• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2007년도 제38회 하계학술대회
• /
• pp.1599-1600
• /
• 2007

The DTL water skid cooling system and Resonant Control Cooling Systems (RCCS) will employ a control system that can be operated by a local, programmable logic controller (PLC), interfaced through a touch screen interface, mobile alarm SMS server system, or it can be operated through the PEFP global control system network. The RCCS is implemented using Experimental Physics and Control System (EPICS) based hardware and software and is integrated with other networked PEFP EPICS systems. This presentation discusses the features of the local control system.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2008년도 추계학술대회B
• /
• pp.2064-2069
• /
• 2008

The Resonance Control Cooling System (RCCS) prototype installed in KAERI site has been designed to control the resonant frequency of the normal conducting drift tube linac (DTL) for the Proton Engineering Frontier Project (PEFP). The RCCS water pumping skid is composed of two channels as a by-passing the cooling water and a plate heat exchanger. The required temperature can be achieved by mixing both channels in order to control its the resonant frequency at 350 MHz. The temperature controlled water pumping skid operates in combination with the Low Level Radio Frequency (LLRF) system. We have discussed the design, modeling with each components, control scheme, fabrication and test results of the water pumping skid for resonant frequency control of the DTL cavity. In conclusion, the fabricated RCCS prototype through the optimization of modeling has corresponded with the design requirement and concept.

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2003년도 추계학술발표대회 요약집
• /
• pp.153-153
• /
• 2003

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2004년도 추계학술발표회 발표논문집
• /
• pp.161-162
• /
• 2004

• Journal of Yeungnam Medical Science
• /
• 제23권1호
• /
• pp.82-89
• /
• 2006

최근 여러 종양에서 단백분해효소의 분비와 암의 악성도에 대한 연구가 이루어져 왔으며, 이를 신세포암종 환자의 예후 측정인자로 사용하려는 시도가 진행되고 있다. 이에 저자들은 제 4형 collagenase 중 대표적인 MMP-9의 발현정도를 정상 신조직과 신세포암종 조직에서 비교하였고, 또 암의 침윤 및 전이정도와의 관계와 다른 임상적 인자들과의 상관성을 분석하여 암의 단계적 진행과정에서의 MMP-9의 발현변화에 대하여 조사하였다. 그 결과 정상 신 조직에 비해 신세포암종 조직에서 MMP-9의 발현이 증가되며 암의 크기가 크고 혈관침범이 있으며 병기가 높을수록 MMP-9의 발현이 증가됨을 관찰할 수 있었다. 이는 MMP-9 발현의 증가가 신세포암종의 발생과정 및 암의 후기 진행에 관여함을 시사하므로 향후 신세포암종의 예후척도로 사용되어 치료방침을 결정하는데 도움을 줄 수 있을 것으로 생각한다.

• Journal of Korean Neurosurgical Society
• /
• 제66권1호
• /
• pp.82-89
• /
• 2023

Objective : Rathke's cleft cysts (RCCs) are nonneoplastic cysts. Most of them are asymptomatic and stable; when symptomatic, RCCs are surgically fenestrated and drained. However, the outcomes remain unclear. The authors evaluated the outcomes of RCC decompression. Methods : Between 2004 and 2019, 32 RCCs were decompressed in a single tertiary institution. The clinical characteristics, intraoperative findings, postoperative complications, and endocrinological and surgical outcomes were retrospectively reviewed. Patients who underwent sequential imaging at least twice and at least 12 months after surgery were included in the analysis. Results : Patients' mean age was 40.8±14.9 years, and 62.5% were women. The mean follow-up duration was 62.3±48.6 months. In 21 patients (65.6%), no residual cysts were identified on postoperative magnetic resonance imaging. Of the 18 patients with preoperative visual field defects, 17 (94.4%) experienced postoperative visual improvement. Postoperative complications included endocrinological deterioration in 11 patients (34.4%), permanent diabetes insipidus in 11 (34.4%), infection in four (12.5%), intrasellar hemorrhage in three (9.4%), and cerebrospinal fluid leak in two (6.3%). Follow-up images revealed cyst recurrence in nine patients (28.1%), an average of 20.4 months after surgery; in three patients, the cysts were symptomatic, and resection was repeated. Multivariable analysis revealed that postoperative endocrinological deterioration was the only independent factor associated with cyst recurrence (p=0.028; hazard ratio, 6.800). Conclusion : Our findings showed that although only cyst fenestration for decompression was performed to preserve pituitary function, more pituitary dysfunction occurred than expected. Besides, the postoperative hormonal deterioration itself acted as a risk factor for cyst recurrence. In conclusion, surgery for RCC should be more careful.

