to the development of icon which it related to human's association structure.

• 한국멀티미디어학회논문지
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• 제16권5호
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• pp.558-565
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• 2013

X-ray를 이용한 여성의 유방암 검사인 유방조영술은 유방암의 초기 단계에서의 진단을 위한 효과적인 방법이다. 컴퓨터 지원 검출(CAD) 시스템은 유방조영술을 통한 진단 시 의사가 놓치기 쉬운 유방암의 징후인 종괴의 검출을 도와 유방암 진단율을 높이는 수단이다. 종괴는 다양한 모양을 지니며 경계가 뚜렷하지 않기 때문에 검출이 어렵고 결과적으로 비-종괴 영역을 포함한 많은 수의 종괴 후보영역이 CAD 시스템에서 검출된다. 따라서 CAD 시스템 설계 시 검출된 많은 수의 종괴 후보영역으로부터 실제 악성 종괴 영역을 분류할 수 있도록 우수한 성능의 분류기가 요구된다. 본 논문에서는 피셔 분별 사전학습을 통해 개선된 Sparse 표현(SR) 기반 분류방법을 제안한다. 개선된 SR 기반 분류기가 기존의 CAD 시스템에서 주로 사용되어온 Support Vector Machine (SVM) 분류기 보다 우수함을 비교실험을 통해 확인했다.

• 펄프종이기술
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• 제43권3호
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• pp.52-58
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• 2011

Proton-NMR spectroscopic method was applied to kinetic study of concentrated sulfuric acid hydrolysis reaction, especially focused on 2nd step of acid hydrolysis with deferent reaction time and temperature as main variables. Commercial xylan extracted from beech wood was used as model compound. In concentrated acid hydrolysis, xylan was converted to xylose, which is unstable in 2nd hydrolysis condition, which decomposed to furfural or other reaction products. Without neutralization steps, proton-NMR spectroscopic analysis method was valid for analysis of not only monosaccharide (xylose) but also other reaction products (furfural and formic acid) in acid hydrolyzates from concentrated acid hydrolysis of xylan, which was the main advantages of this analytical method. Higher temperature and longer reaction time at 2nd step acid hydrolysis led to less xylose concentration in xylan acid hydrolyzate, especially at $120^{\circ}C$ and 120 min, which meant hydrolyzed xylose was converted to furfural or other reaction products. Loss of xylose was not match with furfural formation, which meant part of furfural was degraded to other undetected compounds. Formation of formic acid was unexpected from acidic dehydration of pentose, which might come from the glucuronic acid at the side chain of xylan.

• 열처리공학회지
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• 제4권3호
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• pp.13-20
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• 1991

The present work was aimed to examine the variation of precipitations and mechanical properties by thermomechanical treatments (TMT) in Al-2.19 wt%Li and Al-2.0 wt%Li-0.11 wt%Zr alloys. This study was performed by TEM, SEM observation, DSC, electrical resistance measurement, hardness and tensile strength measurement. First peak of resistivity aged at $90^{\circ}C$ was caused by precipitation of ${\delta}^{\prime}$-precursor phase, and second peak was caused by precipitation of ${\delta}^{\prime}$ phase. According to this result, the precipitation process of Al-2.19 wt%Li alloy was as follow : $SSSS{\rightarrow}{\delta}^{\prime}$-precursor phase ${\rightarrow}{\delta}^{\prime}$ (Coherent ${\rightarrow}$ Semi-coherent) ${\rightarrow}{\delta}$. In a Al-2.0 wt%Li-0.11 wt%Zr ternary alloy, the first peak of resistivity was appeared at initial aging heat-treatment. It is result from exsistant of ${\delta}^{\prime}$-precursor phase. The effect acceleration in a binary alloy was not appeared and the over-aging ternary alloy was accelerated with increase of the reduction rate. It is caused by combination effect of ${\delta}^{\prime}$ and composite phase.

• 한국산업융합학회 논문집
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• 제12권2호
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• pp.99-105
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• 2009

Among a few items with world wide competitiveness are the semiconductor and the LCD. Grinding/polishing is the most significant process in manufacturing semiconductor wafers and LCD panels, the most critical quality of which is the precision rate of the machined surfaces. It is well known that the control of the vibrations is the major factor in maintaining superb machined surfaces. In this paper the dynamic properties of a grinding machine have been investigated through the frequency analysis test and the computer simulation to deduce ideas of design modifications for improved stability. The alterations have been applied to the simulation model, which is supposed to have identical dynamic property with the original structure, to identify the effects and to finally achieve the satisfactory level of stability. The result shows that the machine can have much improved stability with relatively simple design changes, and also can improve the surface quality of the products.

