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The Role of SDF-1𝛼-CXCR4/CXCR7 in Migration of Human Periodontal Ligament Stem Cells

  • Jialei Xu;Fan Yang;Shuhan Luo;Yuan Gao;Dingming Huang;Lan Zhang
    • International Journal of Stem Cells
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    • v.16 no.2
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    • pp.180-190
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    • 2023
  • Background and Objectives: Regenerative endodontic procedures (REPs) are a research hotspot in the endodontic field. One of the biggest problems of REPs is that it is difficult to realize regeneration of pulp-dentin complex and functional reconstruction. The reason is still not clear. We hypothesize that the migration may be different in different dental stem cells. Periodontal ligament stem cells (PDLSCs) may migrate faster than stem cells of apical papilla (SCAPs), differentiating into cementum-like tissue, bone-like tissue and periodontal ligament-like tissue and, finally affecting the outcomes of REPs. Hence, this study aimed to explore the mechanism that regulates the migration of PDLSCs. Methods and Results: After isolating and culturing PDLSCs and SCAPs from human third molars, we compared the migration of PDLSCs and SCAPs. Then we investigated the role of SDF-1𝛼-CXCR4/CXCR7 axis in PDLSC migration. We further investigated the impact of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on PDLSC migration and the potential mechanism. PDLSCs showed better migration under both noninflammatory and inflammatory conditions than SCAPs. SDF-1𝛼 can promote the migration of PDLSCs by elevating the expression of CXCR4 and CXCR7, increasing the interaction between them, promoting expression of 𝛽-arrestin1 and activating the ERK signaling pathway. P. gingivalis LPS can promote the migration of PDLSCs toward SDF-1𝛼 through increasing the expression of CXCR4 via the NF-𝜅B signaling pathway, promoting the expression of 𝛽-arrestin1, and activating the ERK signaling pathway. Conclusions: This study helped elucidate the potential reason for the difficulty in forming pulp-dentin complex.

Transcholecystic Duodenal Drainage as an Alternative Decompression Method for Afferent Loop Syndrome: Two Case Reports (들장관증후군의 대체 감압 치료로서 경담낭 십이지장 배액술: 두 건의 증례 보고)

  • Jihoon Hong;Gab Chul Kim;Jung Guen Cha;Jongmin Park;Byunggeon Park;Seo Young Park;Sang Un Kim
    • Journal of the Korean Society of Radiology
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    • v.85 no.3
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    • pp.661-667
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    • 2024
  • Afferent loop syndrome (ALS) is a rare complication of gastrectomies and gastrointestinal reconstruction. This can predispose patients to fatal conditions, such as cholangitis, pancreatitis, and duodenal perforation with peritonitis. Therefore, emergency decompression is necessary to prevent these complications. Herein, we report two cases in which transcholecystic duodenal drainage, an alternative decompression treatment, was performed in ALS patients without bile duct dilatation. Two patients who underwent distal gastrectomy with Billroth II anastomosis sought consultation in an emergency department for epigastric pain and vomiting. On CT, ALS with acute pancreatitis was diagnosed. However, biliary access could not be achieved because of the absence of bile duct dilatation. To overcome this problem, a duodenal drainage catheter was placed to decompress the afferent loop after traversing the cystic duct via a transcholecystic approach. The patients were discharged without additional surgical treatment 2 weeks and 1 month after drainage.

A method for localization of multiple drones using the acoustic characteristic of the quadcopter (쿼드콥터의 음향 특성을 활용한 다수의 드론 위치 추정법)

  • In-Jee Jung;Wan-Ho Cho;Jeong-Guon Ih
    • The Journal of the Acoustical Society of Korea
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    • v.43 no.3
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    • pp.351-360
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    • 2024
  • With the increasing use of drone technology, the Unmanned Aerial Vehicle (UAV) is now being utilized in various fields. However, this increased use of drones has resulted in various issues. Due to its small size, the drone is difficult to detect with radar or optical equipment, so acoustical tracking methods have been recently applied. In this paper, a method of localization of multiple drones using the acoustic characteristics of the quadcopter drone is suggested. Because the acoustic characteristics induced by each rotor are differentiated depending on the type of drone and its movement state, the sound source of the drone can be reconstructed by spatially clustering the results of the estimated positions of the blade passing frequency and its harmonic sound source. The reconstructed sound sources are utilized to finally determine the location of multiple-drone sound sources by applying the source localization algorithm. An experiment is conducted to analyze the acoustic characteristics of the test quadcopter drones, and the simulations for three different types of drones are conducted to localize the multiple drones based on the measured acoustic signals. The test result shows that the location of multiple drones can be estimated by utilizing the acoustic characteristics of the drone. Also, one can see that the clarity of the separated drone sound source and the source localization algorithm affect the accuracy of the localization for multiple-drone sound sources.

