• Bulletin of the Korean Chemical Society
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• v.27 no.7
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• pp.1038-1042
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• 2006

A new type of DTPA-bis-amides (L1-L4) and their Gd(III)-complexes of the type $[Gd(L)(H_2O)]{\cdot}nH_2O$ (5: L1; 6: L2; 7: L3; 8: L4) have been prepared and characterized by analytical and spectroscopic techniques. The X-ray crystal structure of 8 has been determined for structural confirmation. The coordination geometry adopts a tricapped trigonal prism geometry with L4 acting as a chelate octadentate and a water molecule in the coordination sphere. Crystals are monoclinic, $P2_1$, a = 14.468(3), b = 19.235(4), c = 13.527(2) $\AA$ $\beta$ = $107.245(3)^{\circ}$, V = 3595.2(11) $\AA^3$, Z = 4, $D_{calc}$ = 1.570. Significant increases in relaxivities are observed with 6 and 7 as compared with that of $Omniscan^{(R)}$, a commercial MR agent: R1 = 12.46 $mM^{-1}\;s^{-1}$, R2 = 8.76 $mM^{-1}\;s^{-1}$ for 6; R1 = 12.77 nm-1 s-1, R2 = 7.60 mM-1 s-1 for 7; R1 = 4.9 $mM^{-1}\;s^{-1}$, R2 = 4.8 $mm^{-1}\;s^{-1}$ for $Omniscan^{(R)}$. In the case of 5, however, both R1 and R2 are found to be lower to show 2.09 $mM^{-1}\;s^{-1}$, and 1.82 $mM^{-1}\;s^{-1}$, respectively.

• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.176-180
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• 2012

The stability of triamcinolone in three kinds of oral liquid syrups at 4 and $25^{\circ}C$ was studied for 21 days. Twenty tablets of 4 mg triamcinolone were mixed with 100 mL of each oral liquid syrup, which is Levotuss$^{(R)}$Syrup (levodropropizine 6 mg/mL), Ucerax$^{(R)}$Syrup (hydroxyzine 2 mg/mL), and Xyzal$^{(R)}$Liquid (levocetirizine 0.5 mg/mL). The chromatographic analysis after deliberate degradation showed no evidence of any breakdown product likely to interfere with the chromatographic peak of the parent substance. The relationship between triamcinolone concentrations and peak areas was linear from 50 to 1000 ${\mu}g/mL$ ($r^2$ = 0.9998). The analysis method was precise, with coefficients of variation no greater than 5.4%. Triamcinolone was stable for up to 14 and 21 days in Levotuss$^{(R)}$Syrup at 25 and $4^{\circ}C$, respectively; in Ucerax$^{(R)}$Syrup and Xyzal$^{(R)}$Syrup, it was stable for at least 21 days at both temperatures. The percentages of initial triamcinolone concentration remaining after 21 days were $72.3{\pm}3.2$ and $94.9{\pm}6.0%$ and $93.2{\pm}4.9$ and $92.4{\pm}5.7%$, and $92.6{\pm}1.2$ and $92.7{\pm}2.2%$ in Levotuss$^{(R)}$Syrup, Ucerax$^{(R)}$Syrup, and Xyzal$^{(R)}$Syrup at 25 and $4^{\circ}C$, respectively. The pH variations of all test solutions were within 0.8. Based on the results, it was concluded that triamcinolone in three oral liquid syrups which are Levotuss$^{(R)}$syrup, Ucerax$^{(R)}$syrup and Xyzal$^{(R)}$syrup was chemically and physically stable in both states of refrigeration and room temperature for at least 14 days.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.4
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• pp.540-548
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• 2015

This study examined the cultural characteristics and biological activities of fermented rice and amaranth with Bacillus subtilis KMKW4. These samples were made with various amounts of rice and amaranth [100:0 (R100), 90:10 (R90), 80:20 (R80), and 70:30 (R70)]. B. subtilis KMKW4 was used as starter for the fermentation, and its cultures at the lated logarithmic growth were inoculated for final concentration of 2% (v/v). Number of viable cells of fermented R80 (7.67 log CFU/mL) was greater than those of R100, R90, and R70 (7.48 log CFU/mL, 7.38 log CFU/mL, and 7.09 CFU/mL, respectively) during the fermentation period (120 h). Amylase activities of fermented R80 and R100 were 57.77 U/mL and 19.91 U/mL, respectively. Furthermore, amylase activities of fermented freeze-dried powders of R100 and R80 were 24.31 U/g and 9.12 U/g, respectively. Free sugar contents of R100 and R80 increased after fermentation, and that of R80 (5,454.15 mg/100 g) significantly increased compared to that of R100 (4,274.85 mg/100 g). The free amino acid content of R80 was higher than that of R100. DPPH and superoxide radical scavenging activities of 5 mg/mL of fermented freeze-dried powder (R80) were 44.21% and 89.76%, respectively. ACE inhibition rates and ${\alpha}$-glucosidase inhibitory activities were significantly higher in R80 than R100. This study suggested that fermentation of R80 might be a new potential source of antioxidant, anti-diabetic, and anti-hypertensive agents applicable to grain enzyme-containing foods.