• Journal of Pharmaceutical Investigation
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• 제39권4호
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• pp.263-267
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• 2009

The purpose of this study is to evaluate the efficacy of stipulated cleaning process, and the prohibition of cross-contamination and microbiological contamination, which inadequate cleaning in multi-production could occur, through cleaning validation of multi-purpose facility used to produce five biopharmaceutical products as sterile injection. After production of five biopharmaceutical products such as hGH, rhGCSF, rhEPO, rhFSH and rhIFN using vial filling machine, the cleaning validation such as residual analysis of active ingredients or human serum albumin, measurement of total organic carbon (TOC), residual analysis of detergent and microbiological contamination were carried out. In the case of rhGH and rhGCSF clean validations, drug residues were not detected. Furthermore, in the case of rhEPO, rhFSH and rhIFN clean validations, human serum albumin residues were not detected. At TOC (total organic carbon) analysis, all clean validations gave the TOC of about average 137.93%, not more than 150% of acceptance criteria. At sodium analysis for the checking of residues of cleaning agent, sodium residues were not detected. In sterility test, they showed no microbiological contamination of bacteria and fungi. Thus, this cleaning validation was determined as successful in protection of cross-contamination and induction of safety in multi-purpose facility.

• 한국화재소방학회논문지
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• 제13권3호
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• pp.19-26
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• 1999

이산화탄소 소화설비는 가스계 소화설비 중 비용의 저렴함과 작동후의 청결함, 그리고 절연성등의 특성으로 인하여 통신기기설, 전산실, 전기실 등에 많이 사용되고 있다. 이산화탄소는 저장시 액체이다가 방출과 동시에 가스상태로 기화하는데 이때 온도가 급격히 내려간다. 이러한 냉각효과에 의하여 반도체장비나 정보저장장치에 손상을 줄 수 있다. 본 연구는 이산화탄소 방사시 구획내부의 온도분포와 손상정도를 규명하여 차후 연구의 기초자료를 제공하고 $CO_2$소화설비 설계나 관련규정의 정비에 도움이 되고자 시행했다. $CO_2$ 소화설비 방사 시 노즐부분의 순간방출온도는 $-82.53^{\circ}C$까지 내려갔다. 소화약제가 모두 방사되는 1분경의 실내평균온도는 $-40^{\circ}C$이며 이는 충분히 정보저장 장치류에 피해를 입힐 수 있는 온도이다. 플로피 디스켓을 설치하고 실험한 결과 70%의 고장율을 보였다. 컴퓨터를 넣고 실제 화재를 일으켜 실험한 결과, 특별한 고장이 없었으나, 작동으로 인한 내부의 열과의 온도차이에 의하여 수증기가 응결되고 녹아 흐르는 현상을 보여 Water Damage의 발생가능성을 발견할 수 있었다. 또한 저온지속시간(-5$^{\circ}C$기준)이 각 시나리오에서 평균 5분이상 나타났으며, 만약 실내의 단열과 밀폐조건이 더욱 좋은 경우라면 더 장시간 지속될 수 있다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 추계학술대회
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• pp.409-411
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• 2013

본 논문은 인접 심볼 간의 간섭(ISI)이 발생하지 않는 최대 데이터 전송률인 Nyquist rate 보다 빠르게 데이터를 전송하는 방법인 Faster than Nyquist(FTN)을 다룬다. FTN 신호는 인접 심볼 간의 간섭을 일으키지만, 신호대역폭을 유지하면서 비트 전송률을 증가시킨다. 그러므로 FTN에 의한 ISI를 보상해주는 것이 필요하다. 본 논문에서는 FTN 신호를 제안하는 BCJR Equalizer 와 Turbo Equali zation을 이용하여 복호한다. BCJR Equalizer를 이용하여 최대한 인접 심볼 간의 간섭을 복원한 신호를 LDPC 복호기에 입력해주어 복호를 한다. 그리고 이 과정을 반복하는 Turbo Equalization을 이용해 성능을 높인다. 마지막으로 FTN 신호의 축소 %별로 성능을 비교한다.