Morbidity and Mortality After Laparoscopy-Assisted Distal Gastrectomy and Totally Laparoscopic Distal Gastrectomy to Treat Gastric Cancer: An Interim Report: A Phase III Multicenter, Prospective, Randomized Trial (The KLASS-07 Trial)

  • Han Hong Lee;Chang Min Lee;Moon-Soo Lee ;In Ho Jeong;Myoung Won Son;Chang Hyun Kim;Moon-Won Yoo;Sung Jin Oh;Young-Gil Son;Sung Il Choi;Mi Ran Jung;Sang Hyuk Seo;Shin-Hoo Park;Seong Ho Hwang;Jae-Seok Min;Sungsoo Park
    • Journal of Gastric Cancer
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    • v.24 no.3
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    • pp.257-266
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    • 2024
  • Purpose: We conducted a randomized prospective trial (KLASS-07 trial) to compare laparoscopy-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG) for gastric cancer. In this interim report, we describe short-term results in terms of morbidity and mortality. Methods and Methods: The sample size was 442 participants. At the time of the interim analysis, 314 patients were enrolled and randomized. After excluding patients who did not undergo planned surgeries, we performed a modified per-protocol analysis of 151 and 145 patients in the LADG and TLDG groups, respectively. Results: The baseline characteristics, including comorbidity status, did not differ between the LADG and TLDG groups. Blood loss was somewhat higher in the LADG group, but statistical significance was not attained (76.76±72.63 vs. 62.91±65.68 mL; P=0.087). Neither the required transfusion level nor the operation or reconstruction time differed between the 2 groups. The mini-laparotomy incision in the LADG group was significantly longer than the extended umbilical incision required for specimen removal in the TLDG group (4.79±0.82 vs. 3.89±0.83 cm; P<0.001). There were no between-group differences in the time to solid food intake, hospital stay, pain score, or complications within 30 days postoperatively. No mortality was observed in either group. Conclusions: Short-term morbidity and mortality rates did not differ between the LADG and TLDG groups. The KLASS-07 trial is currently underway.

Interpreting the Meaning of War Heritage Through World Heritage Case Studies (세계유산 사례를 통해 본 전쟁 유산의 의미 해석)

  • LEE Jaei;SUNG Jongsang
    • Korean Journal of Heritage: History & Science
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    • v.57 no.3
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    • pp.202-222
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    • 2024
  • War is one of the most tragic and destructive incidents in human history, and it destroys precious cultural heritage. However, even amidst such devastation, certain cultural heritages convey messages of peace and human rights. This study aims to provide an in-depth interpretation of the significance of cultural heritage related to war. The research method involved an extensive review of theoretical discussions on war-related heritage. Based on this foundation, 18 cases of war heritage registered as UNESCO World Heritage Sites were selected. These cases were classified and analyzed into three categories: "physical traces of war and military fortresses," "memories of war and atrocities, and messages of peace," and "restoration and reconstruction of cities destroyed by war." The results of this study confirm that war heritage encompasses not only physical evidence of war but also multilayered and complex meanings such as the memories and traumas of war, scars and healing, and conflict and reconciliation. Based on these findings, the study proposes that war heritage should be reinterpreted and expanded to represent a "heritage of peace" and transcend its role of only including physical traces of war to embody the values of peace. This demands a shift in perception that confronts the painful memories of war while transforming them into assets for building peace. Furthermore, it urges the active exploration of ways to utilize war heritage for peaceful purposes. This study distinguishes itself from existing research by deepening the academic discourse on war-related heritage and providing a theoretical foundation for the registration of war-related heritage as World Heritage Sites.

Assessing the relationship between muscle-to-fat ratio in pork belly and Boston butt using magnetic resonance imaging

