• Journal of Acupuncture Research
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• v.29 no.5
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• pp.127-137
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• 2012

Objectives : The purpose of this study is to review on current status of use and measurement condition of heart rate variability(HRV) by reviewing clinical studies published in journal of Korean medicine registered Korea citraion index(KCI). Methods : One hundred twenty articles were found by searching the representative Korean databases. At first analysis was performed by current status of use(journal, academic field of corresponing author, purpose of study, disease of subject, HRV measurement devices, intervention methods and tests compared to HRV). At second analysis was performed by measurement condition(uncontrolled study, relaxation before measurement, measurement position, measurement place, measurement time period and restriction of smoking, alcohol, caffeine, meal). Results : The analysis showed that department of acupuncture & moxibustion, department of oriental neuropsychiatry are major part in journal & academic field. The purpose of study were classified under studies to verify therapeutic effect on normal subject(39%), to verify therapeutic effect on the patients(8%), to investigate characteristics of the patients(34%) and to be compared with other test(19%). Disease of subject & measurement devices in article were so various. Major intervention methods were acupuncture(61.4%), mind-body intervention(19.2%). Studies that measurement condition were not controlled were relax time(24%), measurement position(19%), measurement place(26%), measurement time period(91%) and restriction of smoking, alcohol, caffeine, meal(49%). Conclusions : This study showed that current status of use of HRV is widespread in Korean medicine but more controlled measurement conditon are needed to get more reliable result from clinical studies and to improve diagnosis and treatment of Korean medicine.

• The Journal of the Acoustical Society of Korea
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• v.22 no.7
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• pp.603-611
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• 2003

This paper proposes an effective feature compensation scheme based on speech model for achieving robust speech recognition. Conventional model-based method requires off-line training with noisy speech database and is not suitable for online adaptation. In the proposed scheme, we can relax the off-line training with noisy speech database by employing the parallel model combination technique for estimation of correction factors. Applying the model combination process over to the mixture model alone as opposed to entire HMM makes the online model combination possible. Exploiting the availability of noise model from off-line sources, we accomplish the online adaptation via MAP (Maximum A Posteriori) estimation. In addition, the online channel estimation procedure is induced within the proposed framework. For more efficient implementation, we propose a selective model combination which leads to reduction or the computational complexities. The representative experimental results indicate that the suggested algorithm is effective in realizing robust speech recognition under the combined adverse conditions of additive background noise and channel distortion.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.46 no.1
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• pp.68-75
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• 2009

In this paper, an efficient proposed CDR(Clock and Data Recovery Circuits) using 1/4-rate clock based on dual-interpolator is proposed. The CDR is aimed to overcome problems that using multi-phase clock to decrease the clock generator frequency causes side effects such as the increased power dissipation and hardware complexity, especially when the number of channels is high. To solve these problems, each recovery part generates needed additional clocks using only inverters, but not flip-flops while maintaining the number of clocks supplied from a clock generator the same as 1/2-rate clock method. Thus, the reduction of a clock generator frequency using 1/4-rate clocking helps relax the speed limitation and power dissipation when higher data rate transfer is demanded.

• The Journal of Internal Korean Medicine
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• v.16 no.1
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• pp.104-129
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• 1995

Sabaeksan and Sabaeksangagaryureuk, a traditional prescription, has been used in Korea for many centuries as a treatment for chronic respiratory disease. The purpose of the present study was to determine the effect of Sabaeksan and Sabaeksangagaryureuk on acetylcholine-induced tracheal smooth muscle contraction in guinea pigs and norepinephrine-induced vascular smooth muscle contraction in pigs. Guinea pig (500g, female) were killed by CO2 exposure and a segment (8-10mm) of the thoracic trachea from each guinea pig and renal artery from each pig were cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of acetylcholine (Ach) and norepinephrine (NE) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for acetylcholine (10-7-10-4M) and norepinephrine (10-7-10-4M). Contractions of tracheal smooth muscle evoked by Ach ($ED_{50}$) were inhibited significantly by Sabaeksan and Sabaeksangagaryureuk. Propranolol (10-7M) slightly but significantly attenuated the inhibitory effects of Sabaeksan and Sabaeksangagaryureuk. Indomethacin and methylene blue (10-7M) did not significantly alter the inhibitory effect of Sabaeksan and Sabaeksanga-garyureuk. Contractions of vascular smooth muscle evoked by NE (NE50) were inhibited significantly by Sabaeksan and Sabaeksangagaryureuk. Propranolol (10-7M) slightly but significantly attenuated the inhibitory effects of Sabaeksan and Sabaeksangagaryureuk. Indomethacin and methylene blue (10-7M) did not significantly alter the inhibitory effect of Sabaeksan and Sabaeksangagaryureuk. These results indicate that Sabaeksan and Sabaeksangagaryureuk can relax acetylcholine-induced contraction of guinea pig tracheal smooth muscle, and norepinephrine-induced contraction of pig vascular smooth muscle that this inhibition involves, in part, the relation of adrenergic receptor.

