• International Journal of Industrial Entomology and Biomaterials
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• v.23 no.1
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• pp.123-128
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• 2011

1-Deoxynojirimycin (DNJ) is an alkaloid that is found at relatively high concentrations in mulberry leaf and tissues of the silkworm, $Bombyx$ $mori$. DNJ is a well known inhibitor of ${\alpha}$-glucosidase, an enzyme that is involved in the early stages of the $N$-linked glycoprotein synthesis pathway. ${\alpha}$-Glucosidase activity in the cell extract from $B.$ $mori$-derived Bm5 cells showed approximately 40-fold less sensitivity to DNJ than ${\alpha}$-glucosidase activity in the cell extract from $Spodoptera$ $frugiperda$-derived Sf9 cells. The replication of $B.$ $mori$ nucleopolyhedrovirus (BmNPV) was not inhibited when it was propagated in BmN cells that were grown in medium containing up to 10 mM DNJ. In contrast, the replication of $Autographa$ $californica$ multiple NPV (AcMNPV) was reduced by 67% when it was propagated in Sf9 cells that were grown in medium containing 10 mM DNJ. The viability of Bm5 and Sf9 cells that were grown in medium containing up to 10 mM DNJ was not affected. Our results suggested that the reduced replication of AcMNPV was the result of the higher sensitivity of ${\alpha}$-glucosidase activity in Sf9 cells to DNJ.

• Journal of the Korea Convergence Society
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• v.11 no.3
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• pp.369-377
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• 2020

Self-leadership is a positive factor for the organization and individuals, and it is a necessary competency for nursing students. The purpose of present study was to examine the factors affecting self-leadership. 173 nursing students in D city were collected and analyzed through a structured questionnaire. Self-leadership of nursing students had a positive correlation with creativity (r=.546, p<.001), self-assertion (r=.217, p=.004) and self-esteem (r=.258, p=.001). In addition, the influencing factors for self-leadership of nursing students were gender(β=.212, p=.001), grade(β=.123, p=.060), interpersonal relationship 'very good'(β=.327,p=.007), 'good'(β=.395, p=.023), 'moderate' (β=.328, p=.040) and creativity(β=.578, p<.001). Explanatory power was 35.5%. It is noteworthy to consider creativity and interpersonal relationship in developing strategy to improve self-leadership of nursing students.

• The Journal of the Convergence on Culture Technology
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• v.7 no.4
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• pp.237-242
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• 2021

The purpose of this study was to investigate the effect of patient safety competencies and ethical climate in long-term care hospital nurses and to provide the basic data. Data were collected from 120 in D city and analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple regression using SPSS/WIN 25.0. The degree of Patient Safety Competencies in long-term care hospital nurses was 3.45± .41. There were not significant differences in Patient Safety. There was positive correlation between patient safety competencies and peer(r=.123, p<.001), manager(r=.241, p<.001), and hospital(r=.241, p<.001). The factors affecting the patient safety competencies confidence of the study subjects were peer(β=.23, p=.003), manager(β=.55, p=.004), hospital(β=.43, p=.031), with an explanatory power of 33.5%. Through this research requires the fellow study to determine the factors affecting patient safety competencies confidence of long-term care hospital nurses.

• Journal of Applied Biological Chemistry
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• v.52 no.4
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• pp.163-169
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• 2009

A total of 155 microbial strains were isolated from the Korean traditional soybean paste based on their morphological features on the growth of agar plate. Among the isolated strains, a total of 28 strains were capable of hydrolyzing isoflavone glycoside to isoflavone aglycone efficiently in the soybean paste. Finally, two strains, K123-1 and SI, were selected because of their resistance to 15% NaCl and ability to convert isoflavone glycoside to isoflavone aglycone efficiently during the fermentation of soybean paste. The isolated strains K123-1 and SI were identified to be Pichia guilliermondii and Candida fermentati, respectively, using the partial 26S rDNA sequence analysis and phylogenic analysis. Pichia guilliermondii K123-1 and Candida fermentati SI converted daidzin to daidzein up to 96% and 95%, respectively, and genistin to genistein up to 92% when soybean pastes were fermented at $30^{\circ}C$ for 20 days with a single isolated strain. Pichia guilliermondii K123-1 and Candida fermentati SI were able to grow in the presence of 15% NaCl on both liquid medium and agar plate. We think that Pichia guilliermondii K123-1 and Candida fermentati SI might be one of good candidates for making functional soybean paste because they are isolated from the Korean traditional soybean paste and have a good ability to convert isoflavone glycosides to isoflavone aglycones and a high salt tolerance.