• Journal of applied mathematics & informatics
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• v.5 no.3
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• pp.819-826
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• 1998

The purpose of this paper is to prove the following results; (1) Let R be a prime ring of char $(R)\neq 2$ and I a nonzero left ideal of R. The existence of a nonzero symmetric bi-derivation D : $R\timesR\;\longrightarrow\;$ such that d is sew-commuting on I where d is the trace of D forces R to be commutative (2) Let m and n be integers with $m\;\neq\;0.\;or\;n\neq\;0$. Let R be a noncommutative prime ring of char$ (R))\neq \; 2-1\; p_1 \;n_1$ where p is a prime number which is a divisor of m, and I a nonzero two-sided ideal of R. Let $D_1$ ; $R\;\times\;R\;\longrightarrow\;and\;$ $D_2\;:\;R\;\times\;R\;longrightarrow\;R$ be symmetric bi-derivations. Suppose further that there exists a symmetric bi-additive mapping B ; $R\;\times\;R\;\longrightarrow\;and\;$ such that $md_1(\chi)\chi ＋ n\chi d_2(\chi)=f(\chi$) holds for all $\chi$$\in$I, where $d_1 \;and\; d_2$ are the traces of $D_1 \;and\; D_2$ respectively and f is the trace of B. Then we have $D_1=0 \;and\; D_2=0$.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4937-4944
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• 2015

MicroRNAs (miRNAs) are emerging as critical regulators in carcinogenesis and tumor progression. Recently, miR-99a has been reported as a tumor suppressor gene in various human cancers, but its functions in the context of anaplastic thyroid cancer (ATC) remain unknown. In this study, we reported that miR-99a was commonly downregulated in ATC tissue specimens and cell lines with important functional consequences. Overexpression of miR-99a not only dramatically reduced ATC cell viability by inducing cell apoptosis and accumulation of cells at G1 phase, but also inhibited tumorigenicity in vivo. We then screened and identified a novel miR-99a target, mammalian target of rapamycin (mTOR), and it was further confirmed by luciferase assay. Up-regulation of miR-99a would markedly reduce the expression of mTOR and its downstream phosphorylated proteins (p-4E-BP1 and p-S6K1). Similar to restoring miR-99a expression, mTOR down-regulation suppressed cell viability and increased cell apoptosis, whereas restoration of mTOR expression significantly reversed the miR-99a antitumor activity and the inhibition of mTOR/p-4E-BP1/p-S6K1 signal pathway profile. In clinical specimens and cell lines, mTOR was commonly overexpressed and its protein levels were statistically inversely correlated with miR-99a expression. Taken together, our results demonstrated for the first time that miR-99a functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting the mTOR/p-4E-BP1/p-S6K1 pathway in ATC cells. Given these, miR-99a may serve as a novel prognostic/diagnostic and therapeutic target for treating ATC.

• Communications of the Korean Mathematical Society
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• v.34 no.1
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• pp.1-16
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• 2019

Let a, b, P, and Q be real numbers with $PQ{\neq}0$ and $(a,b){\neq}(0,0)$. The Horadam sequence $\{W_n\}$ is defined by $W_0=a$, $W_1=b$ and $W_n=PW_{n-1}+QW_{n-2}$ for $n{\geq}2$. Let the sequence $\{X_n\}$ be defined by $X_n=W_{n+1}+QW_{n-1}$. In this study, we obtain some new identities between the Horadam sequence $\{W_n\}$ and the sequence $\{X_n\}$. By the help of these identities, we show that Diophantine equations such as $$x^2-Pxy-y^2={\pm}(b^2-Pab-a^2)(P^2+4),\\x^2-Pxy+y^2=-(b^2-Pab+a^2)(P^2-4),\\x^2-(P^2+4)y^2={\pm}4(b^2-Pab-a^2),$$ and $$x^2-(P^2-4)y^2=4(b^2-Pab+a^2)$$ have infinitely many integer solutions x and y, where a, b, and P are integers. Lastly, we make an application of the sequences $\{W_n\}$ and $\{X_n\}$ to trigonometric functions and get some new angle addition formulas such as $${\sin}\;r{\theta}\;{\sin}(m+n+r){\theta}={\sin}(m+r){\theta}\;{\sin}(n+r){\theta}-{\sin}\;m{\theta}\;{\sin}\;n{\theta},\\{\cos}\;r{\theta}\;{\cos}(m+n+r){\theta}={\cos}(m+r){\theta}\;{\cos}(n+r){\theta}-{\sin}\;m{\theta}\;{\sin}\;n{\theta},$$ and $${\cos}\;r{\theta}\;{\sin}(m+n){\theta}={\cos}(n+r){\theta}\;{\sin}\;m{\theta}+{\cos}(m-r){\theta}\;{\sin}\;n{\theta}$$.