• IMMUNE NETWORK
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• v.2 no.4
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• pp.208-216
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• 2002

Background: Reactive oxygen and nitrogen are produced by rheumatoid arthritis (RA) synovial tissue and can induce mutations in key genes. Normally, this process is prevented by a DNA mismatch repair (MMR) system that maintains sequence fidelity. Key members of the MMR system include MutS${\alpha}$ (comprised of hMSH2 and hMSH6), which can sense and repair single base mismatches and 8-oxoguanine, and MutS${\beta}$ (comprised of hMSH2 and hMSH3), which repairs longer insertion/deletion loops. Methods: To provide further evidence of DNA damage, we analyzed synovial tissues for microsatellite instability (MSI). MSI was examined by PCR on genomic DNA of paired synovial tissue and peripheral blood cells (PBC) of RA patients using specific primer sequences for 5 key microsatellites. Results: Surprisingly, abundant MSI was observed in RA synovium compared with osteoarthritis (OA) tissue. Western blot analysis of the same tissues for the expression of MMR proteins demonstrated decreased hMSH6 and increased hMSH3 in RA synovium. To evaluate potential mechanisms of MMR regulation in arthritis, fibroblast-like synoviocytes (FLS) were isolated from synovial tissues and incubated with the nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP). Western blot analysis demonstrated constitutive expression of hMSH2, 3 and 6 in RA and OA FLS. When FLS were cultured with SNAP, the RA synovial pattern of MMR expression was reproduced (high hMSH3, low hMSH6). Conclusion: Therefore, oxidative stress can relax the DNA MMR system in RA by suppressing hMSH6. Decreased hMSH6 can subsequently interfere with repair of single base mutations, which is the type observed in RA. We propose that oxidative stress not only creates DNA adducts that are potentially mutagenic, but also suppresses the mechanisms that limit the DNA damage.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1999.06a
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• pp.187-207
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• 1999

The thermal distributions near the growth interface of 150mm CZ crystals were measured by three thermocouples installed at the center, middle (half radius) and edge (10m from surface) of the crystals. The results show that larger growth rates produced smaller thermal gradients. This contradicts the widely used heat flux balance equation. Using this fact, it si confirmed in CZ crystals that the type of point defects created is determined by the value of the thermal gradient (G) near the interface during growth, as already reported for FZ crystals. Although depending on the growth systems the effective lengths of the thermal gradient for defect generation are varied, were defined the effective length as 10mm from the interface in this experiment. If the G is roughly smaller than 20C/cm, vacancy rich CZ crystals are produced. If G is larger than 25C/cm, the species of point defects changes dramatically from vacancies to interstitial. The experimental results which FZ and CZ crystals are detached from the melt show that growth interfaces are filled with vacancy. We propose that large G produces shrunk lattice spacing and in order to relax such lattice excess interstitial are necessary. Such interstitial recombine with vacancies which were generated at the growth interface, next occupy interstitial sites and residuals aggregate themselves to make stacking faults and dislocation loops during cooling. The shape of the growth interface is also determined by the distributions of G across the interface. That is, the small G and the large G in the center induce concave and convex interfaces to the melt, respectively.