• Nuclear Engineering and Technology
• /
• 제56권3호
• /
• pp.832-845
• /
• 2024

Reactor cavity cooling systems (RCCSs) comprising passive safety features use the atmosphere as a coolant, which cannot be lost. However, their drawback is that they are easily affected by atmospheric disturbances. To realize the commercial application of the two types of passive RCCSs, namely RCCSs based on atmospheric radiation and atmospheric natural circulation, their safety must be evaluated, that is, they must be able to remove heat from the reactor pressure vessel (RPV) surface at all times and under any condition other than under normal operating conditions. These include both expected and unexpected natural phenomena and accidents. Moreover, they must be able to eliminate the heat leakage emitted from the RPV surface during normal operation. However, utilizing all of the heat emitted from the RPV surface increases the degree of waste heat utilization. This study aims to understand the characteristics and degree of passive safety features for heat removal by comparing RCCSs based on atmospheric radiation and atmospheric natural circulation under the same conditions. It was concluded that the proposed RCCS based on atmospheric radiation has an advantage in that the temperature of the RPV could be stably maintained against disturbances in the ambient air.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권9호
• /
• pp.4071-4075
• /
• 2015

Background: Retinoblastoma protein-interacting zinc finger gene 1(RIZ1) functions as a tumor suppressor. Hypermethylation-mediated RIZ1 silencing has been reported in several cancers, but not in renal cell carcinoma (RCC) yet. Materials and Methods: We examined the RIZ1 expression and methylation in a panel of RCC cell lines and 50 primary tumors using semiquantitative/quantitative polymerase chain reaction (PCR), methylation specific PCR, and bisulfite sequencing genomic. We also explored the relationship between methylation status of RIZ1 and clinicopathological features in RCC patients. Results: RIZ1 expression was down-regulated or lost in OS-RC-2, 769-P, Caki-1, 786-O and A498 RCC cell lines. Restored expression of RIZ1 was detected after addition of 5-aza-2'-deoxycytidine with/without trichostatin A, suggesting that DNA methylation directly mediates its silencing. The RIZ1 expression was significantly reduced in RCCs compared to adjacent non-malignant renal samples (P<0.001). Aberrant methylation was detected in 15 of 50 (30%) RCCs and in 2 of 28 (7%) adjacent non-malignant renal samples (P=0.02). No statistically significant correlation between methylated and unmethylated cases with regard to age, gender, pathological stage and grade was observed. Conclusions: RIZ1 expression is down-regulated in human RCC, and this down-regulation is associated with methylation. RIZ1 methylation may play a role in renal carcinogenesis.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권1호
• /
• pp.363-365
• /
• 2015

Background: Kidney cancer is the third most frequent urologic cancer in Lebanon after prostate and bladder cancer, accounting for 1.5% of all diagnosed cancers. In this paper, we report the histologic characteristics and distribution of kidney cancer, never described in Lebanon or the Middle East. Materials and Methods: Pathology results of operated kidney cancer were collected during a two year period (2010-2011) from two different Lebanese hospitals (Hotel-Dieu de France University Hospital and Saint Joseph Hospital). A total of 124 reports were reviewed and analyzed according to WHO classification of 2009. Results: The 124 patients diagnosed with kidney cancer had a median age of 62.4 [18-86], 75% being men and 25% women. Some 71 % of the lesions were renal cell carcinoma (RCC), 25.8% had a urothelial histology, 1.6% were lymphomas and 1.6% were metastases to the kidney. Patients having RCC had a median age of 60.3 [18-85], 77.3% were men and 22.7% women. Of the RCCs, 59.1% were clear cell carcinoma, 22.7% papillary, 11.4% chromophobic, 3.4% rom the collecting ducts of Bellini and 3.4% were not otherwise classified. Conclusions: Histological distribution of Lebanese kidney cancer seems unusual when compared to the literature. The percentage of urothelial renal pelvis tumors is strikingly high. Moreover, clear cell carcinoma accounts for only 59.1% of RCCS in contrast to the 75% described elsewhere, while papillary carcinoma represents more than 22.7% compared to 10%.

• 한국도로학회논문집
• /
• 제11권3호
• /
• pp.23-32
• /
• 2009

본 연구에서는 콘크리트포장의 단면보수용 복합재료 8개(초속경시멘트계열 : RCC 3종, 폴리머시멘트계열 : PCC 2종, 폴리머계열 : PC 3종)에 대해 역학적인 특성 및 내구성 실험을 수행하였다. 역학적 특성으로서 응결시간, 압축강도, 휨강도, 탄성계수, 경화수축에 대해 실험하였고, 내구성으로서 동탄성계수 및 동결융해 후 부착강도, 흡수율, 내화학성, 자외선 노출 실험을 수행하였다. 탄성계수는 RCC>PCC>PC계열의 순으로 나타나서 폴리머가 사용되면서 연성의 특성을 보였다. 초기 재령에서의 폴리머 콘크리트의 경화수축이 상대적으로 큰 것으로 관찰되었지만 재령 28일에서는 다소 안정된 결과를 보였다. 상대동탄성계수, 흡수율, 10% $CaCl_2$와 10% $Na_2SO_4$의 화학용액을 사용한 내화학성 실험결과 PC계열, PCC계열, RCC계열 순으로 저항성이 우수한 것으로 나타났다. 200~300회 동결융해 이후의 부착강도 실험결과 PC-2를 제외하고는 모두 1.3MPa 이상을 확보하였고, PC 및 PCC 제품의 부착강도가 RCC 제품보다 전체적인 면에서 우수한 것으로 나타났다. 또한 시편을 500시간동안 자외선 노출시험 결과 모든 패치재료 시편에서 균열 및 표면 결함 등이 발견되지 않아 PC 및 PCC 제품의 자외선에 대한 내구성이 확보됨을 확인하였다.