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A Study on Preparation of Water in Oil in Water (W1/O/W2) Emulsion Containing Titrated Extract of Centella asiatica (센텔라 아시아티카 정량추출물을 함유한 Water in Oil in Water (W1/O/W2) 에멀젼 제조에 관한 연구)

  • Seo, Dong Hoan;Lee, Hong Seon;Yoon, Jong Hyuk;Kim, Youn Joon;Byun, Sang Yo
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.41 no.4
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    • pp.303-313
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    • 2015
  • Titrated extract of Centella asiatica (TECA), which is poorly soluble in water is well known for wound healing and anti wrinkle agent. This study was conducted to find the optimum condition for the preparation of water in oil in water ($W_1/O/W_2$) emulsion containing TECA. Solubility of TECA were measured by UV spectrophotometer. 2.55 g of TECA was dissolved in solution composed of dipropylene glycol (40.0 g), ethanol (20.0 g), and water (10.0 g). Factors affecting stability of the emulsions ($W_1/O$, $W_1/O/W_2$) was investigated. The optimum conditions for the preparation of $W_1/O$ emulsion was composed of dipropylene glycol : ethanol : water : TECA in a weight ratio of 40.0 : 20.0 : 10.0 : 2.5 for water phase and squalane : cetyl PEG/PPG-10/1 dimethicone : cetearyl alcohol in a weight ratio of 22.5 : 4.0 : 2.5 for oil phase. The optimum conditions for the preparation of $W_1/O/W_2$ multiple emulsion was composed of water : $W_1/O$ emulsion : polysorbate 80 : carbomer : triethanolamine in a weight ratio of 55.8 : 40.0 : 4.0 : 0.1 : 0.1.

A STUDY OF ORAL STATUS OF MENTAL RETARDED CHILDREN (정신(精神) 박약아(薄弱兒)의 구강(口腔) 상태(狀態)에 관(關)한 고찰(考察))

  • Jhee, In-Ae
    • Journal of the korean academy of Pediatric Dentistry
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    • v.8 no.1
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    • pp.77-88
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    • 1981
  • The purpose of this study was to make a comprehensive study & evaluation of the oral status of mental retarded children. The auther examined intraorally 486 (male; 311, female;175) mental retarded children. The result was as follows; (General mental retarded children means the children who live in their parent's home, & orphan mental retarded children means the children who live in orphanage.) 1. The dft rate was 31.6% in general mental retarded children (G.m.r.c.) & 20.7% in orphan mental retarded children (O. m. r. c.). The dft index was 3.73 in G.m.r.c. & 2.15 in O.m.r.c. 2. The DMFT rate was 24.6% in female G.m.r.c., 16.7% in male G.m.r.c., 12.7% in female O.m.r.c., 8.4% in male O.m.r.c. The DMFT index was 4.94 in female G.m.r.c., 4.01 in male G.m.r.c., 1.40 in male O.m.r.c., 2.75 in female O.m.r.c. 3. The malocclusion prevalence was 57.3%. the class I malocclusion was 14.2% Class II malocclusion 19.3%, Class III malocclusion 23.5%. The children with Down's syndrome had 60.0% of class III malocclusion prevalence. 4. The dental calculus index was 1.97 in male O.m.r.c., 1.81 in female O.m.r.c., 1.30 in male G.m.r.e., 1.13 in female G.m.r.c. 5. The dental plaque index was 3.06 in female G.m.r.c., 3.00 in male Gm.r.e. 2.70 in male O.m.r,c., 2.32 in female O.m.r.c.

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유럽의 최근 콜드체인 R&D 동향

  • O, Jong-Taek
    • The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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    • v.40 no.6
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    • pp.34-39
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    • 2011
  • 식품의 생산부터 최종 소비자에 이르기까지 그 품질 유지와 지구환경 보존을 위한 콜드체인의 최근 유럽 연구개발 동향을 알아본다.

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Cloning and Characterization of a Novel Carboxylesterase Gene from Cow Rumen Metagenomic Library (소 반추위 메타게놈에서 새로운 carboxylesterase 유전자 클로닝 및 유전산물의 특성)