• Journal of Dental Rehabilitation and Applied Science
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• v.33 no.3
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• pp.169-177
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• 2017

Patient management is considered an important factor in dental field. The aim of this review is to analyze the efficacy of hypnosis to treat fear, anxiety, pain, stress of dental patients, and see how it can be adopted in dentistry for improving patient satisfaction. Medline research was carried out to find the use of hypnosis in dentistry and other aspects of hypnosis in medical area. It can help patient more comfortable, relax, and accordingly reduce patient's negative feelings such as fear, anxiety, pain, stress during dental treatment. Also, it affects patient recovery after surgery by accelerating healing speed and reinforce immune system. When hypnosis is used with other anesthetic method, it can reduce the use of main medication, leading to reduce possibility of side effect. Therefore, using Hypnosis can give patients more comfortable dental experience, both mentally and physically, ultimately making patients more satisfied with the dental treatment.

• Journal of the Korean Society of Radiology
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• v.8 no.7
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• pp.397-400
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• 2014

This study purpose is to know about the effect of Cobb's angle of scoliosis patient by Pilates ecercise. It was executed for prove this exercise with Pilates Postural Correct Exercise(PCE), Spine Stretching Exercis(SSE), Muscle Strengthing Exercise(MSE). PCE is useful for unbalanced muscle energy and SSE gives relax for hypertensioned muscles and MSE is correcting balance for prime mover and secondary mover and so it will be recovery for elasticity and flexibility of paraspine muscles. The method study was proved with a Cobb's angle measurement of Lumbar spine by X-ray test before and after. As a result for the test, Cobb's angle by X-ray it shows reduced about 5 degree in statistics(p=0.005). And so It shows the Pilates exercise gives reduce for Scoliosis.

• Science of Emotion and Sensibility
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• v.18 no.3
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• pp.63-70
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• 2015

This study identified heart response of participants while listening to sounds which have 1/f fluctuations with exponent ${\alpha}$ gradient. The participants were engaged in emotional stress work. Prior studies related to 1/f fluctuation sound have reported that sound source can alleviate psychological and physiological state of users. Subjects of this study were exposed to sound with three levels of ${\alpha}$ gradient. Heart response of subjects were measured with Photoplethysmography(PPG) sensor simultaneously. The dependent variables of this study were beat per minute(BPM), very low frequency percent of pulse rate variability (VLF percent), the standard deviation of all normal RR intervals (SDNN), and high frequency power(HF power). Subject showed arousal response when exposed to sound with exponent ${\alpha}$ gradient of 3 whereas the sound with exponent ${\alpha}$ gradient of 1 and 2 resulted in relax effect. The characteristic of 1/f fluctuation sounds can be applied to alleviate stress for employers under emotional labor.

• Journal of Families and Better Life
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• v.29 no.2
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• pp.13-22
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• 2011

Since environmental problems were globalized, discussions on 'Sustainable Development' started from Rio Declaration on Environment and Development(Rio Agenda 21). In Korea, the idea of 'Green Growth' was introduced and generalized since the celebration speech made on 8.15(Independence Day of South Korea) on 2008. And Low Carbon- Green Growth Basic Law was established on 2010. There are 3 strategies and 10 sub-tasks to achieve green country-traffic and green revolution of life. Family resource management is capable of changing life style from energy wasty to ecologically green. The value of family resource management plays a critical role in changing the lifestyle through influencing the goal and standard setting. So, this study is aimed to suggest the green value and green way of life from the perspective of family resource management. Results are as follow. First, the green value is to change from 'material-oriented' to 'people-oriented'. The 'material-oriented value pursues pleasure from possessing, but the 'people-oriented' value pursues pleasure from being itself. Second, the change from the value of 'human-mastery of the nature' to the value of 'mother -nature' is necessary. The value of 'human-mastery of the nature' seeks pleasure from the velocity and tangible outcome. But the value of 'mother- nature' seeks pleasure from the time to relax and slow way of life. 'Third, the change from the value of 'individualism' to the value of 'community sprit' is necessary. Individualism focuses on man's achievement, which may fall into family egoism. And the green way of life suggests the change from 'results-oriented' to 'enjoy the process itself", from 'consumption' to 'ecological restoration' and from 'work to home and then home to community'.