• Advances in materials Research
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• v.11 no.1
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• pp.59-73
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• 2022

In the construction industry, thin-walled frame elements with very slender open cross-sections and low torsional stiffness are often subjected to a complex loading condition where axial, bending, shear and torsional stresses are present simultaneously. Hence, these often fail in instability even before the yield capacity is reached. One of the most common instability conditions associated with thin-walled structures is Lateral Torsional Buckling (LTB). In this study, a first order Generalized Beam Theory (GBT) formulation and numerical analysis of cold-formed steel lipped channel beams (C80×40×10×1, C90×40×10×1, C100×40×10×1, C80×40×10×1.6, C90×40×10×1.6 and C100×40×10×1.6) subjected to uniform moment is carried out to predict pure Lateral Torsional Buckling (LTB). These results are compared with the Finite Element Analysis of the beams modelled with shell elements using ABAQUS and analytical results based on Euler's buckling formula. The mode wise deformed shape and modal participation factors are obtained for comparison of the responses along with the effect of varying the length of the beam from 2.5 m to 10 m. The deformed shapes of the beam for different modes and GBTUL plots are analyzed for comparative conclusions.

• ETRI Journal
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• v.29 no.5
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• pp.633-640
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• 2007

We report an experimental demonstration of 40 Gbps all-optical 3R regeneration with all-optical clock recovery based on InP semiconductor devices. We also obtain alloptical non-return-to-zero to return-to-zero (NRZ-to-RZ) format conversion using the recovered clock signal at 10 Gbps and 40 Gbps. It leads to a good performance using a Mach-Zehnder interferometric wavelength converter and a self-pulsating laser diode (LD). The self-pulsating LD serves a recovered clock, which has an rms timing jitter as low as sub-picosecond. In the case of 3R regeneration of RZ data, we achieve a 1.0 dB power penalty at $10^{-9}$ BER after demultiplexing 40 Gbps to 10 Gbps with an eletroabsorption modulator. The regenerated 3R data shows stable error-free operation with no BER floor for all channels. The combination of these functional devices provides all-optical 3R regeneration with NRZ-to-RZ conversion.

• Biomedical Science Letters
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• v.19 no.4
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• pp.348-352
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• 2013

microRNAs (miRNAs) play pivotal roles in controlling cell proliferation and differentiation. miRNA expression in human is becoming recognized as a new molecular mechanism of carcinogenesis. microRNA-34a (miR-34a), a member of the p53 network, was found to be regulated in multiple types of tumor. The purpose of this study was to define roles of miR-34a expression in cervical intraepithelial neoplasia with human papillomavirus infection, and its relationship with p53 protein expression. This study was performed to analyze expression of miR-34a by using qRT-PCR, and to evaluate p53 protein expression by using immunohistochemistry in 40 cases. Down-regulation of miR-34a expression was detected in 27 (67.5%) out of 40 cases and Immunoreactivity for p53 was found in 17 (42.5%) out of 40 cases. Nineteen (82.6%) of the 23 cases with a negative p53 expression showed a down-regulation miR-34a expression, there was a significant associations between miR-34a and p53 protein expression (P=0.04). These results suggest that miRNA-34a expression tend to be reduced depending on the advanced histologic grade, and down-regulation of miR-34a expression might be associated with inactivation of p53 protein expression by human papillomavirus infection.

• Honam Mathematical Journal
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• v.40 no.2
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• pp.211-218
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• 2018

Let R be a commutative Noetherian ring, a be an ideal of R and M be an R-module. It is shown that if $Ext^i_R(R/a,M)$ is minimax for all $i{\leq}{\dim}\;M$, then the R-module $Ext^i_R(N,M)$ is minimax for all $i{\geq}0$ and for any finitely generated R-module N with $Supp_R(N){\subseteq}V(a)$ and dim $N{\leq}1$. As a consequence of this result we obtain that for any a-torsion R-module M that $Ext^i_R(R/a,M)$ is minimax for all $i{\leq}dim$ M, all Bass numbers and all Betti numbers of M are finite. This generalizes [8, Corollary 2.7]. Also, some equivalent conditions for the cominimaxness of local cohomology modules with respect to ideals of dimension at most one are given.

• The Journal of the Korean life insurance medical association
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• v.2 no.1
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• pp.253-259
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• 1985

In medical selection of Daehan Education Insurance, for 6 months from June 1st, 1984 to November 30th, 1984 we examined 2523 persons, who were supposed to receive general test and Normal subject test Then we did syphilis test by selecting the way of R.P.R. card test and repeatedly confirming the examination serologically. The results are as follows: 1) As results of R.P.R. card test, 30 out of 1592 males are positive(1.89%) and 10 out of 931 females are positive(1.1%). 40 out of total 2523 persons are positive(1.6%). 2) As results of T.P.H.A, 28 out of 1592 males are positive(1.76%) and 9 out of 931 females are positive. 37 out of total 2523 persons are positive(1.47%). 3) When R.P.R. card test is compared with T.P.H.A test, 40 persons by R.P.R. showed that 2 males and female are negative and only 37 persons are positive in T.P.H.A test. And so the result agreement rate of R.P.R. card test and T.P.H.A test showed 92.5%. 4) In the age-distribution males have high positive rates in 30's and 40's and females have high positive rates in 20's and 40's when the subjects are normal.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1851-1855
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• 2015

