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Monte Carlo Simulation of Plasma Caffeine Concentrations by Using Population Pharmacokinetic Model

  • Han, Sungpil;Cho, Yong-Soon;Yoon, Seok-Kyu;Bae, Kyun-Seop
    • Proceeding of EDISON Challenge
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    • 2017.03a
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    • pp.677-687
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    • 2017
  • Caffeine has a long history of human consumption but the consumption of caffeine due to caffeinated energy drinks(CEDs) is rapidly growing. Marketing targets of CED sales are children, adolescents and young adults, possibly caffeine-sensitive groups and its effect for them can be significantly different from healthy adults. Caffeine-related toxicities among these groups are growing in number and a number of countries are recognizing severity of caffeine toxicities. Previous research showed prediction of maximal plasma caffeine concentration profiles after the single CED ingestion and the primary aim of this study is to visually predict plasma caffeine concentration after the single and multiple ingestion of standard servings of CED. Based on the population pharmacokinetic model using Monte Carlo simulation, prediction of caffeine concentration leading to caffeine intoxication in the sensitive groups is quantitatively presented and visualized. This research also broadens the perspective by creating and utilizing diverse open science tools including R package, Edison Science App and Shiny apps.

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A Comparative Study of Radiographic Images on Normal Anatomical Structures (정상 해부학적 구조물에 대한 X-선 영상의 비교 연구)

  • Choi Heang-Hee;Choi Eui-Hwan;Kim Jae-Duk
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.29 no.1
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    • pp.283-297
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    • 1999
  • Purpose: To compare radiographic images of Digora/sup (R)/ system and Ektaspeed Plus film obtained from normal adults. Materials and methods: Storage phosphor plate(SPP) was placed in a film holder behind Ektaspeed Plus film package without lead foil. The effect of film on SPP was studied in a separate in vitro experiment. Forty-seven sets of images were prepared for the evaluaton. The regions of interest(ROI) for evaluation were designated at seven sites including normal anatomical structures. The image quality for each ROI was evaluated on enhanced and unenhanced storage phosphor(SP) images and Ektaspeed Plus film. Results: Two film-SPP configurations showed significantly different gray levels at each step of the aluminum step wedge(p<0.05). The contrasts were comparable. Enhanced SP images were significantly superior to unenhaned images and film in all anatomical sturctures(p<0.01). The differences between unenhanced SP images and film were significant(p<0.05) except root canal and cortical bone on alveolar crest. For anatomical items. there were statistically significant difference among five observers(p<0.05). Conclusions: The image quality of enhanced SP images were superior to Ektaspeed Plus film. and Digora system is potentially applicable to clinical diagnosis.

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Time-domain analysis of nonlinear motion responses and structural loads on ships and offshore structures: development of WISH programs

  • Kim, Yong-Hwan;Kim, Kyong-Hwan;Kim, Jae-Han;Kim, Tae-Young;Seo, Min-Guk;Kim, Yoo-Il
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.3 no.1
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    • pp.37-52
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    • 2011
  • The present paper introduced a computer program, called WISH, which is based on a time-domain Rankine panel method. The WISH has been developed for practical use to predict the linear and nonlinear ship motion and structural loads in waves. The WISH adopts three different levels of seakeeping analysis: linear, weakly-nonlinear and weak-scatterer approaches. Later, WISH-FLEX has been developed to consider hydroelasticity effects on hull-girder structure. This program can solve the springing and whipping problems by coupling between the hydrodynamic and structural problems. More recently this development has been continued to more diverse problems, including the motion responses of multiple adjacent bodies, the effects of seakeeping in ship maneuvering, and the floating-body motion in finite-depth domain with varying bathymetry. This paper introduces a brief theoretical and numerical background of the WISH package, and some validation results. Also several applications to real ships and offshore structures are shown.

