• Title/Summary/Keyword: RI

Search Result 7,224, Processing Time 0.036 seconds

Molecular imaging of atherosclerosis using reporter gene system

  • Yoo, Ran Ji;Lee, Kyochul;Kang, Joo Hyun;Lee, Yong Jin
    • Journal of Radiopharmaceuticals and Molecular Probes
    • /
    • v.4 no.1
    • /
    • pp.26-31
    • /
    • 2018
  • Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using $^{99m}Tc-SPECT$. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.

The Comparative Consideration on the Basic pattern of Geo-go-ri (저고리 원형제도의 비교고찰)

  • 정옥임
    • Journal of the Korean Home Economics Association
    • /
    • v.32 no.1
    • /
    • pp.211-228
    • /
    • 1994
  • We consider the irrational part of the basic pattern drafting of the Geo-Ko-ri so that we want to design it more scientically. So there are problems which is found after we considered with comparison about the existingly basic pattern drafting of Geo-go-ri. (1) there is a difference between the practical and Calculation. (2) The part of the curved line was mad indistinctly There is a difference betweence the calculating expression and calculating value. (4) There are some parts which lack objectivity about the reference size. (5) The calculating method of Collar-width and Neck-Nidth are not formative and rational. These are items that we must consider and study further. Especially if we can make up of the scientific form in consideration of the formativeness focused on "git" I think it will make a great contribution to not only the standardization of the basic pattern of Geo-go-ri and the use of the use of education but also the manufacture of individual clothing the production by Auto CAD. Auto CAD.

  • PDF

A Comparative - Research on the Residence Disposition and Feature of Ground Plan a Clan village in Kyuong-buk Area (경북지방 동성마을의 주거배치 및 평면특성에 관한 비교 연구)

  • Kim, Young-Man;Kwak, Dong-Yeob
    • Proceeding of Spring/Autumn Annual Conference of KHA
    • /
    • 2003.11a
    • /
    • pp.235-242
    • /
    • 2003
  • This reserch is to compare and analyze of the residence disposition and feature of ground plan on Seomi 2 Dong in An-dong and Hyun-ri in Mun-gyong. The scope of this reserch concentrated on 33-housed which are 12-housed in Seomi 2 Dong and 21-housed in Hyun-ri. The focus of this reserch is mainly to investigate the characteristic of the site, and ground plans on individual houses. As result of it, there are mostly Yeo-Kan houses (six spans sized) on Seomi 2-dong village in An-Dong on the other hand there are a lot of Straight-Houses in Hyun-ri in Mun-gyong. Otherwise in characteristic of residence, There is dissimilarity between Seomi 2-dong which located in mountainous districts has space organization of utilitarian and Hyun-Ri has justification primacy as a farm village.

  • PDF

Isolation of Proteinase Inhibitor II Genes from Potato (감자로부터 단백질분해효소 억제제 II 유전자의 분리)

  • 이종섭
    • Journal of Plant Biology
    • /
    • v.32 no.2
    • /
    • pp.79-87
    • /
    • 1989
  • Southern hybridization of genomic DNAs with radioactively labeled cDNA of tomato proteinase inhibitor II revealed that proteinase inhibitor II proteins in potato plants are encoded by a family of about 10 related sequences. Screening of potato EcoRI genomic library with the cDNA resulted in isolation of 13 recombinant phage clones which carry 3 different genomic regions. Of these clones, clones 8, 18, and 39 were subjected to restriction mapping and subcloning. Further characterization of the subclones of clones 8, 18 and 39 indicated that two inhibitor II genes are present on a 8.0 kb EcoRI fragment of clone 8, one on 3.3 and 0.8 kb EcoRI fragments of clone 18 and two genes on a 13.5 kb EcoRI fragment of clone 39.

  • PDF

Heavy Metal Distribution in Soils from the Maehyang-ri Inland Shooting Range Area (매향리 내륙 사격장 토양의 중금속 오염 분포)

  • Lee, Jun-Ho;Park, Kap-Song
    • Journal of Korean Society on Water Environment
    • /
    • v.24 no.4
    • /
    • pp.407-414
    • /
    • 2008
  • This study was conducted to evaluate the heavy metal contamination in the soils of Maehyang-ri inland shooting range area. The texture of the Maehyang-ri inland shooting range soil was sandy. Extraction of heavy metals reached quasi-equilibrium within 6 hours using shaking with 0.1 N HCl. 95% and 94% of extraction efficiency was observed for Cu and Pb in the Maehyang-ri shooting range soils, respectively. And Cu and Pb contamination of level of the T-1 region soil was $114.4{\pm}5.7mg/kg$ and $362.3{\pm}20.5mg/kg$. This may be due to the effects of mineralogical factor, soil particle size and un-residual fractions such as exchangeable, carbonate, Fe-Mn oxide and organic+sulfide.

