Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Depigmenting Effects of Esculetin and Esculin Isolated from Fraxinus rhynchophyllaHance

물푸레나무로부터 분리된 Esculetin와 Esculin의 미백 효능

  • 홍용덕 ((주)아모레퍼시픽 기술연구원) ;
  • 남미희 ((주)아모레퍼시픽 기술연구원) ;
  • 이창석 ((주)아모레퍼시픽 기술연구원) ;
  • 신송석 ((주)아모레퍼시픽 기술연구원) ;
  • 박영호 ((주)아모레퍼시픽 기술연구원)
  • Received : 2013.10.07
  • Accepted : 2013.10.21
  • Published : 2014.03.31
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Abstract

Stem bark extracts of Fraxinus rhynchophylla Hance were found to contain two major bioactive components, esculetin and esculin. Esculetin substantially inhibited melanogenesis in B16F10 melanoma cells, with an $IC_{50}$ value of $2.8{\mu}M$, and reduced melanin synthesis in Melan-A cells. Moreover, esculetin suppressed melanin biosynthesis by inhibiting mushroom tyrosinase activity, with an $IC_{50}$ value of $40{\mu}M$. Taken together, these results suggest that esculetin could serve as an effective skin-lightening agent that inhibits melanin production by regulating the activity of melanogenic enzymes.

물푸레나무 수피 추출물은 주요 생활성 물질로서 esculetin과 esculin을 포함하고 있다. 이 가운데, Esculetin은 B16F10 melanoma cells에서 $IC_{50}$ value $2.8{\mu}M$의 아주 좋은 melanogenesis 억제 활성을 나타내며, 이를 통해 Melan-A cell에서 melanin 합성을 감소시킨다. 더욱이, esculetin은 mushroom tyrosinase에서도 $IC_{50}$ value $40{\mu}M$의 억제 활성을 나타내어 melanin biosynthesis를 저해한다. 위의 결과들로서, 우리는 melanogenic enzyme 활성 조절에 의해 melanin 생성을 저해하는 효과적인 피부미백 물질로서 esculetin을 제안하고자 한다.

Keywords

References

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