HVAC & Refrigeration System for Work Barge Vessel (WORK BARGE 선의 냉동.공조 SYSTEM)

  • Nam, Im-Woo;Jung, Jae-Chun;Kim, Bong-Je
    • Proceedings of the SAREK Conference
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    • 2008.06a
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    • pp.583-590
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    • 2008
  • 최근 작업자 숙소 및 이송용 외에 작업용으로 사용 가능한 Barge선의 일종인 Accommodation Work Barge 선의 건조량이 증가 추세인 바 현재 중국에서 건조 중인 해당 선박의 HVAC & Refrigeration system에 대하여 정리하였다. 본 시스템은 R404A Direct expansion 냉각방식 (직접팽창방식)이 적용되었으며 HVAC system 중 Air conditioning 부분에 대해서는 선박의 각 Deck 기준으로 Zoning 하여 개별적인 Air handling unit와 Condensing unit를 구성하였으며 (각 unit의 용량은 필요용량의 100%), 냉동 창고의 Refrigeration system은 해당 격실 (육고, 어고, 야채고)에 각각 Unit cooler를 설치하고, Condensing unit를 기계실에 설치하였다. 장비는 전체 용량 100%에 대하여 항시 운전하는 100% 용량의 장비와 비상시에 운전하는 100% 용량의 예비 장비로 구성된다. 냉동 창고에 인접한 Dry provision store는 냉동 창고와는 별개로 중앙 공조기로부터의 냉각 공기를 이용하여 Spot cooling하였다. 본 System의 구성에 대한 장점 및 단점은 아래와 같다. 1. Air conditioning system이 각 Zone에 대하여 구성되므로 각 Zone에 대하여 제어가 가능하다. 2. Air con. 실에 Air handling unit와 Condensing unit가 설치되므로 냉매 배관의 길이가 짧다. 3. Air con. 실에 Air handling unit와 Condensing unit가 설치되므로 실내의 Maintenance space 상에 여유가 없다.

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Electrochemical Determination of Bisphenol A at Carbon Nanotube-Doped Titania-Nafion Composite Modified Electrode

  • Kim, Byung Kun;Kim, Ji Yeon;Kim, Dong-Hwan;Choi, Han Nim;Lee, Won-Yong
    • Bulletin of the Korean Chemical Society
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    • v.34 no.4
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    • pp.1065-1069
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    • 2013
  • A highly sensitive electrochemical detection method for bisphenol A (BPA) has been developed by using multi-walled carbon nanotube (CNT)-doped titania-Nafion composite modified glassy carbon (GC) electrode. The CNT-titania-Nafion/GC electrode exhibited excellent electrocatalytic activity towards BPA. Therefore, the CNT-titania-Nafion/GC electrode showed improved voltammetric responses for BPA compared to that obtained with bare GC electrode. In addition, cetyltrimethylammonium bromide (CTAB), a cationic surfactant, was added into the BPA sample solution in order to accumulate BPA through hydrophobic interaction between CTAB and BPA. The CNT-titania-Nafion/GC electrode gave a linear response ($r^2$ = 0.999) for BPA from $1.0{\times}10^{-8}$ M to $5.0{\times}10^{-6}$ M with a detection limit of $9.0{\times}10^{-10}$ M (S/N = 3). The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present electrochemical sensor based on the CNT-titania-Nafion/GC electrode was applied to the determination of BPA in food package samples.

3D FEM Analysis of Warm Forging Process Design for Socket at Automotive Steering Unit (자동차 조향장치용 소???R의 온간단조 공정 설계를 위한 3차원 유한요소해석)

  • Lee Y. S.;Lee J. H.;Lee J. Y.;Bae M. H.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2001.05a
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    • pp.186-189
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    • 2001
  • In keeping with the needs of the times for energy and labor saving and simplifying production processes, interests has been growing in warm forging. Moreover, it is interested in increasing the material usage and production amounts. To improve the productivity and material usage, it is studied the process design of warm forging for socket. Until now, socket is manufactured by hot forging in hammer. The percentage of material usage is under $60\%$ in hammer forging. On the other han4 the percentage can be increased over $90\%$ in warm forging. To change the process from hot forging to warm forging, process designs must be performed. In this time, by using the FEM package, DEFORM-3D, we could get the shape of 1st process and minimum sealing pressure. They are very essential design data to decrease the trial and error. Practically, the overlap defect could be detected and eliminated with design modification of rib height and fillet radius. Moreover, forging load and minimum sealing pressure was defined by the 3D FEM analysis.