A Study on the Youth's Rural Rehabilitation Movement in Shiryang-ri, Yesan under Japanese Rule (일제하 예산군 시량리 청년들의 농촌개발운동에 관한 연구)

  • Kim, Myung-Hee;Choe, Pyeong-Ik;Yoon, Jun-Sang
    • Journal of Agricultural Extension & Community Development
    • /
    • v.16 no.2
    • /
    • pp.385-404
    • /
    • 2009
  • The youth's rural rehabilitation movement started the crusade against illiteracy and poverty with all young educated elites including Whang Jongjin(a student of Yesan Public Agricultural High School) of the village, Shiryang-ri. Deoksan-myon. Yesan-gun. Among others, Patriot Youn(1908-1932) initiated the movement. The main projects of the agricultural extension were the Evening School(1926), Reading Club, the Woljin.Hoe(1929), Puheung.Won(1928), a Mutual Financing Association for Swine Farming, Sweet Potato Cultivation, Cooperative Planting, the Shuam.Sports Club and Consumer's Cooperative Society. The idea in Nongmindokbon (Famer's Text, 1927) is based on liberalism, equality, independence, a pioneer and cooperative spirit or realization of a physiocratical Utopia. Most references about Patriot Youn are concerned with his heroic deed in Shanghai, however the youth in Shinyang-Ri are typical agricultural extension workers or in other words, a forerunner of Saemaul Undong.

  • PDF

방사선동위원소를 이용한 밀도/수분함량 측정계기의 회로설계

  • 송정호;황주호;길경석;김기준
    • Proceedings of the Korean Nuclear Society Conference
    • /
    • 1997.05b
    • /
    • pp.365-372
    • /
    • 1997
  • 이 연구의 목적은 밀도측정 및 수분함량측정용 RI 계기의 개발에 있다. 방사성동위원소를 이용하여 성토시공의 현장다짐 밀도 및 수분함량 측정에 이용되곤 있는 RI 계기는 중성자 검출부분, 감마선 검출부분, 고전압 공급부분, 마이크로 컴퓨터 부분으로 크게 나눌 수 있다. 감마선을 검출하는 G-M 검출기는 그 특징으로 인해 방사선검출 전기회로가 간단하다. 그러나 열중성자를 검출하는 He-3 검출기는 검출기에서 발생하는 신호원이 매우 작아서 검출회로의 상호 간섭으로 인한 전기적 잡음이 발생한다 이 잡음을 제거하는 것이 He-3 중성자 검출기로 열중성자를 검출하는데 중요한 문제이다. 본 연구에서 제작하는 RI 계기는 원자력법에서 제한하는 방사능 이하를 (100$\mu$Ci 의 밀봉선원) 사용하므로 종래의 RI 계기에 비해 방사선의 검출수가 줄어든다. 이에 따라 검출기의 개수를 늘려서 방사선을 검출해야 한다. 또한 본 연구에서는 He-3검출기의 검출 스펙트럼을 분석하여 적정한 방사선 검출 측정영역을 결정하였다.

  • PDF

Synthesis and evaluation of metal purine-type complexes for lung cancer imaging

  • Kang, Kyeung Jun;Ko, In Ok;Park, Ji-Ae;Kim, Jung Young
    • Journal of Radiopharmaceuticals and Molecular Probes
    • /
    • v.5 no.1
    • /
    • pp.61-68
    • /
    • 2019
  • Purine type compounds has been recently reported to cause the death for lung cancer cell, related to microtubules-targeting agents (MTAs). Therefore it can be used to develop as theranostic radiopharmceuticals in nuclear medicine or gadolinium-based MRI imaging agents by chelate chemistry. In the study, we tried to chemically bind a DOTA chelate on the end of purine compound and obtained a specific conjugate of DOTA-purine for metal coordination. In particular, radiometal like Cu-64, for the development of MRI imaging agents, can be utilized to choice good candidates before the synthesis of gadolinium complexes. By the screening of radioisotope technique, Gd-DOTA-purine type complex was successfully prepared and showed MRI imaging for lung cancer cell into the mouse model.

