Browse > Article
http://dx.doi.org/10.15230/SCSK.2015.41.4.303

A Study on Preparation of Water in Oil in Water (W1/O/W2) Emulsion Containing Titrated Extract of Centella asiatica  

Seo, Dong Hoan (Cosmax R&I Center)
Lee, Hong Seon (Cosmetic Science Major, Applied Biotechnology Department, Graduate School, Ajou University)
Yoon, Jong Hyuk (Cosmax R&I Center)
Kim, Youn Joon (Cosmax R&I Center)
Byun, Sang Yo (Cosmetic Science Major, Applied Biotechnology Department, Graduate School, Ajou University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.41, no.4, 2015 , pp. 303-313 More about this Journal
Abstract
Titrated extract of Centella asiatica (TECA), which is poorly soluble in water is well known for wound healing and anti wrinkle agent. This study was conducted to find the optimum condition for the preparation of water in oil in water ($W_1/O/W_2$) emulsion containing TECA. Solubility of TECA were measured by UV spectrophotometer. 2.55 g of TECA was dissolved in solution composed of dipropylene glycol (40.0 g), ethanol (20.0 g), and water (10.0 g). Factors affecting stability of the emulsions ($W_1/O$, $W_1/O/W_2$) was investigated. The optimum conditions for the preparation of $W_1/O$ emulsion was composed of dipropylene glycol : ethanol : water : TECA in a weight ratio of 40.0 : 20.0 : 10.0 : 2.5 for water phase and squalane : cetyl PEG/PPG-10/1 dimethicone : cetearyl alcohol in a weight ratio of 22.5 : 4.0 : 2.5 for oil phase. The optimum conditions for the preparation of $W_1/O/W_2$ multiple emulsion was composed of water : $W_1/O$ emulsion : polysorbate 80 : carbomer : triethanolamine in a weight ratio of 55.8 : 40.0 : 4.0 : 0.1 : 0.1.
Keywords
titrated extract of Centella asiatica; $W_1/O/W_2$ multiple emulsion; $W_1/O$ emulsion; solubility; ethanol;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 I. D. Kim, R. H. Kwon, Y. Y. Heo, H. J. Jung, H. Y. Kang, and B. J. Ha, Supercritical extraction of oriental herb: anti-aging and anti-wrinkles effects, Kor. J. Biotechnol. Bioeng., 23(6), 529 (2008).
2 E. J. Lee, The development of anti-wrinkle cosmeceutical ingredients from glehniae radix cum rhizoma, Master's Thesis Dissertation, Chung Ang Univ., Seoul, Korea (2010).
3 Y. K. Jo, The development of anti-wrinkle cosmeceutical ingredients from leonuri herba extrat, Master's Thesis Dissertation, Chung Ang Univ., Seoul, Korea (2011).
4 S. Lee, Novel nantural products as active material for beauty food, J. Food Sci., 40, 10 (2008).
5 M. S. Lim, M. A Pack, and S. N. Park, Preparation of nano-emulsion containing Polygonum aviculare extract for enhanced transdermal delivery, Appl. Chem. Eng., 23(2), 222 (2012).
6 D. W. Kim, M. H. Cho, S. Y. Park, J. H. Lee, G. W. Lee, M. S. Park, J. K. Park, and U. K. Jee, Preparation and evaluation of titrated extract of Centella asiatica niosome/w/o system cream for site specific targeting, J. Kor. Pharm. Sci., 32(4), 291 (2002).
7 A. Segall, M. Sosa, A. Alami, C. Enero, F. Hormaechea, M. T. Pizzorno, C. Bregni, and R. Serrao, Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application, J. Cosmet. Sci., 55, 449 (2004).
8 E. Touitou, N. Dayana, L. Bergelsonb, B. Godina, and M. Eliaza, Ethosomes-novel vesicular carriers for enhanced delivery: characterization and skin penetration properties, J. of Controlled Release, 65(3), 403 (2000).   DOI
9 A. C. Williams and B. W. Barry, Penetration enhancers, Advanced Drug Delivery Reviews, 64, 128 (2012).   DOI
10 K. J. Lissant, Structure of high-internal-phase-ratio emulsions, J. Colloid Interface Sci., 47(2), 416 (1974).   DOI
11 W. H. Kim, K. S. Lee, and K. K. Lee, An experimental study on the property and stability of W/O emulsion by various structures of emulsifier, J. Soc. Cosmet. Scientists Korea, 38(2), 119 (2012).   DOI
12 R. Jantharaprapap and G. Stagni, Effects of penetaration enhancers on in vitro permeability of meloxicam gels, Int. J. Pharm., 343, 26 (2007).   DOI
13 J. Y. Yeon, B. R. Shin, T. G. Kim, J. M. Seo, C. H. Lee, S. G. Lee, and H. B. Pyo, A study on emulsion stability of O/W and W/S emulsion according to HLB of emulsifier, J. Soc. Cosmet. Scientists Korea, 40(3), 227 (2014).   DOI
14 E. J. Lim, A study on the release of electrolyte from W/O/W multiple emulsion stabilized with xanthan gum and cetostearyl alcohol, Master's Thesis Dissertation, Kon Kuk Univ., Seoul, Korea (1995).
15 C. K. Zhoh, K. Y. Lee, and D. N. Kim, The influences of fatty alcohol and fatty acid on rheological properties of o/w emulsion, J. Soc. Cosmet. Scientists Korea, 35(2), 103 (2009).
16 W. Liu, D. Sun, C. Li, Q. Liu, and J. Xu, Formation and stability of paffin oil-in-water nano-emulsions prepared by the emulsion inversion point method, J. Colloid. Interface. Sci., 303, 557 (2006).   DOI
17 N. Anarjan and C. P. Tan, Effects of selected polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions, Molecules, 18, 768 (2013).   DOI
18 C. Anchisi, A. M. Maccioni, C. Sinico, and D. Valenti, Stability studies of new cosmetic formulations with vegetable extracts as functional agents, Il Farmaco, 56, 427 (2001).   DOI