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A Study on the Effect of Insulating Sleeve on Solidification Characteristics of A356 Aluminum Alloy (절연슬리브가 A356 알루미늄 합금의 응고과정에 미치는 영향에 대한 연구)

  • Oh, Min-Joo;Yoo, Seung-Mok;Cho, In-Sung;Kim, Young-Hyun
    • Journal of Korea Foundry Society
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    • v.31 no.4
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    • pp.205-211
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    • 2011
  • Al-Si alloys have been steadily used as a potential material for the achievement of an efficient weight reduction in the automobile and aerospace industries due to its excellent castability and high strength-to-weight ratio. In this study, riser effect and mechanical properties were investigated according to the size of the sleeve. In addition, the effects of riser size on mechanical properties of castings were investigated. On the other hand flow and solidification process were simulated with a hybrid FDM/FEM package named ZCast. As a result, results of simulation and experiments were comparable regarding to the yield strength, tensile strength, elongation and hardness of casting. It proves the reliability of the simulation. It is expected that the proper size of riser can improve the recycling rate of metallic materials and reduce the cost of casting.

A Study on Effects of Critical Thinking Dispositions on Vocational Personality in University Students (대학생들의 비판적 사고 성향이 직업적 성격에 미치는 영향)

  • Yune, So-Jung;Shin, Su-Jin;Lee, Eun-Young
    • Journal of Fisheries and Marine Sciences Education
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    • v.19 no.2
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    • pp.206-218
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    • 2007
  • The purpose of this study was to investigate effects of critical thinking dispositions on vocational personalities in university students. Subjects were 111 University students in Busan. The questionnaire used in this research were Holland's Vocational Personality Questionnaire and California Critical Thinking Disposition Inventory. The results were analyzed by correlation analysis and enter multiple regression using the SPSS statistical package (SPSS for windows 12.0; SPSS Inc., Chicago, IL, USA). The study results were as follow: First, the students had much more S and R vocational personality characteristics than the others in vocational personality characteristics and had higher inquisitiveness and self-confidence scores than the others in critical thinking dispositions. Second, there were significant relationships between vocational personality types and critical thinking dispositions. Third, some of the vocational personality types were affected by the critical thinking dispositions. Especially I, E, and C personality of vocational personalities were prospected by critical thinking dispositions. Therefore, It's necessary that we understand the relationships between vocational personality types and critical thinking dispositions. Also we have to think over how to development career programs for university students to match to the learner's vocational personality type and critical thinking dispositions.

VLSI Implementation of Forward Error Control Technique for ATM Networks

  • Padmavathi, G.;Amutha, R.;Srivatsa, S.K.
    • ETRI Journal
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    • v.27 no.6
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    • pp.691-696
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    • 2005
  • In asynchronous transfer mode (ATM) networks, fixed length cells of 53 bytes are transmitted. A cell may be discarded during transmission due to buffer overflow or a detection of errors. Cell discarding seriously degrades transmission quality. The quality degradation can be reduced by employing efficient forward error control (FEC) to recover discarded cells. In this paper, we present the design and implementation of decoding equipment for FEC in ATM networks based on a single parity check (SPC) product code using very-large-scale integration (VLSI) technology. FEC allows the destination to reconstruct missing data cells by using redundant parity cells that the source adds to each block of data cells. The functionality of the design has been tested using the Model Sim 5.7cXE Simulation Package. The design has been implemented for a $5{\times}5$ matrix of data cells in a Virtex-E XCV 3200E FG1156 device. The simulation and synthesis results show that the decoding function can be completed in 81 clock cycles with an optimum clock of 56.8 MHz. A test bench was written to study the performance of the decoder, and the results are presented.

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Method for improving calculation of nonharmonic constants of tidal stations in Korea (한국연안의 비조화상수 개선에 관한 연구)

  • Kim, Yeong-Taek;Yu, Hak-Ryeol;Lee, Eun-Il
    • 한국지구과학회:학술대회논문집
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    • 2010.04a
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    • pp.59-62
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    • 2010
  • The limitation of constant for tide correction is identified using the T_tide $MATLAB^{(R)}$ package. A suggestion is presented in calculation of local phase lag(k) by a/15 (a is angular speed of any constituent in degree) from the g, phase lag measured by standard time meridian latitude.

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