• Bulletin of the Korean Mathematical Society
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• v.56 no.5
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• pp.1187-1198
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• 2019

Let R be a domain with its field Q of quotients. An R-module M is said to be weak w-projective if $Ext^1_R(M,N)=0$ for all $N{\in}{\mathcal{P}}^{\dagger}_w$, where ${\mathcal{P}}^{\dagger}_w$ denotes the class of GV-torsionfree R-modules N with the property that $Ext^k_R(M,N)=0$ for all w-projective R-modules M and for all integers $k{\geq}1$. In this paper, we define a domain R to be w-Matlis if the weak w-projective dimension of the R-module Q is ${\leq}1$. To characterize w-Matlis domains, we introduce the concept of w-Matlis cotorsion modules and study some basic properties of w-Matlis modules. Using these concepts, we show that R is a w-Matlis domain if and only if $Ext^k_R(Q,D)=0$ for any ${\mathcal{P}}^{\dagger}_w$-divisible R-module D and any integer $k{\geq}1$, if and only if every ${\mathcal{P}}^{\dagger}_w$-divisible module is w-Matlis cotorsion, if and only if w.w-pdRQ/$R{\leq}1$.

• Journal of The Korean Society of Grassland and Forage Science
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• v.20 no.4
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• pp.285-294
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• 2000

To investigate the effect of Mycorrhiza (Glomus intradics) and Rhizobium inoculation on the N, P utilization and growth response of Alfalfa (Medicago saliva L.) and Perennial ryegrass (Lolium perenne L.) in mixed sward, four treatments (non-inoculation, Control; Mycorrhiza inoculation: M; Rhizobium inoculation, R and Mycorrhiza and Rhizobium inoculation, M+R) were applied. The associated analyses were canied out on the early vegetative growth stage (DAS 56, 56 days after seeding) and on the early flowering stage (DAS 126). The decreased rate of total N and P content in soil, with advancing plant growth, was relatively higher in the M and M + R treatment than control. The content of availabie phosphorus in soil at DAS 126 increased by about 34 and 38 % in M and M+R treatment compared to control (189.2 mg PzOskg DM), while non-significant changes was observed in R treatment. Total N uptake and P uptake in the control at DAS 126 were 44.71 and 3.52 mglplant in mixed sward, respectively. About 71, 98 and 197 % of increases in total N uptake and 70, 72 and 11 1 % of increases in total P uptake were estimated in M, R and M+R treatment. Comparing to control, total dry matter yield significantly increased by 27, 33 and 53 %, and crude protein yield also by 78, 83 and 204 %, respectively, in M, R and M+R treatment. The present data indicated that mycorrhiza orland rhizobium inoculation improved N, P utilization of both alfalfa and perennial ryegrass plants, and consequently increased total yield (especially by dual inoculation, M+R). (Key words : Alfalfa, Perennial ryegrass, Mycorrhiza, Rhizobium, N and P Utilization, Growth, Yield)

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.3
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• pp.619-626
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• 2013

The design of PN(Pseudo Noise) sequences with good cross-correlation properties is important for many research areas in communication systems. In this paper we propose new family of binary sequences $S^r=\{Tr_1^m\{[Tr_m^n(a{\alpha}^t+{\alpha}^{dt})]^r\}{\mid}a{\in}GF(2^n),\;0{\leq}t<2^n-1\}$ composed of Gold-like sequences and find the value of cross-correlation function when $d=2^{n-1}(3{\cdot}2^m-1)$, where n=2k, gcd(r, $2^m-1$)=1. Also we analyze the linear span of $S^r$ for some special r. Proposed sequences are extension of Gold-like sequences and GMW-sequences.

• Bulletin of the Korean Mathematical Society
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• v.47 no.3
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• pp.611-622
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• 2010

A ring R is called left max-coherent provided that every maximal left ideal is finitely presented. $\mathfrak{M}\mathfrak{I}$ (resp. $\mathfrak{M}\mathfrak{F}$) denotes the class of all max-injective left R-modules (resp. all max-flat right R-modules). We prove, in this article, that over a left max-coherent ring every right R-module has an $\mathfrak{M}\mathfrak{F}$-preenvelope, and every left R-module has an $\mathfrak{M}\mathfrak{I}$-cover. Furthermore, it is shown that a ring R is left max-injective if and only if any left R-module has an epic $\mathfrak{M}\mathfrak{I}$-cover if and only if any right R-module has a monic $\mathfrak{M}\mathfrak{F}$-preenvelope. We also give several equivalent characterizations of MI-injectivity and MI-flatness. Finally, $\mathfrak{M}\mathfrak{I}$-dimensions of modules and rings are studied in terms of max-injective modules with the left derived functors of Hom.