Background: There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. In this study, we aimed to investigate the miRNA expression profiles in surgically resected specimens of patients with recurrent and non-recurrent colorectal cancer. Materials and Methods: The study population included 40 patients with stage II colorectal cancer (20 patients with recurrent tumors, and 20 sex and age matched patients without recurrence), who underwent curative colectomy between 2004 and 2011 without adjuvant therapy. Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. Data analyses were carried out using SPSS 15 software. Values were statistically significantly changed in 40 cancer tissues when compared to the corresponding 40 normal colonic tissues (p<0.001). MiR-30d, miR-133a, miR-143, miR-145 and miR-362 expression was statistically significantly downregulated in 40 resected colorectal cancer tissue samples (p<0.001). When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. However in 20 non-recurrent cancer tissues, miR-133a expression was not significantly downregulated, moreover miR-133b expression was significantly upregulated (p<0.05). Conclusions: Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.

• Bulletin of the Korean Mathematical Society
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• v.40 no.1
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• pp.29-51
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• 2003

In this paper we construct a natural filtration associated to the plethysm $S_{r}(\wedge^2 \varphi)$ over arbitrary commutative ring R. Let $\phi$ : G longrightarrow F be a morphism of finite free R-modules. We construct the natural filtration of $S_{r}(\wedge^2 \varphi)$ as a $GL(F){\times}GL(G)$- complex such that its associated graded complex is ${\Sigma}_{{\lambda}{\in}{\Omega}_{\gamma}}=L_{2{\lambda}{\varphi}$, where ${{\Omega}_{\gamma}}^{-}$ is a set of partitions such that $│\wedge│\;=;{\gamma}\;and\;2{\wedge}$ is a partition of which i-th term is $2{\wedge}_{i}$. Specializing our result, we obtain the filtrations of $S_{r}(\wedge^2 F)\;and\;D_{r}(D_2G).

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.4
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• pp.373-382
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• 2014

The skin is an organ that covers the outside of the human body. And it regulates body temperature, performs sensory function, deliveries the drug, and represents the abnormality of the internal organs. For these reasons, people have been expressing the condition of the body based on the state of the skin of the face to detect sign of health, "you look well", "face with vitality". Depending on the degree of aging and the environment, it is a fact that skin color, skin texture, moisture and firmness could be different. In particular, the color of the skin acts as a factor that affects to determine the subjective impression such as beauty and charm. We could expect consumer's demand through the market of whitening cosmetics and skin treatment. However, existing most of the cosmetics focus on improving whiteness. The number of studies that focused on skin color is not enough. In this study, we found out the skin color condition by carrying out surveys of 100 women between 30s and 40s. Our study would be very useful to develop new cosmetic products and to satisfy customer's needs.

• Journal of Pharmaceutical Investigation
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• v.40 no.1
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• pp.33-38
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• 2010

Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. The oral administration of sibutramine is followed by its dose-related side effects. In this study, sibutramine was formulated into drug in adhesive (DIA) patches in an attempt to overcome these problems. The effects of different formulation variables including pressure-sensitive adhesive (PSA), loading amount of drug, thickness of matrix and enhancer on the skin permeation of the drug were evaluated using excised hairless mouse skin. In the acrylic adhesive with carboxyl functional group, low release of sibutramine was observed due to the strong interaction between carboxyl group of adhesive and amine group of sibutramine. The acrylic adhesive without functional group provided good adhesion force and allowed high drug loading. Changing drug load as well as thickness of the matrix was found to alter permeation rate. $Crovol^{(R)}$ PK40 and $Crovol^{(R)}$ A40, were found to be effective enhancers for sibutramine. The optimized patch contained 20% sibutramine, and 5% $Crovol^{(R)}$ A40 as permeation enhancer, in $80\;{\mu}m$ thick Duro-$Tak^{(R)}$ 87-9301 matrix.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.1
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• pp.89-94
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• 2014

Stem bark extracts of Fraxinus rhynchophylla Hance were found to contain two major bioactive components, esculetin and esculin. Esculetin substantially inhibited melanogenesis in B16F10 melanoma cells, with an $IC_{50}$ value of $2.8{\mu}M$, and reduced melanin synthesis in Melan-A cells. Moreover, esculetin suppressed melanin biosynthesis by inhibiting mushroom tyrosinase activity, with an $IC_{50}$ value of $40{\mu}M$. Taken together, these results suggest that esculetin could serve as an effective skin-lightening agent that inhibits melanin production by regulating the activity of melanogenic enzymes.