  • Sheena Kim;Jeongin Choi;Eun Sol Kim;Gi Beom Keum;Hyunok Doo;Jinok Kwak;Sumin Ryu;Yejin Choi;Juyoun Kang;Haram Kim;Yeongjae Chae;Yujung Lee;Dongjun Kim;Kuk-Hwan Seol;Sun Moon Kang;Yunseok Kim;Pil Nam Seong;In-Seon Bae;Soohyun Cho;Hyo Jung Kwon;Samooel Jung;Youngwon Lee;Hyeun Bum Kim
    • Korean Journal of Agricultural Science
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    • v.51 no.2
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    • pp.187-192
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    • 2024
  • This research aimed to investigate the relationship between meat quality and muscle-to-fat ratio in specific cuts of pork (pork belly and Boston butt) utilizing magnetic resonance imaging (MRI). Twenty-eight pigs were selected, and 24 hours post-slaughter, pork belly and Boston butt samples were individually extracted from the left half carcass for MRI assessment. The MRI scans were reviewed using the Picture Archiving and Communications System. Muscle and fat volumes in the pork belly and Boston butt from the cross-sectional images captured by MRI were estimated using Vitrea workstation version 7. Subsequently, these data were processed using Vitrea post-processing software to automatically determine the volumes, measured in milliliters (mL). Additionally, a three-dimensional reconstruction of the organ being studied was generated. The relationship between regions (pork belly and Boston butt) was assessed using Pearson's correlation coefficient, and statistical analysis was conducted using Graph Pad Prism 8. The muscle-to-fat ratio determined by MRI for pork belly was 1 : 0.64, whereas for Boston butt it was 1 : 0.35. Results of comparing the muscle-fat ratio, the correlation coefficient between pork belly and Boston butt was found to be 0.6127 (R2 = 0.3754, p < 0.001) based on MRI analysis. As a result of measuring the muscle-to-fat ratio using MRI as a non-destructive approach, there was a positive correlation between the muscle-to-fat ratios of pork belly and Boston butt.

Restoration-oriented anatomical analysis of alveolar bone at mandibular first molars and implications for immediate implant placement surgery: a CBCT study

  • Quan Shi;Yang Huang;Na Huo;Yi Jiang;Tong Zhang;Juncheng Wang
    • The Journal of Advanced Prosthodontics
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    • v.16 no.4
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    • pp.212-220
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    • 2024
  • PURPOSE. This cone-beam computed tomography (CBCT) study aimed to analyze the anatomical characteristics of alveolar bone at mandibular first molar (MFM) and their implications for immediate implant placement surgery. MATERIALS AND METHODS. 100 patients with 140 MFMs were reviewed retrospectively. We first performed a 3D reconstruction of the patient's CBCT data to determine a reference plane with ideal implant placement and orientation. The following parameters of MFM region were analyzed: mesial-distal socket size (MDSS), buccal-lingual socket size (BL-SS), root furcation fornix to inferior alveolar nerve (IAN) distance (RF-I), interradicular bone thickness (IRB), mesial/distal root apex to the IAN distance (MRA-I/DRA-I), thickness of the buccal/lingual bone of the mesial root (MR-B/MR-L), thickness of the buccal/lingual bone of the distal root (DR-B/DR-L). RESULTS. The MD-SS of MFM was 8.74 ± 0.76 mm, and the BLSS was 8.26 ± 0.72 mm. The MR-B, DR-B was 1.01 ± 0.40 mm and 1.14 ± 0.50 mm, and the difference was statistically significant (P = .001). The values of the MR-L, DR-L were 2.71 ± 0.78 mm and 3.09 ± 0.73 mm, and the difference was also statistically significant (P < .001). The mean distance of RF-I was 15.68 ± 2.13 mm, and the MRA-I was 7.06 ± 2.22 mm, which was greater than that of DRA-I (6.48 ± 2.30 mm, P < .001). The IRB at 2 mm, 4 mm apical from the furcation fornix, and at apex level was 2.81 ± 0.50 mm, 3.30 ± 0.62 mm, and 4.44 ± 1.02 mm, respectively. CONCLUSION. There is relatively sufficient bone mass in interradicular bone in height, but an adequate width is lacking for the bone between the mesial and distal root after the extraction of the MFM for immediate implantation. The thickness of the MFM buccal bone is relative thin, especially for the mesial root.

A novel brief questionnaire using a face rating scale to assess dental anxiety and fear