Differential regulation of phospholipase $C\gamma$ isoforms through Fc$\varepsilon$RI, high affinity IgE receptor

  • Yoon, Eung-Joo;Beom, Sun-Ryeo;Kim, Kyeong-Man
    • Proceedings of the PSK Conference
    • /
    • 2003.10b
    • /
    • pp.93.3-94
    • /
    • 2003
  • The signaling components of high affinity IgE receptor (Fc RI) were searched by yeast-hybrid screening of the cDNA library constructed from RBL-2H3 cells. The cytoplasmic part of the Fc RI- chain was found to specifically interact with PLC 2, and further comparatives studies were conducted focusing on the differential regulation of two PLC- isoforms through Fc RI. The inhibitors of Src, Syk, and protein kinase C similarly affected the tyrosine phosporylations of PLC 1 and PLC 2 but the inhibitors of PI3-kinase and p42/44 ERK effectively inhibited the activation of PLC 1 but not PLC 2. (omitted)

  • PDF

Investigation of the location of Jagiso eunchon in Goheung-hyeon and review the characteristics of Undae-ri kiln (고흥현 자기소(磁器所) 은촌(犾村)의 위치 탐색과 운대리 가마터 성격 검토)

  • SUNG Yungil
    • Korean Journal of Heritage: History & Science
    • /
    • v.56 no.4
    • /
    • pp.72-92
    • /
    • 2023
  • As described above, the location of Jagiso eunchon in Goheung-hyeon and the nature of Undae-ri kiln site were examined. Goheung-hyeon's administrative agency was moved to Joyang-hyeon, which is now Joseong-myeon, Boseong-gun in 1395. Therefore, Goheung-hyeon Jagiso Eunchon in Sejongsillok Jiriji corresponding to 1424~1432 should be found in the west of Joseong-myeon, Boseong, where the administrative agency was moved in 1395. Among the four boundaries of Goheung-hyeon recorded in the 『Sejongsillok』 Jiriji, it is recorded as 2-ri by the sea in the south and 8-ri by Nakan in the east. If the current Goheung-hyeon is Goheung-hyeon's administrative agency in the Sejongsillok Jiriji Records Compilation Period, it cannot be the boundary the south and east mentioned above. This is because it cannot be 2-ri from the current Goheung-eup to the sea in the south, and Nakan is close to the north, not the east, as recorded. However, it has already been suggested that Joyanghyeonseong(朝陽縣城), located in Gonae Village, Ucheon-ri, Josung-myeon, Boseonggun is an Goheunghyeon's administrative agency. And if the four-way boundary of Goheung-hyeon was converted into the current distance unit based on this place(Joyanghyeonseong, 朝陽縣城), an approximate result could be obtained even if it did not exactly match. Therefore, it is highly likely that Goheung-hyeon's administrative agency, which was moved to Joyang-hyeon, Boseong in 1395, is Gonae Village, Ucheon-ri, JoSeong-myeon, Boseong. Jagiso eunchon(犾村) in Goheung-hyeon can be interpreted as a "dog-shouting village." It is thought to be a meaning structure of "animal + sound". A place name thought to have the same structure was identified in Jeongheung-ri, west of Ucheon-ri, Joseongmyeon, Boseong. It is the name of a village called Hoeum-dong(虎吟洞), and it is interpreted as the sound of a tiger or the bark of a tiger, which is the same as the meaning structure of Eunchon. However, there is Gaesan Village in the south of Hoeum-dong, and a Buncheong ware kiln site was identified around it. At this kiln site, a fragment of carved Buncheong ware engraved with the character "Eon", which corresponds to the right stroke of the character "Seom (贍)" in the name "Naeseom (內贍)" was identified. A small amount of Buncheong ware and Joseon celadon pieces were also identified. It can be seen that the Buncheong ware paid to the government was made by checking the Buncheong ware with the government name engraved on it. On the west side of Joyanghyeonseong Fortress in Ucheon-ri, joseong-myeon, Boseong, which was the administrative agency of Goheung-hyeon and the area around the Gaesan Buncheong ware kiln site in Jeongheung-ri, where the Buncheong ware paid to the government was, is thought to be Jagiso Eunchon, Goheung-hyeon. Jagiso and Dogiso are located in the four directions based on the administrative agency. Naturally, the location of Jagiso and Dogiso is also determined on where the administrative agency of Hyeon is. Since the Goheung-hyeon's administrative agency in the early Joseon Dynasty was moved to Ucheon-ri, joseong-myeon, Boseong-myeon, it is necessary to naturally find Jagiso and Dogiso in Boseong. In addition, regarding the nature of the kiln site in Undae-ri, the aspects of the excavated relics were considered. As a result, it is believed that the Undae-ri kiln site functioned as a jagiso in Heungyang-hyeon from February 1441 to the 1470s. If so, the "Ye" Buncheong ware, which was collected around Undae-ri kiln No. 7, could be naturally understood.