  • Asraful Islam, Shah Md.;Kim, Min-Keun;Renukaradhya, K. Math;Srinivasa, Reddy R.N.;Kim, Eun-Jin;Kim, Jung-Ho;Kim, Hoon;Yun, Han-Dae
    • Journal of Life Science
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    • v.20 no.9
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    • pp.1306-1313
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    • 2010
  • The gene encoding esterase enzyme was cloned from a metagenomic library of cow rumen bacteria. The esterase gene (est1R) was 2,465 bp in length, encoding a protein of 366 amino acid residues, and the molecular weight of the enzyme was 61,166 Da. Est1R of rumen cosmid library shared 5.9% amino acid identity with Est1R (P37967) of PNB carboxylesterase, 6.1% with Est1R (1EEAA) of acetylcholinesterase and 6.1% with Est1R (1H23A) of chain A. BlastP in NCBI database analysis of Est1R revealed that it was not homologous to previous known lipases and esterases. Est1R showed optimum activity at pH 7.0 and $40^{\circ}C$. On the other hand, the enzyme was found to be most active without organic solvent, followed by 95% activity with methanol, and the enzyme activity was highly affected by hexane (lost 51% activity). Therefore, the novel esterase gene est1R is likely obtainable from cow rumen metagenome and may be utilized for industrial purposes.

The Ratio-Based N Staging System Can More Accurately Reflect the Prognosis of T4 Gastric Cancer Patients with D2 Lymphadenectomy Compared with the 7th American Joint Committee on Cancer/Union for International Cancer Control Staging System

  • Hwang, Sung Hwan;Kim, Hyun Il;Song, Jun Seong;Lee, Min Hong;Kwon, Sung Joon;Kim, Min Gyu
    • Journal of Gastric Cancer
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    • v.16 no.4
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    • pp.207-214
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    • 2016
  • Purpose: The utility of N classification has been questioned after the 7th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) was published. We evaluated the correlation between ratio-based N (rN) classification with the overall survival of pathological T4 gastric cancer patients who underwent D2 lymphadenectomy. Materials and Methods: We reviewed 222 cases of advanced gastric cancer patients who underwent curative gastrectomy between January 2006 and December 2015. The T4 gastric cancer patents were classified into four groups according to the lymph node ratio (the number of metastatic lymph nodes divided by the retrieved lymph nodes): rN0, 0%; rN1, ${\leq}13.3%$; rN2, ${\leq}40.0%$; and rN3, >40.0%. Results: The rN stage showed a large down stage migration compared with pathological T4N3 (AJCC/UICC). There was a significant difference in overall survival between rN2 and rN3 groups in patients with pT4N3 (P=0.013). In contrast, the difference in metastatic lymph nodes was not significant in these patients (${\geq}16$ vs. <15; P=0.177). In addition, the rN staging system showed a more distinct difference in overall survival than the pN staging system for pathological T4 gastric cancer patients. Conclusions: Our results confirm that rN staging could be a good alternative for pathological T4 gastric cancer patients who undergo D2 lymphadenectomy. However, before applying this system to gastric cancer patients who undergo D2 lymphadenectomy, a larger sample size is required to further evaluate the usefulness of the rN staging system for all stages, including less advanced stages.

Effect of Treatment of Lipopolysaccharides on Reproductive Performance in Lactating Dairy Cows (젖소에 있어서 Lipopolysaccharide의 처리가 번식 성적에 미치는 영향)

  • Baek K.S.;Park, S.B.;Park, S.J.;Kim, H.S.;Lee, W.S.;Jeong, G.Y.;Lee, H.J.;Hur, T.Y.;Jeon B.S.;Ahn B.S.;Khan M. Aiumal
    • Journal of Embryo Transfer
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    • v.21 no.3
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    • pp.241-245
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    • 2006
  • This study was carried out to investigate the effect of intra-uterine infusion of lipopolysaccharide (LPS) on reproductive performance in lactating dairy cows. Conception rate at first service was higher (56.0%) in dairy cows treated with LPS compared to non-treated cows (20.0 %). Cumulative conception rate by overall services (more than 2 services) after LPS treatment was also higher (64.0%) in dairy cows treated with LPS compared to non-treated cows (40.0%). Services per conception was significantly higher in control ($2.0{\pm}0.1$) compared with LPS ($1.2{\pm}0.4$) treated group (p<0.05).