  • Takuya Mino;Aya Kimura-Ono;Hikaru Arakawa;Kana Tokumoto;Yoko Kurosaki;Yoshizo Matsuka;Kenji Maekawa;Takuo Kuboki
    • The Journal of Advanced Prosthodontics
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    • v.16 no.4
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    • pp.244-254
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    • 2024
  • PURPOSE. This study aimed to evaluate the reliability and validity of a four-item questionnaire using a face rating scale to measure dental trait anxiety (DTA), dental trait fear (DTF), dental state anxiety (DSA), and dental state fear (DSF). MATERIALS AND METHODS. Participants were consecutively selected from patients undergoing scaling (S-group; n = 47) and implant placement (I-group; n = 25). The S-group completed the questionnaire both before initial and second scaling, whereas the I-group responded on the pre-surgery day (Pre-day), the day of implant placement (Imp-day), and the day of suture removal (Post-day). RESULTS. The reliability in the S-group was evaluated using the test-retest method, showing a weighted kappa value of DTA, 0.61; DTF, 0.46; DSA, 0.67; DSF, 0.52. Criterion-related validity, assessed using the State-Trait Anxiety Inventory's trait anxiety and state anxiety, revealed positive correlations between trait anxiety and DTA/DTF (DTA, ρ = 0.30; DTF, ρ = 0.27, ρ: correlation coefficient) and between state anxiety and all four items (DTA, ρ = 0.41; DTF, ρ = 0.32; DSA, ρ = 0.25; DSF, ρ = 0.25). Known-group validity was assessed using the initial data and Imp-day data from the S-group and I-group, respectively, revealing significantly higher DSA and DSF scores in the I-group than in the S-group. Responsiveness was gauged using I-group data, showing significantly lower DSA and DSF scores on post-day compared to other days. CONCLUSION. The newly developed questionnaire has acceptable reliability and validity for clinical use, suggesting its usefulness for research on dental anxiety and fear and for providing patient-specific dental care.

Performance of ChatGPT 3.5 and 4 on U.S. dental examinations: the INBDE, ADAT, and DAT

  • Mahmood Dashti;Shohreh Ghasemi;Niloofar Ghadimi;Delband Hefzi;Azizeh Karimian;Niusha Zare;Amir Fahimipour;Zohaib Khurshid;Maryam Mohammadalizadeh Chafjiri;Sahar Ghaedsharaf
    • Imaging Science in Dentistry
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    • v.54 no.3
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    • pp.271-275
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    • 2024
  • Purpose: Recent advancements in artificial intelligence (AI), particularly tools such as ChatGPT developed by OpenAI, a U.S.-based AI research organization, have transformed the healthcare and education sectors. This study investigated the effectiveness of ChatGPT in answering dentistry exam questions, demonstrating its potential to enhance professional practice and patient care. Materials and Methods: This study assessed the performance of ChatGPT 3.5 and 4 on U.S. dental exams - specifically, the Integrated National Board Dental Examination (INBDE), Dental Admission Test (DAT), and Advanced Dental Admission Test (ADAT) - excluding image-based questions. Using customized prompts, ChatGPT's answers were evaluated against official answer sheets. Results: ChatGPT 3.5 and 4 were tested with 253 questions from the INBDE, ADAT, and DAT exams. For the INBDE, both versions achieved 80% accuracy in knowledge-based questions and 66-69% in case history questions. In ADAT, they scored 66-83% in knowledge-based and 76% in case history questions. ChatGPT 4 excelled on the DAT, with 94% accuracy in knowledge-based questions, 57% in mathematical analysis items, and 100% in comprehension questions, surpassing ChatGPT 3.5's rates of 83%, 31%, and 82%, respectively. The difference was significant for knowledge-based questions(P=0.009). Both versions showed similar patterns in incorrect responses. Conclusion: Both ChatGPT 3.5 and 4 effectively handled knowledge-based, case history, and comprehension questions, with ChatGPT 4 being more reliable and surpassing the performance of 3.5. ChatGPT 4's perfect score in comprehension questions underscores its trainability in specific subjects. However, both versions exhibited weaker performance in mathematical analysis, suggesting this as an area for improvement.

Characteristics Analysis of Traffic Flow in BRT section according to Market Penetration Rates of Autonomous Vehicles (자율주행자동차 혼입률에 따른 BRT 구간 교통류 특성 분석)

  • Do, Myungsik;Chae, Un Hyeok
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.44 no.4
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    • pp.531-544
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    • 2024
  • The purpose of this study is to analyze traffic flow characteristics according to the market penetration rate (MPR) of autonomous vehicles (AV) on road sections where bus rapid transit (BRT) is actually operating. Furthermore, the maximum traffic volume was set through estimation of future traffic demand, and traffic flow characteristics were analyzed through traffic simulation for each scenario considering of a combination of BRT introduction and AV's MPR. To test statistical significance, Kruskal-Willis test and Jonckheere-Terpstra test were used to examine the impact of the market penetration rate of Autonomous vehicles on travel time and delay time etc. At the same time, the existence of the order relationship among travel time data according to the market penetration rate of autonomous vehicle was examined. As a result of the analysis, it was founded that the travel time significantly decreased as the MPR of AV increases in both intermittent flow and continuous flow environments. In particular, in the case of continuous flow, the law of increasing returns was satisfied in the effect of increasing travel speed and reducing travel time as the MPR of AV increases. The results of this study are expected to be used as a basic information for design plans for road reconstruction and space utilization after the commercialization of AV in the future.