• The Korean Journal of Nuclear Medicine
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• v.39 no.6
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• pp.481-488
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• 2005

Purpose: Functional imaging of dopamine transporter (DAT) defines integrity of the dopaminergic system, and DAT is the target site of drugs of abuse such as cocaine and methamphetamine. Functional imaging the DAT may be a sensitive and selective indicator of neurotoxic change by the drug. The aim of the present study is to evaluate the clinical implications of qualitative/quantitative analyses of dopamine transporter imaging in methamphetamine abusers. Materials and Methods: Six detoxified methamphetamine abusers (abuser group) and 4 volunteers (control group) were enrolled in this study. Brain MRI was performed in all of abuser group. Abuser group underwent psychiatric and depression assessment using brief psychiatric rating scale (BPRS) and Hamilton depression rating scale (HAMD), respectively. All of the subjects underwent I-123 IPT SPECT (IPT SPECT). IPT SPECT image was analysed with visual qualitative method and quantitative method using basal ganglia dopamine transporter (DAT) specific/non-specific binding ratio (SBR). Comparison of DAT SBR between abuser and control groups was performed. We also performed correlation tests between psychiatric and depression assessment results and DAT SBR in abuser group. Results: All of abuser group showed normal MRI finding, but had residual psychiatric and depressive symptoms, and psychiatric and depressive symptom scores were exactly correlated (r=1.0, p=0.005) each other. Five of them showed abnormal finding on qualitative visual I-123 IPT SPECT Abuser group had lower basal ganglia DAT SBR than that of control ($2.38{\pm}0.20\;vs\;3.04{\pm}0.27$, p=0.000). Psychiatric and depressive symptoms were negatively well correlated with basal ganglia DAT SBR (r=-0.908, p=0.012, r=-0.924, p=0.009). Conclusion: These results suggest that dopamine transporter imaging using I-123 IPT SPECT may be used to evaluate dopaminergic system of the basal ganglia and the clinical status in methamphetamine abusers.

• Proceedings of the Korean Information Science Society Conference
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• 2012.06d
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• pp.121-123
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• 2012

스마트폰 이용자가 지속적으로 증가하면서 공공정보에 대한 관심이 높아지고 있다. 국가R&D사업 관련 정보를 종합적으로 서비스 중인 국가과학기술지식정보서비스(NTIS)도 국가연구개발 조사 분석 원시자료 등 국가R&D 데이터 제공 요구가 지속적으로 증가하고 있다. 본 논문에서는 선진국의 공공정보 제공 현황과 국내 현황을 살펴보고, 국가R&D정보 공개 개방 확대 전략 및 국가R&D정보 공유 확대를 위한 모바일 서비스 개선 방안을 제안한다.

• International Journal of Reliability and Applications
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• v.1 no.2
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• pp.123-131
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• 2000

This paper concerns with the consistent estimator for the fuzzy expectation of a random variable taking values in the space F($R^p$) of upper semicontinuous convex fuzzy subsets of $R^p$ with compact support. We introduce the concept of a fuzzy sample mean and show that the fuzzy sample mean is a strong consistent estimator for the fuzzy expectation. Some examples are given to illustrate the main result.

• Journal of the Korean Chemical Society
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• v.39 no.2
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• pp.123-126
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• 1995

• Proceedings of the Korean Information Science Society Conference
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• 2002.10e
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• pp.121-123
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• 2002

본 논문은 기업 및 개인간의 정보 교환을 지원하는 토픽 기반 메시지 시스템을 구현한다. 기존의 등록(Subscribe)／발표(Publish) 메시지 시스템과 동일한 기능을 수행하는 등록(Subscribe)／발표(Post) 메시지 시스템으로 메시지를 처리하는 서버인 메시지 처리기와 ActiveX 컨트롤을 사용한 클라이언트로 구성된다. 메시지 처리기는 운영체계에 의존하지 않고 독립적으로 작동하고, 클라이언트는 Win32용과 웹 기반으로 구현하여 특정 운영체계에 국한되지 않고 웹 기반을 포함한 다양한 환경에서 사용 가능하도록 가용성을 높였다.

• Journal of Technology Innovation
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• v.11 no.2
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• pp.123-149
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• 2003

The paper examines the effects of tax incentives on corporate R&D expenditures. We regress tax incentives and financial variables on the increase or the level of corporate R&D expenditures. Tax incentive variables are the magnitude of R&D tax credit and the level of reserve for R&D, while financial variables are the amount or increase of R&D expenditures in prior years, profitability, cash flows and Tobin Q. Sample firms are selected among the listed companies which reported R&D expenditures in the financial statements from 1995 to 2000. The results indicate that increase and level of R&D expenditures is positively influenced by the magnitude of R&D tax credit and the level of reserve for R&D. The amount of R&D expenditures has positive relationship with prior one-year R&D expenditures, while the increase of R&D expenditures has negative relationship with prior year increase and recent three year's average of R&D expenditures. The evidence is consistent to the hypothesis and results of other studies, which suggest that tax incentives for R&D encourage the corporate R&D expenditures.