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http://dx.doi.org/10.15230/SCSK.2014.40.1.89

Depigmenting Effects of Esculetin and Esculin Isolated from Fraxinus rhynchophyllaHance  

Hong, Yong Deog (Amorepacific Corporation R&D Unit)
Nam, Mi Hee (Amorepacific Corporation R&D Unit)
Lee, Chang Suk (Amorepacific Corporation R&D Unit)
Shin, Song Seok (Amorepacific Corporation R&D Unit)
Park, Young Ho (Amorepacific Corporation R&D Unit)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.40, no.1, 2014 , pp. 89-94 More about this Journal
Abstract
Stem bark extracts of Fraxinus rhynchophylla Hance were found to contain two major bioactive components, esculetin and esculin. Esculetin substantially inhibited melanogenesis in B16F10 melanoma cells, with an $IC_{50}$ value of $2.8{\mu}M$, and reduced melanin synthesis in Melan-A cells. Moreover, esculetin suppressed melanin biosynthesis by inhibiting mushroom tyrosinase activity, with an $IC_{50}$ value of $40{\mu}M$. Taken together, these results suggest that esculetin could serve as an effective skin-lightening agent that inhibits melanin production by regulating the activity of melanogenic enzymes.
Keywords
Fraxinus rhynchophylla Hance; melanogenesis; tyrosinase; esculetin; esculin;
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