EVALUATION OF ENTEROCOCCUS FAECALIS REMOVAL EFFICACY OF THE ENDOVAC® AND ENDOACTIVATOR® INTRACANAL IRRIGATION METHODS (EndoVac®과 EndoActivator®를 이용한 근관세척법의 Enterococcus faecalis 제거 효율 평가)

  • Song, Seung-Gon;Park, Se-Hee;Cho, Kyung-Mo;Kim, Jin-Woo
    • Restorative Dentistry and Endodontics
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    • v.34 no.5
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    • pp.390-396
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    • 2009
  • The aim of this study was to evaluate endodontic irrigation methods with $EndoVac^{(R)}$ and $EndoActivator^{(R)}$ in the elimination of Enterococcus faecalis from the root canals. Extracted 70 human single-rooted teeth were used. The canals were instrumented by a crown-down technique with .04 taper ProFile to ISO size 40. After the teeth were autoclaved, the canals were inoculated with E. faecalis and incubated for 48 h. The teeth were randomly divided into three experimental groups of 20 teeth each according to canal irrigation methods and two control groups as follows: group 1 - $EndoVac^{(R)}$; group 2 - $EndoActivator^{(R)}$; group 3-Conventional needle irrigation method. After canal irrigation using 2.5% NaOCl. first samples (S1) were taken using sterile paper point. And the canals were filled with sterile brain heart infusion (BHI) broth and incubated for 24 h, then second samples (S2) were taken. The samples were cultured on BHI agar plate to determine the numbers of colony forming units (CFU). In first sampling (S1), only one canal of conventional method among the all experimental groups was positive cultured. In second sampling (S2), $EndoVac^{(R)}$ group showed the least positive culture numbers of E. faecalis. There was statistically significant difference between the $EndoVac^{(R)}$ and conventional needle irrigation methods in the mean value of Log CFU. According to the results of this study, $EndoVac^{(R)}$ showed better efficacy than conventional needle irrigation method in the elimination of E. faecalis from the root canal.

Effects of Dietary Supplementation of Fermented Microbial Complex (Eco-Farm$^{(R)/}$) on Performance of Finishing Pigs and Air Quality in Finishing Building (복합미생물 발효제(Eco-Farm$^{(R)}$ ) 급여가 비육돈 생산성과 돈사 환경개선에 미치는 영향)

  • 김두환;정치섭
    • Journal of Animal Environmental Science
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    • v.9 no.1
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    • pp.27-34
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    • 2003
  • This experiment was carried out to investigate the effect of dietary supplementation of fermented microbial complex(Eco-Farm$^{(R)}$) on performance of finishing pigs and indoor air quality in finishing building. A total 135 crossbred [(Landrace ${\times}$ Yorkshire) ${\times}$ Duroc] pigs were randomly arranged into nine groups and assigned to three treatments. Pigs were fed a basal diet supplemented with 0, 0.5 and 1% level of fermented microbial complex(Eco-Farm$^{(R)}$) until the market weight for 40 days of the experimental period. Average daily feed intake and feed conversion ratio were significantly improved (p<0.05) with dietary supplementation of 0.5% fermented microbial complex (Eco-Farm$^{(R)}$): however, average daily gain was not affected by dietary supplementation of fermented microbial complex(Eco-Farm$^{(R)}$). Indoor ammonia and hydrogen sulfide concentrations in the finishing building were significantly(p<0.05) decreased by dietary supplementation of fermented microbial complex(Eco-Farm$^{(R)}$) compared with those of control, however, indoor carbon dioxide concentration was not affected by dietary supplementation of fermented microbial complex(Eco-Farm$^{(R)}$). In conclusion, the results obtained from this experiment suggest that the dietary supplementation of fermented microbial complex(Eco-Farm$^{(R)}$) for finishing pigs improved performance and indoor air quality in the finishing building.hing building.

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Optimization of Approximate Modular Multiplier for R-LWE Cryptosystem (R-LWE 암호화를 위한 근사 모듈식 다항식 곱셈기 최적화)

  • Jae-Woo, Lee;Youngmin, Kim
    • Journal of IKEEE
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    • v.26 no.4
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    • pp.736-741
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    • 2022
  • Lattice-based cryptography is the most practical post-quantum cryptography because it enjoys strong worst-case security, relatively efficient implementation, and simplicity. Ring learning with errors (R-LWE) is a public key encryption (PKE) method of lattice-based encryption (LBC), and the most important operation of R-LWE is the modular polynomial multiplication of rings. This paper proposes a method for optimizing modular multipliers based on approximate computing (AC) technology, targeting the medium-security parameter set of the R-LWE cryptosystem. First, as a simple way to implement complex logic, LUT is used to omit some of the approximate multiplication operations, and the 2's complement method is used to calculate the number of bits whose value is 1 when converting the value of the input data to binary. We propose a total of two methods to reduce the number of required adders by minimizing them. The proposed LUT-based modular multiplier reduced both speed and area by 9% compared to the existing R-LWE modular multiplier, and the modular multiplier using the 2's complement method reduced the area by 40% and improved the speed by 2%. appear. Finally, the area of the optimized modular multiplier with both of these methods applied was reduced by up to 43% compared to the previous one, and the speed was reduced by up to 10%.